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Hepatitis and co-infections

Section edited by Jean-Claude Desenclos

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Content type: Research article

    Spontaneous bacterial peritonitis (SBP) is a serious complication and common cause of death in patients with liver cirrhosis. This study was conducted to compare the microbiological characteristics, drug resis...

    Authors: Xiurong Ding, Yanhua Yu, Ming Chen, Chen Wang, Yanfang Kang and Jinli Lou

    Citation: BMC Infectious Diseases 2019 19:463

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  2. Content type: Research article

    To investigate the carbapenem resistance mechanisms and clonal relationship of carbapenem-resistant Acinetobacter baumannii (CRAB) strains isolated in the intensive care unit (ICU) of the First Affiliated Hospita...

    Authors: Yongxin Zhao, Kewang Hu, Jisheng Zhang, Yuhang Guo, Xuecai Fan, Yong Wang, Sedzro Divine Mensal and Xiaoli Zhang

    Citation: BMC Infectious Diseases 2019 19:452

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  3. Content type: Research article

    Hepatitis B virus (HBV) infection is a major public health burden in China although it has steadily declined over the last two decades. A valid updated prevalence of HBV infection in China relies on a large sa...

    Authors: Jing Meng, Hongqin Xu, Dongming Sui, Jing Jiang, Jie Li, Yanhang Gao and Junqi Niu

    Citation: BMC Infectious Diseases 2019 19:440

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  4. Content type: Research article

    Human immunodeficiency virus, hepatitis B virus and hepatitis C virus are among the greatest threats to blood safety for the recipient. They are also the leading cause of death, chronic and life-threatening ab...

    Authors: Abiye Tigabu, Tigist Engda and Feleke Mekonnen

    Citation: BMC Infectious Diseases 2019 19:393

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  5. Content type: Research article

    The epidemiology of hepatitis B virus (HBV) infection in the general population in Rwanda is not well known. This study examined the prevalence of HBV surface antigen (HBsAg) positivity and associated risk fac...

    Authors: Jean Damascene Makuza, Jean Olivier Twahirwa Rwema, Corneille Killy Ntihabose, Donatha Dushimiyimana, Justine Umutesi, Marie Paul Nisingizwe, Janvier Serumondo, Muhamed Semakula, David J. Riedel and Sabin Nsanzimana

    Citation: BMC Infectious Diseases 2019 19:381

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  6. Content type: Research article

    In the UK, hepatitis B virus (HBV) incidence is associated with migrants from particular high-burden countries and population groups deemed ‘hard-to-reach’ by standard healthcare services: the homeless, people...

    Authors: Josephine E. B. Taylor, Julian Surey, Jennifer MacLellan, Marie Francis, Ibrahim Abubakar and Helen R. Stagg

    Citation: BMC Infectious Diseases 2019 19:372

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  7. Content type: Research article

    Hepatitis B virus (HBV) reactivation is one of the most common precipitating events associated with acute decompensation (AD) or acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB)-related cirrh...

    Authors: Jian-Hua Lei, Feng Peng, Zi Chen and Xin-Qiang Xiao

    Citation: BMC Infectious Diseases 2019 19:363

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  8. Content type: Research article

    The objective of the present study was to analyze the factors associated with non-completion of the hepatitis B vaccine series among men who have sex with men and use geosocial dating apps in Brazil.

    Authors: Artur Acelino Francisco Luz Nunes Queiroz, Álvaro Francisco Lopes de Sousa, Matheus Costa Brandão Matos, Telma Maria Evangelista de Araújo, Sandra Brignol, Renata Karina Reis, Elucir Gir and Maria Eliete Batista Moura

    Citation: BMC Infectious Diseases 2019 19:335

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  9. Content type: Research article

    Over the last 20 years, Hepatitis C virus (HCV) infection prevalence has dramatically increased among HIV-infected men who have sex with men (MSM) in many countries worldwide. It is suspected that this increas...

    Authors: Sophie Vaux, Stéphane Chevaliez, Leïla Saboni, Claire Sauvage, Cécile Sommen, Francis Barin, Antonio Alexandre, Marie Jauffret-Roustide, Florence Lot and Annie Velter

    Citation: BMC Infectious Diseases 2019 19:315

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  10. Content type: Research article

    To fulfill epidemiological data and investigate possible interspecies transmission, this study shall attempt to sequence representative HEV strains of human, swine and wild boar origin collected from 2010 to 2...

    Authors: Lorena Jemeršić, Jelena Prpić, Dragan Brnić, Tomislav Keros, Nenad Pandak and Oktavija Đaković Rode

    Citation: BMC Infectious Diseases 2019 19:269

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  11. Content type: Research article

    Infection with Hepatitis B virus (HBV) is a serious public health problem worldwide, with over 360 million carriers. Sixty million of these are resident in Sub-saharan Africa. Hepatitis B infection is the caus...

    Authors: Mustapha Bittaye, Patrick Idoko, Bissallah Ahmed Ekele, Samuel Amenyi Obed and Ousman Nyan

    Citation: BMC Infectious Diseases 2019 19:259

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  12. Content type: Research article

    Hepatitis B virus (HBV) infection remains a serious global health challenge. The widespread distribution of HBV is highlighted by multiple HBV genotypes associated with different geographical origin and transm...

    Authors: John H.-O. Pettersson, Solveig Myking, Hilde Elshaug, Kirsten Irene Ege Bygdås and Kathrine Stene-Johansen

    Citation: BMC Infectious Diseases 2019 19:236

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  13. Content type: Research article

    Hepatitis B virus (HBV) replicates non-cytopathically in the hepatocytes and HBV-related diseases are caused by immune-mediated inflammatory events. This study aimed to identify the relationship between clinic...

    Authors: Yurong Gu, Yifan Lian, Lin Gu, Lubiao Chen, Xiaoyan Li, Liang Zhou, Yanlin Huang, Jialiang Wang and Yuehua Huang

    Citation: BMC Infectious Diseases 2019 19:216

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  14. Content type: Research article

    The relationship between chronic hepatitis B virus (HBV) infection with gestational diabetes mellitus (GDM) remains unclear. This study aimed to identify the association between maternal HBsAg-positive status ...

    Authors: Songxu Peng, Zhihua Wan, Xiaofang Lin, Xiu Li and Yukai Du

    Citation: BMC Infectious Diseases 2019 19:147

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  15. Content type: Research article

    Hepatitis C virus (HCV) is one of the main causes of chronic liver disease worldwide. Prevalence of HCV in homeless populations ranges from 3.9 to 36.2%. The HepCheck study sought to investigate and establish ...

    Authors: John S. Lambert, Ross Murtagh, Dee Menezes, Austin O’Carroll, Carol Murphy, Walter Cullen, Tina McHugh, Gordana Avramovic, Willard Tinago and Marie Claire Van Hout

    Citation: BMC Infectious Diseases 2019 19:128

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  16. Content type: Case report

    After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syn...

    Authors: Jing-Wen Zhang, Xiang-Zhong Zhang, Yan-Ling Sun, Bing Long, Xiao-Zhen Wang and Xu-Dong Li

    Citation: BMC Infectious Diseases 2019 19:57

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  17. Content type: Case report

    For patients with chronic hepatitis B and cirrhosis in less developed western regions in China, due to constraints of local economic conditions, the choice of treatment measures is often limited. However if pa...

    Authors: Yue-Rong Zhang, De-Ming Wu, Xiong-Chang Liu, Ning Zhou, Chang-Chun Cao, Wu-Hua Liu, Chun-Xia Wang and Hui Wang

    Citation: BMC Infectious Diseases 2019 19:49

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  18. Content type: Research article

    Hepatitis E virus (HEV) is a leading cause of hepatitis worldwide. However, its infection biology and pathogenesis remain largely elusive. Furthermore, no proven medication is available for treating hepatitis ...

    Authors: Wenhai Yu, Chenchen Yang, Xianhui Hao, Tianwu Ma and Fen Huang

    Citation: BMC Infectious Diseases 2018 18:687

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  19. Content type: Case report

    Hepatitis C virus (HCV) infection is a recognised cause of secondary immune thrombocytopenia (ITP). While its incidence has been largely described during chronic HCV infection, only one case of ITP secondary t...

    Authors: Vincent Alcazer, Patrick Miailhes, Christophe Ramière, Caroline Charre and Laurent Cotte

    Citation: BMC Infectious Diseases 2018 18:682

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  20. Content type: Research article

    Among HIV-infected MSM who have been treated for HCV infection, the HCV reinfection rate is high. It is therefore essential to understand their perceptions of HCV risk behaviour and risk-reducing strategies.

    Authors: Femke Lambers, Wendy van der Veldt, Maria Prins and Udi Davidovich

    Citation: BMC Infectious Diseases 2018 18:678

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  21. Content type: Research article

    The frequency of mild forms of hepatitis A, especially in children, could lead to underreporting. The objective of the study was to investigate the sensitivity of two surveillance systems, mandatory Statutory ...

    Authors: Gloria Carmona, Marta Vilaró, Pilar Ciruela, Mireia Jané, Lluis Giralt, Laura Ruiz, Sergi Hernández and Àngela Domínguez

    Citation: BMC Infectious Diseases 2018 18:633

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  22. Content type: Research article

    Nucleic acid tests performed on blood samples collected on Dried Blood Spot (DBS) and detection of HCV core antigen (HCVcAg) are two approaches that may facilitate access to HCV diagnosis in low and middle inc...

    Authors: Truong Tam Nguyen, Véronique Lemee, Karine Bollore, Hai Vinh Vu, Karine Lacombe, Xuan Lien Truong Thi, Que Anh Luong, Charline Dubos, Jean-Christophe Plantier, Huong Duong Thi, Didier Laureillard, Maud Lemoine and Edouard Tuaillon

    Citation: BMC Infectious Diseases 2018 18:622

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  23. Content type: Research article

    Hepatitis C Virus infection has been considered an important hidden pandemic in developing countries, particularly in Africa. It varies greatly from one region to another and even within districts of the same ...

    Authors: Mohamed A. Daw, Lutfi A. Buktir Ali, Amina M. Daw, Nadia E. M. Sifennasr, Aghnyia A. Dau, Mohamed M. Agnan and Abdallah El-Bouzedi

    Citation: BMC Infectious Diseases 2018 18:594

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  24. Content type: Research article

    According to the EASL and AASLD guidelines, the recommended treatment for patients who failed to achieve a sustained virologic response (SVR) on prior interferon-based triple therapy with protease inhibitors (...

    Authors: Ewa Janczewska, Dorota Zarębska-Michaluk, Hanna Berak, Anna Piekarska, Andrzej Gietka, Dorota Dybowska, Włodzimierz Mazur, Teresa Belica-Wdowik, Witold Dobracki, Magdalena Tudrujek-Zdunek, Zbigniew Deroń, Iwona Buczyńska, Marek Sitko, Agnieszka Czauż-Andrzejuk, Beata Lorenc, Jolanta Białkowska-Warzecha…

    Citation: BMC Infectious Diseases 2018 18:580

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  25. Content type: Research article

    Hepatitis B virus (HBV) genotype E is a poorly studied genotype that almost exclusively occurs in African people. It seems to harbour intrinsic potential oncogenic activity and virological characteristics of i...

    Authors: José Ángel Cuenca-Gómez, Ana Belén Lozano-Serrano, María Teresa Cabezas-Fernández, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, Matías Estévez-Escobar, Isabel Cabeza-Barrera and Joaquín Salas-Coronas

    Citation: BMC Infectious Diseases 2018 18:568

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  26. Content type: Research article

    There are randomized trials assessing a variety of antiviral drugs for hepatitis B virus (HBV), but the relative effectiveness of these drugs in the treatment of patients co-infected with human immunodeficienc...

    Authors: Cho Naing, Yong Poovorawan and Kew Siang Tong

    Citation: BMC Infectious Diseases 2018 18:564

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  27. Content type: Research article

    Clinical progression of HBV-related liver diseases is largely associated with the activity of HBV-specific T cells. Soluble fibrinogen-like protein 2 (sFGL2), mainly secreted by T cells, is an important effect...

    Authors: Hoang Van Tong, Nguyen Van Ba, Nghiem Xuan Hoan, Mai Thanh Binh, Dao Thanh Quyen, Ho Anh Son, Hoang Van Luong, Do Quyet, Christian G. Meyer, Le Huu Song, Nguyen Linh Toan and Thirumalaisamy P. Velavan

    Citation: BMC Infectious Diseases 2018 18:553

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  28. Content type: Research article

    Possible cardiotoxicity of sofosbuvir in humans has not been demonstrated yet. Also, since HCV can exert deleterious effects on hearth function, it is of interest to know whether HCV eradication provides any b...

    Authors: Maria Mazzitelli, Carlo Torti, Jolanda Sabatino, Greta Luana D’Ascoli, Chiara Costa, Vincenzo Pisani, Elena Raffetti, Salvatore De Rosa, Alessio Strazzulla, Alfredo Focà, Maria Carla Liberto and Ciro Indolfi

    Citation: BMC Infectious Diseases 2018 18:518

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  29. Content type: Research article

    Viral hepatitis is an important public health issue in sub-Saharan Africa. Due to rising mortality from cirrhosis and hepatocellular carcinoma and limited implementation of screening and treatment programmes, ...

    Authors: Alexander J Stockdale, Collins Mitambo, Dean Everett, Anna Maria Geretti and Melita A Gordon

    Citation: BMC Infectious Diseases 2018 18:516

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  30. Content type: Study protocol

    The World Health Organization recommends all men who have sex with men (MSM) receive Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) testing. MSM in China are a high-risk group for HBV and HCV infection, b...

    Authors: Thomas Fitzpatrick, Kali Zhou, Yu Cheng, Po-Lin Chan, Fuqiang Cui, Weiming Tang, Katie R Mollan, Wilson Guo and Joseph D Tucker

    Citation: BMC Infectious Diseases 2018 18:489

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  31. Content type: Research article

    As direct acting antiviral (DAA) therapy is progressively rolled out for patients with hepatitis C virus (HCV) infection, careful scrutiny of HCV epidemiology, diagnostic testing, and access to care is crucial...

    Authors: Emily Adland, Gerald Jesuthasan, Louise Downs, Victoria Wharton, Gemma Wilde, Anna L. McNaughton, Jane Collier, Eleanor Barnes, Paul Klenerman, Monique Andersson, Katie Jeffery and Philippa C. Matthews

    Citation: BMC Infectious Diseases 2018 18:461

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  32. Content type: Research article

    Despite the high sustained virological response rates achieved with current directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of treated patients do not respond to current a...

    Authors: María Eugenia Soria, Josep Gregori, Qian Chen, Damir García-Cehic, Meritxell Llorens, Ana I. de Ávila, Nathan M. Beach, Esteban Domingo, Francisco Rodríguez-Frías, María Buti, Rafael Esteban, Juan Ignacio Esteban, Josep Quer and Celia Perales

    Citation: BMC Infectious Diseases 2018 18:446

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  33. Content type: Research article

    This study was conducted to determine the prevalence of HBV, HCV, and HDV in urban populations and Amerindians living in the state of Tocantins (Eastern Amazon).

    Authors: Livia Melo Villar, Flavio Augusto Pádua Milagres, Elisabeth Lampe, Helena Medina Cruz, Leticia de Paula Scalioni, Monica de Avelar Figueiredo Mafra Magalhães, Anselmo Rocha Romão, Renata Gracie and Vanessa Salete de Paula

    Citation: BMC Infectious Diseases 2018 18:411

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  34. Content type: Research article

    It is difficult to diagnose ascites infection early in cirrhotic patients. The present study was to create and evaluate a new bioscore combined with PCT, sNFI and dCHC in the diagnosis of ascites infection in ...

    Authors: Han Wang, Yan Li, Fangfang Zhang, Ning Yang, Na Xie, Yuanli Mao and Boan Li

    Citation: BMC Infectious Diseases 2018 18:389

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  35. Content type: Research article

    Hepatitis C virus (HCV) infection is a widespread problem in prisons. The present study aimed to assess the prevalence of HCV seropositivity, HCV genotypes, factors associated with HCV seropositivity in newly ...

    Authors: Kristel Kivimets, Anneli Uusküla, Jeffrey V. Lazarus and Kristi Ott

    Citation: BMC Infectious Diseases 2018 18:339

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  36. Content type: Database

    There are several epidemiological studies available on hepatitis B virus among pregnant women in Ethiopia. These individual studies revealed wide variation over time and across geographical areas. The aim of t...

    Authors: Kindie Mitiku Kebede, Dejene Derseh Abateneh and Alemayehu Sayih Belay

    Citation: BMC Infectious Diseases 2018 18:322

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  37. Content type: Research article

    Tuberculosis (TB) and chronic Hepatitis B virus (HBV) infection are common in China. Fist-line anti-TB medications often produce drug-induced liver injury (DILI). This study sought to investigate whether TB pa...

    Authors: Lubiao Chen, Dujing Bao, Lin Gu, Yurong Gu, Liang Zhou, Zhiliang Gao and Yuehua Huang

    Citation: BMC Infectious Diseases 2018 18:295

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  38. Content type: Research article

    Hepatitis B vaccination is the most effective method of prevention for hepatitis B virus infection. It is a major public health problem in Nigeria, and health workers are at increased risk. This study determin...

    Authors: I. B. Omotowo, I. A. Meka, U. N. Ijoma, V. E. Okoli, O. Obienu, T. Nwagha, A. C. Ndu, D. O. Onodugo, L. C. Onyekonwu and E. O. Ugwu

    Citation: BMC Infectious Diseases 2018 18:288

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  39. Content type: Research article

    From September 2016–April 2017, Am Timan, Chad, experienced a large HEV outbreak in an urban setting with a limited impact in terms of morbidity and mortality. To better understand HEV epidemiology in this con...

    Authors: Larissa Vernier, Annick Lenglet, Boris M. Hogema, Ali M. Moussa, Cono Ariti, Simone Vollmer, Andrea Irwin, Prince Alfani, Sibylle Sang and Charity Kamau

    Citation: BMC Infectious Diseases 2018 18:287

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  40. Content type: Research article

    Hepatitis C (HCV) diagnosis and care is a major challenge for people who use illicit drugs, and is characterised by low rates of testing and treatment engagement globally. New approaches to fostering engagemen...

    Authors: Andy Guise, T. Charles Witzel, Sema Mandal, Caroline Sabin, Tim Rhodes, Anthony Nardone and Magdalena Harris

    Citation: BMC Infectious Diseases 2018 18:281

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  41. Content type: Research article

    Infants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of i...

    Authors: Meng Zhuo Cao, Yan Hua Wu, Si Min Wen, Yu Chen Pan, Chong Wang, Fei Kong, Chuan Wang, Jun Qi Niu, Jie Li and Jing Jiang

    Citation: BMC Infectious Diseases 2018 18:274

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  42. Content type: Research article

    Female gender and favorable IFNL3 genotypes are the primary independent predictors of spontaneous clearance of HCV infection. However, chronic hepatitis C infection occurs in numerous women carrying favorable IFN...

    Authors: Zhe Xie, Yuantao Li, Lu Long, Hua Liang, Weiping Cai and Tao Shen

    Citation: BMC Infectious Diseases 2018 18:254

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  43. Content type: Research article

    Spontaneous bacterial peritonitis (SBP) and bacterascites (BA) represent frequent and serious complications in cirrhosis patients with ascites. However, few detailed data are available regarding the clinical a...

    Authors: Nian-zhi Ning, Tao Li, Ju-ling Zhang, Fen Qu, Jie Huang, Xiong Liu, Zhan Li, Wei Geng, Jun-liang Fu, Wang Huan, Shu-yong Zhang, Chun-mei Bao and Hui Wang

    Citation: BMC Infectious Diseases 2018 18:253

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  44. Content type: Research article

    HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons can enhan...

    Authors: Luna Colagrossi, Lucas E. Hermans, Romina Salpini, Domenico Di Carlo, Suzan D. Pas, Marta Alvarez, Ziv Ben-Ari, Greet Boland, Bianca Bruzzone, Nicola Coppola, Carole Seguin-Devaux, Tomasz Dyda, Federico Garcia, Rolf Kaiser, Sukran Köse, Henrik Krarup…

    Citation: BMC Infectious Diseases 2018 18:251

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