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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. The prevalence of diabetes mellitus continues to inexorably rise in the United States and throughout the world. Lower limb amputations are a devastating comorbid complication of diabetes mellitus. Osteomyeliti...

    Authors: Mary T. Bessesen, Gheorghe Doros, Adam M. Henrie, Kelly M. Harrington, John A. Hermos, Robert A. Bonomo, Ryan E. Ferguson, Grant D. Huang and Sheldon T. Brown

    Citation: BMC Infectious Diseases 2020 20:23

    Content type: Study protocol

    Published on:

  2. Bacillus cereus sometimes causes central nervous system infection, especially in compromised hosts. In cases of meningitis arising during neutropenia, CSF abnormalities tend to be subtle and can be easily overloo...

    Authors: Yusuke Koizumi, Takafumi Okuno, Hitoshi Minamiguchi, Keiko Hodohara, Hiroshige Mikamo and Akira Andoh

    Citation: BMC Infectious Diseases 2020 20:15

    Content type: Case report

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  3. The development of respiratory infections secondary to Aspergillus spp. spores found ubiquitously in the ambient environment is uncommon in immunocompetent patients. Previous reports of invasive upper airway aspe...

    Authors: Shihan N. Khan, Rashmi Manur, John S. Brooks, Michael A. Husson, Kevin Leahy and Matthew Grant

    Citation: BMC Infectious Diseases 2020 20:13

    Content type: Case report

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  4. Brucellosis is endemic in many areas in China. The current diagnosis of Brucellosis predominantly relies on the traditional bacterial culture and serum agglutination test. In this study, we aimed to explore th...

    Authors: Nannan Xu, Wei Wang, Fengzhe Chen, Wen Li and Gang Wang

    Citation: BMC Infectious Diseases 2020 20:11

    Content type: Research article

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  5. There have been no systematic studies of microbiological differences before and after antibiotics treatment. The aim of this study was to evaluate the effect of prior receipt of antibiotics on the microorganis...

    Authors: Leiqing Li, Lingcheng Xu, Rongsheng Zhu, Jiaojiao Song and Xuanding Wang

    Citation: BMC Infectious Diseases 2020 20:8

    Content type: Research article

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  6. Mycoplasma sp. are well recognized as etiological agents of respiratory and sexually transmitted disease. Mycoplasma penetrans, a species of Mycoplasma sp., has been frequently detected in HIV-positive patients a...

    Authors: Benjamin Preiswerk, Frank Imkamp, Denise Vorburger, Rico V. Hömke, Peter M. Keller and Karoline Wagner

    Citation: BMC Infectious Diseases 2020 20:7

    Content type: Case report

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  7. Accurate determination of the efficacy of antimicrobial agents requires neutralization of residual antimicrobial activity in the samples before microbiological assessment of the number of surviving bacteria. S...

    Authors: Gabrielle Sherella Dijksteel, Peter H. Nibbering, Magda M. W. Ulrich, Esther Middelkoop and Bouke K. H. L. Boekema

    Citation: BMC Infectious Diseases 2019 19:1093

    Content type: Research article

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  8. This study investigated predominant microorganisms causing community-onset bacteraemia at the medical emergency department (ED) of a tertiary-care university hospital in Germany from 2013 to 2018 and their ant...

    Authors: Kathrin Rothe, Nina Wantia, Christoph D. Spinner, Jochen Schneider, Tobias Lahmer, Birgit Waschulzik, Roland M. Schmid, Dirk H. Busch and Juri Katchanov

    Citation: BMC Infectious Diseases 2019 19:1091

    Content type: Research article

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  9. Treatment of enterococcal periprosthetic joint infections (PJI) is challenging due to non-standardized management strategies and lack of biofilm-active antibiotics. The optimal surgical and antimicrobial thera...

    Authors: Nora Renz, Rihard Trebse, Doruk Akgün, Carsten Perka and Andrej Trampuz

    Citation: BMC Infectious Diseases 2019 19:1083

    Content type: Research article

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  10. Community-onset pneumonia (COP) is a combined concept of community acquired pneumonia and the previous classification of healthcare-associated pneumonia. Although ceftriaxone (CRO) is one of the treatment choi...

    Authors: Shinya Hasegawa, Ryuichi Sada, Makito Yaegashi, Konosuke Morimoto and Takahiro Mori

    Citation: BMC Infectious Diseases 2019 19:1079

    Content type: Research article

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  11. Trachoma is the commonest infectious cause of blindness. It is prevalent in areas where personal and community hygiene is poor, and it mainly affects deprived and marginalized communities most importantly in E...

    Authors: Alemu Gebrie, Animut Alebel, Abriham Zegeye, Bekele Tesfaye and Fasil Wagnew

    Citation: BMC Infectious Diseases 2019 19:1073

    Content type: Research article

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  12. Klebsiella species are among the most common causes of bloodstream infection (BSI). However, few studies have evaluated their epidemiology in non-selected populations. The objective was to define the incidence of...

    Authors: Connor B. Reid, Lisa Steele, Kelsey Pasquill, Elizabeth C. Parfitt and Kevin B. Laupland

    Citation: BMC Infectious Diseases 2019 19:1070

    Content type: Research article

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  13. Symptomatic and asymptomatic enteric infections in early childhood are associated with negative effects on childhood growth and development, especially in low and middle-income countries, and food may be an impor...

    Authors: Jane Mumma, Sheillah Simiyu, Evalyne Aseyo, John Anderson, Alexandra Czerniewska, Elizabeth Allen, Robert Dreibelbis, Kelly K. Baker and Oliver Cumming

    Citation: BMC Infectious Diseases 2019 19:1066

    Content type: Study protocol

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  14. To investigate the cumulative incidence of and factors associated with mortality among patients with infective endocarditis (IE) at Thailand’s largest national tertiary referral center.

    Authors: Taksaon Angsutararux and Nasikarn Angkasekwinai

    Citation: BMC Infectious Diseases 2019 19:1062

    Content type: Research article

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  15. The diagnosis of infective endocarditis (IE) is based on microbiological analyses and diagnostic imaging of cardiac manifestations. Echocardiography (ECHO) is preferred for visualization of IE-induced cardiac ...

    Authors: A. Damlin, K. Westling, E. Maret, C. Stålsby Lundborg, K. Caidahl and M. J. Eriksson

    Citation: BMC Infectious Diseases 2019 19:1052

    Content type: Research article

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  16. Diphtheria has been reported as an outbreak in some regions in Indonesia, most especially in East Java Province. Resistance to penicillin, erythromycin, and other antibiotics, single or multiple, has been repo...

    Authors: Dominicus Husada, Sugi Deny Pranoto Soegianto, Indra Suwarin Kurniawati, Adi Pramono Hendrata, Eveline Irawan, Leny Kartina, Dwiyanti Puspitasari, Parwati Setiono Basuki and Ismoedijanto

    Citation: BMC Infectious Diseases 2019 19:1049

    Content type: Research article

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  17. Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp.

    Authors: Stuart D. Blacksell, Matthew T. Robinson, Paul N. Newton, Soiratchaneekorn Ruanchaimun, Jeanne Salje, Tri Wangrangsimakul, Matthew D. Wegner, Mohammad Yazid Abdad, Allan M. Bennett, Allen L. Richards, John Stenos and Nicholas P. J. Day

    Citation: BMC Infectious Diseases 2019 19:1044

    Content type: Debate

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  18. Shigella spp. and entero-invasive E. coli (EIEC) use the same invasive mechanism to cause diarrheal diseases. Public health regulations apply only to Shigella spp. infections, but are hampered by the lack of simp...

    Authors: Maaike J. C. van den Beld, Esther Warmelink, Alexander W. Friedrich, Frans A. G. Reubsaet, Maarten Schipper, Richard F. de Boer, Daan W. Notermans, Mariska W. F. Petrignani, Evert van Zanten, John W. A. Rossen, Ingrid H. M. Friesema and A. M. D. ( Mirjam) Kooistra-Smid

    Citation: BMC Infectious Diseases 2019 19:1037

    Content type: Research article

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  19. The cytokine gene polymorphism is important for the genetic susceptibility of infectious diseases. The aim of the present study was to investigate the relationship between TNF-α, IL-12, and IL-13 gene polymorp...

    Authors: Sima Kazemi, Asad Vaisi-Raygani, Fariba Keramat, Massoud Saidijam, Ali Reza Soltanian, Mahdi Alahgholi-Hajibehzad, Seyed Hamid Hashemi and Mohammad Yousef Alikhani

    Citation: BMC Infectious Diseases 2019 19:1036

    Content type: Research article

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  20. The incidence of Taralomyces marneffei infection in HIV-infected individuals has been decreasing, whereas its rate is rising among non-HIV immunodeficient persons, particularly patients with anti-interferon-gamma...

    Authors: Thanyarak Wongkamhla, Piriyaporn Chongtrakool and Anupop Jitmuang

    Citation: BMC Infectious Diseases 2019 19:1034

    Content type: Case report

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  21. Staphylococcus aureus carriage is a known risk factor for staphylococcal disease. However, the carriage rates vary by country, demographic group and profession. This study aimed to determine the S. aureus carriag...

    Authors: David Patrick Kateete, Benon B. Asiimwe, Raymond Mayanja, Brian Mujuni, Freddie Bwanga, Christine F. Najjuka, Karin Källander and Elizeus Rutebemberwa

    Citation: BMC Infectious Diseases 2019 19:1023

    Content type: Research article

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  22. Vitamin D deficiency, determined by blood levels of 25-hydroxyvitamin D [25(OH) D, i.e. the major vitamin D form in blood], has been shown to associate with all-cause mortalities. We recently demonstrated that...

    Authors: Chih-Huang Li, Xiaolei Tang, Samiksha Wasnik, Xiaohua Wang, Jintao Zhang, Yi Xu, Kin-Hing William Lau, H. Bryant Nguyen and David J. Baylink

    Citation: BMC Infectious Diseases 2019 19:1020

    Content type: Research article

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  23. Although, India has made steady progress in reducing deaths in children younger than 5 years, the proportional mortality accounted by diarrhoeal diseases still remains high. The present hospital based cross se...

    Authors: Sonam S. Moharana, Rakesh K. Panda, Muktikesh Dash, Nirupama Chayani, Priyanka Bokade, Sanghamitra Pati and Debdutta Bhattacharya

    Citation: BMC Infectious Diseases 2019 19:1018

    Content type: Research article

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  24. Antibiotics remain the cornerstone of modern medicine. Yet there exists an inherent dilemma in their use: we are able to prevent harm by administering antibiotic treatment as necessary to both humans and anima...

    Authors: Gwenan M. Knight, Nicholas G. Davies, Caroline Colijn, Francesc Coll, Tjibbe Donker, Danna R. Gifford, Rebecca E. Glover, Mark Jit, Elizabeth Klemm, Sonja Lehtinen, Jodi A. Lindsay, Marc Lipsitch, Martin J. Llewelyn, Ana L. P. Mateus, Julie V. Robotham, Mike Sharland…

    Citation: BMC Infectious Diseases 2019 19:1011

    Content type: Debate

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  25. Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection a...

    Authors: Yoan Mboussou, Julien Jaubert, Sophie Larrieu, Laura Atiana, Florence Naze, Christine Folio, Hanitra Randrianaivo, Antoine Bertolotti, Sandrine Picot, Pierre-Yves Robillard, Malik Boukerrou and Patrick Gérardin

    Citation: BMC Infectious Diseases 2019 19:1001

    Content type: Research article

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  26. Histoplasmosis is one of the invasive fungal infections and presents with symptoms mainly in the lungs. Disseminated histoplasmosis (DH) is rare and its lesions in the gastrointestinal tract are even uncommon....

    Authors: Yini Dang, Longfeng Jiang, Jianfu Zhang, Beijing Pan, Guoqin Zhu, Feipeng Zhu, Zhe Guo, Biao Wang, Guoxin Zhang, Yali Weng and Jun Li

    Citation: BMC Infectious Diseases 2019 19:992

    Content type: Case report

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  27. A bacteremia diagnosis with speeded-up identification and antimicrobial susceptibility testing (AST) is mandatory to adjust empirical broad-spectrum antibiotherapy and avoid the emergence of multi-resistant ba...

    Authors: Lidvine Boland, Corentin Streel, Hélène De Wolf, Hector Rodriguez and Alexia Verroken

    Citation: BMC Infectious Diseases 2019 19:989

    Content type: Research article

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  28. Infective endocarditis (IE) is a serious mainly bacterial infection associated with high mortality. Epidemiology of fatal IE is however largely unknown. We studied occurrence and trends of fatal IE in a popula...

    Authors: Elina Ahtela, Jarmo Oksi, Jussi Sipilä, Päivi Rautava and Ville Kytö

    Citation: BMC Infectious Diseases 2019 19:987

    Content type: Research article

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  29. Burkholderia pseudomallei is a gram-negative bacterium and the causative pathogen of melioidosis, which manifests a variety ranges of infection symptoms. However, deep venous thrombosis (DVT) and pulmonary emboli...

    Authors: Hua Wu, Dongliang Huang, Biao Wu, Mengjie Pan and Binghuai Lu

    Citation: BMC Infectious Diseases 2019 19:984

    Content type: Case report

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  30. Dermatophytosis is a fungal infectious disease caused by dermatophytes, which produce protease and keratinase to digest keratin, leading to the colonization, invasion, and infection of the stratum corneum of t...

    Authors: Mingrui Zhang, Lanxiang Jiang, Fuqiu Li, Yangchun Xu, Sha Lv and Bing Wang

    Citation: BMC Infectious Diseases 2019 19:983

    Content type: Case report

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  31. Intra-abdominal infections (IAIs) represent a most frequent gastrointestinal emergency and serious cause of morbimortality. A full classification, including all facets of IAIs, does not exist. Two classificati...

    Authors: João Silva-Nunes and Teresa Cardoso

    Citation: BMC Infectious Diseases 2019 19:980

    Content type: Research article

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  32. Fluoroquinolones are commonly recommended as treatment for urinary tract infections (UTIs). The development of resistance to these agents, particularly in gram-negative microorganisms complicates treatment of ...

    Authors: Dalia Nabil Kotb, Wafaa Khairy Mahdy, Mahmoud Shokry Mahmoud and Rasha M. M. Khairy

    Citation: BMC Infectious Diseases 2019 19:979

    Content type: Research article

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  33. Diagnosing pneumonia can be challenging in general practice but is essential to distinguish from other respiratory tract infections because of treatment choice and outcome prediction. We determined predictive ...

    Authors: G. H. Groeneveld, J. W. van ’t Wout, N. J. Aarts, C. J. van Rooden, T. J. M. Verheij, C. M. Cobbaert, E. J. Kuijper, J. J. C. de Vries and J. T. van Dissel

    Citation: BMC Infectious Diseases 2019 19:976

    Content type: Research article

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  34. Diabetes is one of the underlying risk factors for developing community-acquired pneumonia (CAP). The high prevalence of diabetes among population and the rising incidence of this illness, converts it as an im...

    Authors: Loreto Arias Fernández, Jacobo Pardo Seco, Miriam Cebey-López, Ruth Gil Prieto, Irene Rivero-Calle, Federico Martinon-Torres, Ángel Gil de Miguel, F. Martinón-Torres, D. Vargas, E. Mascarós, E. Redondo, J. L. Díaz-Maroto, M. Linares-Rufo, A. Gil, J. Molina, D. Ocaña…

    Citation: BMC Infectious Diseases 2019 19:973

    Content type: Research article

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  35. Recent reports of the National Ministry of Health and Treatment of Iran (NMHT) show that Gilan has a higher annual incidence rate of leptospirosis than other provinces across the country. Despite several effor...

    Authors: Ali Mohammadinia, Bahram Saeidian, Biswajeet Pradhan and Zeinab Ghaemi

    Citation: BMC Infectious Diseases 2019 19:971

    Content type: Research article

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  36. This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus...

    Authors: Juhyun Song, Dae Won Park, Sungwoo Moon, Han-Jin Cho, Jong Hak Park, Hyeri Seok and Won Seok Choi

    Citation: BMC Infectious Diseases 2019 19:968

    Content type: Research article

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  37. Clostridioides difficile is considered the main pathogen responsible for hospital-acquired infections. This prospective study determined the prevalence, molecular epidemiological characteristics, and risk factors...

    Authors: Yingchao Cui, Danfeng Dong, Lihua Zhang, Daosheng Wang, Cen Jiang, Qi Ni, Chen Wang, Enqiang Mao and Yibing Peng

    Citation: BMC Infectious Diseases 2019 19:961

    Content type: Research article

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  38. Streptococcus oralis belongs to the Streptococcus mitis group and is part of the normal flora of the nasal and oropharynx (Koneman et al., The Gram-positive cocci part II: streptococci, enterococci and the ‘Strep...

    Authors: Kishan Patel, Zain Memon, Adam Prince, Connie Park, Abin Sajan and Nazish Ilyas

    Citation: BMC Infectious Diseases 2019 19:960

    Content type: Case report

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  39. Patients with multiple myeloma (MM) are known to be immune incompetent and experience higher incidences of infectious diseases. However, infective endocarditis (IE) is rarely observed in patients with MM and Morg...

    Authors: Renée van Bentum, Judith Nieken, Esther de Waal and Mels Hoogendoorn

    Citation: BMC Infectious Diseases 2019 19:957

    Content type: Case report

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  40. Localized `and disseminated Nocardia farcinica infection is frequently reported in immunocompromised patients. However, orbital nocardiosis is rare, and, to our knowledge, traumatic orbital nocardiosis that affec...

    Authors: Anan Wang, Qihua Xu, Yaohua Wang and Hongfei Liao

    Citation: BMC Infectious Diseases 2019 19:953

    Content type: Case report

    Published on:

  41. Osteomyelitis of the pubic symphysis is a rare cause of pelvic pain after delivery, mainly caused by Staphylococcus aureus and Pseudomonas aeruginosa.

    Authors: Stefano Cosma, Fulvio Borella, Andrea Carosso, Agata Ingala, Federica Fassio, Tiziana Robba, Aldo Maina, Luca Bertero and Chiara Benedetto

    Citation: BMC Infectious Diseases 2019 19:952

    Content type: Case report

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  42. Bacterial infection of the urinary tract is among the common reasons for seeking medical attention in the community. Rapidly increasing antibiotic resistance of uropathogens is resulting in limited treatment o...

    Authors: Guesh Gebremariam, Haftom Legese, Yemane Woldu, Tadele Araya, Kiflom Hagos and Araya GebreyesusWasihun

    Citation: BMC Infectious Diseases 2019 19:950

    Content type: Research article

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  43. Enterohemorrhagic Escherichia coli (EHEC) is an important pathogen that causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). After an EHEC outbreak involving uncooked beef, serving raw beef ...

    Authors: Kentaro Iwata and Michihiko Goto

    Citation: BMC Infectious Diseases 2019 19:949

    Content type: Research article

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  44. In the pre-vaccine era, invasive disease with Haemophilus influenzae, type b (Hib) commonly presented with osteoarticular involvement. Haemophilus influenzae, type a (Hia) sepsis is a rare but emerging problem in...

    Authors: Tiffany Albrecht, Kristina Poss, Satja Issaranggoon Na Ayuthaya, Lori Triden, Katherine L. Schleiss and Mark R. Schleiss

    Citation: BMC Infectious Diseases 2019 19:947

    Content type: Case report

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  45. Infective endocarditis (IE) is a lethal disease which has been changing significantly over the past decades; however, information about IE in China remains scarce. This study surveyed the changes in clinical c...

    Authors: Zuning Ren, Xichao Mo, Hongjie Chen and Jie Peng

    Citation: BMC Infectious Diseases 2019 19:945

    Content type: Research article

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