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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Case report

    Tularemia is a rare zoonotic infection caused by bacterium Francisella tularensis. It has been well described in immunocompetent patients but poorly described in immunocompromised patients notably in solid organ ...

    Authors: Olivier Bahuaud, Cécile Le Brun, Thomas Chalopin, Marion Lacasse, Julien Le Marec, Clémence Pantaleon, Charlotte Nicolas, Louise Barbier, Louis Bernard and Adrien Lemaignen

    Citation: BMC Infectious Diseases 2019 19:238

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  2. Content type: Research article

    The clinical course of Campylobacter infection varies in symptoms and severity depending on host factors, virulence of the pathogen and initiated therapy. The type VI secretion system (T6SS) has been identified a...

    Authors: Jessica Agnetti, Helena M. B. Seth-Smith, Sebastian Ursich, Josiane Reist, Marek Basler, Christian Nickel, Stefano Bassetti, Nicole Ritz, Sarah Tschudin-Sutter and Adrian Egli

    Citation: BMC Infectious Diseases 2019 19:237

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  3. Content type: Research article

    Pyogenic liver abscess (PLA) in the elderly is insufficiently elucidated. A few studies attempted to investigate the role of age in PLA have yielded controversial results. The purpose of this study was to expl...

    Authors: Jia Zhang, Zhaoqing Du, Jianbin Bi, Zheng Wu, Yi Lv, Xufeng Zhang and Rongqian Wu

    Citation: BMC Infectious Diseases 2019 19:233

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  4. Content type: Research article

    Clostridium difficile infection (CDI) is an emerging healthcare problem in the world. The purpose of this study was to perform a systematic epidemiological research of CDI in Tongji hospital, the central of China...

    Authors: Yu Zhou, Liyan Mao, Jing Yu, Qun Lin, Ying Luo, Xuhui Zhu and Ziyong Sun

    Citation: BMC Infectious Diseases 2019 19:232

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  5. Content type: Research article

    The prevalence of Helicobacter pylori (H. pylori) infection increases with age. However, the relationship between H. pylori infection and anemia in the elderly population remains to be identified. The aim of this...

    Authors: Baicun Hou, Meifang Zhang, Miao Liu, Wei Dai, Yunjuan Lin, Yuan Li, Meiliang Gong and Gangshi Wang

    Citation: BMC Infectious Diseases 2019 19:228

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  6. Content type: Research article

    Extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) represent a major problem in the management of nosocomial infections. However, ESBL-PE are not systematically monitored in African countries. T...

    Authors: Oumar Ouchar Mahamat, Manon Lounnas, Mallorie Hide, Yann Dumont, Abelsalam Tidjani, Kadidja Kamougam, Madina Abderrahmane, Julio Benavides, Jérôme Solassol, Anne-Laure Bañuls, Hélène jean-Pierre, Christian Carrière and Sylvain Godreuil

    Citation: BMC Infectious Diseases 2019 19:205

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  7. Content type: Case report

    Until now, the prevalence of macrolide-resistant Mycoplasma pneumoniae (MP) infection among adult patients has been low, and severe MP pneumonia due to a macrolide-resistant strain has seldom been reported. Here,...

    Authors: Munehiro Matsumoto, Kentaro Nagaoka, Masaru Suzuki, Satoshi Konno, Kei Takahashi, Taichi Takashina, Nobuhisa Ishiguro and Masaharu Nishimura

    Citation: BMC Infectious Diseases 2019 19:204

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  8. Content type: Research article

    Korean surveillance program for bovine brucellosis was improved by extending it to beef slaughterhouses and by pre-movement testing of bulls on May 2005 (Intervention 1). The bovine brucellosis surveillance pr...

    Authors: Sukhyun Ryu, Ricardo J. Soares Magalhães and Byung Chul Chun

    Citation: BMC Infectious Diseases 2019 19:201

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  9. Content type: Case report

    Bacillus cereus is a gram-positive rod bacterium that is responsible for food poisoning. It is naturally widely distributed, and thus often contaminates cultures. Although it is rarely considered responsible, it ...

    Authors: Ryosuke Ishida, Kazunori Ueda, Tadashi Kitano, Tomohiko Yamamoto, Yasuyoshi Mizutani, Yutaka Tsutsumi, Koji Imoto and Yuji Yamamori

    Citation: BMC Infectious Diseases 2019 19:197

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  10. Content type: Research article

    Patients with pneumonia who are elderly or severely ill are at a particularly high risk of mortality. This post hoc retrospective analysis of data from two Phase III studies evaluated early improvement outcome...

    Authors: Thomas W. L. Scheeren, Tobias Welte, Mikael Saulay, Marc Engelhardt, Anne Santerre-Henriksen and Kamal Hamed

    Citation: BMC Infectious Diseases 2019 19:195

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  11. Content type: Research article

    Clinical guidelines for the diagnosis of group A streptococcal (GAS) pharyngitis recommend the use of a rapid antigen detection test (RADT) and/or bacterial culture. This study evaluated the overall diagnosis ...

    Authors: Robert Luo, Joanna Sickler, Farnaz Vahidnia, Yuan-Chi Lee, Bianca Frogner and Matthew Thompson

    Citation: BMC Infectious Diseases 2019 19:193

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  12. Content type: Case report

    Salmonella is a notorious pathogen that causes gastroenteritis in humans and the emergence of resistance to third-generation cephalosporins and azithromycin have raised concern. There has been rare case of Salmon...

    Authors: Hye-Ran Park, Dong-Min Kim, Na-Ra Yun and Choon-Mee Kim

    Citation: BMC Infectious Diseases 2019 19:191

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  13. Content type: Case report

    Mucormycosis is a group of rare but life threatening angioinvasive infections caused by fungi of the order Mucorales that often occurs in immunocompromised patients and individuals with poorly controlled diabetes...

    Authors: Farheen Manji, John C. Lam, Bonnie L. Meatherall, Deirdre Church and Bayan Missaghi

    Citation: BMC Infectious Diseases 2019 19:184

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  14. Content type: Research article

    Osteomyelitis is often challenging to treat. This analysis examined the clinical experience of patients with gram-positive osteomyelitis treated with ceftaroline fosamil in the phase 4 Clinical Assessment Prog...

    Authors: Leonard B. Johnson, Ananthakrishnan Ramani and David J. Guervil

    Citation: BMC Infectious Diseases 2019 19:183

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  15. Content type: Research article

    Streptococcus agalactiae or Group B Streptococcus (GBS) is the leading cause of neonatal morbidity and mortality resulting in septicaemia, bacteraemia and meningitis. Long term problems in children range from los...

    Authors: Munyaradzi Mukesi, Benson C. Iweriebor, Larry C. Obi, Uchechukwu U. Nwodo, Sylvester R. Moyo and Anthony I. Okoh

    Citation: BMC Infectious Diseases 2019 19:179

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  16. Content type: Research article

    In January 2011, there was an outbreak of Panton-Valentine Leukocidin-positive methicillin-sensitive Staphylococcus aureus (PVL-MSSA) infection in a neonatal unit (NNU).

    Authors: G. Gopal Rao, R. Batura, R. Nicholl, F. Coogan, B. Patel, P. Bassett and A. M. Kearns

    Citation: BMC Infectious Diseases 2019 19:178

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  17. Content type: Case report

    Melioidosis is a life-threatening infectious disease that is caused by gram negative bacteria Burkholderia pseudomallei. This bacteria occurs as an environmental saprophyte typically in endemic regions of south-e...

    Authors: Neha Shrestha, Mahesh Adhikari, Vivek Pant, Suman Baral, Anjan Shrestha, Buddha Basnyat, Sangita Sharma and Jeevan Bahadur Sherchand

    Citation: BMC Infectious Diseases 2019 19:176

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  18. Content type: Research article

    Solithromycin, the fourth generation of ketolides, has been demonstrated potent antibacterial effect against commonly-isolated gram-positive strains. However, Staphylococcus aureus (S. aureus) strains with a high...

    Authors: Weiming Yao, Guangjian Xu, Duoyun Li, Bing Bai, Hongyan Wang, Hang Cheng, Jinxin Zheng, Xiang Sun, Zhiwei Lin, Qiwen Deng and Zhijian Yu

    Citation: BMC Infectious Diseases 2019 19:175

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  19. Content type: Research article

    In the event of a shigellosis outbreak in a childcare setting, exclusion policies are typically applied to afflicted children to limit shigellosis transmission. However, there is scarce evidence of their impact.

    Authors: Cristina Carias, Eduardo A. Undurraga, Jacqueline Hurd, Emily B. Kahn, Martin I. Meltzer and Anna Bowen

    Citation: BMC Infectious Diseases 2019 19:172

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  20. Content type: Research article

    Community- associated methicillin resistant Staphylococcus aureus (CA-MRSA) cause serious infections and rates continue to rise worldwide. Use of geocoded electronic health record (EHR) data to prevent spread of ...

    Authors: Lilly Cheng Immergluck, Traci Leong, Khusdeep Malhotra, Trisha Chan Parker, Fatima Ali, Robert C. Jerris and George S. Rust

    Citation: BMC Infectious Diseases 2019 19:170

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    The Correction to this article has been published in BMC Infectious Diseases 2019 19:396

  21. Content type: Research article

    The etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptoco...

    Authors: Jinjian Fu, Ling Li, Zhuoxin Liang, Shaolin Xu, Nan Lin, Peixu Qin, Xiaohua Ye and Eric McGrath

    Citation: BMC Infectious Diseases 2019 19:168

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  22. Content type: Research article

    To evaluate the in vitro activities of plazomicin and comparator aminoglycosides and elucidate the underlying aminoglycoside resistance mechanisms among carbapenemase-producing K. pneumoniae isolates collected du...

    Authors: Irene Galani, Konstantina Nafplioti, Panagiota Adamou, Ilias Karaiskos, Helen Giamarellou and Maria Souli

    Citation: BMC Infectious Diseases 2019 19:167

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    The Correction to this article has been published in BMC Infectious Diseases 2019 19:230

  23. Content type: Case report

    Helicobacter cinaedi is a microaerobic Gram-negative spiral-shaped bacterium that causes enteritis, cellulitis, and bacteremia in both immunocompromised and immunocompetent patients. While there have been increas...

    Authors: Tomohiro Takehara, Tetsuo Tani, Ken Yajima, Mako Watanabe, Yoshihito Otsuka and Hidefumi Koh

    Citation: BMC Infectious Diseases 2019 19:166

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  24. Content type: Research article

    Bacterial resistance to first line antibiotics used to treat community-onset urinary tract infections (UTIs) continues to emerge. We sought to determine the association between extended-spectrum cephalosporin ...

    Authors: Judith A. Anesi, Ebbing Lautenbach, Irving Nachamkin, Charles Garrigan, Warren B. Bilker, Jacqueline Omorogbe, Lois Dankwa, Mary Wheeler, Pam Tolomeo and Jennifer H. Han

    Citation: BMC Infectious Diseases 2019 19:163

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  25. Content type: Research article

    A reduction in duration of antibiotic therapy is crucial in minimizing the development of antimicrobial resistance, drug-related side effects and health care costs. The minimal effective duration of antimicrob...

    Authors: Janneke Evelyne Stalenhoef, Cees van Nieuwkoop, Darius Cameron Wilson, Willize Elizabeth van der Starre, Tanny J. K. van der Reijden, Nathalie Manon Delfos, Eliane Madeleine Sophie Leyten, Ted Koster, Hans Christiaan Ablij, Johannes (Jan) Willem van ‘t Wout and Jaap Tamino van Dissel

    Citation: BMC Infectious Diseases 2019 19:161

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  26. Content type: Research article

    Clinical characteristics (taxonomy, virulence genes and antimicrobial resistance ) of Aeromonas in isolated from extra-intestinal and intestinal infections were investigated to describe epidemiology, associated v...

    Authors: Yanyan Zhou, Li Yu, Zheng Nan, Pingping Zhang, Biao Kan, Donghui Yan and Jianrong Su

    Citation: BMC Infectious Diseases 2019 19:158

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  27. Content type: Research article

    Uncomplicated urinary tract infection (uUTI) is common and a majority of patients are prescribed antibiotics. There is little knowledge about antibiotic resistance in urine samples from patients with uUTI in p...

    Authors: Helena Kornfält Isberg, Eva Melander, Katarina Hedin, Sigvard Mölstad and Anders Beckman

    Citation: BMC Infectious Diseases 2019 19:155

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  28. Content type: Research article

    The aim of this study was to evaluate whether Interleukin-6 (IL-6) could be a faster indicator of treatment success in adults with severe sepsis and septic shock compared to procalcitonin (PCT) and C-reactive ...

    Authors: Lorenz Weidhase, Daniel Wellhöfer, Gero Schulze, Thorsten Kaiser, Tim Drogies, Ulrike Wurst and Sirak Petros

    Citation: BMC Infectious Diseases 2019 19:150

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  29. Content type: Research article

    The prognostic capability of the quick Sequential Organ Failure Assessment (qSOFA) bedside scoring tool is uncertain in non-ICU patients with sepsis due to bacteremia given the low number of patients previousl...

    Authors: Emi Minejima, Vanessa Delayo, Mimi Lou, Pamela Ny, Paul Nieberg, Rosemary C. She and Annie Wong-Beringer

    Citation: BMC Infectious Diseases 2019 19:149

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  30. Content type: Technical advance

    Emerging antimicrobial resistance is a significant threat to human health. However, methods for rapidly diagnosing antimicrobial resistance generally require multi-day culture-based assays. Macrolide efflux ge...

    Authors: Megan M. Nelson, Christopher L. Waldron and John R. Bracht

    Citation: BMC Infectious Diseases 2019 19:144

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  31. Content type: Case report

    Melioidosis is an infection caused by Burkholderia pseudomallei, which is more prevalent in the tropics and leads to significant morbidity and mortality. It characteristically produces widespread caseous lesions ...

    Authors: H. L. P. Amarasena, F. H. D. S. Silva, P. M. Y. I. Tilakaratna, S. F. Jayamanne and U. K. Ranawaka

    Citation: BMC Infectious Diseases 2019 19:143

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  32. Content type: Case report

    Roseomonas mucosa, as a Gram-negative coccobacilli, is an opportunistic pathogen that has rarely been reported in human infections. Here we describe a case of bacteremia in an infective endocarditis patient with ...

    Authors: Shayuan Shao, Xin Guo, Penghao Guo, Yingpeng Cui and Yili Chen

    Citation: BMC Infectious Diseases 2019 19:140

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  33. Content type: Research article

    Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli are responsible for severe infections worldwide. Whereas their genotypic and pathogenic characteristics are not documented in Democratic Republic...

    Authors: Leonid M. Irenge, Jerome Ambroise, Bertrand Bearzatto, Jean-François Durant, Raphaël B. Chirimwami and Jean-Luc Gala

    Citation: BMC Infectious Diseases 2019 19:137

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  34. Content type: Research article

    Voriconazole is well established as standard treatment for invasive aspergillosis (IA). In 2017, isavuconazole, a new antifungal from the azole class, with a broader pathogen spectrum, was introduced in Sweden...

    Authors: Lefteris Floros, Daniel Kuessner, Jan Posthumus, Emma Bagshaw and Jan Sjölin

    Citation: BMC Infectious Diseases 2019 19:134

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  35. Content type: Research article

    There is a lack of data regarding the prevalence of invasive group B streptococcus (GBS) infection among neonates in China. This study aimed to investigate the incidence and mortality of invasive GBS infection...

    Authors: Qunhua Ying, Shutan Wang, Xiuming Lou, Jinlong Ding and Jiefeng Ding

    Citation: BMC Infectious Diseases 2019 19:123

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  36. Content type: Research article

    More than 50% of the people are infected worldwide with H. pylori which causes significant public health morbidity and mortality. The distribution is quite different from country to country. Hence, early informat...

    Authors: Gemechu Shiferaw and Dessie Abera

    Citation: BMC Infectious Diseases 2019 19:118

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  37. Content type: Research article

    For definitive diagnosis of cryptococcal meningitis, Cryptococcus neoformans and/or C. gattii must be identified within cerebral spinal fluid from the patients. The traditional methods for detecting Cryptococcus ...

    Authors: Qinglin Ma, Jilong Yao, Shixin Yuan, Houming Liu, Ning Wei, Jianming Zhang and Wanshui Shan

    Citation: BMC Infectious Diseases 2019 19:108

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  38. Content type: Research article

    War-wounded civilians in Middle East countries are at risk of post-traumatic osteomyelitis (PTO). We aimed to describe and compare the bacterial etiology and proportion of first-line antibiotics resistant bact...

    Authors: Fabien Fily, Jean-Baptiste Ronat, Nada Malou, Rupa Kanapathipillai, Caroline Seguin, Nagham Hussein, Rasheed M. Fakhri and Céline Langendorf

    Citation: BMC Infectious Diseases 2019 19:103

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  39. Content type: Case report

    Infective endocarditis (IE) is defined as endocarditis caused by microorganisms (bacteria or fungi) involving either the heart or great vessels. The clinical course of IE can be complicated by cardiac dysfunct...

    Authors: Nao Ogura, Kouki Tomari, Tomotada Takayama, Naoya Tonegawa, Teppei Okawa, Takashi Matsuoka, Mami Nakayashiro and Tsutomu Matsumora

    Citation: BMC Infectious Diseases 2019 19:102

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  40. Content type: Research article

    The human respiratory tract represents the major portal of entry for numerous microorganisms, primarily those occurring as airborne particles such as viral and bacterial entities, or fungal spores. Microorgani...

    Authors: Giovanna Elisiana Carpagnano, Antonia Susca, Giulia Scioscia, Donato Lacedonia, Grazia Cotugno, Piera Soccio, Sonia Santamaria, Onofrio Resta, Giuseppe Logrieco and Maria Pia Foschino Barbaro

    Citation: BMC Infectious Diseases 2019 19:78

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  41. Content type: Research article

    Cholera has been endemic in Ghana since its detection in 1970. It has been shown that long-term survival of the bacteria may be attained in aquatic environments. Consequently, cholera outbreaks may be triggere...

    Authors: David Abana, Elizabeth Gyamfi, Magdalene Dogbe, Grace Opoku, David Opare, Gifty Boateng and Lydia Mosi

    Citation: BMC Infectious Diseases 2019 19:76

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  42. Content type: Case report

    Periodontal disease, including periodontitis, has been reported to be a rare cause of septic pulmonary embolism (SPE). It is however extremely difficult to isolate the causative pathogen of periodontal disease...

    Authors: Tsuyoshi Watanabe, Masamichi Yokoe and Yoshinori Noguchi

    Citation: BMC Infectious Diseases 2019 19:74

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  43. Content type: Technical advance

    Rapid and accurate pathogen identification in blood cultures is very important for septic patients and has major consequences on morbidity and mortality rates. In recent years, matrix-assisted laser desorption...

    Authors: Maya Azrad, Yoram Keness, Orna Nitzan, Nina Pastukh, Linda Tkhawkho, Victoria Freidus and Avi Peretz

    Citation: BMC Infectious Diseases 2019 19:72

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  44. Content type: Research article

    Staphylococcus aureus is a common bacterium found in the nose and throat of healthy individuals, and presents risk factors for infection and death. We investigated environmental contamination of fitness facilitie...

    Authors: Mark Dalman, Sabana Bhatta, Nagashreyaa Nagajothi, Dipendra Thapaliya, Hailee Olson, Haji Mohammad Naimi and Tara C. Smith

    Citation: BMC Infectious Diseases 2019 19:69

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  45. Content type: Research article

    Excess water in all its forms (moisture, dampness, hidden water) in buildings negatively impacts occupant health but is hard to reliably detect and quantify. Recent advances in through-wall imaging recommend m...

    Authors: Andrew Horsley and David S. Thaler

    Citation: BMC Infectious Diseases 2019 19:67

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  46. Content type: Case report

    Pneumocystis pneumonia (PCP) is a common opportunistic infection caused by Pneumocystis jirovecii. Its incidence at 2 years or more after liver transplant (LT) is < 0.1%. PCP-related spontaneous pneumothorax and/...

    Authors: Wong Hoi She, Kenneth S. H. Chok, Iris W. S. Li, Ka Wing Ma, Sui Ling Sin, Wing Chiu Dai, James Y. Y. Fung and Chung Mau Lo

    Citation: BMC Infectious Diseases 2019 19:66

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