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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    Acute febrile illness (AFI) represent a significant health challenge in the Peruvian Amazon basin population due to their diverse etiologies and the unavailability of specific on-site diagnostic methods, resul...

    Authors: Fiorella Ricapa-Antay, Katia Diaz-Melon, Wilmer Silva-Caso, Luis J. del Valle, Miguel Angel Aguilar-Luis, Fernando Vasquez-Achaya, Carlos Palomares-Reyes, Pablo Weilg, Dongmei Li, Carlos Manrique and Juana del Valle-Mendoza

    Citation: BMC Infectious Diseases 2018 18:618

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  2. Content type: Research article

    Brucellosis is a neglected debilitating zoonosis with a high prevalence in many developing countries. Bovine brucellosis is widespread in Cameroon but the epidemiological situation of human brucellosis is not ...

    Authors: Julius Awah-Ndukum, Mohamed Moctar Mouliom Mouiche, Lucy Kouonmo-Ngnoyum, Houli Nicolas Bayang, Tanyi Kingsley Manchang, Rodrigue Simonet Namegni Poueme, Justin Kouamo, Victor Ngu-Ngwa, Emmanuel Assana, Kameni Jean Marc Feussom and André Pagnah Zoli

    Citation: BMC Infectious Diseases 2018 18:611

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  3. Content type: Research article

    There is no consensus on the most accurate combination of diagnostic criteria to define community acquired pneumonia (CAP). We describe inclusion criteria in randomized controlled trials (RCT) of CAP and asses...

    Authors: Clara Flateau, Josselin Le Bel, Sarah Tubiana, François-Xavier Blanc, Christophe Choquet, Blandine Rammaert, Patrick Ray, Christophe Rapp, Cécile Ficko, Catherine Leport, Yann-Erick Claessens and Xavier Duval

    Citation: BMC Infectious Diseases 2018 18:607

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  4. Content type: Research article

    Leptospirosis is an important zoonotic disease worldwide, caused by spirochetes bacteria of the genus Leptospira. In Thailand, cattle and buffalo used in agriculture are in close contact with human beings. During...

    Authors: Sudarat Chadsuthi, Karine Chalvet-Monfray, Anuwat Wiratsudakul, Duangjai Suwancharoen and Julien Cappelle

    Citation: BMC Infectious Diseases 2018 18:602

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  5. Content type: Case report

    American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infect...

    Authors: C. Nabet, C. Belzunce, D. Blanchet, P. Abboud, F. Djossou, B. Carme, C. Aznar and M. Demar

    Citation: BMC Infectious Diseases 2018 18:595

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  6. Content type: Research article

    Several different IgA-proteases exist in Haemophilus influenzae. The variants have been suggested to play differential roles in pathogenesis, but there is limited information on their distribution in clinical iso...

    Authors: Fredrik Resman, Guillaume Manat, Victor Lindh, Timothy F. Murphy and Kristian Riesbeck

    Citation: BMC Infectious Diseases 2018 18:592

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  7. Content type: Research article

    In recent years, there has been a significant increase in the incidence of fungal infections attributed to Candida species worldwide, with a major shift toward non-albicans Candida (NAC). In this study, we have d...

    Authors: Lyn Awad, Hani Tamim, Dania Abdallah, Mohammad Salameh, Anas Mugharbil, Tamima Jisr, Kamal Zahran, Nabila Droubi, Ahmad Ibrahim and Rima Moghnieh

    Citation: BMC Infectious Diseases 2018 18:589

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  8. Content type: Research article

    The aim was to evaluate the value of organ-specific weighted incidence antibiogram (OSWIA) percentages for bacterial susceptibilities of Gram-negative bacteria (GNB) collected from intra-abdominal infections (...

    Authors: Lianxin Liu and Yuxing Ni

    Citation: BMC Infectious Diseases 2018 18:584

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  9. Content type: Research article

    Leptospirosis is a zoonotic disease associated with occupations which exposed workers to environments contaminated with urine of infected animals. The objective of this study was to determine the seroprevalenc...

    Authors: Mas Harithulfadhli Agus Ab Rahman, Suhaily Mohd Hairon, Rukman Awang Hamat, Tengku Zetty Maztura Tengku Jamaluddin, Mohd Nazri Shafei, Norazlin Idris, Malina Osman, Surianti Sukeri, Zainudin A. Wahab, Wan Mohd Zahiruddin Wan Mohammad, Zawaha Idris and Aziah Daud

    Citation: BMC Infectious Diseases 2018 18:569

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  10. Content type: Research article

    Methicillin resistant Staphylococcus aureus (MRSA) is recognized worldwide as a leading cause of hospital and community infections. Biofilm formation by MRSA is an extremely important virulence factor to be under...

    Authors: Ons Haddad, Abderrahmen Merghni, Aida Elargoubi, Hajer Rhim, Yosr Kadri and Maha Mastouri

    Citation: BMC Infectious Diseases 2018 18:560

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  11. Content type: Research article

    The prevalence and risk factors for persistent candidemia among very low birth weight infants are poorly understood. This study aimed to investigate the epidemiology of persistent candidemia over a 4-year peri...

    Authors: Jinjian Fu, Yanling Ding, Yongjiang Jiang, Shengfu Mo, Shaolin Xu and Peixu Qin

    Citation: BMC Infectious Diseases 2018 18:558

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  12. Content type: Research article

    Infection after vertebroplasty (VP) is a rare but serious complication. Previous literatures showed most pathogens for infection after VP were bacteria; tuberculosis (TB) induced infection after VP was extreme...

    Authors: Jen-Chung Liao, Po-Liang Lai, Lih-Hui Chen and Chi-Chien Niu

    Citation: BMC Infectious Diseases 2018 18:555

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  13. Content type: Case report

    Genetic mutations that reduce intracellular superoxide production by granulocytes causes chronic granulomatous disease (CGD). These patients suffer from frequent and severe bacterial and fungal infections thro...

    Authors: Esmaeil Mortaz, Somayeh Sarhifynia, Majid Marjani, Afshin Moniri, Davood Mansouri, Payam Mehrian, Karin van Leeuwen, Dirk Roos, Johan Garssen, Ian M. Adcock and Payam Tabarsi

    Citation: BMC Infectious Diseases 2018 18:552

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  14. Content type: Case report

    The Leuconostoc mesenteroides are members of the Streptococcae family and currently has been recognized as potential pathogens. This case describes a bacteremia caused by L. mesenteroides in an immunocompetent pa...

    Authors: Mayra Gonçalves Menegueti, Gilberto Gambero Gaspar, Ana Maria Laus, Anibal Basile-Filho, Fernando Bellissimo-Rodrigues and Maria Auxiliadora-Martins

    Citation: BMC Infectious Diseases 2018 18:547

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  15. Content type: Research article

    Classification of pathogenic Escherichia coli (E. coli) has traditionally relied on detecting specific virulence associated genes (VAGs) or combinations thereof. For E. coli isolated from faecal samples, the pres...

    Authors: Bjørn-Arne Lindstedt, Misti D. Finton, Davide Porcellato and Lin T. Brandal

    Citation: BMC Infectious Diseases 2018 18:544

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  16. Content type: Research article

    Community acquired bloodstream infection (CABSI) in low- and middle income countries is associated with a high mortality. This study describes the clinical manifestations, laboratory findings and correlation o...

    Authors: Vu Quoc Dat, Nguyen Thanh Long, Vu Ngoc Hieu, Nguyen Dinh Hong Phuc, Nguyen Van Kinh, Nguyen Vu Trung, H. Rogier van Doorn, Ana Bonell and Behzad Nadjm

    Citation: BMC Infectious Diseases 2018 18:535

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  17. Content type: Research article

    Injection drug use (IDU) is a growing public health threat in Virginia, though there is limited knowledge of related morbidity. The purpose of this study was to describe the temporal, geographic and clinical t...

    Authors: Megan E. Gray, Elizabeth T. Rogawski McQuade, W. Michael Scheld and Rebecca A. Dillingham

    Citation: BMC Infectious Diseases 2018 18:532

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  18. Content type: Case report

    Gemella bergeri is one of the nine species of the genus Gemella and is relatively difficult to identify. We herein describe the first case of septic shock due to a Gemella bergeri coinfection with Eikenella corro...

    Authors: Toshinobu Yamagishi, Mayu Hikone, Kazuhiro Sugiyama, Takahiro Tanabe, Yasuhiro Wada, Michiko Furugaito, Yuko Arai, Yutaka Uzawa, Ryo Mizushima, Keisuke Kamada, Yasutomo Itakura, Shigekazu Iguchi, Atsushi Yoshida, Ken Kikuchi and Yuichi Hamabe

    Citation: BMC Infectious Diseases 2018 18:523

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  19. Content type: Case report

    Aerococcus urinae is a gram-positive, alpha-hemolytic coccus bacterium primarily implicated in less than 1 % of all symptomatic urinary tract infections. Risk factors for disease include male gender, advanced age...

    Authors: Joseph M. Yabes, Serafim Perdikis, David B. Graham and Ana Markelz

    Citation: BMC Infectious Diseases 2018 18:522

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  20. Content type: Research article

    We aimed to identify the main spreading clones, describe the resistance mechanisms associated with carbapenem- and/or multidrug-resistant P. aeruginosa and characterize patients at risk of acquiring these strains...

    Authors: Kaidi Telling, Mailis Laht, Age Brauer, Maido Remm, Veljo Kisand, Matti Maimets, Tanel Tenson and Irja Lutsar

    Citation: BMC Infectious Diseases 2018 18:513

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  21. Content type: Research article

    Antistaphylococcal penicillins (ASPs) and cefazolin have become the most frequent choices for the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) infections. However, the best therapeutic agent ...

    Authors: Changcheng Shi, Yubo Xiao, Qi Zhang, Qingyu Li, Fei Wang, Jing Wu and Nengming Lin

    Citation: BMC Infectious Diseases 2018 18:508

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  22. Content type: Research article

    Identification of factors associated with antifungal utilization in neonatal, pediatric, and adult patient groups is needed to guide antifungal stewardship initiatives in academic medical centers.

    Authors: Jeremy S. Stultz, Rose Kohinke and Amy L. Pakyz

    Citation: BMC Infectious Diseases 2018 18:501

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  23. Content type: Research article

    To evaluate the susceptibility rates of aerobic and facultative Gram-negative bacterial isolates from Chinese intra-abdominal infections (IAI) and urinary tract infections (UTI) focusing on carbapenems and com...

    Authors: Hui Zhang, Haishen Kong, Yunsong Yu, Anhua Wu, Qiong Duan, Xiaofeng Jiang, Shufang Zhang, Ziyong Sun, Yuxing Ni, Weiping Wang, Yong Wang, Kang Liao, Huayin Li, Chunxia Yang, Wenxiang Huang, Bingdong Gui…

    Citation: BMC Infectious Diseases 2018 18:493

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  24. Content type: Research article

    Staphylococcus aureus bacteraemia is a common and significant infection, associated with high rates of mortality. Therefore, early identification is important for the initiation of appropriate treatment. The obje...

    Authors: Yoshiro Hadano, Miwako Isoda, Kazushige Ishibashi and Tatsuyuki Kakuma

    Citation: BMC Infectious Diseases 2018 18:490

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  25. Content type: Research article

    Salmonella Typhi is a human pathogen that causes typhoid fever. It is a major cause of morbidity and mortality in developing countries and is responsible for several outbreaks in developed countries. Studying cer...

    Authors: Adedoyin Awofisayo-Okuyelu, Noel McCarthy, Ifunanya Mgbakor and Ian Hall

    Citation: BMC Infectious Diseases 2018 18:483

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  26. Content type: Research article

    Burkholderia pseudomallei is a gram negative bacteria that causes a spectrum of human diseases in the tropics. Although melioidosis is endemic in Southeast Asia, large clinical case series were rarely reported fr...

    Authors: Jaime Mei-Fong Chien, Seyed Ehsan Saffari, Ai-Ling Tan and Thuan-Tong Tan

    Citation: BMC Infectious Diseases 2018 18:482

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  27. Content type: Research article

    Candida albicans, Candida glabrata, and Candida parapsilosis are three prevalent causes of candidiasis, worldwide. These species are considered as nine medically important complex species. Limited knowledge about...

    Authors: Amir Arastehfar, Wenjie Fang, Weihua Pan, Wanqing Liao, Liang Yan and Teun Boekhout

    Citation: BMC Infectious Diseases 2018 18:480

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  28. Content type: Research article

    Despite advances in the development of pneumococcal conjugate vaccines, acute otitis media (AOM) is a common childhood infection, caused mainly by Streptococcus pneumoniae. It has been suggested that persistence ...

    Authors: Izabela Korona-Glowniak, Piotr Zychowski, Radoslaw Siwiec, Elżbieta Mazur, Grażyna Niedzielska and Anna Malm

    Citation: BMC Infectious Diseases 2018 18:478

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  29. Content type: Study protocol

    Pneumonia is the leading infectious cause of death in children under 5 years of age around the globe. In addition to preventing pneumonia, there is a critical need to provide greater access to appropriate and ...

    Authors: Amy Sarah Ginsburg, Susanne J. May, Evangelyn Nkwopara, Gwen Ambler, Eric D. McCollum, Tisungane Mvalo, Ajib Phiri, Norman Lufesi and Salim Sadruddin

    Citation: BMC Infectious Diseases 2018 18:476

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  30. Content type: Case report

    Trichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunoc...

    Authors: Eveline Pipolo Milan, Walicyranison Plinio Silva-Rocha, Jéssica Jacinto Salviano de Almeida, Tatiane Uetti Gomes Fernandes, André Luciano de Araújo Prudente, Matheus Firmino de Azevedo, Elaine Cristina Francisco, Analy Salles de Azevedo Melo, Arnaldo Lopes Colombo and Guilherme Maranhão Chaves

    Citation: BMC Infectious Diseases 2018 18:470

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  31. Content type: Research article

    Most guidelines recommend 6 to 12 weeks of parenteral antibiotic treatment for pyogenic spondylodiscitis. When surgical debridement is adequately performed, further intravenous antibiotic treatment duration ca...

    Authors: Yun-Da Li, Chak-Bor Wong, Tsung-Ting Tsai, Po-Liang Lai, Chi-Chien Niu, Lih-Huei Chen and Tsai-Sheng Fu

    Citation: BMC Infectious Diseases 2018 18:468

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  32. Content type: Research article

    Helicobacter pylori is a major aetiologic agent associated with gastritis. H. pylori infections increase the expression of the Toll-like receptor (TLR), which in turn modulates the expression of microRNA (miRNA)-...

    Authors: Ana Caren Cortés-Márquez, Sandra Mendoza-Elizalde, Francisco Arenas-Huertero, Jimena Trillo-Tinoco, Pedro Valencia-Mayoral, Alejandra Consuelo-Sánchez, Jonathan Zarate-Franco, Ada Ruth Dionicio-Avendaño, José de Jesús Herrera-Esquivel, Elio Germán Recinos-Carrera, Christian Colín-Valverde, Sandra Rivera-Gutiérrez, Alfonso Reyes-López, Juan Carlos Vigueras-Galindo and Norma Velázquez-Guadarrama

    Citation: BMC Infectious Diseases 2018 18:463

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  33. Content type: Research article

    Multiplex real-time polymerase chain reaction assays have improved diagnostic sensitivity for a wide range of pathogens. However, co-detection of multiple agents and bacterial colonization make it difficult to...

    Authors: Clarence C. Tam, Vittoria Offeddu, Kathryn B. Anderson, Alden L. Weg, Louis R. Macareo, Damon W. Ellison, Ram Rangsin, Stefan Fernandez, Robert V. Gibbons, In-Kyu Yoon and Sriluck Simasathien

    Citation: BMC Infectious Diseases 2018 18:462

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  34. Content type: Research article

    Microbial contamination of hospital environment, especially in operating theatres (OT) and other specialized units has greatly contributed to continuous and multiple exposure to nosocomial infections by patien...

    Authors: Sandra Matinyi, Muwanguzi Enoch, Deborah Akia, Valentine Byaruhanga, Edson Masereka, Isaac Ekeu and Collins Atuheire

    Citation: BMC Infectious Diseases 2018 18:460

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  35. Content type: Case report

    Burkholderia pseudomallei is the causative agent of melioidosis, which is a potentially life threatening disease endemic in Southeast Asian countries. In Malaysia, cystic fibrosis (CF) is an uncommon condition. T...

    Authors: Vanitha Mariappan, Surendran Thavagnanam, Kumutha Malar Vellasamy, Cindy Ju Shuan Teh, Nadia Atiya, Sasheela Ponnampalavanar and Jamuna Vadivelu

    Citation: BMC Infectious Diseases 2018 18:455

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  36. Content type: Case report

    Members of Shewanella species are opportunistic pathogens that are found in marine environments. Currently more than sixty species have been identified, whereas the most commonly clinical cases associated with Sh...

    Authors: Furong Zhang, Yujie Fang, Feng Pang, Shengnan Liang, Xin Lu, Biao Kan, Jianguo Xu, Jinxing Zhao, Yinju Du and Duochun Wang

    Citation: BMC Infectious Diseases 2018 18:454

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  37. Content type: Case report

    Melioidosis is endemic in Southeast Asia and northern Australia. Infection usually follows percutaneous inoculation or inhalation or ingestion of the causative bacterium, Burkholderia pseudomallei, which is prese...

    Authors: X. Y. Li, B. X. Ke, C. N. Chen, H. L. Xiao, M. Z. Liu, Y. C. Xiong, R. Bai, J. D. Chen and C. W. Ke

    Citation: BMC Infectious Diseases 2018 18:452

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  38. Content type: Research article

    Psittacosis outbreak investigations require rapid identification of cases in order to trace possible sources and perform public health risk assessments. In recent outbreaks in the Netherlands, such investigati...

    Authors: Annelies A. Nieuwenhuizen, Frederika Dijkstra, Daan W. Notermans and Wim van der Hoek

    Citation: BMC Infectious Diseases 2018 18:442

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  39. Content type: Research article

    Chronic rhinosinusitis is an inflammatory disorder in which the role of bacteria remains uncertain. While sinus outflow obstruction is often an initiating event, mucosal inflammation and dysbiosis may persist ...

    Authors: Ioannis Koutsourelakis, Ashleigh Halderman, Syed Khalil, Lauren E. Hittle, Emmanuel F. Mongodin and Andrew P. Lane

    Citation: BMC Infectious Diseases 2018 18:441

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  40. Content type: Research article

    Streptococcus pneumoniae is a commensal of the human upper respiratory tract and a major cause of morbidity and mortality worldwide. This paper presents the distribution of serotypes and antimicrobial resistance ...

    Authors: Rachid Y. Yahiaoui, Hester J. Bootsma, Casper D. J. den Heijer, Gerlinde N. Pluister, W. John Paget, Peter Spreeuwenberg, Krzysztof Trzcinski and Ellen E. Stobberingh

    Citation: BMC Infectious Diseases 2018 18:440

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  41. Content type: Research article

    Increasing numbers of refractory or severe, even fatal, cases of Mycoplasma pneumoniae infections have been reported in recent years. Excessive inflammatory responses play a vital role in the pathogenesis of refr...

    Authors: Ying Ding, Chu Chu, Yuqin Li, Gen Li, Xiaoli Lei, Weifang Zhou and Zhengrong Chen

    Citation: BMC Infectious Diseases 2018 18:439

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  42. Content type: Research article

    To compare the risk of severe hepatotoxicity with anidulafungin versus caspofungin and micafungin in hospitalized adults.

    Authors: Francis Vekeman, Lisa Weiss, Jalal Aram, Raluca Ionescu-Ittu, Shahrzad Moosavi, Yongling Xiao, Wendy Y. Cheng, Rachel H. Bhak, Margaret Tawadrous, M. Rita Capparella, Philippe Montravers and Mei Sheng Duh

    Citation: BMC Infectious Diseases 2018 18:438

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  43. Content type: Case report

    Septic cardiomyopathy represents cardiac impairment in sepsis and is a part of systemic involvement in sepsis. Cytokine storm is responsible for septic shock and for myocardial dysfunction of potentially rever...

    Authors: Andreja Sinkovic, Barbara Kit and Andrej Markota

    Citation: BMC Infectious Diseases 2018 18:433

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  44. Content type: Research article

    Necrotizing soft tissue infection is the most serious of all soft tissue infections. The patient’s life is dependent on prompt diagnosis and aggressive treatment. Diagnostic delays are related to increased mor...

    Authors: Annette Erichsen Andersson, Ingrid Egerod, Vibeke E. Knudsen and Ann-Mari Fagerdahl

    Citation: BMC Infectious Diseases 2018 18:429

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  45. Content type: Research article

    Oxidative stress is a modifiable risk-factor in infection causing damage to human cells. As an adaptive response, cells catabolize Tyrosine to 3-Nitrotyrosine (Tyr-NO2) by nitrosylation. We investigated whethe...

    Authors: Thomas Baumgartner, Giedré Zurauskaité, Yannick Wirz, Marc Meier, Christian Steuer, Luca Bernasconi, Andreas Huber, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Robert Thomann, Werner Zimmerli, Beat Mueller and Philipp Schuetz

    Citation: BMC Infectious Diseases 2018 18:423

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