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Hepatitis and co-infections

Section edited by Jean-Claude Desenclos

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Content type: Research article

    Chronic infection with hepatitis B virus (HBV) is a serious global health problem. Persistence of the virus occurs as a result of stability of the replication intermediate comprising covalently closed circular...

    Authors: Kristie Bloom, Haajira Kaldine, Toni Cathomen, Claudio Mussolino, Abdullah Ely and Patrick Arbuthnot

    Citation: BMC Infectious Diseases 2019 19:802

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  2. Content type: Research article

    Almost 1% of Canadians are hepatitis C (HCV)-infected. The liver-specific complications of HCV are established but the extra-hepatic comorbidity, multimorbidity, and its relationship with HCV treatment, is les...

    Authors: Curtis L. Cooper, Chrissi Galanakis, Jessy Donelle, Jeff Kwong, Rob Boyd, Lisa Boucher and Claire E. Kendall

    Citation: BMC Infectious Diseases 2019 19:712

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  3. Content type: Technical advance

    The technique most frequently used to genotype HCV is quantitative RT-PCR. This technique is unable to provide an accurate genotype/subtype for many samples; we decided to develop an in-house method with the g...

    Authors: Sylvie Goletti, Siméon Zuyten, Léonie Goeminne, Chris Verhofstede, Hector Rodriguez-Villalobos, Monique Bodeus, Peter Stärkel, Yves Horsmans and Benoît Kabamba-Mukadi

    Citation: BMC Infectious Diseases 2019 19:738

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  5. Content type: Research article

    Hepatitis C virus (HCV) is a major public health problem in correctional settings. HCV treatment is often not possible in U.S. jails due to short lengths of stay. Linkage to care is crucial in these settings, ...

    Authors: Matthew J. Akiyama, Devin Columbus, Ross MacDonald, Alison O. Jordan, Jessie Schwartz, Alain H. Litwin, Benjamin Eckhardt and Ellie Carmody

    Citation: BMC Infectious Diseases 2019 19:703

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  6. Content type: Research article

    Hepatitis C infection is a major public health concern globally. In Ireland, like other European countries, people who use drugs (PWUD) and prisoners carry a larger HCV disease burden than the general populati...

    Authors: D. Crowley, R. Murtagh, W. Cullen, J. S. Lambert, T. McHugh and M. C. Van Hout

    Citation: BMC Infectious Diseases 2019 19:702

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  7. Content type: Research article

    The epidemiology and risk factors for hepatitis C virus (HCV) infection in Rwanda are not well known; however, this information is crucial to shaping the country’s public health approach to hepatitis C control.

    Authors: Jean Damascene Makuza, Carol Y. Liu, Corneille Killy Ntihabose, Donatha Dushimiyimana, Sabine Umuraza, Marie Paul Nisingizwe, Justine Umutesi, Janvier Serumondo, Soline Dusabeyesu Mugeni, Muhamed Semakula, Neil Gupta, Margaret Hellard and Sabin Nsanzimana

    Citation: BMC Infectious Diseases 2019 19:688

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  8. Content type: Case report

    Hepatitis E virus (HEV) infection is now recognized as a major cause of acute hepatitis worldwide. HEV specific antibodies develop shortly after infection and are thought to confer protection.

    Authors: Marcus Panning, Kristi Basho, Andreas Fahrner and Christoph Neumann-Haefelin

    Citation: BMC Infectious Diseases 2019 19:675

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  9. Content type: Research article

    Although significant improvement in efficacy measured by a sustained virological response, the high acquisition costs of direct-acting antivirals limit the access for patients and influence the costs of health...

    Authors: Ru Han, Junwen Zhou, Clément François and Mondher Toumi

    Citation: BMC Infectious Diseases 2019 19:655

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  10. Content type: Research article

    Hepatitis A, caused by the hepatitis A virus (HAV), is a vaccine preventable disease. In Low and Middle-Income Countries (LMICs), poor hygiene and sanitation conditions are the main risk factors contributing t...

    Authors: Jenna Patterson, Leila Abdullahi, Gregory D. Hussey, Rudzani Muloiwa and Benjamin M. Kagina

    Citation: BMC Infectious Diseases 2019 19:651

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  11. Content type: Research article

    Long-term outcome of DAAs therapy in kidney transplant recipients was unknown. Thus, we aimed to evaluate it in a Chinese cohort of HCV-infected kidney transplant recipients.

    Authors: Jian Zhang, Wen Sun, Jun Lin, Ye Tian, Linlin Ma, Lei Zhang, Yichen Zhu and Wei Qiu

    Citation: BMC Infectious Diseases 2019 19:645

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  12. Content type: Research article

    The virological or clinical relapse is common in chronic hepatitis B (CHB) patients after stopping long-term nucleos(t)ide analogue (NA) therapy. Soluble growth stimulation expressed gene 2 (sST2), one of the ...

    Authors: Linqing Xie, Guichan Liao, Hongjie Chen, Muye Xia, Xuan Huang, Rong Fan, Jie Peng, Xiaoyong Zhang and Hongyan Liu

    Citation: BMC Infectious Diseases 2019 19:640

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  13. Content type: Research article

    Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality. High HBV prevalence in immigrants and ethnic minorities and numerous barriers to healthcare access are associated with serio...

    Authors: Chul S. Hyun, Okhyun Ko, Seulgi Lee and Joseph McMenamin

    Citation: BMC Infectious Diseases 2019 19:638

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  14. Content type: Case report

    We describe a case of severe Guillain-Barre syndrome (GBS) associated with chronic active hepatitis C and mixed cryoglobulinemia (MC). To our knowledge, this association between GBS and hepatitis C virus (HCV)...

    Authors: Alexandre Chlilek, Claire Roger, Laurent Muller, Marie-Josée Carles, Robin Stephan, Didier Laureillard, Jean-Philippe Lavigne, Jean-Yves Lefrant and Albert Sotto

    Citation: BMC Infectious Diseases 2019 19:636

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  15. Content type: Research article

    Elevated rates of Hepatitis C Virus (HCV) infection have been reported in epidemiological studies with people who used illicit drugs (PWUIDs) in different Brazilian regions. In Brazil’s Amazon region, studies ...

    Authors: Aldemir B. Oliveira-Filho, Francisco Junior A. Santos, Fabricio Quaresma Silva, Nairis Costa Raiol, Camila Carla S. Costa, Juliana Nadia F. Piauiense, Luisa Caricio Martins, Yasmin Maria N. Cardoso, Jeruza Ferraz F. Di Miceli, Rafael Lima Resque, Gláucia C. Silva-Oliveira, Luiz Marcelo L. Pinheiro, Luiz Fernando A. Machado, João Renato R. Pinho, José Alexandre R. Lemos, Emil Kupek…

    Citation: BMC Infectious Diseases 2019 19:634

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  16. Content type: Research article

    Hepatitis B virus (HBV) testing in oral fluid samples may provide advantages in diagnosis, screening or prevalence studies, especially among individuals with venous access difficulties. This study aims to opti...

    Authors: Helena Medina Cruz, Vanessa Salete de Paula, Elisangela Ferreira da Silva, Kycia Maria Rodrigues do Ó, Flavio Augusto Pádua Milagres, Marcelo Santos Cruz, Francisco Inácio Bastos, Jurema Corrêa da Mota, Priscila Pollo-Flores, Erotildes Leal, Ana Rita Coimbra Motta-Castro, Lia Laura Lewis-Ximenez, Elisabeth Lampe and Livia Melo Villar

    Citation: BMC Infectious Diseases 2019 19:632

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  17. Content type: Research article

    In the United States Hepatitis C virus (HCV) viral clearance is estimated to range between 20 and 30%. The objective of this study was to estimate the frequency of HCV clearance and identify correlates of vira...

    Authors: Mabel Michille Kimble, Marjan Javanbakht, Kara W. Chew, Chrysovalantis Stafylis, Di He, Samantha Ramirez, Yeonsoo Baik, Sammy Saab and Jeffrey D. Klausner

    Citation: BMC Infectious Diseases 2019 19:626

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  18. Content type: Research article

    The major infectious diseases of hepatitis B has constituted an acute public health challenge in China. An effective and affordable HBV control model is urgently needed. A national project of Community-based C...

    Authors: Bing Ruan, Zhixin Yu, Shigui Yang, Kaijin Xu, Jingjing Ren, Jun Yao, Nanping Wu, Chengbo Yu, Min Deng, Tiansheng Xie, Ping Chen, Chencheng Wang, Yiping Li, Yanhong Zhao, Jifang Sheng, Yunde Hou…

    Citation: BMC Infectious Diseases 2019 19:617

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  19. Content type: Research article

    To evaluate the efficacy and safety of telbivudine in chronic hepatitis B women during the second and third trimesters of pregnancy.

    Authors: Li-fen Han, Jian-ming Zheng, Li-qing Zheng, Hai-bing Gao, Li-xia Chen, Qing-ling Xu, Yi-hong Chai, Xin Zhang, Chen Pan and Lv-feng Yao

    Citation: BMC Infectious Diseases 2019 19:614

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  20. Content type: Research article

    Hepatitis B virus (HBV) is a hepatotropic deoxyribonucleic acid (DNA) virus which causes death. More than 300 million people have chronic liver infections globally and about 600,000 people die annually from ac...

    Authors: Abayneh Tunje Tanga, Misanew Andargie Teshome, Desta Hiko, Chaltu Fikru and Gemechu Kejela Jilo

    Citation: BMC Infectious Diseases 2019 19:602

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  21. Content type: Research article

    Varicella zoster virus (VZV) is a highly contagious herpesvirus with potential for nosocomial transmission. However, the importance of nosocomial chickenpox outbreak in China has often been ignored. With the i...

    Authors: Jin Yang, Jieling Liu, Fanfan Xing, Haiyan Ye, Guijian Dai, Meiyuan Liu, Simon Kam-Fai Lo, Ricky Wing-Tong Lau, Kelvin Hei-Yeung Chiu, Jasper Fuk-Woo Chan and Kwok-Yung Yuen

    Citation: BMC Infectious Diseases 2019 19:582

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  22. Content type: Research article

    Blood donor plasma samples were detected by the Ultrio Plus NAT system for HBV, HCV and HIV-1 in Shenzhen blood center, China. Reactive samples underwent further discriminatory testing of a single virus by the...

    Authors: Xianlin Ye, Tong Li, Wen Shao, Jinfeng Zeng, Wenxu Hong, Liang Lu, Weigang Zhu, Chengyao Li and Tingting Li

    Citation: BMC Infectious Diseases 2019 19:574

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  23. Content type: Case report

    Sofosbuvir is the keystone of direct antiviral agents for the chronic hepatitis C (CHC). The safety of sofosbuvir in patients with stage 4–5 chronic kidney disease (CKD) needs further observation in real world.

    Authors: Taotao Yan, Jiuping Wang, Juan Li, Shan Fu, Yi Chen, Chunhua Hu, Rou Zhang, Zhen Tian, Fahui Zhao, Jun Dong, Jinfeng Liu, Yuan Yang, Tianyan Chen, Yingren Zhao and Yingli He

    Citation: BMC Infectious Diseases 2019 19:550

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  24. Content type: Research article

    Treatment failure has become a significant challenge in patients taking antiretroviral therapy (ART). The aim of the present study was to identify risk factors for first-line ART failure among patients attendi...

    Authors: Yihienew Mequanint Bezabih, Fekadu Beyene and Woldesellassie M. Bezabhe

    Citation: BMC Infectious Diseases 2019 19:537

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  25. Content type: Research article

    Distribution of Hepatitis C virus (HCV) genotypes varies significantly worldwide. Genomic diversity between genotypes has implications for treatment, vaccine development and optimal design of HCV diagnostic as...

    Authors: Nicholas Israel Nii-Trebi, Charles Addoquaye Brown, Yaa Difie Osei, William Kwabena Ampofo and Alexander Kwadwo Nyarko

    Citation: BMC Infectious Diseases 2019 19:533

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  26. Content type: Research article

    Due to no clinical symptoms in the compensated stage of cirrhosis, it is usually diagnosed when decompensated complications occur. In this study, the noninvasive circulating biomarkers for early detection to c...

    Authors: Liangshan Hu, Yan Zhu, Jingqian Zhang, Wei Chen, Zeyong Li, Lihua Li, Liping Zhang and Donglin Cao

    Citation: BMC Infectious Diseases 2019 19:523

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  27. Content type: Research article

    There have been a number of studies about seroprevalence of HEV among pregnant women in Africa. However, the finding of seroprevalence of HEV infection among pregnant women is variable and inconsistent. Theref...

    Authors: Mulat Dagnew, Amare Belachew, Moges Tiruneh and Feleke Moges

    Citation: BMC Infectious Diseases 2019 19:519

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  28. Content type: Research article

    Spontaneous bacterial peritonitis (SBP) is a serious complication and common cause of death in patients with liver cirrhosis. This study was conducted to compare the microbiological characteristics, drug resis...

    Authors: Xiurong Ding, Yanhua Yu, Ming Chen, Chen Wang, Yanfang Kang and Jinli Lou

    Citation: BMC Infectious Diseases 2019 19:463

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  29. Content type: Research article

    To investigate the carbapenem resistance mechanisms and clonal relationship of carbapenem-resistant Acinetobacter baumannii (CRAB) strains isolated in the intensive care unit (ICU) of the First Affiliated Hospita...

    Authors: Yongxin Zhao, Kewang Hu, Jisheng Zhang, Yuhang Guo, Xuecai Fan, Yong Wang, Sedzro Divine Mensah and Xiaoli Zhang

    Citation: BMC Infectious Diseases 2019 19:452

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    The Correction to this article has been published in BMC Infectious Diseases 2019 19:621

  31. Content type: Research article

    Hepatitis B virus (HBV) infection is a major public health burden in China although it has steadily declined over the last two decades. A valid updated prevalence of HBV infection in China relies on a large sa...

    Authors: Jing Meng, Hongqin Xu, Dongming Sui, Jing Jiang, Jie Li, Yanhang Gao and Junqi Niu

    Citation: BMC Infectious Diseases 2019 19:440

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  32. Content type: Research article

    Human immunodeficiency virus, hepatitis B virus and hepatitis C virus are among the greatest threats to blood safety for the recipient. They are also the leading cause of death, chronic and life-threatening ab...

    Authors: Abiye Tigabu, Tigist Engda and Feleke Mekonnen

    Citation: BMC Infectious Diseases 2019 19:393

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  34. Content type: Research article

    The epidemiology of hepatitis B virus (HBV) infection in the general population in Rwanda is not well known. This study examined the prevalence of HBV surface antigen (HBsAg) positivity and associated risk fac...

    Authors: Jean Damascene Makuza, Jean Olivier Twahirwa Rwema, Corneille Killy Ntihabose, Donatha Dushimiyimana, Justine Umutesi, Marie Paul Nisingizwe, Janvier Serumondo, Muhamed Semakula, David J. Riedel and Sabin Nsanzimana

    Citation: BMC Infectious Diseases 2019 19:381

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  35. Content type: Research article

    In the UK, hepatitis B virus (HBV) incidence is associated with migrants from particular high-burden countries and population groups deemed ‘hard-to-reach’ by standard healthcare services: the homeless, people...

    Authors: Josephine E. B. Taylor, Julian Surey, Jennifer MacLellan, Marie Francis, Ibrahim Abubakar and Helen R. Stagg

    Citation: BMC Infectious Diseases 2019 19:372

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  37. Content type: Research article

    Hepatitis B virus (HBV) reactivation is one of the most common precipitating events associated with acute decompensation (AD) or acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB)-related cirrh...

    Authors: Jian-Hua Lei, Feng Peng, Zi Chen and Xin-Qiang Xiao

    Citation: BMC Infectious Diseases 2019 19:363

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  38. Content type: Research article

    The objective of the present study was to analyze the factors associated with non-completion of the hepatitis B vaccine series among men who have sex with men and use geosocial dating apps in Brazil.

    Authors: Artur Acelino Francisco Luz Nunes Queiroz, Álvaro Francisco Lopes de Sousa, Matheus Costa Brandão Matos, Telma Maria Evangelista de Araújo, Sandra Brignol, Renata Karina Reis, Elucir Gir and Maria Eliete Batista Moura

    Citation: BMC Infectious Diseases 2019 19:335

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  39. Content type: Research article

    Over the last 20 years, Hepatitis C virus (HCV) infection prevalence has dramatically increased among HIV-infected men who have sex with men (MSM) in many countries worldwide. It is suspected that this increas...

    Authors: Sophie Vaux, Stéphane Chevaliez, Leïla Saboni, Claire Sauvage, Cécile Sommen, Francis Barin, Antonio Alexandre, Marie Jauffret-Roustide, Florence Lot and Annie Velter

    Citation: BMC Infectious Diseases 2019 19:315

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  40. Content type: Research article

    To fulfill epidemiological data and investigate possible interspecies transmission, this study shall attempt to sequence representative HEV strains of human, swine and wild boar origin collected from 2010 to 2...

    Authors: Lorena Jemeršić, Jelena Prpić, Dragan Brnić, Tomislav Keros, Nenad Pandak and Oktavija Đaković Rode

    Citation: BMC Infectious Diseases 2019 19:269

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  41. Content type: Research article

    Infection with Hepatitis B virus (HBV) is a serious public health problem worldwide, with over 360 million carriers. Sixty million of these are resident in Sub-saharan Africa. Hepatitis B infection is the caus...

    Authors: Mustapha Bittaye, Patrick Idoko, Bissallah Ahmed Ekele, Samuel Amenyi Obed and Ousman Nyan

    Citation: BMC Infectious Diseases 2019 19:259

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  42. Content type: Research article

    Hepatitis B virus (HBV) infection remains a serious global health challenge. The widespread distribution of HBV is highlighted by multiple HBV genotypes associated with different geographical origin and transm...

    Authors: John H.-O. Pettersson, Solveig Myking, Hilde Elshaug, Kirsten Irene Ege Bygdås and Kathrine Stene-Johansen

    Citation: BMC Infectious Diseases 2019 19:236

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  43. Content type: Research article

    Hepatitis B virus (HBV) replicates non-cytopathically in the hepatocytes and HBV-related diseases are caused by immune-mediated inflammatory events. This study aimed to identify the relationship between clinic...

    Authors: Yurong Gu, Yifan Lian, Lin Gu, Lubiao Chen, Xiaoyan Li, Liang Zhou, Yanlin Huang, Jialiang Wang and Yuehua Huang

    Citation: BMC Infectious Diseases 2019 19:216

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  45. Content type: Research article

    The relationship between chronic hepatitis B virus (HBV) infection with gestational diabetes mellitus (GDM) remains unclear. This study aimed to identify the association between maternal HBsAg-positive status ...

    Authors: Songxu Peng, Zhihua Wan, Xiaofang Lin, Xiu Li and Yukai Du

    Citation: BMC Infectious Diseases 2019 19:147

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  46. Content type: Research article

    Hepatitis C virus (HCV) is one of the main causes of chronic liver disease worldwide. Prevalence of HCV in homeless populations ranges from 3.9 to 36.2%. The HepCheck study sought to investigate and establish ...

    Authors: John S. Lambert, Ross Murtagh, Dee Menezes, Austin O’Carroll, Carol Murphy, Walter Cullen, Tina McHugh, Gordana Avramovic, Willard Tinago and Marie Claire Van Hout

    Citation: BMC Infectious Diseases 2019 19:128

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  48. Content type: Case report

    After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syn...

    Authors: Jing-Wen Zhang, Xiang-Zhong Zhang, Yan-Ling Sun, Bing Long, Xiao-Zhen Wang and Xu-Dong Li

    Citation: BMC Infectious Diseases 2019 19:57

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  49. Content type: Case report

    For patients with chronic hepatitis B and cirrhosis in less developed western regions in China, due to constraints of local economic conditions, the choice of treatment measures is often limited. However if pa...

    Authors: Yue-Rong Zhang, De-Ming Wu, Xiong-Chang Liu, Ning Zhou, Chang-Chun Cao, Wu-Hua Liu, Chun-Xia Wang and Hui Wang

    Citation: BMC Infectious Diseases 2019 19:49

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