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Bacterial and fungal diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Campylobacter jejuni is a motile, gram-negative rod known for causing self-limiting enterocolitis while rarely causing extraintestinal infections. We report the first case of a patient with Campylobacter jejuni o...

    Authors: Joost Hartman, Matthijs Westerman and Jiri F. P. Wagenaar

    Citation: BMC Infectious Diseases 2020 20:199

    Content type: Case report

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  2. Microbial infection is the main cause of increased morbidity and mortality in burn patients, especially infections caused by multiple drug-resistant organisms (MDRO). The purpose of this study was to explore m...

    Authors: Yin-Yin Chen, Ping-Feng Wu, Chii-Shya Chen, Ian-Horng Chen, Wan-Tsuei Huang and Fu-Der Wang

    Citation: BMC Infectious Diseases 2020 20:193

    Content type: Research article

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  3. Human psittacosis, caused by Chlamydia (C.) psittaci, is likely underdiagnosed and underreported, since tests for C. psittaci are often not included in routine microbiological diagnostics. Source tracing traditio...

    Authors: Lenny Hogerwerf, Inge Roof, Marianne J. K. de Jong, Frederika Dijkstra and Wim van der Hoek

    Citation: BMC Infectious Diseases 2020 20:192

    Content type: Research article

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  4. The presentation of clinical leptospirosis has been historically associated with animal workers, slaughterhouse workers and medical veterinarians. This association has shifted to be related to flooding events ...

    Authors: J. García-Méndez, E. Cervera-Ceballos, D. Atilano-López, S. Arroyo-Escalante, D. Moncada-Barrón, M. Leyva-Leyva, R. Hernández-Castro and E. M. Carrillo-Casas

    Citation: BMC Infectious Diseases 2020 20:186

    Content type: Case report

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  5. Staphylococcus aureus (S. aureus) arthritis is one of the most detrimental joint diseases known and leads to severe joint destruction within days. We hypothesized that the provision of auxiliary immunoregulation ...

    Authors: Berglind Bergmann, Ying Fei, Pernilla Jirholt, Zhicheng Hu, Maria Bergquist, Abukar Ali, Catharina Lindholm, Olov Ekwall, Guillaume Churlaud, David Klatzmann, Tao Jin and Inger Gjertsson

    Citation: BMC Infectious Diseases 2020 20:185

    Content type: Research article

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  6. The burden of leptospirosis in Indonesia is poorly understood. Data from an observational study conducted from 2013 to 2016 in seven cities across Indonesia was used to estimate the incidence of leptospirosis ...

    Authors: Muhammad Hussein Gasem, Usman Hadi, Bachti Alisjahbana, Emiliana Tjitra, M. M. D. E. A. H. Hapsari, Endang Sri Lestari, Abu Tholib Aman, Dewi Lokida, Gustiani Salim, Herman Kosasih, Ketut Tuti Parwati Merati, Kanti Laras, Mansyur Arif, Nurhayati Lukman, Pratiwi Sudarmono, Vivi Lisdawati…

    Citation: BMC Infectious Diseases 2020 20:179

    Content type: Research article

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  7. Trichophyton benhamiae is a zoophilic dermatophyte that can cause tinea in humans and animals. Lesions caused by T. benhamiae tend to be highly inflammatory, and patients are often infected by animals or other pa...

    Authors: Jingwen Tan, Xiaoping Liu, Zhiqin Gao, Hong Yang, Lianjuan Yang and Hai Wen

    Citation: BMC Infectious Diseases 2020 20:171

    Content type: Case report

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  8. Infectious meningitis is a serious disease and patient outcome relies on fast and reliable diagnostics. A syndromic panel testing approach like the FilmArray ME can accelerate diagnosis and therefore decrease ...

    Authors: Susanne Pfefferle, Martin Christner, Martin Aepfelbacher, Marc Lütgehetmann and Holger Rohde

    Citation: BMC Infectious Diseases 2020 20:170

    Content type: Research article

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  9. Even though enterococci can cause serious infections in multiple sites, they are a rare cause of pneumonia. We reported a uremic patient with vancomycin-resistant E. faecium (VRE-fm) pneumonia, possibly related t...

    Authors: Fengqin Li, Yonglan Wang, Linlin Sun and Xiaoxia Wang

    Citation: BMC Infectious Diseases 2020 20:167

    Content type: Case report

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  10. Fever is a cause for concern for both parents and the treating pediatrician and a common reason for antibiotic overuse. However, the proportion of children hospitalized for fever with serious bacterial infecti...

    Authors: Ashish Pathak, Radika Upadhayay, Aditya Mathur, Sunil Rathi and Cecilia Stålsby Lundborg

    Citation: BMC Infectious Diseases 2020 20:162

    Content type: Research article

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  11. Cancer and sepsis comorbidity is a major public health problem in most parts of the world including Zimbabwe. The microbial aetiologies of sepsis and their antibiograms vary with time and locations. Knowledge ...

    Authors: Frank Chinowaita, Wendy Chaka, Tinashe K. Nyazika, Tendai C. Maboreke, Emmanuel Tizauone, Prichard Mapondera, Inam Chitsike, Andrew Z. Cakana and Rooyen T. Mavenyengwa

    Citation: BMC Infectious Diseases 2020 20:161

    Content type: Research article

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  12. S. aureus (SA) infective endocarditis (IE) has a very high mortality, attributed to the age and comorbidities of patients, inadequate or delayed antibiotic treatment, and methicillin resistance, among other cause...

    Authors: Carmen Hidalgo-Tenorio, Juan Gálvez, Francisco Javier Martínez-Marcos, Antonio Plata-Ciezar, Javier De La Torre-Lima, Luis Eduardo López-Cortés, Mariam Noureddine, José M. Reguera, David Vinuesa, Maria Victoria García, Guillermo Ojeda, Rafael Luque, José Manuel Lomas, Jose Antonio Lepe and Arístides de Alarcón

    Citation: BMC Infectious Diseases 2020 20:160

    Content type: Research article

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  13. Sepsis is a life-threatening situation, and it can be rendered more severe by coagulopathy. We here examine a novel plasma biomarker for sepsis-induced coagulopathy.

    Authors: Yishan Wang, Huijuan Wang, Chunfang Zhang, Chao Zhang, Huqin Yang, Ruiyue Gao and Zhaohui Tong

    Citation: BMC Infectious Diseases 2020 20:155

    Content type: Research article

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  14. Brucellosis is a zoonotic disease transmitted to humans through contact with infected animals, animal products or consumption of infected dairy products. Brucella infection during pregnancy is of special interest...

    Authors: Robert Makala, Mtebe V. Majigo, George M. Bwire, Upendo Kibwana, Mariam M. Mirambo and Agricola Joachim

    Citation: BMC Infectious Diseases 2020 20:152

    Content type: Research article

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  15. Early diagnosis of neonatal sepsis is essential to prevent severe complications and avoid unnecessary use of antibiotics. The mortality of neonatal sepsis is over 18%in many countries. This study aimed to deve...

    Authors: Dominicus Husada, Pornthep Chanthavanich, Uraiwan Chotigeat, Piyarat Sunttarattiwong, Chukiat Sirivichayakul, Krisana Pengsaa, Watcharee Chokejindachai and Jaranit Kaewkungwal

    Citation: BMC Infectious Diseases 2020 20:151

    Content type: Research article

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  16. Age is a risk factor for infective endocarditis, and almost half of diagnosed patients are age ≥ 60 years. Large national studies have not evaluated inpatient mortality and surgical valvular interventions betw...

    Authors: Ché Matthew Harris, Waseem Khaliq, Aiham Albaeni and Keith C. Norris

    Citation: BMC Infectious Diseases 2020 20:146

    Content type: Research article

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    The Correction to this article has been published in BMC Infectious Diseases 2020 20:243

  17. Pyogenic liver abscess (PLA) is an inflammatory disease with increasing incidence. When it occurs with diabetes mellitus (DM), the risk of recurrence and mortality may increase. However, the effect of DM on th...

    Authors: Zhaoqing Du, Xingchen Zhou, Junzhou Zhao, Jianbin Bi, Yifan Ren, Jia Zhang, Yuxin Lin, Zheng Wu, Yi Lv, Xufeng Zhang and Rongqian Wu

    Citation: BMC Infectious Diseases 2020 20:145

    Content type: Research article

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  18. Obligate anaerobes usually account for less than 10% of bacteria recovered from blood cultures (BC). The relevance of routine use of the anaerobic bottle is under debate. The aim of this study was to evaluate ...

    Authors: M. Lafaurie, E. d’Anglejan, J. L. Donay, D. Glotz, E. Sarfati, M. Mimoun, M. Legrand, E. Oksenhendler, M. Bagot, S. Valade, B. Bercot and J. M. Molina

    Citation: BMC Infectious Diseases 2020 20:142

    Content type: Research article

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  19. Anthrax is an endemic disease that persists in the rural regions of China. The global genetic population structure of B.anthracis has also been defined by the canonical single-nucleotide polymorphisms (canSNP) an...

    Authors: Enmin Zhang, Huijuan Zhang, Jinrong He, Wei Li and Jianchun Wei

    Citation: BMC Infectious Diseases 2020 20:140

    Content type: Research article

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  20. Scrub typhus is an acute febrile illness caused by the obligate intracellular bacterium, Orientia tsutsugamushi. Immunochromatography (ICT) and IgM ELISA are two of the routinely employed antibody based assays fo...

    Authors: Rajendra Gautam, Keshab Parajuli, Tshokey Tshokey, John Stenos and Jeevan Bahadur Sherchand

    Citation: BMC Infectious Diseases 2020 20:138

    Content type: Research article

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  21. Currently, Staphylococcus aureus is one of the most important pathogens worldwide, especially for methicillin-resistant S. aureus (MRSA) infection. However, few reports referred to patients’ MRSA infections in Yu...

    Authors: Feng Liao, Zhishuo Mo, Wenpeng Gu, Wen Xu, Xiaoqing Fu and Yunhui Zhang

    Citation: BMC Infectious Diseases 2020 20:137

    Content type: Research article

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  22. Salmonellosis remains an important public health problem globally. The disease is among the leading causes of morbidity and mortality in developing countries that experience poor hygiene and lack of access to ...

    Authors: Fadhili A. Ngogo, Agricola Joachim, Ahmed M. Abade, Susan F. Rumisha, Mucho M. Mizinduko and Mtebe V. Majigo

    Citation: BMC Infectious Diseases 2020 20:135

    Content type: Research article

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  23. Vertebral osteomyelitis can be attributed to many factors including immunosuppression, diabetes, malignancy, collagen disease, periodontal disease, open fractures, and endoscopic procedures. Anaerobic bacteria...

    Authors: Abhijith Bathini, Christina R. Maxwell, Hirad Hedayat, James Barrett and Zakaria Hakma

    Citation: BMC Infectious Diseases 2020 20:133

    Content type: Case report

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  24. Coagulase-negative staphylococci belonging to S. haemolyticus, S. hominis subsp. hominis, S. simulans, and S. warneri are often described as etiological factors of infections. Staphylococci are a phylogenetically...

    Authors: Magdalena Szemraj, Magdalena Grazul, Ewa Balcerczak and Eligia M. Szewczyk

    Citation: BMC Infectious Diseases 2020 20:128

    Content type: Research article

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  25. This study is to elucidate the disinfection effect of ozone producing low-pressure Hg vapor lamps against human pathogens. Ozone producing low-pressure Hg vapor lamps emit mainly 254 nm ultraviolet light C (UV...

    Authors: Wai Szeto, W. C. Yam, Haibao Huang and Dennis Y. C. Leung

    Citation: BMC Infectious Diseases 2020 20:127

    Content type: Research article

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  26. Paracoccidioidomycosis is a neglected tropical disease, endemic in several countries of South America including Colombia. We report a case of a patient with Chronic Multifocal Paracoccidioidomycosis with long-...

    Authors: Deving Arias Ramos, John Alexander Alzate, Ángela María Giraldo Montoya, Yessica Andrea Trujillo and Leidy Yurany Arias Ramos

    Citation: BMC Infectious Diseases 2020 20:119

    Content type: Case report

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  27. Pneumocystis pneumonia (PCP) is increasingly being diagnosed in patients with systemic lupus erythematosus (SLE), and hydroxychloroquine (HCQ) has been found to possess antifungal activities. We hence aimed to...

    Authors: Kai-Jieh Yeo, Hsin-Hua Chen, Yi-Ming Chen, Ching-Heng Lin, Der-Yuan Chen, Chih-Ming Lai and Wen-Cheng Chao

    Citation: BMC Infectious Diseases 2020 20:112

    Content type: Research article

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  28. Urinary tract infection (UTI) is a common cause of morbidity worldwide. Uropathogenic Escherichia coli (UPEC) bacteria are the major cause of urinary tract infections. UPEC strains derive from different phylogene...

    Authors: Belayneh Regasa Dadi, Tamrat Abebe, Lixin Zhang, Adane Mihret, Workeabeba Abebe and Wondwossen Amogne

    Citation: BMC Infectious Diseases 2020 20:108

    Content type: Research article

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  29. Vibrio spp. are aquatic bacteria that are ubiquitous in warm estuarine and marine environments, of which 12 species are currently known to cause infections in humans. So far, only five human infections with V. ha...

    Authors: Thomas Theo Brehm, Laura Berneking, Holger Rohde, Martin Chistner, Carsten Schlickewei, Meike Sena Martins and Stefan Schmiedel

    Citation: BMC Infectious Diseases 2020 20:104

    Content type: Case report

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  30. Minimising antimicrobial overuse is needed to limit antimicrobial resistance. There is little evidence on how often microbiological testing informs antimicrobial de-escalation (e.g. stopping, shortening durati...

    Authors: William L. Hamilton, Sacha-Marie Pires, Samantha Lippett, Vikesh Gudka, Elizabeth L. A. Cross and Martin J. Llewelyn

    Citation: BMC Infectious Diseases 2020 20:102

    Content type: Research article

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  31. Invasive infections caused by Capnocytophaga canimorsus are rare. Immunocompromised patients, who report being bitten by or having a close contact with an animal, represent a high-risk group for this infection. T...

    Authors: Petr Prasil, Lenka Ryskova, Stanislav Plisek and Pavel Bostik

    Citation: BMC Infectious Diseases 2020 20:100

    Content type: Case report

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  32. The identification of the pathogens in pleural effusion has mainly relied on conventional bacterial culture or single species polymerase chain reaction (PCR), both with relatively low sensitivity. We investiga...

    Authors: Léo Franchetti, Desiree M. Schumann, Michael Tamm, Kathleen Jahn and Daiana Stolz

    Citation: BMC Infectious Diseases 2020 20:99

    Content type: Research article

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  33. Potentially pathogenic bacteria that colonise the lower genital tract of women in labour can be passed to the baby during birth. While many babies become colonised with these bacteria after delivery, a few dev...

    Authors: Josephine Tumuhamye, Hans Steinsland, James K. Tumwine, Olive Namugga, David Mukunya, Freddie Bwanga, Halvor Sommerfelt and Victoria Nankabirwa

    Citation: BMC Infectious Diseases 2020 20:98

    Content type: Research article

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  34. Salmonella species commonly causes infection in humans and on occasion leads to serious complications, such as mycotic aneurysms. Here, we present the first case reported of a patient with a mycotic aneurysm like...

    Authors: Jakub Nagrodzki, Katherine E. Sharrocks, Vanessa K. Wong and Andrew J. Carmichael

    Citation: BMC Infectious Diseases 2020 20:97

    Content type: Case report

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  35. Enterobacter cloacae complex (ECC) is one of the most common extended-spectrum β-lactamase and carbapenemase-producing pathogen that threatens millions of the elderly and vulnerable sick persons. The objective of...

    Authors: Yongxin Zhao, Jisheng Zhang, Yanjun Fu, Chunjiang Li, Kewang Hu, Shanshan Su, Lan Yu, Yuhang Guo, Yu Fu and Xiaoli Zhang

    Citation: BMC Infectious Diseases 2020 20:94

    Content type: Research article

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  36. We compared the cryptococcal antigen detection and imaging findings between immunocompetent and immunocompromised patients in whom pulmonary cryptococcosis had been diagnosed. The aim of our study was to deter...

    Authors: Jingqi Min, Kunlun Huang, Chanmei Shi, Laifu Li, Fuye Li, Tao Zhu and Huojin Deng

    Citation: BMC Infectious Diseases 2020 20:91

    Content type: Research article

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  37. Plague is a highly fatal disease caused by Yersinia pestis. Late diagnosis hampers disease outcome and effectiveness of control measures, induces death and disease spread. Advance on its diagnosis was the use of ...

    Authors: Minoarisoa Rajerison, Marie Melocco, Voahangy Andrianaivoarimanana, Soloandry Rahajandraibe, Feno Rakotoarimanana, André Spiegel, Maherisoa Ratsitorahina and Laurence Baril

    Citation: BMC Infectious Diseases 2020 20:90

    Content type: Technical advance

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  38. Outbreaks of acute undifferentiated febrile illness (AUFI) are common in Nepal, but the exact etiology or risk factors for them often go unrecognized. Diseases like influenza, enteric fever and rickettsial fev...

    Authors: Sunil Pokharel, Manan Karki, Bhim Acharya, Baburam Marasini and Amit Arjyal

    Citation: BMC Infectious Diseases 2020 20:89

    Content type: Research article

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  39. Little is known about the potential use of the eosinophil count as a predictive marker of bloodstream infection. In this study, we aimed to assess the reliability of eosinopenia as a predictive marker of blood...

    Authors: Takanobu Hirosawa, Yukinori Harada, Kohei Morinaga, Hiroshi Takase, Michihiro Nin and Taro Shimizu

    Citation: BMC Infectious Diseases 2020 20:85

    Content type: Research article

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  40. The more quickly bacterial pathogens responsible for foodborne illness outbreaks can be linked to a vehicle of transmission or a source, the more illnesses can be prevented. Whole genome sequencing (WGS) based...

    Authors: Andrea Ottesen, Padmini Ramachandran, Yi Chen, Eric Brown, Elizabeth Reed and Errol Strain

    Citation: BMC Infectious Diseases 2020 20:83

    Content type: Research article

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  41. Staphylococcus aureus is one of the major causes of bloodstream infections (BSI) worldwide, representing a major challenge for public health due to its resistance profile. Higher vancomycin minimum inhibitory con...

    Authors: Thaina Miranda da Costa, Gabriel Trova Cuba, Priscylla Guimarães Migueres Morgado, David P. Nicolau, Simone Aranha Nouér, Kátia Regina Netto dos Santos and Carlos Roberto Veiga Kiffer

    Citation: BMC Infectious Diseases 2020 20:74

    Content type: Research article

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  42. Whipple’s disease (WD) is a rare multisystem infectious disorder that is caused by the actinomycete Tropheryma whipplei. It presents with joint pain followed by abdominal pain, diarrhea, malabsorption and finally...

    Authors: Maxim Olivier, Carmelo Licitra, Zachary Field, Li Ge, Dustin Hill, Mario Madruga and S. J. Carlan

    Citation: BMC Infectious Diseases 2020 20:71

    Content type: Case report

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  43. Cryptococcal meningitis (CM) is the most common fungal infection of the central nervous system and has high morbidity and mortality. Almost studies about prognostic factors have largely focused on the immunoco...

    Authors: Chen Zhang, Zheren Tan and Fafa Tian

    Citation: BMC Infectious Diseases 2020 20:69

    Content type: Research article

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  44. Necrotizing fasciitis (NF) is a rare and life-threatening necrotizing skin and soft-tissue infection. Infectious pathogens of NF must be detected early and treated rapidly to prevent loss of limb or a fatal ou...

    Authors: Tsung-Yu Huang, Kuo-Ti Peng, Cheng-Ting Hsiao, Wen-Chih Fann, Yao-Hung Tsai, Yen-Yao Li, Chien-Hui Hung, Fang-Yi Chuang and Wei-Hsiu Hsu

    Citation: BMC Infectious Diseases 2020 20:60

    Content type: Research article

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