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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    In sub-Saharan Africa, efforts to control antimicrobial resistance (AMR) are aggravated by unregulated drug sales and use, and high connectivity between human, livestock, and wildlife populations. Our previous...

    Authors: Casey J. Roulette, Mark A. Caudell, Jennifer W. Roulette, Robert J. Quinlan, Marsha B. Quinlan, Murugan Subbiah and Douglas R. Call

    Citation: BMC Infectious Diseases 2017 17:770

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  2. Content type: Research article

    The clinical manifestation of pulmonary cryptococcosis varies notably between immunocompromised and immunocompetent patients. To better understand pulmonary cryptococcosis, we compared the clinical features of...

    Authors: Qian He, Yuan Ding, Wei Zhou, Hongxing Li, Ming Zhang, Yi Shi and Xin Su

    Citation: BMC Infectious Diseases 2017 17:768

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  3. Content type: Case report

    Elizabethkingia miricola is a rare Gram-negative bacterium found in water and clinical specimens. Typical culturing methods often misidentify Elizabethkingia spp. as Flavobacterium or

    Authors: Przemysław Zdziarski, Mariola Paściak, Klaudia Rogala, Agnieszka Korzeniowska-Kowal and Andrzej Gamian

    Citation: BMC Infectious Diseases 2017 17:763

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  4. Content type: Research article

    Speeding up identification and antimicrobial susceptibility testing (AST) is of foremost importance in the management of blood cultures. Here, we describe a simple, rapid, and standardized approach based on a ...

    Authors: Carola Mauri, Luigi Principe, Silvia Bracco, Elisa Meroni, Nicoletta Corbo, Beatrice Pini and Francesco Luzzaro

    Citation: BMC Infectious Diseases 2017 17:749

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  5. Content type: Research article

    The mortality of Candida Bloodstream Infection (CBSI) remains high. Antifungal susceptibility breakpoints were recently updated for Candida species, the impact remains unknown. In this study we evaluated the impa...

    Authors: María Fernanda González-Lara, Pedro Torres-González, Patricia Cornejo-Juárez, Consuelo Velázquez-Acosta, Areli Martinez-Gamboa, Andrea Rangel-Cordero, Miriam Bobadilla-del-Valle, Luis Ostrosky-Zeichner, Alfredo Ponce-de-León and José Sifuentes-Osornio

    Citation: BMC Infectious Diseases 2017 17:753

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  6. Content type: Case report

    We report the first adult case of Neisseria meningitidis W-135 presenting with meningococcal arthritis and myopericarditis concomitantly, without other classical features of meningococcal disease.

    Authors: Lloyd Steele, Katie Bechman, Eoghan De Barra and Charles Mackworth-Young

    Citation: BMC Infectious Diseases 2017 17:751

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  7. Content type: Research article

    As several studies indicated an increase in Lyme disease (LD), notably in neighbouring countries, concerns have arisen regarding the evolution of Lyme disease in Belgium. In order to confirm or infirm the incr...

    Authors: Mathilde De Keukeleire, Sophie O. Vanwambeke, Benoît Kabamba, Leila Belkhir, Philippe Pierre, Victor Luyasu and Annie Robert

    Citation: BMC Infectious Diseases 2017 17:748

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  8. Content type: Research article

    Lyme borreliosis (LB) is the most common reported tick-borne infection in Europe, and involves transmission of Borrelia by ticks. As long as a vaccine is not available and effective measures for controlling tick ...

    Authors: L. Antonise-Kamp, D. J. M. A. Beaujean, R. Crutzen, J. E. van Steenbergen and D. Ruwaard

    Citation: BMC Infectious Diseases 2017 17:744

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  9. Content type: Research article

    In the eighties, a multidrug resistant clone of Salmonella Typhimurium DT104 emerged in UK and disseminated worldwide. This clone harbored a Salmonella genomic island 1 (SGI1) that consists of a backbone and a mu...

    Authors: Claire de Curraize, Lucie Amoureux, Julien Bador, Angélique Chapuis, Eliane Siebor, Claire Clément, Juliette Sauge, Ludwig-Serge Aho-Glélé and Catherine Neuwirth

    Citation: BMC Infectious Diseases 2017 17:741

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  10. Content type: Research article

    Resistant staphylococcal organisms remain a serious problem in the treatment of periprosthetic joint infection (PJI). Higher failure rates have been reported when vancomycin was used. The purpose of this study...

    Authors: Yu-Jui Chang, Mel S. Lee, Chen-Hsiang Lee, Po-Chun Lin and Feng-Chih Kuo

    Citation: BMC Infectious Diseases 2017 17:736

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  11. Content type: Research article

    Staphylococcus aureus (S. aureus) is a major pathogen implicated in skin and soft tissue infections, abscess in deep organs, toxin mediated diseases, respiratory tract infections, urin...

    Authors: Haji Mohammad Naimi, Hamidullah Rasekh, Ahmad Zia Noori and Mohammad Aman Bahaduri

    Citation: BMC Infectious Diseases 2017 17:737

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  12. Content type: Research article

    This study aimed to investigate the clinical and molecular epidemiology and biofilm formation of Staphylococcus aureus (SA) isolated from pediatricians in China.

    Authors: Xin Yang, Suyun Qian, Kaihu Yao, Lijuan Wang, Yingchao Liu, Fang Dong, Wenqi Song, Jinghui Zhen, Wei Zhou, Hong Xu, Hongyan Zheng and Wenting Li

    Citation: BMC Infectious Diseases 2017 17:733

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  13. Content type: Research article

    Antifungal susceptibility testing is a subject of interest in the field of medical mycology. The aim of the present study were the distributions and antifungal susceptibility patterns of various Candida species i...

    Authors: Parisa Badiee, Hamid Badali, Teun Boekhout, Kambiz Diba, Abdolkarim Ghadimi Moghadam, Ali Hossaini Nasab, Hadis Jafarian, Rasoul Mohammadi, Hossein Mirhendi, Mohammad Javad Najafzadeh, Ahmad Shamsizadeh and Jafar Soltani

    Citation: BMC Infectious Diseases 2017 17:727

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  14. Content type: Research article

    Prior to the 2007–2010 Q fever epidemic in the Netherlands, the seroprevalence of antibodies against Coxiella burnetii in the general population was 1.5%, which is low compared to other countries. We aimed to det...

    Authors: Roan Pijnacker, Johan Reimerink, Lidwien A. M. Smit, Arianne B. van Gageldonk-Lafeber, Jan-Paul Zock, Floor Borlée, Joris Yzermans, Dick J. J. Heederik, Catharina B. M. Maassen and Wim van der Hoek

    Citation: BMC Infectious Diseases 2017 17:725

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  15. Content type: Research article

    Detection, confirmation and monitoring of cholera outbreaks in many developing countries including Uganda is a big challenge due to lack of the required resources and the time the test takes. Culture method wh...

    Authors: Godfrey Bwire, Christopher Garimoi Orach, Dauda Abdallah, Amanda Kay Debes, Atek Kagirita, Malathi Ram and David A. Sack

    Citation: BMC Infectious Diseases 2017 17:726

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  16. Content type: Case report

    Haematobacter massiliensis, a rare species of fastidious Gram-negative, non-motile, non-sporing, non-fermentative, pleomorphic, aerobic bacilli, has rarely been documented as the cause...

    Authors: Jing-wei Cheng, Peng Wang, Meng Xiao, Ying Yuan, Timothy Kudinha, Ying Zhao, Fanrong Kong and Ying-chun Xu

    Citation: BMC Infectious Diseases 2017 17:709

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  17. Content type: Research article

    People working with pigs are at elevated risk of harboring methicillin resistant S. aureus (MRSA) in their nose, which is attributable to occupational exposure to animals harboring livestock adapted S. aureus. To...

    Authors: Jisun Sun, My Yang, Srinand Sreevatsan, Jeffrey B. Bender, Randall S. Singer, Todd P. Knutson, Douglas G. Marthaler and Peter R. Davies

    Citation: BMC Infectious Diseases 2017 17:690

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  18. Content type: Research article

    Acute uncomplicated cystitis (AUC) is a common ailment in the urological setting. Guidelines for urinary tract infections are based on large-scale multi-centre, epidemiological and international studies. The o...

    Authors: Michael Seitz, Christian Stief and Raphaela Waidelich

    Citation: BMC Infectious Diseases 2017 17:685

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  19. Content type: Research article

    Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of spondylodiscitis, but there are no series of CoNS-spondylodiscitis available. The objective of this study was to ...

    Authors: Julien Lopez, Zuzana Tatar, Anne Tournadre, Marion Couderc, Bruno Pereira, Martin Soubrier and Jean-Jacques Dubost

    Citation: BMC Infectious Diseases 2017 17:683

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  20. Content type: Research article

    There are many case reports of septic arthritis complicating invasive pneumococcal disease (IPD); however, no study has compared patients with IPD with septic arthritis to those who didn’t develop septic arthr...

    Authors: Thomas J. Marrie, Gregory J. Tyrrell, Sumit R. Majumdar and Dean T. Eurich

    Citation: BMC Infectious Diseases 2017 17:680

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  21. Content type: Case report

    Tsukamurella pulmonis is an aerobic gram-positive and rod-shaped organism that causes central catheter-related bloodstream infections in immunocompromised hosts. However, peripherally ...

    Authors: Jun Suzuki, Teppei Sasahara, Masaki Toshima and Yuji Morisawa

    Citation: BMC Infectious Diseases 2017 17:677

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  22. Content type: Research article

    Laboratory-based respiratory pathogen (RP) results are often available too late to influence clinical decisions such as hospitalisation or antibiotic treatment due to time delay in transport of specimens and test...

    Authors: Denise Andrews, Yumela Chetty, Ben S. Cooper, Manjinder Virk, Stephen K Glass, Andrew Letters, Philip A. Kelly, Malur Sudhanva and Dakshika Jeyaratnam

    Citation: BMC Infectious Diseases 2017 17:671

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  23. Content type: Research article

    Escherichia coli is the most common pathogen causing Urinary Tract Infections (UTI). Data from the current National Surveillance program in Denmark (DANMAP) may not accurately represen...

    Authors: Gloria Córdoba, Anne Holm, Frank Hansen, Anette M. Hammerum and Lars Bjerrum

    Citation: BMC Infectious Diseases 2017 17:670

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  24. Content type: Research article

    Group B Streptococcus (GBS) is a common commensal capable of causing severe invasive infections. Most GBS infections occur in neonates (often as pneumonia). GBS can also cause infection in adults with diabetes...

    Authors: Kate Skolnik, Austin Nguyen, Christina S. Thornton, Barbara Waddell, Tyler Williamson, Harvey R. Rabin and Michael D. Parkins

    Citation: BMC Infectious Diseases 2017 17:660

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  25. Content type: Research article

    Salmonella enterica serovar Enteritidis (Salmonella Enteritidis) has become a significant pathogen in South Africa, and the need for improved molecular surveillance of this pathogen ha...

    Authors: Munyadziwa Muvhali, Anthony Marius Smith, Andronica Moipone Rakgantso and Karen Helena Keddy

    Citation: BMC Infectious Diseases 2017 17:661

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  26. Content type: Research article

    Non-cystic fibrosis bronchiectasis is a chronic structural lung condition that courses with recurrent infectious exacerbations that lead to frequent antibiotic treatment making this population more susceptible...

    Authors: Rosario Menéndez, Raúl Méndez, Eva Polverino, Edmundo Rosales-Mayor, Isabel Amara-Elori, Soledad Reyes, José Miguel Sahuquillo-Arce, Laia Fernández-Barat, Victoria Alcaraz and Antoni Torres

    Citation: BMC Infectious Diseases 2017 17:659

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  27. Content type: Research article

    Workers in clinical microbiology laboratories are exposed to a variety of pathogenic microorganisms. Salmonella species is among the most commonly reported bacterial causes of laboratory-acquired infections. We r...

    Authors: Anthony Marius Smith, Shannon Lucrecia Smouse, Nomsa Pauline Tau, Colleen Bamford, Vineshree Mischka Moodley, Charlene Jacobs, Kerrigan Mary McCarthy, Adré Lourens and Karen Helena Keddy

    Citation: BMC Infectious Diseases 2017 17:656

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  28. Content type: Case report

    Orbital apex syndrome is a localized type of orbital cellulitis, where mass lesions occur at the apex of the cranial nerves. Although nasal septal abscess is uncommon, the organism most likely to cause nasal s...

    Authors: Ippei Kishimoto, Shogo Shinohara, Tetsuhiro Ueda, Shoichi Tani, Hajime Yoshimura and Yukihiro Imai

    Citation: BMC Infectious Diseases 2017 17:649

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  29. Content type: Case report

    Bordetella bronchiseptica (B.bronchiseptica) is a frequent cause of respiratory infections in animals but rarely causes serious infection in humans. We present a rare case of B. bronch...

    Authors: Manlio Monti, Danila Diano, Francesco Allegrini, Angelo Delmonte, Valentina Fausti, Paola Cravero, Giulia Marcantognini and Giovanni Luca Frassineti

    Citation: BMC Infectious Diseases 2017 17:644

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  30. Content type: Research article

    Neonatal tetanus continues to occur in many resource-limited settings but there are few data regarding long-term neurological outcome from the disease, especially in settings with critical care facilities.

    Authors: Huynh T. Trieu, Nguyen Thi Kim Anh, Huynh Ngoc Thien Vuong, T. T. M. Dao, Nguyen Thi Xuan Hoa, Vo Ngoc Cat Tuong, Pham Tam Dinh, Bridget Wills, Phan Tu Qui, Le Van Tan, Lam Minh Yen, Saraswathy Sabanathan and Catherine Louise Thwaites

    Citation: BMC Infectious Diseases 2017 17:646

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  31. Content type: Research article

    Between January and June, 2015, a large typhoid fever outbreak occurred in Kampala, Uganda, with 10,230 suspected cases. During the outbreak, area surgeons reported a surge in cases of typhoid intestinal perfo...

    Authors: Lilian Bulage, Ben Masiira, Alex R. Ario, Joseph K.B Matovu, Peter Nsubuga, Frank Kaharuza, Victoria Nankabirwa, Janell Routh and Bao-Ping Zhu

    Citation: BMC Infectious Diseases 2017 17:641

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  32. Content type: Research article

    Stenotrophomonas maltophilia (S. maltophilia) bacteremia causes significant morbidity and mortality in immunocompromised hosts. However, incidence and risk factors for mortality in S. ...

    Authors: Kaito Harada, Noritaka Sekiya, Tatsuya Konishi, Akihito Nagata, Yuta Yamada, Toshiaki Takezaki, Satoshi Kaito, Shuhei Kurosawa, Masahiro Sakaguchi, Shunichiro Yasuda, Shugo Sasaki, Kosuke Yoshioka, Kyoko Watakabe-Inamoto, Aiko Igarashi, Yuho Najima, Takeshi Hagino…

    Citation: BMC Infectious Diseases 2017 17:638

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  33. Content type: Research article

    The purpose of this study was to determine the shifting trends in bacteriology and antimicrobial resistance of infectious specimens isolated from gastrointestinal (GI) fistula patients over eight years in China.

    Authors: Qinjie Liu, Jianan Ren, Xiuwen Wu, Gefei Wang, Zhiwei Wang, Jie Wu, Jinjian Huang, Tianyu Lu and Jieshou Li

    Citation: BMC Infectious Diseases 2017 17:637

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  34. Content type: Research article

    Current knowledge of the epidemiology of Clostridium difficile infection in Asia, and in particular the Greater Mekong Subregion, is very limited. Only a few studies from Thailand and Vietnam have been reported f...

    Authors: Elaine Cheong, Tamalee Roberts, Sayaphet Rattanavong, Thomas V. Riley, Paul N. Newton and David A. B. Dance

    Citation: BMC Infectious Diseases 2017 17:635

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  35. Content type: Technical advance

    Infectious disease is the leading cause of death worldwide, and diagnosis of polymicrobial and fungal infections is increasingly challenging in the clinical setting. Conventionally, molecular detection is stil...

    Authors: Lalanika M. Abayasekara, Jennifer Perera, Vishvanath Chandrasekharan, Vaz S. Gnanam, Nisala A. Udunuwara, Dileepa S. Liyanage, Nuwani E. Bulathsinhala, Subhashanie Adikary, Janith V. S. Aluthmuhandiram, Chrishanthi S. Thanaseelan, D. Portia Tharmakulasingam, Tharaga Karunakaran and Janahan Ilango

    Citation: BMC Infectious Diseases 2017 17:631

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  36. Content type: Research article

    Leptospirosis is a re-emerging zoonotic disease caused by pathogenic strains of bacteria belonging to genus Leptospira whose symptoms can range from mild clinical manifestations to a severe life threatening illne...

    Authors: Lalmani Regmi, Kishor Pandey, Meena Malla, Santosh Khanal and Basu Dev Pandey

    Citation: BMC Infectious Diseases 2017 17:628

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  37. Content type: Research article

    Antimicrobial resistance (AMR) is widely acknowledged as a global problem, yet in many parts of the world its magnitude is still not well understood. This review, using a public health focused approach, aimed ...

    Authors: Birkneh Tilahun Tadesse, Elizabeth A. Ashley, Stefano Ongarello, Joshua Havumaki, Miranga Wijegoonewardena, Iveth J. González and Sabine Dittrich

    Citation: BMC Infectious Diseases 2017 17:616

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  38. Content type: Research article

    Bacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. Thi...

    Authors: Xiaoguang He, Mingyu Xie, Siping Li, Junqin Ye, Qi Peng, Qiang Ma, Xiaomei Lu and Baimao Zhong

    Citation: BMC Infectious Diseases 2017 17:614

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  39. Content type: Case report

    Kerstersia gyiorum is an extremely rare pathogen of human infection. It can cause chronic infection in patients with underlying conditions. It can easily be misdiagnosed if proper diag...

    Authors: Irmak Baran, Arife Polat Düzgün, İpek Mumcuoğlu and Neriman Aksu

    Citation: BMC Infectious Diseases 2017 17:608

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  40. Content type: Research article

    The majority of antibiotics consumed in developed countries are prescribed in primary care. However, little is known about resistance levels in the primary care population.

    Authors: Mia Tyrstrup, Eva Melander, Katarina Hedin, Anders Beckman and Sigvard Mölstad

    Citation: BMC Infectious Diseases 2017 17:603

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  41. Content type: Research article

    Information is limited about the effect of restricted carbapenem use on clearance of multi-drug resistant Acinetobacter baumannii (MDRAB). We sought to determine the time effect of antibiotic exposure on multi-dr...

    Authors: Po-Yen Huang, Shian-Sen Shie, Jung-Jr Ye, Shih-Pin Lin, Tsui-Ping Liu, Ting-Shu Wu, Tsu-Lan Wu, Shiow-Shuh Chuang, Ming-Huei Cheng, Yu-Chia Hsieh and Ching-Tai Huang

    Citation: BMC Infectious Diseases 2017 17:598

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  42. Content type: Research article

    A marked increase in the incidence rate of scarlet fever imposed a considerable burden on the health of children aged 5 to 15 years. The main purpose of this study was to depict the spatiotemporal epidemiologi...

    Authors: Qi Zhang, Wendong Liu, Wang Ma, Yingying Shi, Ying Wu, Yuan Li, Shuyi Liang, Yefei Zhu and Minghao Zhou

    Citation: BMC Infectious Diseases 2017 17:596

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  43. Content type: Research article

    Staphylococcus aureus bacteremia (SAB) is the leading cause of infective endocarditis in several countries. Since socioeconomic status (SES) is known to influence the risk of infectiou...

    Authors: Louise Bruun Oestergaard, Michelle D. Schmiegelow, Niels Eske Bruun, Robert L. Skov, Andreas Petersen, Paal Skytt Andersen and Christian Torp-Pedersen

    Citation: BMC Infectious Diseases 2017 17:589

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  44. Content type: Research article

    A combination of laboratory, histopathological and microbiological tests for diagnosis of prosthetic joint infection (PJI) have been strongly recommended. This study aims to characterize the accuracy of indivi...

    Authors: M. Fernández-Sampedro, C. Fariñas-Alvarez, C. Garces-Zarzalejo, M. A. Alonso-Aguirre, C. Salas-Venero, L. Martínez-Martínez and M. C. Fariñas

    Citation: BMC Infectious Diseases 2017 17:592

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  45. Content type: Case report

    It has been suggested that more than 100 bacterial species can be identified using only seven universal bacterial primer sets in the melting temperature (Tm) mapping method and that these findings can be obtai...

    Authors: Yoshitsugu Higashi, Shigeki Nakamura, Hideki Niimi, Tomohiro Ueno, Kaoru Matsumoto, Koyomi Kawago, Ippei Sakamaki, Isao Kitajima and Yoshihiro Yamamoto

    Citation: BMC Infectious Diseases 2017 17:584

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  46. Content type: Case report

    The presence of more than one bacterial agent is relatively rare in infective endocarditis, although more common in prosthetic cases. Molecular diagnosis from a removed heart tissue is considered a quick and e...

    Authors: Iva Kotaskova, Petr Nemec, Martina Vanerkova, Barbora Malisova, Renata Tejkalova, Marek Orban, Vita Zampachova and Tomas Freiberger

    Citation: BMC Infectious Diseases 2017 17:563

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  47. Content type: Research article

    In the aftermath of the largest Q fever outbreak in the world, diagnosing the potentially lethal complication chronic Q fever remains challenging. PCR, Coxiella burnetii IgG phase I antibodies, CRP and 18F–FDG-PE...

    Authors: Anne F. M. Jansen, Teske Schoffelen, Julien Textoris, Jean-Louis Mege, Marrigje Nabuurs-Franssen, Ruud P. H. Raijmakers, Mihai G. Netea, Leo A. B. Joosten, Chantal P. Bleeker-Rovers and Marcel van Deuren

    Citation: BMC Infectious Diseases 2017 17:556

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  48. Content type: Research article

    Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical int...

    Authors: Sonja Hamed, Michael Behnes, Dominic Pauly, Dominic Lepiorz, Max Barre, Tobias Becher, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch and Ursula Hoffmann

    Citation: BMC Infectious Diseases 2017 17:554

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