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Hepatitis and co-infections

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of hepatitis in humans as well as related molecular genetics, pathophysiology, and epidemiology

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  1. Hepatitis B and C infections and transmission are a serious challenge to all healthcare systems. We studied seroprevalence rates of Transfusion Transmitted Diseases (TTD) among blood bank donors in Jordan from...

    Authors: Lina Souan, Mahmoud Siag, Hala Al-Salahat, Tareq Al-Atrash and Maher A. Sughayer

    Citation: BMC Infectious Diseases 2021 21:508

    Content type: Research article

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  2. In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C...

    Authors: Machiko Umemura, Goki Suda, Shihori Tsukamoto, Ko Ebata, Shinjiro Takahash, Takashi Sasaki, Sae Nakajima, Koji Hirata, Mariko Ozasa, Masatoshi Takano, Masaki Katagiri and Naoya Sakamoto

    Citation: BMC Infectious Diseases 2021 21:389

    Content type: Case report

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  3. Direct-Acting agents (DAAs) target and inhibit essential viral replication proteins. They have revolutionized the treatment of Hepatitis C virus (HCV) infection reaching high levels of sustained virologic resp...

    Authors: Fabián Aldunate, Natalia Echeverría, Daniela Chiodi, Pablo López, Adriana Sánchez-Cicerón, Martín Soñora, Juan Cristina, Gonzalo Moratorio, Nelia Hernández and Pilar Moreno

    Citation: BMC Infectious Diseases 2021 21:387

    Content type: Case report

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  4. Acute kidney injury (AKI) is expected to occur commonly in patients with chronic hepatitis C. In addition, AKI may affect the survival of patients with chronic hepatitis C. However, few studies are available o...

    Authors: Hankyu Jeon, Jae Heon Kim, Sang Soo Lee, Hee Jin Kim, Ra Ri Cha, Hyun Chin Cho, Jae Min Lee, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok-Jae Lee

    Citation: BMC Infectious Diseases 2021 21:301

    Content type: Research article

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  5. Despite a dramatic reduction in HCV drug costs and simplified models of care, many countries lack important information on prevalence and risk factors to structure effective HCV services.

    Authors: Emily Lynch, Gregoire Falq, Chhorvy Sun, Pharm D Tek Bunchhoeung, Helena Huerga, Anne Loarec, Jean-Phillipe Dousset, Tonia Marquardt, Mickael Le Paih and David Maman

    Citation: BMC Infectious Diseases 2021 21:223

    Content type: Research article

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  6. T cells play an important role in the prognosis of hepatitis B virus (HBV) infection, and are involved in the seroconversion of a patient from HBsAb negative to positive. To compare the T-cell receptor β-chain...

    Authors: Dangsheng Xiao, Ju Wang, Zhitao Chen, Xiuyuan Jin, Yirui Xie, Dong Yan and Jiezuan Yang

    Citation: BMC Infectious Diseases 2021 21:111

    Content type: Research article

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  7. In order to reduce the burden on organ shortage around the world, using potential infectious donor might be an option. However, scarce evidences have been published on kidney transplantation (KTx) from hepatit...

    Authors: Xian-ding Wang, Shi-jian Feng, Jin-peng Liu, Tu-run Song, Zhong-li Huang, Yu Fan, Yun-ying Shi, Li-yu Chen, Yuan-hang Lv, Zi-lin Xu, Xiao-hong Li, Li Wang and Tao Lin

    Citation: BMC Infectious Diseases 2021 21:41

    Content type: Research article

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  8. Serum levels of procalcitonin (PCT) are considered a useful biomarker for the diagnosis of bacterial infection or inflammation. There are few reports of high PCT levels in end-stage liver disease regardless of...

    Authors: Juan Lu, Chun-lei Chen, Jian-di Jin, Jun Chen and Cheng-bo Yu

    Citation: BMC Infectious Diseases 2021 21:29

    Content type: Case report

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  9. Chronic Sedentary lifestyles have been linked to increased odds of stress, elevated anxiety and diminished wellbeing, inducing cytokine production and predispose to hypertension and other cardiovascular diseas...

    Authors: Nsoh Godwin Anabire, Paul Armah Aryee, Zulka Ziblim, Jonathan Suurbaar, Felix Ansah and Gideon Kofi Helegbe

    Citation: BMC Infectious Diseases 2020 20:957

    Content type: Research article

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  10. Treatment of chronic hepatitis C virus infection with direct acting antiviral therapy results in viral elimination in over 90% of cases. The duration of treatment required to achieve cure differs between indiv...

    Authors: Cody Orr, Wenjie Xu, Henry Masur, Shyam Kottilil and Eric G. Meissner

    Citation: BMC Infectious Diseases 2020 20:929

    Content type: Research article

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  11. Cigarette smoking has emerged as a leading cause of mortality among people with hepatitis C virus (HCV). People who inject drugs (PWID) represent the largest group of adults infected with HCV in the US. Howeve...

    Authors: Irene Pericot-Valverde, Moonseong Heo, Matthew J. Akiyama, Brianna L. Norton, Linda Agyemang, Jiajing Niu and Alain H. Litwin

    Citation: BMC Infectious Diseases 2020 20:928

    Content type: Research article

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  12. Hepatitis B virus (HBV), Human Immunodeficiency virus (HIV) and Tuberculosis (TB) are common infections in South Africa. We utilized the opportunity of care provision for HIV-TB co-infected patients to better ...

    Authors: Nokukhanya Msomi, Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Nesri Padayatchi, Kerusha Govender, Jerome Amir Singh, Salim Abdool-Karim, Quarraisha Abdool-Karim and Koleka Mlisana

    Citation: BMC Infectious Diseases 2020 20:847

    Content type: Research article

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  13. Hepatitis B virus (HBV) infection is a public health problem in Togo and transmission to the child occurs mainly during childbirth. The objective of this study was to estimate the prevalence of HBV among child...

    Authors: Didier K. Ekouevi, Lucile Larrouy, Fifonsi A. Gbeasor-Komlanvi, Vincent Mackiewicz, Martin K. Tchankoni, Alexandra M. Bitty-Anderson, Gatibe Yendu-suglpak Gnatou, Arnold Sadio, Mounerou Salou, Claver A. Dagnra, Diane Descamps and Patrick A. Coffie

    Citation: BMC Infectious Diseases 2020 20:839

    Content type: Research article

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  14. The availability of effective, oral direct acting antivirals (DAAs) for hepatitis C virus (HCV) treatment has put elimination of HCV as a public health challenge within reach. However, little is known about th...

    Authors: Oluwaseun Falade-Nwulia, Jada Hackman, Shruti H. Mehta, Sean D. McCormick, Gregory D. Kirk, Mark Sulkowski, David Thomas, Carl Latkin, Oliver Laeyendecker and Stuart C. Ray

    Citation: BMC Infectious Diseases 2020 20:815

    Content type: Research article

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  15. This study aimed at determining the prevalence of and risk factors for hepatitis B virus (HBV) and hepatitis C virus (HCV) among incarcerated people who inject drugs (PWID) in Iran in 2015–16.

    Authors: Ghobad Moradi, Parvin Mohamadi, Bushra Zareie, Mohammad Aziz Rasouli, Mohammad Mehdi Gouya and Saeede Jafari

    Citation: BMC Infectious Diseases 2020 20:806

    Content type: Research article

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  16. Safe, highly curative, short course, direct acting antiviral (DAA) therapies are now available to treat chronic hepatitis C. DAA therapy is freely available to all adults chronically infected with the hepatiti...

    Authors: Jessica Ramsay, Julie Marsh, Alisa Pedrana, Nada Andric, Richard Norman, Wendy Cheng, Steve Webb, Nikolajs Zeps, Matthew Bellgard, Todd Graves, Margaret Hellard and Tom Snelling

    Citation: BMC Infectious Diseases 2020 20:802

    Content type: Study protocol

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  17. Hepatitis C virus (HCV) elimination by 2030, as targeted by the World Health Organization (WHO), requires that 90% of people with chronic infection be diagnosed and 80% treated. We estimated the cascade of car...

    Authors: Cécile Brouard, Josiane Pillonel, Marjorie Boussac, Victor de Lédinghen, Antoine Rachas, Christine Silvain, Nathalie Lydié, Stéphane Chevaliez, Corinne Pioche, Julien Durand, Florence Lot and Elisabeth Delarocque-Astagneau

    Citation: BMC Infectious Diseases 2020 20:759

    Content type: Research article

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  18. Chronic hepatitis C virus (HCV), which is a concern in many countries, is the leading cause of liver cancer around the world. Since Taiwan launched its national health insurance system in 1995, it has managed ...

    Authors: Wei Li, Te-Sheng Chang, Shu-Zhi Chang, Ching-Hwa Chen and Mei-Yen Chen

    Citation: BMC Infectious Diseases 2020 20:737

    Content type: Research article

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  19. Blood transfusion is associated with potential risks of transfusion-transmitted infections (TTIs). Different strategies are needed to monitor blood safety and screen the donors’ efficacy, such as evaluation of...

    Authors: Azadeh Omidkhoda, Bahman Razi, Ali Arabkhazaeli and Sedigheh Amini Kafi-Abad

    Citation: BMC Infectious Diseases 2020 20:736

    Content type: Research article

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  20. Hepatitis C virus (HCV) infections in people who inject drugs (PWID) can now be treated and cured. However, the impact that HCV treatment has on drug-user health, practices and wellbeing is not known. The aim ...

    Authors: Marta Torrens, Tokunbo Soyemi, Darcy Bowman and Eberhard Schatz

    Citation: BMC Infectious Diseases 2020 20:702

    Content type: Research article

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  21. Hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM) are two major public health problems associated with increasing complications and mortality rates worldwide. The objective of this study is...

    Authors: James A. Ndako, Akinyomade O. Owolabi, Joseph A. Olisa, Jeremiah A. Akinwumi, Victor T. Dojumo, Oludolapo Olatinsu and Blessing A. Adebayo

    Citation: BMC Infectious Diseases 2020 20:664

    Content type: Research article

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  22. People who use drugs including people who inject drugs (PWUD/ID), sex workers (SWs) and men who have sex with men (MSM) are at increased risk of HIV and viral hepatitis infection. Limited epidemiological data ...

    Authors: Andrew Scheibe, Katherine Young, Anna Versfeld, C. Wendy Spearman, Mark W. Sonderup, Nishi Prabdial-Sing, Adrian Puren and Harry Hausler

    Citation: BMC Infectious Diseases 2020 20:655

    Content type: Research article

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  23. Viral relapse is a major concern in hepatitis C virus (HCV) antiviral therapy. Currently, there are no satisfactory methods to predict viral relapse, especially in the era of direct acting antivirals in which ...

    Authors: Peng Peng, Yanjuan Xu, Michael W. Fried, Adrian M. Di Bisceglie and Xiaofeng Fan

    Citation: BMC Infectious Diseases 2020 20:632

    Content type: Technical advance

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  24. Patients coinfected with HBV and hepatitis D virus (HDV) have a greater risk of HCC and cirrhosis. The current study was undertaken to assess HDV genotype distribution and determine clinical characteristics of...

    Authors: Shanshan Wu, Yi Zhang, Yuyan Tang, Ting Yao, Mengjiao Lv, Zhenghao Tang, Guoqing Zang, Yongsheng Yu and Xiaohua Chen

    Citation: BMC Infectious Diseases 2020 20:565

    Content type: Research article

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  25. Monitoring hepatitis B surveillance data is important for evaluating progress towards global hepatitis B elimination goals. Accurate classification of acute and chronic hepatitis infections is essential for as...

    Authors: Hui Zheng, Alexander J. Millman, Jeanette J. Rainey, Fuzhen Wang, Rui Zhang, Hong Chen, Zundong Yin, Huaqing Wang and Guomin Zhang

    Citation: BMC Infectious Diseases 2020 20:547

    Content type: Research article

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    The Correction to this article has been published in BMC Infectious Diseases 2020 20:962

  26. The risk of viral hepatitis among healthcare students (HCSs) is greater than that among the general population. Therefore, this study was conducted to investigate the seroprevalence of the hepatitis A virus (H...

    Authors: Ayla Acikgoz, Dilek Cimrin, Servet Kizildag, Nuran Esen, Pinar Balci and Ayca Arzu Sayiner

    Citation: BMC Infectious Diseases 2020 20:529

    Content type: Research article

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  27. Hepatitis B virus (HBV) infection is one of the major public health problems worldwide. Limited information exists about the epidemiology of HBV infection in Ethiopia. This study aimed to assess sero-prevalenc...

    Authors: Bedru Argaw, Adane Mihret, Abraham Aseffa, Azeb Tarekegne, Siraj Hussen, Demelash Wachamo, Techalew Shimelis and Rawleigh Howe

    Citation: BMC Infectious Diseases 2020 20:528

    Content type: Research article

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  28. Hepatitis E virus (HEV) may be resistant to immunosuppression reduction and ribavirin treatment in kidney transplant recipients because of mutant strains and severe side effects of ribavirin which conduct to d...

    Authors: I. Ollivier-Hourmand, L. Lebedel, A. Lecouf, M. Allaire, T. T. N. Nguyen, C. Lier and T. Dao

    Citation: BMC Infectious Diseases 2020 20:522

    Content type: Case report

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  29. Complete clearance of intracellular viruses depends on effector cells of innate and adaptive immune systems. This study aimed to identify the relationships among antiviral cytokines produced by natural killer ...

    Authors: Yurong Gu, Yifan Lian, Qiaolan Zheng, Zexuan Huang, Lin Gu, Yanhua Bi, Jing Li, Yanlin Huang, Yuankai Wu, Lubiao Chen and Yuehua Huang

    Citation: BMC Infectious Diseases 2020 20:509

    Content type: Research article

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  30. Hepatitis B virus (HBV) infection is one of the greatest public health burdens, particularly for people living with several barriers to access to health care services, such as the hill tribe adult population i...

    Authors: Panupong Upala, Tawatchai Apidechkul, Ratipark Tamornpark, Chalitar Chomchoei and Fartima Yeemard

    Citation: BMC Infectious Diseases 2020 20:494

    Content type: Research article

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  31. Bhutan is committed to eliminating hepatitis B and hepatitis C, though recent baseline estimates of disease burden in the general population are unknown. In 2017, we carried out a biomarker survey in the gener...

    Authors: N. Tshering, G. P. Dhakal, U. Wangchuk, S. Wangdi, L. Khandu, S. Pelden, F. Nogareda, M. K. Patel, Y. J. F. Hutin, K. Wannemuehler, B. B. Rewari and S. Wangchuk

    Citation: BMC Infectious Diseases 2020 20:485

    Content type: Research article

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  32. Tanzania has a high prevalence (7.17%) of chronic hepatitis B infection. Mother to Child transmission is very common, resulting in high rate of chronic infections. Currently, there is no screening program for ...

    Authors: Karin Geffert, Tongai G. Maponga, Shimba Henerico, Wolfgang Preiser, Stella Mongella, August Stich, Samuel Kalluvya, Andreas Mueller and Christa Kasang

    Citation: BMC Infectious Diseases 2020 20:395

    Content type: Research article

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  33. Hepatitis C virus (HCV) is highly prevalent among homeless persons, yet barriers continue to impede HCV testing and treatment in this population. We studied the experiences of homeless individuals related to a...

    Authors: Carmen L. Masson, J. Konadu Fokuo, August Anderson, Jesse Powell, Barry Zevin, Dylan Bush and Mandana Khalili

    Citation: BMC Infectious Diseases 2020 20:386

    Content type: Research article

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  34. Hepatitis E virus (HEV) infection is an important cause of acute hepatitis worldwide. In pregnant women, HEV can cause more severe symptoms, with high rates of fatal hepatic failure in endemic countries. Howev...

    Authors: Gabriela Tissera, María Cecilia Lardizabal, Sofía Belén Torres, Anabella Clara Fantilli, Maribel G. Martínez Wassaf, Fernando Venezuela, Raúl Capra, Domingo C. Balderramo, Claudia Travella, Viviana E. Ré and María Belén Pisano

    Citation: BMC Infectious Diseases 2020 20:368

    Content type: Research article

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  35. This study aimed to detect Hepatitis B virus (HBV) genome sequences and their variants as of nationwide scale using dried blood spot (DBS) samples and to provide up-to-date reference data for infection control...

    Authors: Ko Ko, Kazuaki Takahashi, Shintaro Nagashima, Chikako Yamamoto, Vichit Ork, Aya Sugiyama, Tomoyuki Akita, Masayuki Ohisa, Channarena Chuon, Md. Shafiqul Hossain, Bunsoth Mao and Junko Tanaka

    Citation: BMC Infectious Diseases 2020 20:305

    Content type: Research article

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  36. Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease and hepatocellular carcinoma. Treatment with first generation protease inhibitors (PI) + peg-interferon (pegIFN) and ribavirin (RBV...

    Authors: Liat Deutsch, Inbal Houri, Ziv Ben-Ari, Amir Shlomai, Ella Veitsman, Oranit Cohen-Ezra, Assaf Issachar, Orna Mor, Yael Gozlan, Rafael Bruck, Yoram Menachem, Shira Zelber-Sagi, Helena Katchman and Oren Shibolet

    Citation: BMC Infectious Diseases 2020 20:264

    Content type: Research article

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  37. Hepatitis B virus (HBV) infection is a major public health problem worldwide. More than 2 billion people have been exposed to HBV, and about 257 million individuals are chronic carriers of HBV. HBV reactivatio...

    Authors: Kuniyasu Niizuma, Yoshikazu Ogawa, Takayuki Kogure and Teiji Tominaga

    Citation: BMC Infectious Diseases 2020 20:230

    Content type: Case report

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  38. Hepatitis C virus (HCV) infection is a major global health problem. WHO guidelines recommend screening all people living with HIV for hepatitis C. Considering the limited resources for health in low and middle...

    Authors: Jozefien Buyze, Anja De Weggheleire, Johan van Griensven and Lutgarde Lynen

    Citation: BMC Infectious Diseases 2020 20:209

    Content type: Research Article

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  39. Few data are available regarding the use of direct antiviral agents (DAAs) for chronic hepatitis C in psychiatric patients. The aim of the study is to assess safety and outcome of DAAs in patients with psychia...

    Authors: Nicolò de Gennaro, Lucia Diella, Laura Monno, Gioacchino Angarano, Michele Milella and Annalisa Saracino

    Citation: BMC Infectious Diseases 2020 20:196

    Content type: Research article

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  40. Hepatitis B virus disease is a potentially life-threatening liver infection and a major global health problem. It causes chronic infection and puts people at high risk of death from cirrhosis and liver cancer....

    Authors: Garba Umar Mustapha, Abdulrasul Ibrahim, Muhammad Shakir Balogun, Chukwuma David Umeokonkwo and Aisha Indo Mamman

    Citation: BMC Infectious Diseases 2020 20:194

    Content type: Research article

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  41. Hepatitis C virus is one of the leading causes of chronic liver disease and liver-related deaths worldwide. The estimated prevalence of chronic hepatitis C viral infection among the general Belgian population ...

    Authors: Dana Busschots, Samira Toghanian, Rob Bielen, Stina Salomonsson, Özgür M. Koc, Greet Hendrickx, Michel Jadoul, Frederik Nevens, Etienne Sokal, Christian Brixko, Kathelijne Peerlinck, Ludwig Apers, Geert Robaeys and Jeffrey V. Lazarus

    Citation: BMC Infectious Diseases 2020 20:181

    Content type: Research article

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  42. Identifying patients with hepatitis C virus (HCV) infection and enhancing the cascade of care are essential for eliminating HCV infection. This study aimed to estimate the prevalence of positive anti-HCV serol...

    Authors: Daniela Mariano Carvalho-Louro, Eric Bassetti Soares, Jose Eduardo Trevizoli, Thayna Moreira Gomes Marra, Alexandre Lima Rodrigues da Cunha, Marcelo Palmeira Rodrigues, Adriana Claudia Lopes Carvalho-Furtado, Beatriz Taynara Araujo dos Santos and Francisco de Assis da Rocha Neves

    Citation: BMC Infectious Diseases 2020 20:114

    Content type: Research article

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  43. Hepatitis B virus (HBV) infection is a global health problem and interferon-alpha (IFN-α) is one of the effective therapies. However, little is known about the genetic background of the HBV infection or the ge...

    Authors: Zebin Zhu, Shanzhou Huang, Yixi Zhang, Chengjun Sun, Yunhua Tang, Qiang Zhao, Qi Zhou, Weiqiang Ju and Xiaoshun He

    Citation: BMC Infectious Diseases 2020 20:84

    Content type: Research article

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  44. At the end of the 1970s, in Italy more than 2% of the general population was HBsAg carrier. In the late ‘70s and late ‘80s, two remarkable events might have impacted on HBV strains transmitted in North-East It...

    Authors: Roberto Bruni, Umbertina Villano, Stefania Taffon, Michele Equestre, Elisabetta Madonna, Paola Chionne, Angela Candido, Stefano Dettori, Giulio Pisani, Maria Rapicetta, Flavia Bortolotti and Anna Rita Ciccaglione

    Citation: BMC Infectious Diseases 2020 20:78

    Content type: Research article

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  45. Georgia has one of the highest HCV prevalence in the world and launched the world’s first national HCV elimination programs in 2015. Georgia set the ambitious target of diagnosing 90% of people living with HCV...

    Authors: Tengiz Tsertsvadze, Amiran Gamkrelidze, Muazzam Nasrullah, Lali Sharvadze, Juliette Morgan, Shaun Shadaker, Lia Gvinjilia, Maia Butsashvili, David Metreveli, Vakhtang Kerashvili, Marina Ezugbaia, Nikoloz Chkhartishvili, Akaki Abutidze, Valeri Kvaratskhelia and Francisco Averhoff

    Citation: BMC Infectious Diseases 2020 20:30

    Content type: Research article

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  46. Nucleic acid hybridization (NAH) of hepatitis C virus (HCV) is a practical and reliable tool for virus genotyping. Genotype assignment is an important factor in the prediction of treatment success in chronic h...

    Authors: Malik Sallam, Rawan Batarseh, Anas Natsheh, Jumana Abbadi, Esraa Al-Fraihat, Alaa’ Yaseen, Doaa Kaddomi, Nadia Khamees, Azmi Mahafzah and Gülşen Özkaya Şahin

    Citation: BMC Infectious Diseases 2019 20:3

    Content type: Research article

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  47. Viral hepatitis is a global public health problem affecting millions of people worldwide, causing thousands of deaths due to acute and persistent infection, cirrhosis, and liver cancer. Providing updated serol...

    Authors: Mohammad Amin Behzadi, Victor Hugo Leyva-Grado, Mandana Namayandeh, Atoosa Ziyaeyan, Roya Feyznezhad, Hedayat Dorzaban, Marzieh Jamalidoust and Mazyar Ziyaeyan

    Citation: BMC Infectious Diseases 2019 19:1027

    Content type: Research article

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  48. Chronic hepatitis C is a major public health burden. With new interferon-free direct-acting agents (showing sustained viral response rates of more than 98%), elimination of HCV seems feasible for the first tim...

    Authors: Christian Krauth, Siegbert Rossol, Gustaf Ortsäter, Achim Kautz, Kathrin Krüger, Babette Herder and Jona Theodor Stahmeyer

    Citation: BMC Infectious Diseases 2019 19:1019

    Content type: Research article

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  49. Hepatitis B (HBV) and Human Immunodeficiency Virus (HIV) share common risk factors for exposure. Co-infected patients have an increased liver-related mortality risk and may have accelerated HIV progression. Th...

    Authors: Urvi Rana, Matt Driedger, Paul Sereda, Shenyi Pan, Erin Ding, Alex Wong, Sharon Walmsley, Marina Klein, Deborah Kelly, Mona Loutfy, Rejean Thomas, Stephen Sanche, Abigail Kroch, Nima Machouf, Marie-Helene Roy-Gagnon, Robert Hogg…

    Citation: BMC Infectious Diseases 2019 19:982

    Content type: Research article

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  50. Identification and knowledge of settings with high prevalence of hepatitis C virus (HCV) infection is important when aiming for elimination of HCV. The primary aim of this study was to estimate the prevalence ...

    Authors: Caroline Gahrton, Gabriel Westman, Karin Lindahl, Fredrik Öhrn, Olav Dalgard, Christer Lidman, Lars-Håkan Nilsson, Karouk Said, Ann-Sofi Duberg and Soo Aleman

    Citation: BMC Infectious Diseases 2019 19:955

    Content type: Research article

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BMC Infectious Diseases

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