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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    Trends in antimicrobial resistance help inform infection control efforts. We examined trends in resistance for Enterobacteriaceae and Acinetobacter spp. from 2013 to 2017 in hospitalized US patients.

    Authors: Vikas Gupta, Gang Ye, Melanie Olesky, Kenneth Lawrence, John Murray and Kalvin Yu

    Citation: BMC Infectious Diseases 2019 19:742

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  2. Content type: Study protocol

    Lyme borreliosis (LB) is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato species. Due to a variety of clinical manifestations, diagnosing LB can be challenging, and lab...

    Authors: F. R. van de Schoor, M. E. Baarsma, S. A. Gauw, L. A. B. Joosten, B. J. Kullberg, C. C. van den Wijngaard and J. W. Hovius

    Citation: BMC Infectious Diseases 2019 19:732

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  3. Content type: Case report

    Solobacterium moorei, the only species in the genus Solobacterium, is a Gram-positive, non-spore-forming, strict anaerobic, short to long bacillus. It has rarely been documented to cause blood stream infections. ...

    Authors: Wen-Jing Liu, Meng Xiao, Jie Yi, Ying Li, Timothy Kudinha and Ying-Chun Xu

    Citation: BMC Infectious Diseases 2019 19:730

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  4. Content type: Case report

    Coccidioides spp. are dimorphic fungi endemic to Central America, regions of South America and southwestern USA. Two species cause most human disease: Coccidioides immitis (primarily California isolates) and Cocc...

    Authors: Raynell Lang, William Stokes, Jane Lemaire, Andrew Johnson and John Conly

    Citation: BMC Infectious Diseases 2019 19:722

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  5. Content type: Case report

    Clostridium perfringens can cause various infections, including food poisoning, gas gangrene, cellulitis and fasciitis. C. perfringens septicemia is rare, but is a known cause of hemolysis by damaging red blood c...

    Authors: Masahide Sakaue, Koshi Ota, Eriko Nakamura, Masahiko Nitta, Masahiro Oka, Yasuo Oishi, Yohei Sano, Shinya Yonogi and Akira Takasu

    Citation: BMC Infectious Diseases 2019 19:719

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  6. Content type: Research article

    We developed a clinical bedside tool to simultaneously estimate the probabilities of third-generation cephalosporin-resistant Enterobacteriaceae (3GC-R), carbapenem-resistant Enterobacteriaceae (CRE), and mult...

    Authors: Thomas P. Lodise, Nicole Gidaya Bonine, Jiatao Michael Ye, Henry J. Folse and Patrick Gillard

    Citation: BMC Infectious Diseases 2019 19:718

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  7. Content type: Research article

    Coagulase-negative Staphylococci (CoNS) have emerged as a major causative agent of blood-stream infections (BSI). Linezolid (LZD) is currently used for treating glycopeptide and methicillin-resistant staphyloc...

    Authors: Gajanand Mittal, Vasundhra Bhandari, Rajni Gaind, Vandana Rani, Shimpi Chopra, Reetika Dawar, Raman Sardana and P. K. Verma

    Citation: BMC Infectious Diseases 2019 19:717

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  8. Content type: Research article

    Asymptom of invasive candidiasis (IC) and low positive rate of blood culture lead to delay diagnose of neonatal infection. Serum (1,3)-β-D-glucan (BDG) performs well in adult IC, but its use in neonatal IC is ...

    Authors: Junfei Guo, Yongbing Wu, Weiming Lai, Weiming Lu and Xiaoping Mu

    Citation: BMC Infectious Diseases 2019 19:716

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  9. Content type: Research article

    Management of partially-treated, community-acquired bacterial meningitis (PCBM) is commonly compromised by lack of microbiological diagnosis. We aimed to analyze the impact of FilmArray Meningitis-Encephalitis...

    Authors: Yair Mina, Vered Schechner, Michal Savion, Dafna Yahav, Efraim Bilavsky, Nadav Sorek, Haim Ben-Zvi and Amos Adler

    Citation: BMC Infectious Diseases 2019 19:713

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  10. Content type: Research article

    Vancomycin resistant enterococci (VRE) infections are of increasing concern in many hospitalized patients. Patients with cirrhosis are at added risk of infection with VRE, with associated increased risk for co...

    Authors: Melissa Barger, Emily Blodget, Sol Pena, Wendy Mack and Tse-Ling Fong

    Citation: BMC Infectious Diseases 2019 19:711

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  11. Content type: Case report

    Pulmonary Cryptococcosis (PC) is diagnosed with increasing incidence in recent years, but it does not commonly involve the pleural space. Here, we report a HIV-negative case with advanced stage IIIB non-small ...

    Authors: Yuan Zhang, Sean X. Zhang, Julie Trivedi, Adam D. Toll, Julie Brahmer, Russell Hales, Sarah Bonerigo, Mingying Zeng, Huiping Li and Rex C. Yung

    Citation: BMC Infectious Diseases 2019 19:710

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  12. Content type: Case report

    Talaromyces marneffei is a thermally dimorphic fungus endemic in south-east Asia. It predominantly occurs in both immunocompromised and immunosuppressed patients and can be fatal if diagnosis and treatment are...

    Authors: Jiayi Xian, Xiaowen Huang, Qiaofei Li, Xiaoming Peng and Xuebiao Peng

    Citation: BMC Infectious Diseases 2019 19:707

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  13. Content type: Research article

    S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant recipient (SOTR); nevertheless, the prevalence of colonization and of the colonizing/infecting serotypes has not be...

    Authors: Cristina Roca-Oporto, Tania Cebrero-Cangueiro, María Luisa Gil-Marqués, Gema Labrador-Herrera, Younes Smani, Francisco Manuel González-Roncero, Luis Miguel Marín, Jerónimo Pachón, María Eugenia Pachón-Ibáñez and Elisa Cordero

    Citation: BMC Infectious Diseases 2019 19:697

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  14. Content type: Research article

    Diagnosis is the most strenuous step in the evaluation of neonatal sepsis. No gold standard diagnostic method is available except for blood culture. We aimed to investigate the role of positive and negative ac...

    Authors: Halil Değirmencioğlu, Buse Ozer Bekmez, Turan Derme, Mehmet Yekta Öncel, Fuat Emre Canpolat and Cüneyt Tayman

    Citation: BMC Infectious Diseases 2019 19:695

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  15. Content type: Research article

    Chronic pulmonary aspergillosis (CPA) is an underdiagnosed and misdiagnosed disease and now increasingly recognised. However, the diagnosis of CPA remains challenging. In this study, we aimed to investigate th...

    Authors: Xiuqing Ma, Kaifei Wang, Xin Zhao, Yang Liu, Yanqin Li, Xiaotian Yu, Chunsun Li, David W. Denning and Lixin Xie

    Citation: BMC Infectious Diseases 2019 19:694

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  16. Content type: Research article

    Definitive diagnosis of meningitis is made by analysis of cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR) obtained from a lumbar puncture (LP), which may take days. A timelier diagnostic c...

    Authors: Michelle Troendle and Alexis Pettigrew

    Citation: BMC Infectious Diseases 2019 19:692

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  17. Content type: Research article

    In most developing countries, puerperal sepsis is treated empirically with broad spectrum antibiotics due to lack of resources for culture and antibiotics susceptibility testing. However, empirical treatment d...

    Authors: Raymond Kiponza, Belinda Balandya, Mtebe V. Majigo and Mecky Matee

    Citation: BMC Infectious Diseases 2019 19:690

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  18. Content type: Case report

    Botrytis species are well known fungal pathogens of various plants but have not been reported as human pathogens, except as allergenic precipitants of asthma and hypersensitivity pneumonitis.

    Authors: Seishu Hashimoto, Eisaku Tanaka, Masakuni Ueyama, Satoru Terada, Takashi Inao, Yusuke Kaji, Takehiro Yasuda, Takashi Hajiro, Tatsuo Nakagawa, Satoshi Noma, Gen Honjo, Yoichiro Kobashi, Noriyuki Abe, Katsuhiko Kamei and Yoshio Taguchi

    Citation: BMC Infectious Diseases 2019 19:684

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  19. Content type: Research article

    Fecal colonization with carbapenem-resistant Enterobacteriaceae (CRE) is a risk factor for bacterial translocation resulting in subsequent endogenous infections. The purpose of this study is to investigate the...

    Authors: Fen Pan, Dongxing Tian, Bingjie Wang, Wantong Zhao, Huihong Qin, Tiandong Zhang and Hong Zhang

    Citation: BMC Infectious Diseases 2019 19:678

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  20. Content type: Research article

    Corynebacterium striatum is an emerging multidrug-resistant (MDR) pathogen associated with immunocompromised and chronically ill patients, as well as nosocomial outbreaks. In this study, we characterized 23 MDR C...

    Authors: Juliana Nunes Ramos, Cassius Souza, Yuri Vieira Faria, Eliane Cristine da Silva, João Flávio Carneiro Veras, Paulo Victor Pereira Baio, Sérgio Henrique Seabra, Lilian de Oliveira Moreira, Raphael Hirata Júnior, Ana Luíza Mattos-Guaraldi and Verônica Viana Vieira

    Citation: BMC Infectious Diseases 2019 19:672

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  21. Content type: Research article

    Scrub typhus is a mite borne zoonosis common in the tropics with no good preventive strategy. Children are also affected leading to considerable morbidity and mortality. We conducted a case control study and a...

    Authors: Winsley Rose, Gagandeep Kang, Valsan Philip Verghese, Sadanandane Candassamy, Prasanna Samuel, John Jude Antony Prakash and Jayaprakash Muliyil

    Citation: BMC Infectious Diseases 2019 19:665

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  22. Content type: Research article

    Several studies have identified predictors of severe infections in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the development of oral candidiasis (OC) as a predictor of subsequen...

    Authors: Makoto Yamaguchi, Takayuki Katsuno, Shiho Iwagaitsu, Hironobu Nobata, Hiroshi Kinashi, Shogo Banno and Yasuhiko Ito

    Citation: BMC Infectious Diseases 2019 19:664

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  23. Content type: Research article

    Community-acquired sepsis is a life-threatening systemic reaction, which starts within ≤72 h of hospital admittance in an infected patient without recent exposure to healthcare risks. Our aim was to evaluate t...

    Authors: Balint Gergely Szabo, Rebeka Kiss, Katalin Szidonia Lenart, Bence Marosi, Eszter Vad, Botond Lakatos and Eszter Ostorhazi

    Citation: BMC Infectious Diseases 2019 19:584

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  24. Content type: Case report

    Rapid diagnosis and appropriate treatment is imperative in bacterial sepsis due increasing risk of mortality with every hour without appropriate antibiotic therapy. Atypical infections with fastidious organism...

    Authors: Seweryn Bialasiewicz, Tania P. S. Duarte, Son H. Nguyen, Vichitra Sukumaran, Alexandra Stewart, Sally Appleton, Miranda E. Pitt, Arnold Bainomugisa, Amy V. Jennison, Rikki Graham, Lachlan J. M. Coin and Krispin Hajkowicz

    Citation: BMC Infectious Diseases 2019 19:660

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  25. Content type: Research article

    Cervicofacial necrotizing fasciitis (NF) is a rare life-threatening infection in the head and neck region that characteristically spreads along the fascial planes to involve subcutaneous tissues, fascia and fa...

    Authors: Arnold A. Mtenga, Boniphace M. Kalyanyama, Sira S. Owibingire, Karpal S. Sohal and Elison N.M. Simon

    Citation: BMC Infectious Diseases 2019 19:642

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  26. Content type: Research article

    The outcomes of deep-seated abscesses attributed to chronic disseminated candidiasis (CDC) in patients with hematological malignancies have rarely been reported in recent years.

    Authors: Chien-Yuan Chen, Aristine Cheng, Feng-Ming Tien, Po-Chu Lee, Hwei-Fang Tien, Wang-Huei Sheng and Yee-Chun Chen

    Citation: BMC Infectious Diseases 2019 19:635

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  27. Content type: Study protocol

    Group A Streptococcal (GAS) infections cause the autoimmune disease acute rheumatic fever (ARF), which can progress to chronic rheumatic heart disease (RHD). Treating pharyngitis caused by GAS with antibiotics...

    Authors: Julie Bennett, Nicole J. Moreland, Jane Oliver, Julian Crane, Deborah A. Williamson, Dianne Sika-Paotonu, Matire Harwood, Arlo Upton, Susan Smith, Jonathan Carapetis and Michael G. Baker

    Citation: BMC Infectious Diseases 2019 19:633

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  28. Content type: Research article

    In hospitalised patients with diarrhoea a positive campylobacter stool Polymerase Chain Reaction (PCR) test with negative culture results as well as Enteropathogenic Escherichia coli (EPEC) positive stool PCRs, c...

    Authors: Jan-Erik Berdal, Benoit Follin-Arbelet and Jørgen Vildershøj Bjørnholt

    Citation: BMC Infectious Diseases 2019 19:630

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  29. Content type: Research article

    Nosocomial infections and persistence of multidrug resistant biofilm forming Acinetobacter baumannii in hospitals has made it as a serious problem in healthcare settings worldwide.

    Authors: Habib Zeighami, Fatemeh Valadkhani, Reza Shapouri, Elham Samadi and Fakhri Haghi

    Citation: BMC Infectious Diseases 2019 19:629

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  30. Content type: Research article

    The point mutations in 23S rRNA gene of Mycoplasma pneumoniae (M. pneumoniae) can lead to high-level resistance to macrolides. This study aimed to evaluate allele-specific real-time PCR (ASPCR) to detect the resi...

    Authors: Dongxing Guo, Wenjuan Hu, Baoping Xu, Jingyi Li, Dan Li, Shaogang Li, Zhaoyong Wu, Ran Wei, Xiujun Tian, Kunling Shen and Deli Xin

    Citation: BMC Infectious Diseases 2019 19:616

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  31. Content type: Research article

    Bloodstream infections (BSI) due to Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) have become an important problem and they are associated with a high mortality rate. The aim of our s...

    Authors: Lucia Brescini, Gianluca Morroni, Chiara Valeriani, Sefora Castelletti, Marina Mingoia, Serena Simoni, Annamaria Masucci, Roberto Montalti, Marco Vivarelli, Andrea Giacometti and Francesco Barchiesi

    Citation: BMC Infectious Diseases 2019 19:611

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  32. Content type: Research article

    Bloodstream infections (BSI) are associated with high morbidity and mortality. This scenario worsens with the emergence of drug-resistant pathogens, resulting in infections which are difficult to treat or even...

    Authors: Helena Ferreira Leal, Jailton Azevedo, Giulyana Evelyn Oliveira Silva, Angelica Maria Lima Amorim, Larissa Rangel Cabral de Roma, Ana Carolina Palmeira Arraes, Edilane Lins Gouveia, Mitermayer Galvão Reis, Ana Verena Mendes, Marcio de Oliveira Silva, Maria Goreth Barberino, Ianick Souto Martins and Joice Neves Reis

    Citation: BMC Infectious Diseases 2019 19:609

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  33. Content type: Research article

    Blood culture bottles (BCBs) provide a semiautomated method for culturing periprosthetic tissue specimens. A study evaluating BCBs for culturing clinical samples other than body fluids is needed before impleme...

    Authors: Adriana Sanabria, Merethe E. O. Røkeberg, Mona Johannessen, Johanna Ericson Sollid, Gunnar Skov Simonsen and Anne-Merethe Hanssen

    Citation: BMC Infectious Diseases 2019 19:607

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  34. Content type: Research article

    This study aims to investigate the pathogen distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection.

    Authors: Yu-Xin Liu, Qiu-Mei Cao and Bing-Chen Ma

    Citation: BMC Infectious Diseases 2019 19:603

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  35. Content type: Research article

    Methicillin-resistant Staphylococcus aureus (MRSA) is associated with significant morbidity and mortality and has resultant important economic and societal costs underscoring the need for accurate surveillance. I...

    Authors: Frederick K. Wangai, Moses M. Masika, Marybeth C. Maritim and R. Andrew Seaton

    Citation: BMC Infectious Diseases 2019 19:596

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  36. Content type: Research article

    Antibiotic resistance is a worldwide problem that crosses international boundaries and spread between continents easily. Hence, information on the existence of the causative microorganisms and their susceptibi...

    Authors: Tsegaye Alemayehu, Mulubrahan Ali, Enkosilassie Mitiku and Mengistu Hailemariam

    Citation: BMC Infectious Diseases 2019 19:585

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  37. Content type: Study protocol

    Solid organ transplantation (SOT) is a well-established and life-saving treatment for patients with end-stage organ failure. Organ rejection and infections are among the main complications to SOT and largely d...

    Authors: Camilla Heldbjerg Drabe, Søren Schwartz Sørensen, Allan Rasmussen, Michael Perch, Finn Gustafsson, Omid Rezahosseini, Jens D. Lundgren, Sisse Rye Ostrowski and Susanne Dam Nielsen

    Citation: BMC Infectious Diseases 2019 19:573

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  38. Content type: Research article

    Carbapenemase-producing organisms (CPOs) have emerged as antibiotic-resistant bacteria of global concern. Here we assessed the performance of the Carba (beta) assay, a multiplex real-time PCR assay developed b...

    Authors: Amanda Bordin, Ella Trembizki, Madeline Windsor, Rachel Wee, Lit Yeen Tan, Cameron Buckley, Melanie Syrmis, Haakon Bergh, Kyra Cottrell, Hosam M. Zowawi, Hanna E. Sidjabat, Patrick N. A. Harris, Graeme R. Nimmo, David L. Paterson and David M. Whiley

    Citation: BMC Infectious Diseases 2019 19:571

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  39. Content type: Case report

    Kodamaea ohmeri is a yeast is frequently mistaken for Candida, which belongs to the same family. This micro-organism has been reported to cause life-threatening infections in humans.

    Authors: K. Diallo, B. Lefevre, G. Cadelis, J. C. Gallois, F. Gandon, M. Nicolas and B. Hoen

    Citation: BMC Infectious Diseases 2019 19:570

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  40. Content type: Research article

    To detect carbapenemase-producing Gram-negative bacteria in bacterial laboratories at medical settings, a new immunochromatographic assay for New Delhi metallo-β-lactamases (NDMs) was developed.

    Authors: Tatsuya Tada, Jun-ichiro Sekiguchi, Shin Watanabe, Kyoko Kuwahara-Arai, Naeko Mizutani, Izumi Yanagisawa, Tomomi Hishinuma, Khin Nyein Zan, San Mya, Htay Htay Tin and Teruo Kirikae

    Citation: BMC Infectious Diseases 2019 19:565

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  41. Content type: Research article

    Acute meningitis and encephalitis syndromes (AMES) is a severe neurological infection which causes high case fatality and severe sequelae in children. To determine the etiology of childhood AMES in Shenzhen, a...

    Authors: Hongwei Shen, Chunqing Zhu, Xiaorong Liu, Dongli Ma, Chunli Song, Lintao Zhou, Zuer Wang, Yongxuan Ou, Wen Ma, Xianghui Shi, Xuejun Ma and Yiwen Zhou

    Citation: BMC Infectious Diseases 2019 19:560

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  42. Content type: Research article

    The effectiveness of Helicobacter pylori first-line treatment has decreased drastically with the rise of strains resistant to clarithromycin. Therapy failure has also been described in patients with infections by...

    Authors: Betsy Verónica Arévalo-Jaimes, Diana F. Rojas-Rengifo, Carlos Alberto Jaramillo, Belén Mendoza de Molano, José Fernando Vera-Chamorro and María del Pilar Delgado

    Citation: BMC Infectious Diseases 2019 19:546

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  43. Content type: Research article

    Clinical microbiology laboratories are asked to process large numbers of urine specimens for culture, but only 20–40% of them are positive. Therefore, a rapid, reliable screening method is necessary to speed u...

    Authors: Jong-Mi Lee, Doo-Jin Baek, Kang Gyun Park, Eunhee Han and Yeon-Joon Park

    Citation: BMC Infectious Diseases 2019 19:531

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