Hepatitis and co-infections

Section edited by Jean-Claude Desenclos

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Research article

    Hepatitis a virus genotypes and strains from an endemic area of Europe, Bulgaria 2012–2014

    Hepatitis A virus (HAV) infection is endemic in Eastern European and Balkan region countries. In 2012, Bulgaria showed the highest rate (67.13 cases per 100,000) in Europe. Nevertheless, HAV genotypes and stra...

    Roberto Bruni, Stefania Taffon, Michele Equestre, Eleonora Cella, Alessandra Lo Presti, Angela Costantino, Paola Chionne, Elisabetta Madonna, Elitsa Golkocheva-Markova, Diljana Bankova, Massimo Ciccozzi, Pavel Teoharov and Anna Rita Ciccaglione

    BMC Infectious Diseases 2017 17:497

    Published on: 14 July 2017

  2. Research article

    Risk factors, person, place and time characteristics associated with Hepatitis E Virus outbreak in Napak District, Uganda

    Hepatitis E is self-limiting, but can cause death in most at risk groups like pregnant women and those with preexisting acute liver disease. In developing countries it presents as epidemic, in 2014 Hepatitis E...

    Geofrey Amanya, Samuel Kizito, Immaculate Nabukenya, Joan Kalyango, Collins Atuheire, Hellen Nansumba, Stephen Akena Abwoye, Denis Nixon Opio, Edrisa Kibuuka and Charles Karamagi

    BMC Infectious Diseases 2017 17:451

    Published on: 26 June 2017

  3. Research article

    Early experiences from one of the first treatment programs for chronic hepatitis B in sub-Saharan Africa

    Treatment for chronic hepatitis B (CHB) is virtually absent in sub-Saharan Africa. Here we present early experiences from a pilot program for treatment of CHB in Ethiopia.

    Hanna Aberra, Hailemichael Desalegn, Nega Berhe, Girmay Medhin, Kathrine Stene-Johansen, Svein Gunnar Gundersen and Asgeir Johannessen

    BMC Infectious Diseases 2017 17:438

    Published on: 19 June 2017

  4. Research article

    Adherence to response-guided pegylated interferon and ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: the ACTIVATE study

    The aims of this analysis were to investigate treatment completion and adherence among people with ongoing injecting drug use or receiving opioid substitution therapy (OST) in a study of response-guided therap...

    Evan B. Cunningham, Behzad Hajarizadeh, Olav Dalgard, Janaki Amin, Margaret Hellard, Graham R Foster, Philip Bruggmann, Brian Conway, Markus Backmund, Geert Robaeys, Tracy Swan, Philippa S. Marks, Sophie Quiene, Tanya L Applegate, Martin Weltman, David Shaw…

    BMC Infectious Diseases 2017 17:420

    Published on: 13 June 2017

  5. Research article

    Assessing the knowledge of expectant mothers on mother–to-child transmission of viral hepatitis B in Upper West region of Ghana

    Viral Hepatitis B is of a major public health concern globally, especially in developing countries. Expectant mothers’ knowledge of Mother-To-Child Transmission (MTCT) of the disease is significant in preventi...

    Frederick Dun-Dery, Martin Nyaaba Adokiya, Williams Walana, Ernestina Yirkyio and Juventus B. Ziem

    BMC Infectious Diseases 2017 17:416

    Published on: 12 June 2017

  6. Research article

    Simeprevir with peginterferon α-2a/ribavirin for chronic hepatitis C virus genotype 1 infection in treatment-experienced patients: an open-label, rollover study

    This Phase 3, open-label, rollover study (NCT01323244) investigated the efficacy and safety of simeprevir plus peginterferon α-2a (PegIFNα-2a) and ribavirin (RBV) in a well-characterized population of HCV geno...

    Edward J. Gane, Edwin DeJesus, Ewa Janczewska, Jacob George, Moises Diago, Mariliza Hendrique Da Silva, Henk Reesink, Igor Nikitin, Holger Hinrichsen, Stefan Bourgeois, Peter Ferenci, Umesh Shukla, Ronald Kalmeijer, Oliver Lenz, Bart Fevery, Chris Corbett…

    BMC Infectious Diseases 2017 17:389

    Published on: 2 June 2017

  7. Research article

    Novel serum biomarkers modified by the body mass index z-score for the detection of liver fibrosis and steatosis in children with chronic hepatitis C

    There is a need for validation of noninvasive alternatives to liver biopsy for the evaluation of fibrosis in children with chronic hepatitis C (CHC). The aim of this study was to evaluate the diagnostic perfor...

    Maria Pokorska-Śpiewak, Barbara Kowalik-Mikołajewska, Małgorzata Aniszewska, Magdalena Pluta and Magdalena Marczyńska

    BMC Infectious Diseases 2017 17:361

    Published on: 23 May 2017

  8. Research article

    Promoting notification and linkage of HBs antigen and anti-HCV antibody-positive patients through hospital alert system

    In Japan, approximately 0.9% and 1% of the whole population are infected with HBV and HCV, respectively. Doctors from departments other than gastroenterology often order viral hepatitis tests before an invasiv...

    Naoki Yoshioka, Akihiko Okumura, Yukie Yamamoto, Katsura Yamaguchi, Atsuro Kaga, Kentaro Yamada, Takuya Hirosaki, Daisuke Ishikawa, Shin Kunii, Kazumasa Watanabe, Setsuo Utsunomiya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto and Yoshiki Hirooka

    BMC Infectious Diseases 2017 17:330

    Published on: 8 May 2017

  9. Research article

    Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam: a systematic review

    Hepatitis C infection is a major public health concern in low- and middle-income countries where an estimated 71.1 million individuals are living with chronic infection. The World Health Organization (WHO) has...

    Alessandra Berto, Jeremy Day, Nguyen Van Vinh Chau, Guy E. Thwaites, Ngoc Nghiem My, Stephen Baker and Thomas C. Darton

    BMC Infectious Diseases 2017 17:260

    Published on: 11 April 2017

  10. Research article

    Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus

    In chronic hepatitis C, the fibrosis progression rates are extremely variable and can be influenced by factors associated with the host, virus and environment. Among the associated metabolic factors, hepatic s...

    Mariana Cavalheiro Magri, Thamiris Vaz Gago Prata, Caroline Manchiero, Bianca Peixoto Dantas, Celso Carmo Mazza and Fátima Mitiko Tengan

    BMC Infectious Diseases 2017 17:235

    Published on: 29 March 2017

  11. Research article

    Hepatitis C virus and HIV co-infection among pregnant women in Rwanda

    Hepatitis C virus (HCV) infection is a pandemic causing disease; more than 185 million people are infected worldwide. An HCV antibody (Ab) prevalence of 6.0% was estimated in Central African countries. The stu...

    Mwumvaneza Mutagoma, Helene Balisanga, Dieudonné Sebuhoro, Aimable Mbituyumuremyi, Eric Remera, Samuel S. Malamba, David J. Riedel and Sabin Nsanzimana

    BMC Infectious Diseases 2017 17:167

    Published on: 22 February 2017

  12. Research article

    The need for treatment scale-up to impact HCV transmission in people who inject drugs in Montréal, Canada: a modelling study

    HCV transmission remains high in people who inject drugs (PWID) in Montréal. New direct-acting antivirals (DAAs), highly effective and more tolerable than previous regimens, make a “Treatment as Prevention” (T...

    Anthony Cousien, Pascale Leclerc, Carole Morissette, Julie Bruneau, Élise Roy, Viet Chi Tran, Yazdan Yazdanpanah and Joseph Cox

    BMC Infectious Diseases 2017 17:162

    Published on: 21 February 2017

  13. Research article

    Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status

    The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an associ...

    Sayeh Ezzikouri, Hajar Chihab, Abdellah Elhabazi, Lahcen Wakrim and Soumaya Benjelloun

    BMC Infectious Diseases 2017 17:99

    Published on: 26 January 2017

  14. Research article

    Cocaine/crack use is not associated with fibrosis progression measured by AST-to-Platelet Ratio Index in HIV-HCV co-infected patients: a cohort study

    Cocaine and crack use has been associated with HIV and HCV infections, but its consequences on HCV progression have not been well established. We analyzed the impact of cocaine/crack use on liver fibrosis prog...

    Valérie Martel-Laferrière, Roy Nitulescu, Joseph Cox, Curtis Cooper, Mark Tyndall, Danielle Rouleau, Sharon Walmsley, Leo Wong and Marina B. Klein

    BMC Infectious Diseases 2017 17:80

    Published on: 17 January 2017

  15. Research article

    Anti-hepatitis B virus (HBV) response of imiquimod based toll like receptor 7 ligand in hbv-positive human hepatocelluar carcinoma cell line

    Toll like receptors (TLRs) play an important role in innate immunity and various studies suggest that TLRs play a crucial role in pathogenesis of hepatitis B virus (HBV) infection. The present study aims in lo...

    Dipanwita Das, Isha Sengupta, Neelakshi Sarkar, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivaram Prasad Singh, Sekhar Chakrabarti and Runu Chakravarty

    BMC Infectious Diseases 2017 17:76

    Published on: 14 January 2017

  16. Research article

    The effectiveness of daclatasvir based therapy in European patients with chronic hepatitis C and advanced liver disease

    There is limited evidence for the effectiveness of daclatasvir in patients whose hepatitis C threatens their life expectancy. The Named Patient Program in Europe included patients with advanced chronic hepatit...

    Jim Young, Nina Weis, Harald Hofer, William Irving, Ola Weiland, Emiliano Giostra, Juan Manuel Pascasio, Lluis Castells, Martin Prieto, Roelien Postema, Cinira Lefevre, David Evans, Heiner C. Bucher and Jose Luis Calleja

    BMC Infectious Diseases 2017 17:45

    Published on: 7 January 2017

  17. Research article

    Hepatitis B virus strains from Rwandan blood donors are genetically similar and form one clade within subgenotype A1

    Rwanda is a central African country with about 12 million inhabitants. The 1994 genocide against the Tutsi destroyed much of the infrastructure, including the health system. Although this has improved signific...

    Theogene Twagirumugabe, Gatare Swaibu, Timothy David Walker, Magnus Lindh, Jean Bosco Gahutu, Tomas Bergström and Heléne Norder

    BMC Infectious Diseases 2017 17:32

    Published on: 6 January 2017

  18. Research article

    Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors

    The concentrations of hepatitis B virus (HBV) DNA and surface antigen (HBsAg) are two critical virological variables to be monitored in chronic hepatitis B. HBsAg is derived from the HBV genome. Thus, higher H...

    Chao-Wei Hsu, Kung-Hao Liang, Chih-Lang Lin, Tong-Hong Wang and Chau-Ting Yeh

    BMC Infectious Diseases 2017 17:9

    Published on: 5 January 2017

  19. Research article

    Hepatitis viruses in Ethiopia: a systematic review and meta-analysis

    The existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic...

    Yeshambel Belyhun, Melanie Maier, Andargachew Mulu, Ermias Diro and Uwe Gerd Liebert

    BMC Infectious Diseases 2016 16:761

    Published on: 19 December 2016

    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:114

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