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Hepatitis and co-infections

Section edited by Jean-Claude Desenclos

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Content type: Case report

    After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syn...

    Authors: Jing-Wen Zhang, Xiang-Zhong Zhang, Yan-Ling Sun, Bing Long, Xiao-Zhen Wang and Xu-Dong Li

    Citation: BMC Infectious Diseases 2019 19:57

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  2. Content type: Case report

    For patients with chronic hepatitis B and cirrhosis in less developed western regions in China, due to constraints of local economic conditions, the choice of treatment measures is often limited. However if pa...

    Authors: Yue-Rong Zhang, De-Ming Wu, Xiong-Chang Liu, Ning Zhou, Chang-Chun Cao, Wu-Hua Liu, Chun-Xia Wang and Hui Wang

    Citation: BMC Infectious Diseases 2019 19:49

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  3. Content type: Research article

    Hepatitis E virus (HEV) is a leading cause of hepatitis worldwide. However, its infection biology and pathogenesis remain largely elusive. Furthermore, no proven medication is available for treating hepatitis ...

    Authors: Wenhai Yu, Chenchen Yang, Xianhui Hao, Tianwu Ma and Fen Huang

    Citation: BMC Infectious Diseases 2018 18:687

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  4. Content type: Case report

    Hepatitis C virus (HCV) infection is a recognised cause of secondary immune thrombocytopenia (ITP). While its incidence has been largely described during chronic HCV infection, only one case of ITP secondary t...

    Authors: Vincent Alcazer, Patrick Miailhes, Christophe Ramière, Caroline Charre and Laurent Cotte

    Citation: BMC Infectious Diseases 2018 18:682

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  5. Content type: Research article

    Among HIV-infected MSM who have been treated for HCV infection, the HCV reinfection rate is high. It is therefore essential to understand their perceptions of HCV risk behaviour and risk-reducing strategies.

    Authors: Femke Lambers, Wendy van der Veldt, Maria Prins and Udi Davidovich

    Citation: BMC Infectious Diseases 2018 18:678

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  6. Content type: Research article

    The frequency of mild forms of hepatitis A, especially in children, could lead to underreporting. The objective of the study was to investigate the sensitivity of two surveillance systems, mandatory Statutory ...

    Authors: Gloria Carmona, Marta Vilaró, Pilar Ciruela, Mireia Jané, Lluis Giralt, Laura Ruiz, Sergi Hernández and Àngela Domínguez

    Citation: BMC Infectious Diseases 2018 18:633

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  7. Content type: Research article

    Nucleic acid tests performed on blood samples collected on Dried Blood Spot (DBS) and detection of HCV core antigen (HCVcAg) are two approaches that may facilitate access to HCV diagnosis in low and middle inc...

    Authors: Truong Tam Nguyen, Véronique Lemee, Karine Bollore, Hai Vinh Vu, Karine Lacombe, Xuan Lien Truong Thi, Que Anh Luong, Charline Dubos, Jean-Christophe Plantier, Huong Duong Thi, Didier Laureillard, Maud Lemoine and Edouard Tuaillon

    Citation: BMC Infectious Diseases 2018 18:622

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  8. Content type: Research article

    Hepatitis C Virus infection has been considered an important hidden pandemic in developing countries, particularly in Africa. It varies greatly from one region to another and even within districts of the same ...

    Authors: Mohamed A. Daw, Lutfi A. Buktir Ali, Amina M. Daw, Nadia E. M. Sifennasr, Aghnyia A. Dau, Mohamed M. Agnan and Abdallah El-Bouzedi

    Citation: BMC Infectious Diseases 2018 18:594

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  9. Content type: Research article

    According to the EASL and AASLD guidelines, the recommended treatment for patients who failed to achieve a sustained virologic response (SVR) on prior interferon-based triple therapy with protease inhibitors (...

    Authors: Ewa Janczewska, Dorota Zarębska-Michaluk, Hanna Berak, Anna Piekarska, Andrzej Gietka, Dorota Dybowska, Włodzimierz Mazur, Teresa Belica-Wdowik, Witold Dobracki, Magdalena Tudrujek-Zdunek, Zbigniew Deroń, Iwona Buczyńska, Marek Sitko, Agnieszka Czauż-Andrzejuk, Beata Lorenc, Jolanta Białkowska-Warzecha…

    Citation: BMC Infectious Diseases 2018 18:580

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  10. Content type: Research article

    There are randomized trials assessing a variety of antiviral drugs for hepatitis B virus (HBV), but the relative effectiveness of these drugs in the treatment of patients co-infected with human immunodeficienc...

    Authors: Cho Naing, Yong Poovorawan and Kew Siang Tong

    Citation: BMC Infectious Diseases 2018 18:564

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  11. Content type: Research article

    Hepatitis B virus (HBV) genotype E is a poorly studied genotype that almost exclusively occurs in African people. It seems to harbour intrinsic potential oncogenic activity and virological characteristics of i...

    Authors: José Ángel Cuenca-Gómez, Ana Belén Lozano-Serrano, María Teresa Cabezas-Fernández, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, Matías Estévez-Escobar, Isabel Cabeza-Barrera and Joaquín Salas-Coronas

    Citation: BMC Infectious Diseases 2018 18:568

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  12. Content type: Research article

    Clinical progression of HBV-related liver diseases is largely associated with the activity of HBV-specific T cells. Soluble fibrinogen-like protein 2 (sFGL2), mainly secreted by T cells, is an important effect...

    Authors: Hoang Van Tong, Nguyen Van Ba, Nghiem Xuan Hoan, Mai Thanh Binh, Dao Thanh Quyen, Ho Anh Son, Hoang Van Luong, Do Quyet, Christian G. Meyer, Le Huu Song, Nguyen Linh Toan and Thirumalaisamy P. Velavan

    Citation: BMC Infectious Diseases 2018 18:553

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  13. Content type: Research article

    Possible cardiotoxicity of sofosbuvir in humans has not been demonstrated yet. Also, since HCV can exert deleterious effects on hearth function, it is of interest to know whether HCV eradication provides any b...

    Authors: Maria Mazzitelli, Carlo Torti, Jolanda Sabatino, Greta Luana D’Ascoli, Chiara Costa, Vincenzo Pisani, Elena Raffetti, Salvatore De Rosa, Alessio Strazzulla, Alfredo Focà, Maria Carla Liberto and Ciro Indolfi

    Citation: BMC Infectious Diseases 2018 18:518

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  14. Content type: Research article

    Viral hepatitis is an important public health issue in sub-Saharan Africa. Due to rising mortality from cirrhosis and hepatocellular carcinoma and limited implementation of screening and treatment programmes, ...

    Authors: Alexander J Stockdale, Collins Mitambo, Dean Everett, Anna Maria Geretti and Melita A Gordon

    Citation: BMC Infectious Diseases 2018 18:516

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  15. Content type: Study protocol

    The World Health Organization recommends all men who have sex with men (MSM) receive Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) testing. MSM in China are a high-risk group for HBV and HCV infection, b...

    Authors: Thomas Fitzpatrick, Kali Zhou, Yu Cheng, Po-Lin Chan, Fuqiang Cui, Weiming Tang, Katie R Mollan, Wilson Guo and Joseph D Tucker

    Citation: BMC Infectious Diseases 2018 18:489

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  16. Content type: Research article

    As direct acting antiviral (DAA) therapy is progressively rolled out for patients with hepatitis C virus (HCV) infection, careful scrutiny of HCV epidemiology, diagnostic testing, and access to care is crucial...

    Authors: Emily Adland, Gerald Jesuthasan, Louise Downs, Victoria Wharton, Gemma Wilde, Anna L. McNaughton, Jane Collier, Eleanor Barnes, Paul Klenerman, Monique Andersson, Katie Jeffery and Philippa C. Matthews

    Citation: BMC Infectious Diseases 2018 18:461

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  17. Content type: Research article

    Despite the high sustained virological response rates achieved with current directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of treated patients do not respond to current a...

    Authors: María Eugenia Soria, Josep Gregori, Qian Chen, Damir García-Cehic, Meritxell Llorens, Ana I. de Ávila, Nathan M. Beach, Esteban Domingo, Francisco Rodríguez-Frías, María Buti, Rafael Esteban, Juan Ignacio Esteban, Josep Quer and Celia Perales

    Citation: BMC Infectious Diseases 2018 18:446

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  18. Content type: Research article

    This study was conducted to determine the prevalence of HBV, HCV, and HDV in urban populations and Amerindians living in the state of Tocantins (Eastern Amazon).

    Authors: Livia Melo Villar, Flavio Augusto Pádua Milagres, Elisabeth Lampe, Helena Medina Cruz, Leticia de Paula Scalioni, Monica de Avelar Figueiredo Mafra Magalhães, Anselmo Rocha Romão, Renata Gracie and Vanessa Salete de Paula

    Citation: BMC Infectious Diseases 2018 18:411

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  19. Content type: Research article

    It is difficult to diagnose ascites infection early in cirrhotic patients. The present study was to create and evaluate a new bioscore combined with PCT, sNFI and dCHC in the diagnosis of ascites infection in ...

    Authors: Han Wang, Yan Li, Fangfang Zhang, Ning Yang, Na Xie, Yuanli Mao and Boan Li

    Citation: BMC Infectious Diseases 2018 18:389

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  20. Content type: Research article

    Hepatitis C virus (HCV) infection is a widespread problem in prisons. The present study aimed to assess the prevalence of HCV seropositivity, HCV genotypes, factors associated with HCV seropositivity in newly ...

    Authors: Kristel Kivimets, Anneli Uusküla, Jeffrey V. Lazarus and Kristi Ott

    Citation: BMC Infectious Diseases 2018 18:339

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  21. Content type: Database

    There are several epidemiological studies available on hepatitis B virus among pregnant women in Ethiopia. These individual studies revealed wide variation over time and across geographical areas. The aim of t...

    Authors: Kindie Mitiku Kebede, Dejene Derseh Abateneh and Alemayehu Sayih Belay

    Citation: BMC Infectious Diseases 2018 18:322

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  22. Content type: Research article

    Tuberculosis (TB) and chronic Hepatitis B virus (HBV) infection are common in China. Fist-line anti-TB medications often produce drug-induced liver injury (DILI). This study sought to investigate whether TB pa...

    Authors: Lubiao Chen, Dujing Bao, Lin Gu, Yurong Gu, Liang Zhou, Zhiliang Gao and Yuehua Huang

    Citation: BMC Infectious Diseases 2018 18:295

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  23. Content type: Research article

    Hepatitis B vaccination is the most effective method of prevention for hepatitis B virus infection. It is a major public health problem in Nigeria, and health workers are at increased risk. This study determin...

    Authors: I. B. Omotowo, I. A. Meka, U. N. Ijoma, V. E. Okoli, O. Obienu, T. Nwagha, A. C. Ndu, D. O. Onodugo, L. C. Onyekonwu and E. O. Ugwu

    Citation: BMC Infectious Diseases 2018 18:288

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  24. Content type: Research article

    From September 2016–April 2017, Am Timan, Chad, experienced a large HEV outbreak in an urban setting with a limited impact in terms of morbidity and mortality. To better understand HEV epidemiology in this con...

    Authors: Larissa Vernier, Annick Lenglet, Boris M. Hogema, Ali M. Moussa, Cono Ariti, Simone Vollmer, Andrea Irwin, Prince Alfani, Sibylle Sang and Charity Kamau

    Citation: BMC Infectious Diseases 2018 18:287

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  25. Content type: Research article

    Hepatitis C (HCV) diagnosis and care is a major challenge for people who use illicit drugs, and is characterised by low rates of testing and treatment engagement globally. New approaches to fostering engagemen...

    Authors: Andy Guise, T. Charles Witzel, Sema Mandal, Caroline Sabin, Tim Rhodes, Anthony Nardone and Magdalena Harris

    Citation: BMC Infectious Diseases 2018 18:281

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  26. Content type: Research article

    Infants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of i...

    Authors: Meng Zhuo Cao, Yan Hua Wu, Si Min Wen, Yu Chen Pan, Chong Wang, Fei Kong, Chuan Wang, Jun Qi Niu, Jie Li and Jing Jiang

    Citation: BMC Infectious Diseases 2018 18:274

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  27. Content type: Research article

    Female gender and favorable IFNL3 genotypes are the primary independent predictors of spontaneous clearance of HCV infection. However, chronic hepatitis C infection occurs in numerous women carrying favorable IFN...

    Authors: Zhe Xie, Yuantao Li, Lu Long, Hua Liang, Weiping Cai and Tao Shen

    Citation: BMC Infectious Diseases 2018 18:254

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  28. Content type: Research article

    Spontaneous bacterial peritonitis (SBP) and bacterascites (BA) represent frequent and serious complications in cirrhosis patients with ascites. However, few detailed data are available regarding the clinical a...

    Authors: Nian-zhi Ning, Tao Li, Ju-ling Zhang, Fen Qu, Jie Huang, Xiong Liu, Zhan Li, Wei Geng, Jun-liang Fu, Wang Huan, Shu-yong Zhang, Chun-mei Bao and Hui Wang

    Citation: BMC Infectious Diseases 2018 18:253

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  29. Content type: Research article

    HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons can enhan...

    Authors: Luna Colagrossi, Lucas E. Hermans, Romina Salpini, Domenico Di Carlo, Suzan D. Pas, Marta Alvarez, Ziv Ben-Ari, Greet Boland, Bianca Bruzzone, Nicola Coppola, Carole Seguin-Devaux, Tomasz Dyda, Federico Garcia, Rolf Kaiser, Sukran Köse, Henrik Krarup…

    Citation: BMC Infectious Diseases 2018 18:251

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  30. Content type: Research article

    Direct-acting anti-viral agents have improved the treatment of chronic hepatitis C virus (HCV) infection, but this treatment is challenging for patients using co-medications because of potential drug–drug inte...

    Authors: Daniel J. Ruzicka, Jumpei Tetsuka, Go Fujimoto and Tatsuya Kanto

    Citation: BMC Infectious Diseases 2018 18:237

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  31. Content type: Research article

    Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Her...

    Authors: Simone Lanini, Paola Scognamiglio, Alessandra Mecozzi, Lorella Lombardozzi, Vincenzo Vullo, Mario Angelico, Antonio Gasbarrini, Gloria Taliani, Adolfo Francesco Attili, Carlo Federico Perno, Adriano De Santis, Vincenzo Puro, Fabio Cerqua, Gianpiero D’Offizi, Adriano Pellicelli, Orlando Armignacco…

    Citation: BMC Infectious Diseases 2018 18:223

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  32. Content type: Research article

    Hepatitis C virus (HCV) is the most common blood-borne viral infection in the United States. Previously, we used data from the National Health and Nutrition Examination Survey (NHANES) and mortality data from ...

    Authors: Eric W. Hall, Eli S. Rosenberg and Patrick S. Sullivan

    Citation: BMC Infectious Diseases 2018 18:224

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  33. Content type: Research article

    This study evaluated cause-specific mortality trends including liver-related mortality among people with a hepatitis B virus (HBV) and hepatitis C virus (HCV) notification in New South Wales, Australia.

    Authors: Maryam Alavi, Jason Grebely, Behzad Hajarizadeh, Janaki Amin, Sarah Larney, Matthew G. Law, Jacob George, Louisa Degenhardt and Gregory J. Dore

    Citation: BMC Infectious Diseases 2018 18:215

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  34. Content type: Research article

    Co-infection with HIV negatively impacts the progression of chronic hepatitis B virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan Africa represents arguably the most imp...

    Authors: Tongai Gibson Maponga, Monique I. Andersson, Christoffel J. van Rensburg, Joop E. Arends, Jantjie Taljaard, Wolfgang Preiser and Richard H. Glashoff

    Citation: BMC Infectious Diseases 2018 18:214

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  35. Content type: Research article

    A marked increase of hepatitis E cases has recently been observed in the Netherlands. Causes of the (re-)emergence of hepatitis E virus (HEV) and exact sources and routes of transmission of HEV infection are c...

    Authors: Sofie H. Mooij, Boris M. Hogema, Anna D. Tulen, Wilfrid van Pelt, Eelco Franz, Hans L. Zaaijer, Michel Molier and Agnetha Hofhuis

    Citation: BMC Infectious Diseases 2018 18:173

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  36. Content type: Research article

    Efficient control of acute hepatitis B requires identification of current transmission routes. Countries in Central-Eastern Europe including Poland attribute an important fraction of cases to nosocomial transm...

    Authors: Małgorzata Stępień, Karolina Zakrzewska and Magdalena Rosińska

    Citation: BMC Infectious Diseases 2018 18:164

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  37. Content type: Research article

    People who inject drugs (PWID) are most at risk of hepatitis C virus infection in Australia. The introduction of transient elastography (TE) (measuring hepatitis fibrosis) and direct acting antiviral medicatio...

    Authors: Stelliana Goutzamanis, Joseph S. Doyle, Alexander Thompson, Paul Dietze, Margaret Hellard and Peter Higgs

    Citation: BMC Infectious Diseases 2018 18:151

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  38. Content type: Research article

    As the socioeconomic conditions in Jordan have improved over recent decades the disease and economic burden of Hepatitis A has increased. The purpose of this study is to assess the potential health and economi...

    Authors: Wail A. Hayajneh, Vincent J. Daniels, Cerise K. James, Muhammet Nabi Kanıbir, Matthew Pilsbury, Morgan Marks, Michelle G. Goveia, Elamin H. Elbasha, Erik Dasbach and Camilo J. Acosta

    Citation: BMC Infectious Diseases 2018 18:119

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  39. Content type: Research article

    Characteristics of hepatitis B (HBV) and delta (HDV) coinfection in various geographical regions, including Israel, remain unclear. Here we studied HDV seroprevalence in Israel, assessed HDV/HBV viral loads, c...

    Authors: Rachel Shirazi, Daniela Ram, Aviya Rakovsky, Efrat Bucris, Yael Gozlan, Yaniv Lustig, Pninit Shaked-Mishan, Orit Picard, Yonat Shemer-Avni, Haim Ben-Zvi, Ora Halutz, Yoav Lurie, Ella Veizman, Matthias Carlebach, Marius Braun, Michal Cohen- Naftaly…

    Citation: BMC Infectious Diseases 2018 18:97

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  40. Content type: Research article

    In 2016, the World Health Organisation set a goal to eliminate viral hepatitis by 2030. Robust epidemiological information underpins all efforts to achieve elimination and this systematic review provides estim...

    Authors: Abby May Falla, Sanne Henrietta Ina Hofstraat, Erika Duffell, Susan Josien Maria Hahné, Lara Tavoschi and Irene Karen Veldhuijzen

    Citation: BMC Infectious Diseases 2018 18:79

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  41. Content type: Research article

    Persons with chronic hepatitis B (CHB) infection were reported to suffer severe disease after hepatitis E virus (HEV) superinfection, but the studies regarding HEV seroprevalence in this population were limite...

    Authors: Li Zhang, Zechun Jiang, Jingjing Lv, Jiaye Liu, Bingyu Yan, Yi Feng, Li Li, Guomin Zhang, Fuzhen Wang and Aiqiang Xu

    Citation: BMC Infectious Diseases 2018 18:75

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  42. Content type: Case report

    Hepatitis E infection is a global disorder that causes substantial morbidity. Numerous neurologic illnesses, including Guillain–Barre syndrome (GBS), have occurred in patients with hepatitis E virus (HEV) infe...

    Authors: Xiaoqin Zheng, Liang Yu, Qiaomai Xu, Silan Gu and Lingling Tang

    Citation: BMC Infectious Diseases 2018 18:50

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  43. Content type: Research article

    Increasing the proportion diagnosed with and on treatment for chronic hepatitis C (CHC) is key to the elimination of hepatitis C in Europe. This study contributes to secondary prevention planning in the Europe...

    Authors: A. M. Falla, A. A. Ahmad, E. Duffell, T. Noori and I. K. Veldhuijzen

    Citation: BMC Infectious Diseases 2018 18:42

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  44. Content type: Research article

    Chronic hepatitis B (CHB) related morbidity and mortality can be reduced through risk group screening, linkage to care and anti-viral treatment. This study estimates the number of CHB cases among foreign-born ...

    Authors: Amena A. Ahmad, Abby M. Falla, Erika Duffell, Teymur Noori, Angela Bechini, Ralf Reintjes and Irene K. Veldhuijzen

    Citation: BMC Infectious Diseases 2018 18:34

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  45. Content type: Research article

    The overall prevalence of hepatitis B virus (HBV) infection in China is declining. The purpose of this study was to use a community-based epidemiological study to update the infection status of hepatitis B vir...

    Authors: Ping Chen, Qinfen Xie, Ting Chen, Jiawei Wu, Jie Wu, Bing Ruan, Zhiqin Zhang, Hainv Gao and Lanjuan Li

    Citation: BMC Infectious Diseases 2017 17:809

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  46. Content type: Research article

    The last decade was marked by major advances in HCV treatment with the introduction of first wave protease inhibitors (1st-wave PIs, telaprevir or boceprevir) in 2011 and second direct-acting antivirals (2nd-w...

    Authors: Cécile Brouard, Marjorie Boussac-Zarebska, Christine Silvain, Julien Durand, Victor de Lédinghen, Josiane Pillonel and Elisabeth Delarocque-Astagneau

    Citation: BMC Infectious Diseases 2017 17:784

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  47. Content type: Research article

    Hepatitis B vaccination for healthcare workers (HCWs) is a key component of the WHO Hepatitis B Elimination Strategy 2016–2021. Data on current hepatitis B vaccine coverage among health care workers in Sub-Sah...

    Authors: Dotto Aaron, Tumaini J. Nagu, John Rwegasha and Ewaldo Komba

    Citation: BMC Infectious Diseases 2017 17:786

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  48. Content type: Research article

    Prospective studies have shown that 80% of acute hepatitis C virus (HCV) cases progress to chronic infection; approximately 10-20% of patients with these conditions will develop liver cirrhosis within 2 to 3 d...

    Authors: Caroline Manchiero, Arielle Karen da Silva Nunes, Mariana Carvalheiro Magri, Bianca Peixoto Dantas, Celso Carmo Mazza, Antonio Alci Barone and Fátima Mitiko Tengan

    Citation: BMC Infectious Diseases 2017 17:780

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  49. Content type: Research article

    There are few data available on the prevalence, incidence, and residual risk of transfusion-transmitted HBV (TT-HBV) infections among Chinese blood donors. This study investigated the demographic characteristi...

    Authors: Ling Li, Tingting Han, Liang Zang, Libin Niu, Weifang Cheng, Hongkeng Lin, Ka Yi Li, Ruan Cao, Binghai Zhao, Yuqiang Liu, Guojin Ou, Xiao Liu, Yingjie Qi, Yanhua Li and Zhong Liu

    Citation: BMC Infectious Diseases 2017 17:754

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