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Bacterial and fungal diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Limited data suggest that fluorine-18 fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography combined with computed tomography (PET/CT) scan may be useful for diagnosing infections of the spine. Bruc...

    Authors: Savvas Ioannou, Sofia Chatziioannou, Spiros G Pneumaticos, Alexandra Zormpala and Nikolaos V Sipsas

    Citation: BMC Infectious Diseases 2013 13:73

    Content type: Research article

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  2. Ineffective communication of infection control requirements during transitions of care is a potential cause of non-compliance with infection control precautions by healthcare personnel. In this study, interven...

    Authors: Mei-Sing Ong, Farah Magrabi, Jeffrey Post, Sarah Morris, Johanna Westbrook, Wayne Wobcke, Ross Calcroft and Enrico Coiera

    Citation: BMC Infectious Diseases 2013 13:72

    Content type: Research article

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  3. There is emerging evidence for the presence of an extensive microbiota in human lungs. It is not known whether variations in the prevalence of species of microbiota in the lungs may have aetiological significa...

    Authors: Hugo Cornelis van Woerden, Clive Gregory, Richard Brown, Julian Roberto Marchesi, Bastiaan Hoogendoorn and Ian Price Matthews

    Citation: BMC Infectious Diseases 2013 13:69

    Content type: Research article

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  4. The US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonizati...

    Authors: Todd J Vento, David W Cole, Katrin Mende, Tatjana P Calvano, Elizabeth A Rini, Charla C Tully, Wendy C Zera, Charles H Guymon, Xin Yu, Kristelle A Cheatle, Kevin S Akers, Miriam L Beckius, Michael L Landrum and Clinton K Murray

    Citation: BMC Infectious Diseases 2013 13:68

    Content type: Research article

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  5. Increasing the dosage of daptomycin may be advantageous in severe infection by enhancing bactericidal activity and pharmacodynamics. However, clinical data on using daptomycin at doses above 6 mg/kg in Asian p...

    Authors: Chung-Chih Lai, Wang-Huei Sheng, Jann-Tay Wang, Aristine Cheng, Yu-Chung Chuang, Yee-Chun Chen and Shan-Chwen Chang

    Citation: BMC Infectious Diseases 2013 13:66

    Content type: Research article

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  6. Lack of access to safe and secure water is an international issue recognized by the United Nations. To address this problem, the One Million Cisterns Project was initiated in 2001 in Brazil’s semi-arid region ...

    Authors: Pasha B Marcynuk, James A Flint, Jan M Sargeant, Andria Jones-Bitton, Ana M Brito, Carlos F Luna, Elizabeth Szilassy, M Kate Thomas, Tiago M Lapa, Enrique Perez and André M Costa

    Citation: BMC Infectious Diseases 2013 13:65

    Content type: Research article

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  7. Aspergillus tubingensis is a black Aspergillus belonging to the Aspergillus section Nigri, which includes species that morphologically resemble Aspergillus niger. Recent developments in species determination hav...

    Authors: Erik Bathoorn, Natalia Escobar Salazar, Shahrzad Sepehrkhouy, Martin Meijer, Hans de Cock and Pieter-Jan Haas

    Citation: BMC Infectious Diseases 2013 13:59

    Content type: Case report

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  8. Carbapenemase producing Enterobacteriaceae are becoming a major public health concern globally, however, relatively little is known about the molecular and clinical epidemiology of these organisms in many parts o...

    Authors: Michelle N D Balm, Grace Ngan, Roland Jureen, Raymond T P Lin and Jeanette W P Teo

    Citation: BMC Infectious Diseases 2013 13:58

    Content type: Research article

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  9. Klebsiella pneumoniae liver abscess (KPLA) has been reported with increasing frequency in East Asian countries in the past 3 decades, especially in Taiwan and Korea. Diabetes is a well-known risk factor for KPLA...

    Authors: Yi-Tsung Lin, Fu-Der Wang, Ping-Feng Wu and Chang-Phone Fung

    Citation: BMC Infectious Diseases 2013 13:56

    Content type: Research article

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  10. Heparin Binding Protein (HBP) is released to blood circulation from activated neutrophils in bacterial infections. It is a potential inducer of vascular leakage and precludes the development of septic shock. F...

    Authors: Kirsi-Maija Kaukonen, Heiko Herwald, Lennart Lindbom and Ville Pettila

    Citation: BMC Infectious Diseases 2013 13:51

    Content type: Research article

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  11. Invasive fusariosis (IF) is a rare but often fatal fungal infection in immunosuppressed patients. In 2007, cases of IF above the expected epidemiologic baseline were detected in the hematology ward of a hospit...

    Authors: Christina M Scheel, Steven F Hurst, Gloria Barreiros, Tiyomi Akiti, Marcio Nucci and S Arunmozhi Balajee

    Citation: BMC Infectious Diseases 2013 13:49

    Content type: Research article

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  12. Biofilm formation is a major virulence factor contributing to the chronicity of infections. To date few studies have evaluated biofilm formation in infecting isolates of patients including both Gram-positive a...

    Authors: Carlos J Sanchez Jr, Katrin Mende, Miriam L Beckius, Kevin S Akers, Desiree R Romano, Joseph C Wenke and Clinton K Murray

    Citation: BMC Infectious Diseases 2013 13:47

    Content type: Research article

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  13. Bacterial vaginosis (BV), which is highly prevalent in the African population, is one of the most common vaginal syndromes affecting women in their reproductive age placing them at increased risk for sexually ...

    Authors: Sonal Pendharkar, Tebogo Magopane, Per-Göran Larsson, Guy de Bruyn, Glenda E Gray, Lennart Hammarström and Harold Marcotte

    Citation: BMC Infectious Diseases 2013 13:43

    Content type: Research article

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  14. Leptospirosis is a potentially fatal disease which can cause multi-organ dysfunction. It can rarely present as acute pancreatitis. This is the first ever report of leptospirosis presenting with acute pancreati...

    Authors: Nuwan Ranawaka, Vijayabala Jeevagan, Panduka Karunanayake and Saroj Jayasinghe

    Citation: BMC Infectious Diseases 2013 13:38

    Content type: Case report

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  15. Few data are available regarding the epidemiology of invasive aspergillosis (IA) in ICU patients. The aim of this study was to examine epidemiology and economic outcomes (length of stay, hospital costs) among ...

    Authors: John W Baddley, Jennifer M Stephens, Xiang Ji, Xin Gao, Haran T Schlamm and Miriam Tarallo

    Citation: BMC Infectious Diseases 2013 13:29

    Content type: Research article

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  16. Although cerebrospinal fluid (CSF) culture is the diagnostic reference standard for bacterial meningitis, its sensitivity is limited, particularly when antibiotics were previously administered. CSF Gram staini...

    Authors: Henry M Wu, Soraia M Cordeiro, Brian H Harcourt, Maria da Gloria S Carvalho, Jailton Azevedo, Tainara Q Oliveira, Mariela C Leite, Katia Salgado, Mitermayer G Reis, Brian D Plikaytis, Thomas A Clark, Leonard W Mayer, Albert I Ko, Stacey W Martin and Joice N Reis

    Citation: BMC Infectious Diseases 2013 13:26

    Content type: Research article

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  17. Urinary tract infection (UTI) is one of the most common infectious diseases at the community level. In order to assess the adequacy of the empirical therapy, the prevalence and the resistance pattern of the ma...

    Authors: Inês Linhares, Teresa Raposo, António Rodrigues and Adelaide Almeida

    Citation: BMC Infectious Diseases 2013 13:19

    Content type: Research article

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  18. Listeriosis is a foodborne infection with a low incidence but a high case fatality rate. Unlike common foodborne diseases, the incubation period can be long. The first incubation periods were documented during...

    Authors: Véronique Goulet, Lisa A King, Véronique Vaillant and Henriette de Valk

    Citation: BMC Infectious Diseases 2013 13:11

    Content type: Research article

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  19. The incidence of fungal healthcare-associated infection (HAI) has increased in a major teaching hospital in the northern part of Taiwan over the past decade, especially in the intensive care units (ICUs). The ...

    Authors: Su-Pen Yang, Yin-Yin Chen, Han-Shui Hsu, Fu-Der Wang, Liang-yu Chen and Chang-Phone Fung

    Citation: BMC Infectious Diseases 2013 13:10

    Content type: Research article

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  20. Wide use of ciprofloxacin and levofloxacin has often led to increased resistance. The resistance rate to these two agents varies in different clinical isolates of Enterobacteriaceae. Mutations of GyrA within the ...

    Authors: Yingmei Fu, Wenli Zhang, Hong Wang, Song Zhao, Yang Chen, Fanfei Meng, Ying Zhang, Hui Xu, Xiaobei Chen and Fengmin Zhang

    Citation: BMC Infectious Diseases 2013 13:8

    Content type: Research article

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  21. Chromobacterium violaceum is a proteobacterium found in soil and water in tropical regions. The organism rarely causes infection in humans, yet can cause a severe systemic infection by entering the bloodstream v...

    Authors: James I Campbell, Nguyen Phu Huong Lan, Phan Tu Qui, Le Thi Dung, Jeremy J Farrar and Stephen Baker

    Citation: BMC Infectious Diseases 2013 13:4

    Content type: Case report

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  22. Although cryptococcal meningitis (CM) is an emerging disease worldwide, there have been few studies of the characteristics and risk factors of CM in children.

    Authors: Jianhua Guo, Jikun Zhou, Shiyong Zhang, Xin Zhang, Jing Li, Yinqi Sun and Shunxiang Qi

    Citation: BMC Infectious Diseases 2012 12:376

    Content type: Research article

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  23. There is a lack of consensus regarding the definition of risk factors for healthcare-associated infection (HCAI). The purpose of this study was to identify additional risk factors for HCAI, which are not inclu...

    Authors: Teresa Cardoso, Orquídea Ribeiro, Irene César Aragão, Altamiro Costa-Pereira and António Eugénio Sarmento

    Citation: BMC Infectious Diseases 2012 12:375

    Content type: Research article

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  24. Emergence of rmtB-positive Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) poses a great threat to antimicrobial treatment options.

    Authors: Jun-Jie Li, Zi-Ke Sheng, Mei Deng, Sheng Bi, Fei-Shu Hu, Hai-Feng Miao, Zhong-Kang Ji, Ji-Fang Sheng and Lan-Juan Li

    Citation: BMC Infectious Diseases 2012 12:373

    Content type: Research article

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  25. Fluoroquinolone resistant E. coli isolates, that are also resistant to other classes of antibiotics, is a significant challenge to antibiotic treatment and infection control policies. In Central Greece a signific...

    Authors: Angeliki Mavroidi, Vivi Miriagou, Apostolos Liakopoulos, Εva Tzelepi, Angelos Stefos, George N Dalekos and Efthymia Petinaki

    Citation: BMC Infectious Diseases 2012 12:371

    Content type: Research article

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  26. Clostridium difficile (CD) has increasingly become recognised as a significant international health burden, often associated with the healthcare environment. The upsurge in incidence of CD coincided with the eme...

    Authors: Stefano Di Bella, Maria Grazia Paglia, Emma Johnson and Nicola Petrosillo

    Citation: BMC Infectious Diseases 2012 12:370

    Content type: Research article

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  27. Streptococcus pneumoniae (Pnc), nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are the most important bacterial pathogens associated with otitis media (OM). Previous studies have sugg...

    Authors: Wenxing Sun, Peter Jacoby, Thomas V Riley, Jacinta Bowman, Amanda Jane Leach, Harvey Coates, Sharon Weeks, Allan Cripps and Deborah Lehmann

    Citation: BMC Infectious Diseases 2012 12:366

    Content type: Research article

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  28. This study aimed to investigate the correlation of minimum inhibiting concentrations (MICs), obtained by broth micro-dilution, and clinical response in patients with cryptococcal meningitis.

    Authors: Chen-Hsiang Lee, Tzu-Yao Chang, Jien-Wei Liu, Fang-Ju Chen, Chun-Chih Chien, Ya-Fen Tang and Cheng-Hsien Lu

    Citation: BMC Infectious Diseases 2012 12:361

    Content type: Research article

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  29. Treatment of chronically infected wounds is a challenge, and bacterial environmental contamination is a growing issue in infection control. Ozone may have a role in these situations. The objective of this stud...

    Authors: Belchor Fontes, Ana Maria Cattani Heimbecker, Glacus de Souza Brito, Silvia F Costa, Inneke M van der Heijden, Anna S Levin and Samir Rasslan

    Citation: BMC Infectious Diseases 2012 12:358

    Content type: Research article

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  30. We recently reported the derivation of a diagnostic aid to rule out pneumonia in adults presenting with new onset of cough or worsening of chronic cough and increased body temperature. The aim of the present i...

    Authors: Ulrike Held, Claudia Steurer-Stey, Felix Huber, Sergio Dallafior and Johann Steurer

    Citation: BMC Infectious Diseases 2012 12:355

    Content type: Research article

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  31. Infection with carbapenem-resistant Acinetobacter baumannii has been associated with high morbidity and mortality in solid organ transplant recipients. The main objective of this study was to assess the influence...

    Authors: Erika Ferraz de Gouvêa, Ianick Souto Martins, Marcia Halpern, Adriana Lúcia Pires Ferreira, Samanta Teixeira Basto, Renato Torres Gonçalves, Beatriz Meurer Moreira and Guilherme Santoro-Lopes

    Citation: BMC Infectious Diseases 2012 12:351

    Content type: Research article

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  32. Mycetoma is a chronic, localized, slowly progressing infection of the cutaneous and subcutaneous tissues caused either by fungi (eumycetoma or implantation mycosis) or by aerobic actinomycetes (actinomycetoma)...

    Authors: Sayaphet Rattanavong, Sivay Vongthongchit, Khamhou Bounphamala, Phouvong Vongphakdy, Jacques Gubler, Mayfong Mayxay, Rattanaphone Phetsouvanh, Ivo Elliott, Julie Logan, Robert Hill, Paul N Newton and David Dance

    Citation: BMC Infectious Diseases 2012 12:349

    Content type: Case report

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  33. The incidence and mortality from necrotizing fasciitis (NF) are increasing in New Zealand (NZ). Triggered by a media report that traditional Samoan tattooing was causing NF, we conducted a chart review to inve...

    Authors: Dilip Kumar Das, Michael G Baker and Kamalesh Venugopal

    Citation: BMC Infectious Diseases 2012 12:348

    Content type: Research article

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  34. Internationally, guidelines to prevent secondary transmission of Shigella infection vary widely. Cases, their contacts with diarrhoea, and those in certain occupational groups are frequently excluded from work, s...

    Authors: Lian Boveé, Jane Whelan, Gerard JB Sonder, Alje P van Dam and Anneke van den Hoek

    Citation: BMC Infectious Diseases 2012 12:347

    Content type: Research article

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  35. Current guidelines regarding Lyme neuroborreliosis [LNB] require the presence of intrathecal Borrelia burgdorferi-specific antibody production for the definite diagnosis of LNB. However, about 20% of early stage ...

    Authors: Johannes P Borde, Simone Meier, Volker Fingerle, Christiane Klier, Johannes Hübner and Winfried V Kern

    Citation: BMC Infectious Diseases 2012 12:344

    Content type: Case report

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  36. Activation of the A2A adenosine receptor (A2AAR) decreases production of inflammatory cytokines, prevents C. difficile toxin A-induced enteritis and, in combination with antibiotics, increases survival from sepsi...

    Authors: Yuesheng Li, Robert A Figler, Glynis Kolling, Tara C Bracken, Jayson Rieger, Ralph W Stevenson, Joel Linden, Richard L Guerrant and Cirle Alcantara Warren

    Citation: BMC Infectious Diseases 2012 12:342

    Content type: Research article

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  37. Bronchofiberscopy, a widely used procedure for the diagnosis of various pulmonary diseases within intensive care units, has a history of association with nosocomial infections. Between September and November 2...

    Authors: Yukun Xia, CuiLing Lu, Jingya Zhao, Gaige Han, Yong Chen, Fang Wang, Bin Yi, Guoqin Jiang, Xiaohua Hu, Xianfeng Du, Zheng Wang, Hong Lei, Xuelin Han and Li Han

    Citation: BMC Infectious Diseases 2012 12:335

    Content type: Research article

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  38. Brain abscess is a potentially fatal disease. This study assesses clinical aspects of brain abscess in a large hospital cohort.

    Authors: Jannik Helweg-Larsen, Arnar Astradsson, Humeira Richhall, Jesper Erdal, Alex Laursen and Jannick Brennum

    Citation: BMC Infectious Diseases 2012 12:332

    Content type: Research article

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  39. Critically ill patients including trauma patients are at high risk of urinary tract infection (UTI). The composition of urine in trauma patients may be modified due to inflammation, systemic stress, rhabdomyol...

    Authors: Cecile Aubron, Olivier Huet, Sylvie Ricome, Didier Borderie, Eric Pussard, Pierre-Etienne Leblanc, Odile Bouvet, Eric Vicaut, Erick Denamur and Jacques Duranteau

    Citation: BMC Infectious Diseases 2012 12:330

    Content type: Research article

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  40. Emphysematous cystitis (EC) is a comparatively rare urinary tract infection characterized by air within the bladder wall and lumen and is usually associated with immunosuppression or poorly controlled diabetes...

    Authors: Takeshi Hashimoto, Kazunori Namiki, Ayako Tanaka, Kenji Shimodaira, Tatsuo Gondo and Masaaki Tachibana

    Citation: BMC Infectious Diseases 2012 12:322

    Content type: Case report

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  41. Chronic wounds affect millions of people and cost billions of dollars in the United States each year. These wounds harbor polymicrobial biofilm communities, which can be difficult to elucidate using culturing ...

    Authors: Daniel D Rhoads, Stephen B Cox, Eric J Rees, Yan Sun and Randall D Wolcott

    Citation: BMC Infectious Diseases 2012 12:321

    Content type: Research article

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  42. Campylobacter is a common cause of bacterial gastro-enteritis characterized by multiple environmental sources and transmission pathways. Ecological studies can be used to reveal important regional characterist...

    Authors: Julie Arsenault, Olaf Berke, Pascal Michel, André Ravel and Pierre Gosselin

    Citation: BMC Infectious Diseases 2012 12:318

    Content type: Research article

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  43. The increasing incidence of community acquired infection due to Extended-Spectrum Beta-Lactamase (ESBL) -Producing Enterobacteriaceae represent a great concern because there are few therapeutic alternatives. The ...

    Authors: André Birgy, Robert Cohen, Corinne Levy, Philippe Bidet, Céline Courroux, Mohamed Benani, Franck Thollot and Edouard Bingen

    Citation: BMC Infectious Diseases 2012 12:315

    Content type: Research article

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  44. An outbreak of Legionnaires’ Disease took place in the Swedish town Lidköping on Lake Vänern in August 2004 and the number of pneumonia cases at the local hospital increased markedly. As soon as the first pati...

    Authors: Peter Ulleryd, Anna Hugosson, Görel Allestam, Sverker Bernander, Berndt EB Claesson, Ingrid Eilertz, Anne-Christine Hagaeus, Martin Hjorth, Agneta Johansson, Birgitta de Jong, Anna Lindqvist, Peter Nolskog and Nils Svensson

    Citation: BMC Infectious Diseases 2012 12:313

    Content type: Research article

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  45. Acute Otitis Media (AOM) is an important and common disease of childhood. Bacteria isolated from cases of clinically problematic AOM in German children were identified and characterized.

    Authors: Gerhard Grevers, Susanne Wiedemann, Jan-Christof Bohn, Rolf-Werner Blasius, Thomas Harder, Werner Kroeniger, Volker Vetter, Jean-Yves Pirçon and Cinzia Marano

    Citation: BMC Infectious Diseases 2012 12:312

    Content type: Research article

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    The Erratum to this article has been published in BMC Infectious Diseases 2016 16:118

  46. To understand epidemiologic patterns of meningococcal disease in Asia, we performed a retrospective molecular analysis of cerebrospinal fluid (CSF) specimens collected in prospective surveillance among childre...

    Authors: Soon Ae Kim, Dong Wook Kim, Bai Qing Dong, Jung Soo Kim, Dang Duc Anh and Paul E Kilgore

    Citation: BMC Infectious Diseases 2012 12:310

    Content type: Research article

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  47. Pseudomonas aeruginosa has gained an increasing amount of attention in the treatment of patients with pneumonia. However, the benefit of empirical combination therapy for pneumonia remains unclear. We evaluated ...

    Authors: So-Youn Park, Hyun Jung Park, Song Mi Moon, Ki-Ho Park, Yong Pil Chong, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Yang Soo Kim, Jun Hee Woo and Sang-Ho Choi

    Citation: BMC Infectious Diseases 2012 12:308

    Content type: Research article

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  48. Non-brucellar and non-tuberculous infectious sacroiliitis (ISI) is a rare disease, with misleading clinical signs that delay diagnosis. Most observations are based on isolated case reports or small case series...

    Authors: Marion Hermet, Emeline Minichiello, René Marc Flipo, Jean Jacques Dubost, Yannick Allanore, Jean Marc Ziza, Philippe Gaudin, Thierry Thomas, Emmanuelle Dernis, Baptiste Glace, Alain Regnier and Martin Soubrier

    Citation: BMC Infectious Diseases 2012 12:305

    Content type: Research article

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  49. Control of methicillin-resistant Staphylococcus aureus (MRSA) transmission has been unsuccessful in many hospitals. Recommended control measures include isolation of colonized patients, rather than decolonization...

    Authors: Tatiana V Gurieva, Martin CJ Bootsma and Marc JM Bonten

    Citation: BMC Infectious Diseases 2012 12:302

    Content type: Research article

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  50. Isolation of Aspergillus from lower respiratory samples is associated with colonisation in high percentage of cases, making it of unclear significance. This study explored factors associated with diagnosis (infec...

    Authors: Jose Barberan, Bernardino Alcazar, Eduardo Malmierca, Francisco Garcia de la Llana, Jordi Dorca, Daniel del Castillo, Victoria Villena, Melissa Hernandez-Febles, Francisco-Javier Garcia-Perez, Juan-Jose Granizo, Maria-Jose Gimenez and Lorenzo Aguilar

    Citation: BMC Infectious Diseases 2012 12:295

    Content type: Research article

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