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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    Klebsiella pneumoniae bloodstream infections (BSIs) occur with significant prevalence and high mortality worldwide. Antimicrobial resistance and virulence are two main factors participating in the pathogenicity o...

    Authors: Min Xu, Yiqi Fu, Haishen Kong, Xiao Chen, Yu Chen, Lanjuan Li and Qing Yang

    Citation: BMC Infectious Diseases 2018 18:358

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  2. Content type: Research article

    Maternal vaginal colonization with antibiotic resistant organisms is a growing concern in countries with high antibiotic resistance rates.

    Authors: Dulmini Nanayakkara, Veranja Liyanapathirana, Chaminda Kandauda, Champika Gihan, Asela Ekanayake and Dinuka Adasooriya

    Citation: BMC Infectious Diseases 2018 18:351

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  3. Content type: Research article

    One third of travellers to low- and middle-income regions of the tropics and subtropics become colonized by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE). The risk varies by destination ...

    Authors: Tinja Lääveri, Jessica A. Vlot, Alje P. van Dam, Hanni K. Häkkinen, Gerard J. B. Sonder, Leo G. Visser and Anu Kantele

    Citation: BMC Infectious Diseases 2018 18:341

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  4. Content type: Research article

    Neisseria meningitidis serogroup A disease in Burkina Faso has greatly decreased following introduction of a meningococcal A conjugate vaccine in 2010, yet other serogroups continue to pose a risk of life-threate...

    Authors: Adam C. Retchless, Malika Congo-Ouédraogo, Dinanibè Kambiré, Jeni Vuong, Alex Chen, Fang Hu, Absetou Ky Ba, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Jaymin C. Patel, Rasmata Ouédraogo Traoré, Lassana Sangaré and Xin Wang

    Citation: BMC Infectious Diseases 2018 18:337

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  5. Content type: Case report

    Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifes...

    Authors: Syed Mohammed Qasim Hussaini, Deng Madut, Betty C. Tong, Elizabeth N. Pavlisko, Wiley A. Schell, John R. Perfect and Nathan M. Thielman

    Citation: BMC Infectious Diseases 2018 18:336

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  6. Content type: Research article

    Mycoplasma pneumoniae (M. pneumoniae) is a commonly causative pathogen for respiratory tract infections (RTIs) in humans. The epidemiological features of M. pneumoniae infections during post-epidemic, including a...

    Authors: Jiuxin Qu, Chunxia Yang, Fang Bao, Shuyan Chen, Li Gu and Bin Cao

    Citation: BMC Infectious Diseases 2018 18:335

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  7. Content type: Technical advance

    Underlying coinfections may complicate infectious disease states but commonly go unnoticed because an a priori clinical suspicion is usually required so they can be detected via targeted diagnostic tools. Shot...

    Authors: D. N. Birdsell, Y. Özsürekci, A. Rawat, A. E. Aycan, C. L. Mitchell, J. W. Sahl, A. Johansson, R. E. Colman, J. M. Schupp, M. Ceyhan, P. S. Keim and D. M. Wagner

    Citation: BMC Infectious Diseases 2018 18:319

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  8. Content type: Research article

    With a prevalence of 4.7–13% in Danish Ixodes ricinus ticks, Rickettsia helvetica is one of the most frequently detected tick-borne organisms in Denmark. Most reports of human exposure have described asymptomatic...

    Authors: Lukas Frans Ocias, Ram Benny Dessau, Anne-Mette Lebech, Charlotte Sværke Jørgensen, Randi Føns Petersen and Karen Angeliki Krogfelt

    Citation: BMC Infectious Diseases 2018 18:325

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  9. Content type: Case report

    Laryngeal aspergillosis is uncommon and is usually secondary to pulmonary involvement in immunocompromised patients. Primary laryngeal aspergillosis in immunocompetent individuals is extremely rare, with a few...

    Authors: Supram Hosuru Subramanya, Joseph Jillwin, Shivaprakash Mandya Rudramurthy, Krishna Chandra Rijal, Niranjan Nayak, Arunaloke Chakrabarti and Arnab Ghosh

    Citation: BMC Infectious Diseases 2018 18:323

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  10. Content type: Research article

    Streptococcus Group B (GBS) colonization in pregnant women is the most important risk factor for newborn disease due to vertical transmission during delivery. GBS colonization during pregnancy has been implicated...

    Authors: J. A. Carrillo-Ávila, J. Gutiérrez-Fernández, A. I. González-Espín, E. García-Triviño and L. G. Giménez-Lirola

    Citation: BMC Infectious Diseases 2018 18:305

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  11. Content type: Research article

    Among 2179 Salmonella isolates obtained during national surveillance for salmonellosis in China from 2005 to 2013, we identified 46 non-H2S-producing strains originating from different sources.

    Authors: Jing Xie, Fuli Wu, Xuebin Xu, Xiaoxia Yang, Rongtao Zhao, Qiuxia Ma, Peng Li, Ligui Wang, Rongzhang Hao, Leiji Jia, Xinying Du, Shaofu Qiu and Hongbin Song

    Citation: BMC Infectious Diseases 2018 18:292

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  12. Content type: Research article

    Many of the currently used models of bacterial meningitis have limitations due to direct inoculation of pathogens into the cerebrospinal fluid or brain and a relatively insensitive assessment of long-term sequ...

    Authors: Jana Seele, Simone C. Tauber, Stephanie Bunkowski, Christoph G. Baums, Peter Valentin-Weigand, Nicole de Buhr, Andreas Beineke, Asparouh I. Iliev, Wolfgang Brück and Roland Nau

    Citation: BMC Infectious Diseases 2018 18:297

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  13. Content type: Research article

    The epidemiology of maternal and infant Group B streptococcus (GBS) colonization is poorly understood in China. The aim of this study is to explore the prevalence and risk factors associated with maternal and ...

    Authors: Jichang Chen, Jinjian Fu, Wei Du, Xin Liu, Chokechai Rongkavilit, Xuemei Huang, Yubi Wu, Yuanliu Wang and Eric McGrath

    Citation: BMC Infectious Diseases 2018 18:291

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  14. Content type: Research article

    According to the traditional tuberculosis (TB) treatment paradigm, the initial doses of treatment rapidly kill most Mycobacterium tuberculosis (Mtb) bacilli in sputum, yet many more months of daily treatment are ...

    Authors: Nicholas D. Walter, Camille M. Moore, Xavier A. Kayigire, Christian Dide-Agossou, William Worodria, Laurence Huang, Charles K. Everett, Gary S. Schoolnik, Payam Nahid and J. Lucian Davis

    Citation: BMC Infectious Diseases 2018 18:293

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  15. Content type: Case report

    Schizophyllum commune, a basidiomycetous fungus, is a common invader of rotten wood. This fungus rarely causes mycotic disease in humans, especially cutaneous infection. In this paper, we describe the first case ...

    Authors: Lidi Tian, Yunzhu Mu, Hao Zhang, Xiaocui Su, Chuan Yang, Xianzhu Shu and Defu Qing

    Citation: BMC Infectious Diseases 2018 18:286

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  16. Content type: Research article

    Helicobacter pylori is a Gram negative bacterium that colonizes the stomach of approximately two-thirds of the human population and it is involved in the pathogenesis of gastroduodenal diseases. This study sought...

    Authors: Laure Brigitte Kouitcheu Mabeku, Michelle Larissa Noundjeu Ngamga and Hubert Leundji

    Citation: BMC Infectious Diseases 2018 18:278

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  17. Content type: Research article

    Antibiotics with anaerobic coverage are widely used for the treatment of biliary tract infection (BTI), even in the absence of isolated anaerobes. The current study aimed to investigate the differences in clin...

    Authors: Pei-Shan Wu, Chien Chuang, Ping-Feng Wu, Yi-Tsung Lin and Fu-Der Wang

    Citation: BMC Infectious Diseases 2018 18:277

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  18. Content type: Study protocol

    Invasive pulmonary aspergillosis (IPA) has been increasingly reported in patients with underlying respiratory diseases (URD). Early diagnosis of IPA is crucial for mortality reduction and improved prognosis, y...

    Authors: Wei Xiao, De-ying Gong, Bing Mao, Xin-miao Du, Lin-Li Cai, Min-yu Wang and Juan-juan Fu

    Citation: BMC Infectious Diseases 2018 18:271

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  19. Content type: Research article

    Consideration to add empiric MRSA therapy with vancomycin is a common clinical dilemma. However, vancomycin overuse has important adverse events. MRSA colonization screening is commonly performed for infection...

    Authors: Guillaume Butler-Laporte, Matthew P. Cheng, Emily G. McDonald and Todd C. Lee

    Citation: BMC Infectious Diseases 2018 18:270

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  20. Content type: Research article

    Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of...

    Authors: Ki Wook Yun, Eun Hwa Choi, Hoan Jong Lee, Jin Han Kang, Kyung-Hyo Kim, Dong Soo Kim, Yae-Jean Kim, Byung Wook Eun, Sung Hee Oh, Hye-Kyung Cho, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun-Kyung Kim, Hyunju Lee, Taekjin Lee…

    Citation: BMC Infectious Diseases 2018 18:268

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  21. Content type: Research article

    Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection in the world. It can result in various upper gastroduodenal diseases. The prevalence varies among countries, population gro...

    Authors: Abdurahaman Seid and Wondmagegn Demsiss

    Citation: BMC Infectious Diseases 2018 18:260

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  22. Content type: Research article

    Brucella abortus is a highly pathogenic zoonotic agent, tempting for the development of a rapid diagnostic method to enable adequate treatment and prevent further spread. Enrichment of the bacteria is often used ...

    Authors: Rene Kaden, Sevinc Ferrari, Tomas Jinnerot, Martina Lindberg, Tara Wahab and Moa Lavander

    Citation: BMC Infectious Diseases 2018 18:259

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  23. Content type: Case report

    Cryptococcus gattii is known to be an etiologic agent of human cryptococcosis, particularly in immunocompetent persons. C. gattii infection usually involves the central nervous system, the respiratory tract, or m...

    Authors: Wutthiseth Dhitinanmuang, Piriyaporn Chongtrakool and Anupop Jitmuang

    Citation: BMC Infectious Diseases 2018 18:257

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  24. Content type: Research article

    Escherichia coli (E. coli) is known to cause urinary tract infection (UTI) and meningitis in neonates, as well as existing as a commensal flora of the human gut. Extended-spectrum β-lactamase (ESBL)-producing E. ...

    Authors: Young Ah Kim, Kyungwon Lee and Jae Eun Chung

    Citation: BMC Infectious Diseases 2018 18:250

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  25. Content type: Research article

    Bloodstream infections (BSI) caused by carbapenem-resistant K. pneumoniae (CRKP) are associated with high rates of morbidity and mortality. Early identification of patients at highest risk is very important. The ...

    Authors: Ye Zhang, Ling-Yun Guo, Wen-Qi Song, Yan Wang, Fang Dong and Gang Liu

    Citation: BMC Infectious Diseases 2018 18:248

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  26. Content type: Research article

    In recent years, the world has seen a surge in Enterobacteriaceae resistant to broad-spectrum beta-lactam antibiotics due to the production of extended-spectrum beta-lactamases (ESBLs) or plasmid-mediated AmpC...

    Authors: L. M. Chirindze, T. F. Zimba, J. O. Sekyere, U. Govinden, H. Y. Chenia, A. Sundsfjord, S. Y. Essack and G. S. Simonsen

    Citation: BMC Infectious Diseases 2018 18:244

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  27. Content type: Research article

    Development of sepsis is a process with significant variation among individuals. The precise elements of this variation need to be defined. This study was designed to define the way in which comorbidities cont...

    Authors: Dimitrios Sinapidis, Vassileios Kosmas, Vasileios Vittoros, Ioannis M. Koutelidakis, Aikaterini Pantazi, Aggelos Stefos, Konstantinos E. Katsaros, Karolina Akinosoglou, Magdalini Bristianou, Konstantinos Toutouzas, Michael Chrisofos and Evangelos J. Giamarellos-Bourboulis

    Citation: BMC Infectious Diseases 2018 18:242

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  28. Content type: Research article

    Armed conflicts are a major contributor to injury and death globally. Conflict-related injuries are associated with a high risk of wound infection, but it is unknown to what extent infection directly relates t...

    Authors: Andreas Älgå, Sidney Wong, Muhammad Shoaib, Kalle Lundgren, Christian G. Giske, Johan von Schreeb and Jonas Malmstedt

    Citation: BMC Infectious Diseases 2018 18:233

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  29. Content type: Case report

    Kirschsteiniothelia is a saprophytic fungus that is abundantly present in the environment. To date, there have been no reports of human infection caused by this fungus. We report a case of Kirschsteiniothelia inf...

    Authors: Masanori Nishi, Ichiro Okano, Takatoshi Sawada, Yasuka Hara, Kiwamu Nakamura, Katsunori Inagaki and Takashi Yaguchi

    Citation: BMC Infectious Diseases 2018 18:236

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  30. Content type: Case report

    Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired...

    Authors: Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff and François Caron

    Citation: BMC Infectious Diseases 2018 18:226

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  31. Content type: Research article

    Q fever is a zoonotic disease caused by Coxiella burnetii. This bacterium survives harsh conditions and attaches to dust, suggesting environmental dispersal is a risk factor for outbreaks. Spatial epidemiology st...

    Authors: Nicholas J. Clark and Ricardo J. Soares Magalhães

    Citation: BMC Infectious Diseases 2018 18:218

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  32. Content type: Research article

    Antimicrobial resistance (AMR) is a major challenge for global health care. Pharmacists play a key role in the health care setting to help support the quality use of medicines. The education, training, and exp...

    Authors: M. H. F. Sakeena, Alexandra A. Bennett, Shazia Jamshed, Fahim Mohamed, Dilanthi R. Herath, Indika Gawarammana and Andrew J. McLachlan

    Citation: BMC Infectious Diseases 2018 18:209

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  33. Content type: Research article

    Intestinal colonization by pathogenic bacteria is a risk factor for infection, and contributes to environmental contamination and disease dissemination. Alteration of gut microbiota also plays a pivotal role i...

    Authors: Danfeng Dong, Qi Ni, Chen Wang, Lihua Zhang, Zhen Li, Cen Jiang, EnqiangMao and Yibing Peng

    Citation: BMC Infectious Diseases 2018 18:207

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  34. Content type: Research article

    To understand the impact of weather on infectious diseases, information on weather parameters at patient locations is needed, but this is not always accessible due to confidentiality or data availability. Weat...

    Authors: Abdelmajid Djennad, Giovanni Lo Iacono, Christophe Sarran, Lora E. Fleming, Anthony Kessel, Andy Haines and Gordon L. Nichols

    Citation: BMC Infectious Diseases 2018 18:198

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  35. Content type: Research article

    Invasive candidiasis differs greatly between children and neonates. We aimed to investigate the different therapeutic approaches and their effects on treatment outcomes of these two groups.

    Authors: Jen-Fu Hsu, Mei-Yin Lai, Chiang-Wen Lee, Shih-Ming Chu, I-Hsyuan Wu, Hsuan-Rong Huang, I-Ta Lee, Ming-Chou Chiang, Ren-Huei Fu and Ming-Horng Tsai

    Citation: BMC Infectious Diseases 2018 18:194

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  36. Content type: Research article

    Limited information exists on the clinical characteristics predictive of mortality in patients aged ≥65 years in many countries. The impact of adherence to current antimicrobial guidelines on the mortality of ...

    Authors: Xiudi Han, Fei Zhou, Hui Li, Xiqian Xing, Liang Chen, Yimin Wang, Chunxiao Zhang, Xuedong Liu, Lijun Suo, Jinxiang Wang, Guohua Yu, Guangqiang Wang, Xuexin Yao, Hongxia Yu, Lei Wang, Meng Liu…

    Citation: BMC Infectious Diseases 2018 18:192

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  37. Content type: Research article

    Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibiotic resistance in Africa is high with unclear information regarding ...

    Authors: Hyasinta Jaka, Jee Ah. Rhee, Linda Östlundh, Luke Smart, Robert Peck, Andreas Mueller, Christa Kasang and Stephen E. Mshana

    Citation: BMC Infectious Diseases 2018 18:193

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  38. Content type: Research article

    Candida bloodstream infections carry a significant mortality risk, justifying the importance of adequate antifungal therapy. This study describes trends in antifungal consumption using the Defined Daily Dose (...

    Authors: Tatiana Aporta Marins, Alexandre R. Marra, Michael B. Edmond, Marines Dalla Valle Martino, Paula Kiyomi Onaga Yokota, Ana Carolina Cintra Nunes Mafra and Marcelino Souza Durão Junior

    Citation: BMC Infectious Diseases 2018 18:187

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  39. Content type: Research article

    The ability of Staphylococcus aureus to invade tissues and cause an infectious disease is the result of a multi-factorial process supported by the huge number of virulence factors inherent to this microorganism t...

    Authors: Esther Viedma, Dafne Pérez-Montarelo, Jennifer Villa, Irene Muñoz-Gallego, Nieves Larrosa, Nuria Fernández-Hidalgo, Joan Gavaldà, Benito Almirante and Fernando Chaves

    Citation: BMC Infectious Diseases 2018 18:177

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  40. Content type: Research article

    Despite vancomycin use is a major risk factor for the emergence of vancomycin resistance, it is frequently inappropriately prescribed, especially as empirical treatment. We evaluated the effect of an antimicro...

    Authors: Pyoeng Gyun Choe, Hei Lim Koo, Doran Yoon, Ji Yun Bae, Eunyoung Lee, Joo-Hee Hwang, Kyoung-Ho Song, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Myoung-don Oh and Nam Joong Kim

    Citation: BMC Infectious Diseases 2018 18:178

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  41. Content type: Case report

    Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare syndrome characterized by “remitting,” “seronegative” (namely rheumatoid factor-negative), and “symmetrical” synovitis with pit...

    Authors: Moe Kyotani, Tsuneaki Kenzaka, Ryo Nishio and Hozuka Akita

    Citation: BMC Infectious Diseases 2018 18:174

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  42. Content type: Research article

    Quantification of human interactions relevant to infectious disease transmission through social contact is central to predict disease dynamics, yet data from low-resource settings remain scarce.

    Authors: O. le Polain de Waroux, S. Cohuet, D. Ndazima, A. J. Kucharski, A. Juan-Giner, S. Flasche, E. Tumwesigye, R. Arinaitwe, J. Mwanga-Amumpaire, Y. Boum II, F. Nackers, F. Checchi, R. F. Grais and W. J. Edmunds

    Citation: BMC Infectious Diseases 2018 18:172

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  43. Content type: Research article

    A two-stage surgical strategy (debridement-negative pressure therapy (NPT) and flap coverage) with prolonged antimicrobial therapy is usually proposed in pressure ulcer-related pelvic osteomyelitis but has not...

    Authors: Johan Andrianasolo, Tristan Ferry, Fabien Boucher, Joseph Chateau, Hristo Shipkov, Fatiha Daoud, Evelyne Braun, Claire Triffault-Fillit, Thomas Perpoint, Frédéric Laurent, Alain-Ali Mojallal, Christian Chidiac and Florent Valour

    Citation: BMC Infectious Diseases 2018 18:166

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  44. Content type: Research article

    The use of probiotics to improve anti-microbial defence, such as for influenza infections, is increasingly recommended. However, no data are available on the effect of probiotics on flu-associated secondary ba...

    Authors: Nouria Belkacem, Raphaëlle Bourdet-Sicard and Muhamed-Kkeir Taha

    Citation: BMC Infectious Diseases 2018 18:167

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  45. Content type: Research article

    Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated.

    Authors: Longyang Jin, Zhuorui Cao, Qi Wang, Yichen Wang, Xiaojuan Wang, Hongbin Chen and Hui Wang

    Citation: BMC Infectious Diseases 2018 18:162

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  46. Content type: Research article

    Conventional local treatment for medullary osteomyelitis (OM) includes insertion of antibiotic-loaded polymethylmethacrylate (PMMA) cement. Nevertheless, PMMA may delivery irregular concentration of antibiotic...

    Authors: Mateus Trinconi Cunha, Maria Aparecida Murça, Stanley Nigro, Giselle Burlamaqui Klautau and Mauro José Costa Salles

    Citation: BMC Infectious Diseases 2018 18:157

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