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Hepatitis and co-infections

Section edited by Jean-Claude Desenclos

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Content type: Research article

    As direct acting antiviral (DAA) therapy is progressively rolled out for patients with hepatitis C virus (HCV) infection, careful scrutiny of HCV epidemiology, diagnostic testing, and access to care is crucial...

    Authors: Emily Adland, Gerald Jesuthasan, Louise Downs, Victoria Wharton, Gemma Wilde, Anna L. McNaughton, Jane Collier, Eleanor Barnes, Paul Klenerman, Monique Andersson, Katie Jeffery and Philippa C. Matthews

    Citation: BMC Infectious Diseases 2018 18:461

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  2. Content type: Research article

    Despite the high sustained virological response rates achieved with current directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of treated patients do not respond to current a...

    Authors: María Eugenia Soria, Josep Gregori, Qian Chen, Damir García-Cehic, Meritxell Llorens, Ana I. de Ávila, Nathan M. Beach, Esteban Domingo, Francisco Rodríguez-Frías, María Buti, Rafael Esteban, Juan Ignacio Esteban, Josep Quer and Celia Perales

    Citation: BMC Infectious Diseases 2018 18:446

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  3. Content type: Research article

    This study was conducted to determine the prevalence of HBV, HCV, and HDV in urban populations and Amerindians living in the state of Tocantins (Eastern Amazon).

    Authors: Livia Melo Villar, Flavio Augusto Pádua Milagres, Elisabeth Lampe, Helena Medina Cruz, Leticia de Paula Scalioni, Monica de Avelar Figueiredo Mafra Magalhães, Anselmo Rocha Romão, Renata Gracie and Vanessa Salete de Paula

    Citation: BMC Infectious Diseases 2018 18:411

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  4. Content type: Research article

    It is difficult to diagnose ascites infection early in cirrhotic patients. The present study was to create and evaluate a new bioscore combined with PCT, sNFI and dCHC in the diagnosis of ascites infection in ...

    Authors: Han Wang, Yan Li, Fangfang Zhang, Ning Yang, Na Xie, Yuanli Mao and Boan Li

    Citation: BMC Infectious Diseases 2018 18:389

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  5. Content type: Research article

    Hepatitis C virus (HCV) infection is a widespread problem in prisons. The present study aimed to assess the prevalence of HCV seropositivity, HCV genotypes, factors associated with HCV seropositivity in newly ...

    Authors: Kristel Kivimets, Anneli Uusküla, Jeffrey V. Lazarus and Kristi Ott

    Citation: BMC Infectious Diseases 2018 18:339

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  6. Content type: Database

    There are several epidemiological studies available on hepatitis B virus among pregnant women in Ethiopia. These individual studies revealed wide variation over time and across geographical areas. The aim of t...

    Authors: Kindie Mitiku Kebede, Dejene Derseh Abateneh and Alemayehu Sayih Belay

    Citation: BMC Infectious Diseases 2018 18:322

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  7. Content type: Research article

    Tuberculosis (TB) and chronic Hepatitis B virus (HBV) infection are common in China. Fist-line anti-TB medications often produce drug-induced liver injury (DILI). This study sought to investigate whether TB pa...

    Authors: Lubiao Chen, Dujing Bao, Lin Gu, Yurong Gu, Liang Zhou, Zhiliang Gao and Yuehua Huang

    Citation: BMC Infectious Diseases 2018 18:295

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  8. Content type: Research article

    Hepatitis B vaccination is the most effective method of prevention for hepatitis B virus infection. It is a major public health problem in Nigeria, and health workers are at increased risk. This study determin...

    Authors: I. B. Omotowo, I. A. Meka, U. N. Ijoma, V. E. Okoli, O. Obienu, T. Nwagha, A. C. Ndu, D. O. Onodugo, L. C. Onyekonwu and E. O. Ugwu

    Citation: BMC Infectious Diseases 2018 18:288

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  9. Content type: Research article

    From September 2016–April 2017, Am Timan, Chad, experienced a large HEV outbreak in an urban setting with a limited impact in terms of morbidity and mortality. To better understand HEV epidemiology in this con...

    Authors: Larissa Vernier, Annick Lenglet, Boris M. Hogema, Ali M. Moussa, Cono Ariti, Simone Vollmer, Andrea Irwin, Prince Alfani, Sibylle Sang and Charity Kamau

    Citation: BMC Infectious Diseases 2018 18:287

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  10. Content type: Research article

    Hepatitis C (HCV) diagnosis and care is a major challenge for people who use illicit drugs, and is characterised by low rates of testing and treatment engagement globally. New approaches to fostering engagemen...

    Authors: Andy Guise, T. Charles Witzel, Sema Mandal, Caroline Sabin, Tim Rhodes, Anthony Nardone and Magdalena Harris

    Citation: BMC Infectious Diseases 2018 18:281

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  11. Content type: Research article

    Infants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of i...

    Authors: Meng Zhuo Cao, Yan Hua Wu, Si Min Wen, Yu Chen Pan, Chong Wang, Fei Kong, Chuan Wang, Jun Qi Niu, Jie Li and Jing Jiang

    Citation: BMC Infectious Diseases 2018 18:274

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  12. Content type: Research article

    Female gender and favorable IFNL3 genotypes are the primary independent predictors of spontaneous clearance of HCV infection. However, chronic hepatitis C infection occurs in numerous women carrying favorable IFN...

    Authors: Zhe Xie, Yuantao Li, Lu Long, Hua Liang, Weiping Cai and Tao Shen

    Citation: BMC Infectious Diseases 2018 18:254

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  13. Content type: Research article

    Spontaneous bacterial peritonitis (SBP) and bacterascites (BA) represent frequent and serious complications in cirrhosis patients with ascites. However, few detailed data are available regarding the clinical a...

    Authors: Nian-zhi Ning, Tao Li, Ju-ling Zhang, Fen Qu, Jie Huang, Xiong Liu, Zhan Li, Wei Geng, Jun-liang Fu, Wang Huan, Shu-yong Zhang, Chun-mei Bao and Hui Wang

    Citation: BMC Infectious Diseases 2018 18:253

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  14. Content type: Research article

    HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons can enhan...

    Authors: Luna Colagrossi, Lucas E. Hermans, Romina Salpini, Domenico Di Carlo, Suzan D. Pas, Marta Alvarez, Ziv Ben-Ari, Greet Boland, Bianca Bruzzone, Nicola Coppola, Carole Seguin-Devaux, Tomasz Dyda, Federico Garcia, Rolf Kaiser, Sukran Köse, Henrik Krarup…

    Citation: BMC Infectious Diseases 2018 18:251

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  15. Content type: Research article

    Direct-acting anti-viral agents have improved the treatment of chronic hepatitis C virus (HCV) infection, but this treatment is challenging for patients using co-medications because of potential drug–drug inte...

    Authors: Daniel J. Ruzicka, Jumpei Tetsuka, Go Fujimoto and Tatsuya Kanto

    Citation: BMC Infectious Diseases 2018 18:237

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  16. Content type: Research article

    Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Her...

    Authors: Simone Lanini, Paola Scognamiglio, Alessandra Mecozzi, Lorella Lombardozzi, Vincenzo Vullo, Mario Angelico, Antonio Gasbarrini, Gloria Taliani, Adolfo Francesco Attili, Carlo Federico Perno, Adriano De Santis, Vincenzo Puro, Fabio Cerqua, Gianpiero D’Offizi, Adriano Pellicelli, Orlando Armignacco…

    Citation: BMC Infectious Diseases 2018 18:223

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  17. Content type: Research article

    Hepatitis C virus (HCV) is the most common blood-borne viral infection in the United States. Previously, we used data from the National Health and Nutrition Examination Survey (NHANES) and mortality data from ...

    Authors: Eric W. Hall, Eli S. Rosenberg and Patrick S. Sullivan

    Citation: BMC Infectious Diseases 2018 18:224

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  18. Content type: Research article

    This study evaluated cause-specific mortality trends including liver-related mortality among people with a hepatitis B virus (HBV) and hepatitis C virus (HCV) notification in New South Wales, Australia.

    Authors: Maryam Alavi, Jason Grebely, Behzad Hajarizadeh, Janaki Amin, Sarah Larney, Matthew G. Law, Jacob George, Louisa Degenhardt and Gregory J. Dore

    Citation: BMC Infectious Diseases 2018 18:215

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  19. Content type: Research article

    Co-infection with HIV negatively impacts the progression of chronic hepatitis B virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan Africa represents arguably the most imp...

    Authors: Tongai Gibson Maponga, Monique I. Andersson, Christoffel J. van Rensburg, Joop E. Arends, Jantjie Taljaard, Wolfgang Preiser and Richard H. Glashoff

    Citation: BMC Infectious Diseases 2018 18:214

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  20. Content type: Research article

    A marked increase of hepatitis E cases has recently been observed in the Netherlands. Causes of the (re-)emergence of hepatitis E virus (HEV) and exact sources and routes of transmission of HEV infection are c...

    Authors: Sofie H. Mooij, Boris M. Hogema, Anna D. Tulen, Wilfrid van Pelt, Eelco Franz, Hans L. Zaaijer, Michel Molier and Agnetha Hofhuis

    Citation: BMC Infectious Diseases 2018 18:173

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  21. Content type: Research article

    Efficient control of acute hepatitis B requires identification of current transmission routes. Countries in Central-Eastern Europe including Poland attribute an important fraction of cases to nosocomial transm...

    Authors: Małgorzata Stępień, Karolina Zakrzewska and Magdalena Rosińska

    Citation: BMC Infectious Diseases 2018 18:164

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  22. Content type: Research article

    People who inject drugs (PWID) are most at risk of hepatitis C virus infection in Australia. The introduction of transient elastography (TE) (measuring hepatitis fibrosis) and direct acting antiviral medicatio...

    Authors: Stelliana Goutzamanis, Joseph S. Doyle, Alexander Thompson, Paul Dietze, Margaret Hellard and Peter Higgs

    Citation: BMC Infectious Diseases 2018 18:151

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  23. Content type: Research article

    As the socioeconomic conditions in Jordan have improved over recent decades the disease and economic burden of Hepatitis A has increased. The purpose of this study is to assess the potential health and economi...

    Authors: Wail A. Hayajneh, Vincent J. Daniels, Cerise K. James, Muhammet Nabi Kanıbir, Matthew Pilsbury, Morgan Marks, Michelle G. Goveia, Elamin H. Elbasha, Erik Dasbach and Camilo J. Acosta

    Citation: BMC Infectious Diseases 2018 18:119

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  24. Content type: Research article

    Characteristics of hepatitis B (HBV) and delta (HDV) coinfection in various geographical regions, including Israel, remain unclear. Here we studied HDV seroprevalence in Israel, assessed HDV/HBV viral loads, c...

    Authors: Rachel Shirazi, Daniela Ram, Aviya Rakovsky, Efrat Bucris, Yael Gozlan, Yaniv Lustig, Pninit Shaked-Mishan, Orit Picard, Yonat Shemer-Avni, Haim Ben-Zvi, Ora Halutz, Yoav Lurie, Ella Veizman, Matthias Carlebach, Marius Braun, Michal Cohen- Naftaly…

    Citation: BMC Infectious Diseases 2018 18:97

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  25. Content type: Research article

    In 2016, the World Health Organisation set a goal to eliminate viral hepatitis by 2030. Robust epidemiological information underpins all efforts to achieve elimination and this systematic review provides estim...

    Authors: Abby May Falla, Sanne Henrietta Ina Hofstraat, Erika Duffell, Susan Josien Maria Hahné, Lara Tavoschi and Irene Karen Veldhuijzen

    Citation: BMC Infectious Diseases 2018 18:79

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  26. Content type: Research article

    Persons with chronic hepatitis B (CHB) infection were reported to suffer severe disease after hepatitis E virus (HEV) superinfection, but the studies regarding HEV seroprevalence in this population were limite...

    Authors: Li Zhang, Zechun Jiang, Jingjing Lv, Jiaye Liu, Bingyu Yan, Yi Feng, Li Li, Guomin Zhang, Fuzhen Wang and Aiqiang Xu

    Citation: BMC Infectious Diseases 2018 18:75

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  27. Content type: Case report

    Hepatitis E infection is a global disorder that causes substantial morbidity. Numerous neurologic illnesses, including Guillain–Barre syndrome (GBS), have occurred in patients with hepatitis E virus (HEV) infe...

    Authors: Xiaoqin Zheng, Liang Yu, Qiaomai Xu, Silan Gu and Lingling Tang

    Citation: BMC Infectious Diseases 2018 18:50

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  28. Content type: Research article

    Increasing the proportion diagnosed with and on treatment for chronic hepatitis C (CHC) is key to the elimination of hepatitis C in Europe. This study contributes to secondary prevention planning in the Europe...

    Authors: A. M. Falla, A. A. Ahmad, E. Duffell, T. Noori and I. K. Veldhuijzen

    Citation: BMC Infectious Diseases 2018 18:42

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  29. Content type: Research article

    Chronic hepatitis B (CHB) related morbidity and mortality can be reduced through risk group screening, linkage to care and anti-viral treatment. This study estimates the number of CHB cases among foreign-born ...

    Authors: Amena A. Ahmad, Abby M. Falla, Erika Duffell, Teymur Noori, Angela Bechini, Ralf Reintjes and Irene K. Veldhuijzen

    Citation: BMC Infectious Diseases 2018 18:34

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  30. Content type: Research article

    The overall prevalence of hepatitis B virus (HBV) infection in China is declining. The purpose of this study was to use a community-based epidemiological study to update the infection status of hepatitis B vir...

    Authors: Ping Chen, Qinfen Xie, Ting Chen, Jiawei Wu, Jie Wu, Bing Ruan, Zhiqin Zhang, Hainv Gao and Lanjuan Li

    Citation: BMC Infectious Diseases 2017 17:809

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  31. Content type: Research article

    The last decade was marked by major advances in HCV treatment with the introduction of first wave protease inhibitors (1st-wave PIs, telaprevir or boceprevir) in 2011 and second direct-acting antivirals (2nd-w...

    Authors: Cécile Brouard, Marjorie Boussac-Zarebska, Christine Silvain, Julien Durand, Victor de Lédinghen, Josiane Pillonel and Elisabeth Delarocque-Astagneau

    Citation: BMC Infectious Diseases 2017 17:784

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  32. Content type: Research article

    Hepatitis B vaccination for healthcare workers (HCWs) is a key component of the WHO Hepatitis B Elimination Strategy 2016–2021. Data on current hepatitis B vaccine coverage among health care workers in Sub-Sah...

    Authors: Dotto Aaron, Tumaini J. Nagu, John Rwegasha and Ewaldo Komba

    Citation: BMC Infectious Diseases 2017 17:786

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  33. Content type: Research article

    Prospective studies have shown that 80% of acute hepatitis C virus (HCV) cases progress to chronic infection; approximately 10-20% of patients with these conditions will develop liver cirrhosis within 2 to 3 d...

    Authors: Caroline Manchiero, Arielle Karen da Silva Nunes, Mariana Carvalheiro Magri, Bianca Peixoto Dantas, Celso Carmo Mazza, Antonio Alci Barone and Fátima Mitiko Tengan

    Citation: BMC Infectious Diseases 2017 17:780

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  34. Content type: Research article

    There are few data available on the prevalence, incidence, and residual risk of transfusion-transmitted HBV (TT-HBV) infections among Chinese blood donors. This study investigated the demographic characteristi...

    Authors: Ling Li, Tingting Han, Liang Zang, Libin Niu, Weifang Cheng, Hongkeng Lin, Ka Yi Li, Ruan Cao, Binghai Zhao, Yuqiang Liu, Guojin Ou, Xiao Liu, Yingjie Qi, Yanhua Li and Zhong Liu

    Citation: BMC Infectious Diseases 2017 17:754

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  35. Content type: Research article

    Direct acting antivirals are expected to drastically reduce the burden of hepatitis C virus (HCV) in people living with Human Immunodeficiency Virus (HIV). However, rates of HCV testing, re-testing and inciden...

    Authors: David C. Boettiger, Matthew G. Law, Gregory J. Dore, Rebecca Guy, Denton Callander, Basil Donovan, Catherine C. O’Connor, Christopher K. Fairley, Margaret Hellard and Gail Matthews

    Citation: BMC Infectious Diseases 2017 17:740

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  36. Content type: Research article

    Six distinct genetic variants (genotypes 1 − 6) of hepatitis C virus (HCV) exist globally. Certain genotypes are more prevalent in particular countries or regions than in others but, globally, genotype 3 (GT3)...

    Authors: Hosnieh Fathi, Andrew Clark, Nathan R. Hill and Geoffrey Dusheiko

    Citation: BMC Infectious Diseases 2017 17:722

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  37. Content type: Research article

    Non-structural 5A protein (NS5A) resistance-associated substitutions (RASs) have been identified in patients infected with hepatitis C virus (HCV), even prior to exposure to direct-acting antiviral agents (DAA...

    Authors: Fernanda Malta, Karine Vieira Gaspareto, Gaspar Lisboa-Neto, Flair José Carrilho, Maria Cássia Mendes-Correa and João Renato Rebello Pinho

    Citation: BMC Infectious Diseases 2017 17:716

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  38. Content type: Research article

    Schistosoma mansoni and Hepatitis C virus (HCV) are co-existence in sub-Saharan Africa and co-infection is common among humans population. The immunological responses characterized wit...

    Authors: Humphrey D. Mazigo, Stella Kepha, Godfrey M. Kaatano and Safari M. Kinung’hi

    Citation: BMC Infectious Diseases 2017 17:668

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  39. Content type: Research article

    Hepatitis B Virus (HBV) infection is a worldwide public health problem. In Nepal, the prevalence of HBV is found to be low (0.9%), although high prevalence (≥8%) of HBV infection is depicted among subgroup/pop...

    Authors: Purusotam Raj Shedain, Madhu Dixit Devkota, Megha Raj Banjara, Huang Ling and Subash Dhital

    Citation: BMC Infectious Diseases 2017 17:667

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  40. Content type: Research article

    For hepatitis B patients who do not meet the treatment criteria recommended by guidelines, therapy decisions depend on hepatic histology. Angiopoietin-like protein 2 (Angptl2) is a mediator of chronic inflamma...

    Authors: Yongqiong Deng, Hong Zhao, Jiyuan Zhou, Linlin Yan and Guiqiang Wang

    Citation: BMC Infectious Diseases 2017 17:650

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  41. Content type: Research article

    Hepatitis B virus (HBV) affects people worldwide but the local burden especially in pregnant women and their new born babies is unknown. In Rwanda HIV-infected individuals who are also infected with HBV are su...

    Authors: Mwumvaneza Mutagoma, Helene Balisanga, Samuel S. Malamba, Dieudonné Sebuhoro, Eric Remera, David J. Riedel, Steve Kanters and Sabin Nsanzimana

    Citation: BMC Infectious Diseases 2017 17:618

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  42. Content type: Research article

    Hepatitis B virus (HBV) infection is a major public health problem globally. HBV genotypes and subgenotypes influence disease transmission, progression, and treatment outcome. A study was conducted among treat...

    Authors: Thi Ton Taht Bui, Tan Thanh Tran, My Ngoc Nghiem, Pierre Rahman, Thi Thanh Thanh Tran, Man Nguyen Huy Dinh, Manh Hung Le, Van Vinh Chau Nguyen, Guy Thwaites and Motiur Rahman

    Citation: BMC Infectious Diseases 2017 17:601

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  43. Content type: Research article

    Hepatitis B virus (HBV) infection is a major cause of chronic liver disease worldwide. In immunocompromised patients, the chronicity rates of HBV infection are higher, but the rates of hepatitis Be antigen (HB...

    Authors: Fatima Mitiko Tengan, Edson Abdala, Marisa Nascimento, Wanderley Marques Bernardo and Antonio Alci Barone

    Citation: BMC Infectious Diseases 2017 17:587

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  44. Content type: Case report

    HBV reactivation is associated with high mortality rates in hematopoietic stem cell transplantation (HSCT) and prophylactic lamivudine (LMV) treatment is suggested to prevent this phenomenon. However, the dura...

    Authors: C. Cerva, G. Maffongelli, V. Svicher, R. Salpini, L. Colagrossi, A. Battisti, B. Mariotti, R. Cerretti, L. Cudillo and L. Sarmati

    Citation: BMC Infectious Diseases 2017 17:566

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  45. Content type: Research article

    Hepatitis A virus (HAV) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. It is important to characterize circulating strains of HAV in order to prevent HAV...

    Authors: Huseyin Yilmaz, Asiye Karakullukcu, Nuri Turan, Utku Y. Cizmecigil, Aysun Yilmaz, Ayse A. Ozkul, Ozge Aydin, Alper Gunduz, Mahmut Mete, Fadile Y. Zeyrek, Taner T. Kirazoglu, Juergen A. Richt and Bekir Kocazeybek

    Citation: BMC Infectious Diseases 2017 17:561

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  46. Content type: Research article

    Data on the cost effectiveness of hepatitis B virus (HBV) screening and vaccination strategies for prevention of vertical transmission of HBV in resource limited settings is sparse.

    Authors: Angela Devine, Rebecca Harvey, Aung Myat Min, Mary Ellen T. Gilder, Moo Koh Paw, Joy Kang, Isabella Watts, Borimas Hanboonkunupakarn, François Nosten and Rose McGready

    Citation: BMC Infectious Diseases 2017 17:552

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  47. Content type: Research article

    Extensively Drug-Resistant (XDR) Tuberculosis (TB) has posed a great threat to global health and finance systems, especially for developing countries with high TB and Multidrug-Resistant (MDR) TB burden.

    Authors: Xiao-chun He, Ning-ning Tao, Yao Liu, Xian-xin Zhang and Huai-chen Li

    Citation: BMC Infectious Diseases 2017 17:555

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  48. Content type: Research article

    Lack of Hepatitis C virus (HCV) incidence data in (Norwegian) high-risk groups impedes the ability to make informed decisions on prevention measures. Thus we rely on modelling to estimate the incidence and bur...

    Authors: Hinta Meijerink, Richard A White, Astrid Løvlie, Birgitte Freiesleben de Blasio, Olav Dalgard, Ellen J. Amundsen, Espen Melum and Hilde Kløvstad

    Citation: BMC Infectious Diseases 2017 17:541

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  49. Content type: Research article

    Liver-related mortality has been increasing worldwide. We aimed to estimate the age-standardized mortality rates from viral hepatitis in Brazil.

    Authors: Hugo Perazzo, Antonio G Pacheco, Paula M Luz, Rodolfo Castro, Chris Hyde, Juliana Fittipaldi, Caroline Rigolon, Sandra W Cardoso, Beatriz Grinsztejn and Valdiléa G Veloso

    Citation: BMC Infectious Diseases 2017 17:527

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  50. Content type: Research article

    Hepatitis A virus (HAV) infection is endemic in Eastern European and Balkan region countries. In 2012, Bulgaria showed the highest rate (67.13 cases per 100,000) in Europe. Nevertheless, HAV genotypes and stra...

    Authors: Roberto Bruni, Stefania Taffon, Michele Equestre, Eleonora Cella, Alessandra Lo Presti, Angela Costantino, Paola Chionne, Elisabetta Madonna, Elitsa Golkocheva-Markova, Diljana Bankova, Massimo Ciccozzi, Pavel Teoharov and Anna Rita Ciccaglione

    Citation: BMC Infectious Diseases 2017 17:497

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