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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    Antifungal resistance rates are increasing. We investigated the mechanisms of azole resistance of Candida spp. bloodstream isolates obtained from a surveillance study conducted between 2012 and 2015.

    Authors: Jocelyn Qi-Min Teo, Shannon Jing-Yi Lee, Ai-Ling Tan, Robyn Su-May Lim, Yiying Cai, Tze-Peng Lim and Andrea Lay-Hoon Kwa

    Citation: BMC Infectious Diseases 2019 19:63

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  2. Content type: Research article

    Extracellular hydrolases (phospholipase, aspartyl protease and haemolysin) and biofilm production are considered as major virulence factors of the opportunistic pathogenic fungus Candida albicans. However, the im...

    Authors: Houdaii H. El-Houssaini, Omnia M. Elnabawy, Hebatallah A. Nasser and Walid F. Elkhatib

    Citation: BMC Infectious Diseases 2019 19:54

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  3. Content type: Research article

    Clostridium difficile infection (CDI) is an important cause of diarrhea and continues to be a major burden within healthcare institutions and in the community. For a small subset of patients with frequently relap...

    Authors: Kevin Zhang, Patricia Beckett, Salaheddin Abouanaser, Vida Stankus, Christine Lee and Marek Smieja

    Citation: BMC Infectious Diseases 2019 19:51

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  4. Content type: Research article

    Biofilm production by Haemophilus influenzae and Streptococcus pneumoniae has been implicated in the pathogenesis of otitis media, mainly in chronic and recurrent cases. We studied the in vitro biofilm producti...

    Authors: Quentin Vermee, Robert Cohen, Constantin Hays, Emmanuelle Varon, Stephane Bonacorsi, Stephane Bechet, Franck Thollot, François Corrard, Claire Poyart, Corinne Levy and Josette Raymond

    Citation: BMC Infectious Diseases 2019 19:44

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  5. Content type: Research article

    Urinary tract infection (UTIs) is a significant health problem in diabetic patients because of the multiple effects of this disease on the urinary tract and host immune system. Complicated UTIs occur most comm...

    Authors: Hiwot Ketema Woldemariam, Dereje Assefa Geleta, Kassu Desta Tulu, Negga Asamene Aber, Melese Hailu Legese, Genet Molla Fenta and Ibrahim Ali

    Citation: BMC Infectious Diseases 2019 19:43

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  6. Content type: Research article

    Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection has recently become a challenging problem worldwide and in Japan. We experienced 10 pediatric patients infected with CA-MRSA an...

    Authors: Yuki Uehara, Takashi Sasaki, Tadashi Baba, Yujie Lu, Eri Imajo, Yuka Sato, Shigeru Tanno, Munehiro Furuichi, Miki Kawada and Keiichi Hiramatsu

    Citation: BMC Infectious Diseases 2019 19:35

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  7. Content type: Research article

    Almost half the world’s population is infected with Helicobacter pylori (H. pylori) with the highest reported prevalence from Africa. This infection is associated with several morbid gastrointestinal conditions. ...

    Authors: Jeannine A. Aminde, Guisilla A. Dedino, Calypse A. Ngwasiri, Kingsley S. Ombaku, Cedric A. Mahop Makon and Leopold Ndemnge Aminde

    Citation: BMC Infectious Diseases 2019 19:30

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  8. Content type: Research article

    During 2015–2016 an outbreak of invasive meningococcal disease due to N. meningitidis serogroup C ST-11 (cc11) occurred in Tuscany, Italy. The outbreak affected mainly the age group 20–30 years, men who have sex ...

    Authors: Alessandro Miglietta, Francesco Innocenti, Patrizio Pezzotti, Eleonora Riccobono, Maria Moriondo, Patrizia Pecile, Francesco Nieddu, Gian Maria Rossolini, Chiara Azzari, Emanuela Balocchini, Giovanni Rezza, Fabio Voller and Paola Stefanelli

    Citation: BMC Infectious Diseases 2019 19:29

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  9. Content type: Case report

    Thus far, studies on Klebsiella pneumoniae carbapenemase (KPC)-producing organisms have only been reported in those with a history of foreign travel, and a specific Japanese KPC-producing isolate has not yet been...

    Authors: Yusuke Ainoda, Kotaro Aoki, Yoshikazu Ishii, Kentaro Okuda, Hitomi Furukawa, Ryo Manabe, Toshinori Sahara, Fukumi Nakamura-Uchiyama, Hitomi Kurosu, Yukiko Ando, Maki Fujisawa, Hitomi Hoshino, Hideki Arima and Kenji Ohnishi

    Citation: BMC Infectious Diseases 2019 19:20

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  10. Content type: Research article

    Guidelines recommend macrolides and fluoroquinolones in patients hospitalized with community-acquired pneumonia (CAP), but their use has been associated with cardiac events. We quantified associations between ...

    Authors: Douwe F. Postma, Cristian Spitoni, Cornelis H. van Werkhoven, Leontine J. R. van Elden, Jan Jelrik Oosterheert and Marc J. M. Bonten

    Citation: BMC Infectious Diseases 2019 19:17

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  11. Content type: Research article

    The aim of the present study was to gain national data on the clinical and microbiological characteristics of community-acquired infections in the Faroe Islands and to compare these data with data from other g...

    Authors: Marija Todorovic Markovic, Court Pedersen, Magnús Gottfredsson, Mirjana Todorovic Mitic and Shahin Gaini

    Citation: BMC Infectious Diseases 2019 19:16

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  12. Content type: Research article

    For a long time, the Christie-Atkinson-Munch-Peterson (CAMP) test has been a standard test for the identification of Streptococcus agalactiae, and a positive result for S.agalactiae has been considered sensitive ...

    Authors: Dacheng Guo, Yu Xi, Shanmei Wang and Zeyu Wang

    Citation: BMC Infectious Diseases 2019 19:7

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  13. Content type: Research article

    On 18th May 2017, State Ministry of Health of former Warrap State received a report from Tonj East County of an outbreak of acute watery diarrhoea and vomiting in Makuac payam. We conducted this investigation ...

    Authors: Fred Nsubuga, Stephen Chol Garang, Mathew Tut, David Oguttu, Robert Lubajo, Dennis Lodiongo, Michael Lasuba and Allan Mpairwe

    Citation: BMC Infectious Diseases 2019 19:4

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  14. Content type: Case report

    Spotted fever group of rickettsial infections are emerging in Sri Lanka. We describe a patient with rapidly progressing ARDS and myocarditis secondary to spotted fever caused by Rickettsia conorii. ARDS and myoca...

    Authors: H. M. L. Y. Herath, J. M. H. D. Jayasundara, S. D. N. Senadhira, S. A. M. Kularatne and W. K. S. Kularatne

    Citation: BMC Infectious Diseases 2018 18:705

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  15. Content type: Case report

    Primary meningococcal arthritis is a rare infectious disease that occurs in less than 3% of meningococcal infections and is characterized by arthritis without meningitis, fever, rash, or hemodynamic instabilit...

    Authors: S. Ricci, A. Montemaggi, F. Nieddu, D. Serranti, G. Indolfi, M. Moriondo and C. Azzari

    Citation: BMC Infectious Diseases 2018 18:703

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  16. Content type: Case report

    Invasive aspergillosis is a complication in immunocompromised patients and commonly detected in patients with hematological malignancies, which mostly affect the lungs. Because of its high iodine content, rich...

    Authors: Jiaying Tan, Jun Shen, Yong Fang, Liping Zhu, Yang Liu, Ye Gong, Hechen Zhu, Zupeng Hu and Gang Wu

    Citation: BMC Infectious Diseases 2018 18:702

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  17. Content type: Research article

    Routine culture-based diagnosis of Pseudomonas aeruginosa lung infection in Cystic Fibrosis (CF) patients can be hampered by the phenotypic variability of the microorganism, including its transition to a Viable B...

    Authors: Gianmarco Mangiaterra, Mehdi Amiri, Andrea Di Cesare, Sonia Pasquaroli, Esther Manso, Natalia Cirilli, Barbara Citterio, Carla Vignaroli and Francesca Biavasco

    Citation: BMC Infectious Diseases 2018 18:701

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  18. Content type: Research article

    Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We...

    Authors: Roni Nasser, Mohammad E. Naffaa, Tanya Mashiach, Zaher S. Azzam and Eyal Braun

    Citation: BMC Infectious Diseases 2018 18:698

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  19. Content type: Research article

    An explosive outbreak of Legionnaires’ disease (LD) was identified on 11 December 2015 in Manzanares, Ciudad Real, Spain, and was declared closed by 03 February 2016. The number of declared cases was 593 with ...

    Authors: Fernando Cebrián, Juan C. Montero and Pedro J. Fernández

    Citation: BMC Infectious Diseases 2018 18:696

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  20. Content type: Case report

    Leptospirosis is a zoonosis commonly prevalent in tropical countries. Clinical course of leptospirosis varies from mild to severe disease. Here we present a case of leptospirosis complicated with Guillain-Barr...

    Authors: Kavinga Kalhari Kobawaka Gamage and Harshini Fernando

    Citation: BMC Infectious Diseases 2018 18:691

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  21. Content type: Case report

    Central nervous system (CNS) infections caused by Actinomyces spp. including brain abscess, actinomycoma, subdural empyema and epidural abscess are well described, however reports of Actinomyces-associated mening...

    Authors: Béla Kocsis, Zoltán Tiszlavicz, Gabriella Jakab, Réka Brassay, Márton Orbán, Ágnes Sárkány and Dóra Szabó

    Citation: BMC Infectious Diseases 2018 18:686

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  22. Content type: Research article

    Meningitis remains a top cause of premature death and loss of disability-adjusted life years in low-income countries. In resource-limited settings, proper laboratory diagnostics are often scarce and knowledge ...

    Authors: Guro K. Bårnes, Esayas Kebede Gudina, Melkamu Berhane, Alemseged Abdissa, Getnet Tesfaw, Gemeda Abebe, Siri Laura Feruglio, Dominique A. Caugant and Hannah Joan Jørgensen

    Citation: BMC Infectious Diseases 2018 18:684

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  23. Content type: Research article

    Empirical antibiotic coverage for atypical pathogens in community-acquired pneumonia (CAP) has long been debated, mainly because of a lack of epidemiological data. We aimed to assess both testing for atypical ...

    Authors: Andrea Gramegna, Giovanni Sotgiu, Marta Di Pasquale, Dejan Radovanovic, Silvia Terraneo, Luis F. Reyes, Ester Vendrell, Joao Neves, Francesco Menzella, Francesco Blasi, Stefano Aliberti and Marcos I. Restrepo

    Citation: BMC Infectious Diseases 2018 18:677

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  24. Content type: Research article

    Histoplasmosis is a fungal infection highly endemic in the American continent. The disease can be severe in immunocompromised subjects. In immunocompetent subjects the clinical manifestations are variable. Aim...

    Authors: Silvia Staffolani, Dora Buonfrate, Andrea Angheben, Federico Gobbi, Giovanni Giorli, Massimo Guerriero, Zeno Bisoffi and Francesco Barchiesi

    Citation: BMC Infectious Diseases 2018 18:673

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  25. Content type: Case report

    Endogenous endophthalmitis caused by hypervirulent Klebsiella pneumoniae (HVKP) is an emerging infectious disease commonly with a devastating visual outcome. Most HVKP strains display a wild-type susceptibility p...

    Authors: Min Xu, Ang Li, Haishen Kong, Weili Zhang, Hongchao Chen, Yajie Fu and Yiqi Fu

    Citation: BMC Infectious Diseases 2018 18:669

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  26. Content type: Research article

    The increased prevalence of carbapenem-resistant Gram-negative isolates caused by Metallo-β-lactamase (MBL) is worrisome in clinical settings worldwide. The mortality rate associated with infections caused by ...

    Authors: Mudathir Abdallah Adam and Wafa I. Elhag

    Citation: BMC Infectious Diseases 2018 18:668

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  27. Content type: Case report

    Intra-osseous (IO) access is recommended in cases of pre-hospital emergency or resuscitation when intravascular (IV) route is difficult or impossible. Despite recent improvement in IO devices and increasing in...

    Authors: Thomas Chalopin, Adrien Lemaignen, Antoine Guillon, Arnaud Geffray, Gaelle Derot, Olivier Bahuaud, Charles Agout, Philippe Rosset, Claire Castellier, Gonzague De Pinieux, Anne-Sophie Valentin, Louis Bernard and Frederic Bastides

    Citation: BMC Infectious Diseases 2018 18:665

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  28. Content type: Research article

    Early antifungal therapy for invasive aspergillosis (IA) has been associated with improved outcome. Traditionally, of empiric antifungal therapy has been used for clinically suspected IA. We compared outcomes ...

    Authors: Rita Wilson Dib, Ray Y. Hachem, Anne-Marie Chaftari, Fady Ghaly, Ying Jiang and Issam Raad

    Citation: BMC Infectious Diseases 2018 18:656

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  29. Content type: Research article

    Bloodstream infection (BSI) is one of the major causes of morbidity and mortality for patients undergoing hematopoietic stem cell transplantation (HSCT). The unrelated cord blood transplantation (UCBT) can pro...

    Authors: Jing Ge, Tingting Yang, Lei Zhang, Xuhan Zhang, Xiaoyu Zhu, Baolin Tang, Xiang Wan, Juan Tong, Kaidi Song, Wen Yao, Guangyu Sun, Zimin Sun and Huilan Liu

    Citation: BMC Infectious Diseases 2018 18:654

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  30. Content type: Research article

    Infections of the ears, paranasal sinuses, nose and throat are very common and represent a serious issue for the healthcare system. Bacterial biofilms have been linked to upper respiratory tract infections and...

    Authors: Alessandro Bidossi, Roberta De Grandi, Marco Toscano, Marta Bottagisio, Elena De Vecchi, Matteo Gelardi and Lorenzo Drago

    Citation: BMC Infectious Diseases 2018 18:653

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  31. Content type: Case report

    Melioidosis is a tropical disease caused by Burkholderia pseudomallei (B. pseudomallei). It can infect any organ system and lead to multiple abscesses. A few studies reported that central nervous system (CNS) is ...

    Authors: Wei-yuan Huang, Gang Wu, Feng Chen, Meng-meng Li and Jian-jun Li

    Citation: BMC Infectious Diseases 2018 18:649

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  32. Content type: Case report

    Liver transplant recipients are at high risk of developing invasive aspergillosis and in particular by Aspergillus fumigatus which is the most commonly encountered species in this population. Other non-fumigatus ...

    Authors: Nawel Aït-Ammar, Eric Levesque, Jean-Benjamin Murat, Sébastien Imbert, Françoise Foulet, Eric Dannaoui and Françoise Botterel

    Citation: BMC Infectious Diseases 2018 18:648

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  33. Content type: Research article

    The 2010 Infectious Diseases Society of America (IDSA) guidelines for management of cryptococcal diseases recommend high dose fluconazole (≥ 800 mg/day), either alone or with other antifungal drugs, as alterna...

    Authors: Hua-Zhen Zhao, Rui-Ying Wang, Xuan Wang, Ying-Kui Jiang, Ling-Hong Zhou, Jia-Hui Cheng, Li-Ping Huang, Thomas Stephen Harrison and Li-Ping Zhu

    Citation: BMC Infectious Diseases 2018 18:643

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  34. Content type: Research article

    Disease caused by Bacillus anthracis is often accompanied by high mortality primarily due to toxin-mediated injury. In the early disease course, anthrax toxins are secreted; thus, antibiotic use is limited to the...

    Authors: Qi Tang, Siping Xiong, Xudong Liang, Xingwang Kuai, Yiwen Wang, Changjun Wang, Zhenqing Feng and Jin Zhu

    Citation: BMC Infectious Diseases 2018 18:640

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  35. Content type: Research article

    The aim of this study was to estimate the prevalence of pneumonia and secondary bacterial infections during the pandemic of influenza A(H1N1)pdm09.

    Authors: Chandini Raina MacIntyre, Abrar Ahmad Chughtai, Michelle Barnes, Iman Ridda, Holly Seale, Renin Toms and Anita Heywood

    Citation: BMC Infectious Diseases 2018 18:637

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  36. Content type: Research article

    Osteomyelitis is a difficult-to-cure infection with a high relapse rate despite combined medical and surgical therapies. Some severity factors, duration of antimicrobial therapy and type of surgical procedure ...

    Authors: E. Garcia del Pozo, J. Collazos, J. A. Carton, D. Camporro and V. Asensi

    Citation: BMC Infectious Diseases 2018 18:635

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  37. Content type: Study protocol

    Febrile Urinary Tract Infection (FUTI) is frequently treated initially with intravenous antibiotics, followed by oral antibiotics guided by clinical response and bacterial susceptibility patterns. Due to incre...

    Authors: Thijs ten Doesschate, Suzan P. van Mens, Cees van Nieuwkoop, Suzanne E. Geerlings, Andy I. M. Hoepelman and Marc J. M. Bonten

    Citation: BMC Infectious Diseases 2018 18:626

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  38. Content type: Research article

    Temporal relationships between the time to appropriate antibiotic therapy and outcomes are not well described.

    Authors: Thomas P. Lodise, Qi Zhao, Kyle Fahrbach, Patrick J. Gillard and Amber Martin

    Citation: BMC Infectious Diseases 2018 18:625

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  39. Content type: Research article

    Salmonella is an important human pathogen in Australia and annual case rates continue to increase. In addition to foodborne exposures, cases have been associated with animal and contaminated environment contact. ...

    Authors: Kelly M. J. Simpson, Grant A. Hill-Cawthorne, Michael P. Ward and Siobhan M. Mor

    Citation: BMC Infectious Diseases 2018 18:623

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  40. Content type: Research article

    Despite the use of pneumococcal vaccines, indigenous populations are consistently disproportionately affected by invasive pneumococcal disease (IPD). With recent changes in Ontario’s provincial pneumococcal va...

    Authors: Daniel Dalcin, Lee Sieswerda, Sacha Dubois and Marina Ulanova

    Citation: BMC Infectious Diseases 2018 18:621

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  41. Content type: Case report

    Gastrointestinal (GI) cryptococcosis is rarely reported. Most cases were diagnosed during evaluation of comorbid conditions, incidental findings, or postmortem. Here, we present a case of Crohn’s disease with ...

    Authors: Natthakit Chavapradit and Nasikarn Angkasekwinai

    Citation: BMC Infectious Diseases 2018 18:620

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  42. Content type: Research article

    Acinetobacter baumannii is a nosocomial pathogen which is reported as a major cause of morbidity and mortality in intensive care units (ICUs). However, there is a lack of analysis focused on multidrug-resistant A...

    Authors: Yili Chen, Lu Ai, Penghao Guo, Han Huang, Zhongwen Wu, Xiaoling Liang and Kang Liao

    Citation: BMC Infectious Diseases 2018 18:614

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