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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp.

    Authors: Stuart D. Blacksell, Matthew T. Robinson, Paul N. Newton, Soiratchaneekorn Ruanchaimun, Jeanne Salje, Tri Wangrangsimakul, Matthew D. Wegner, Mohammad Yazid Abdad, Allan M. Bennett, Allen L. Richards, John Stenos and Nicholas P. J. Day

    Citation: BMC Infectious Diseases 2019 19:1044

    Content type: Debate

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  2. Shigella spp. and entero-invasive E. coli (EIEC) use the same invasive mechanism to cause diarrheal diseases. Public health regulations apply only to Shigella spp. infections, but are hampered by the lack of simp...

    Authors: Maaike J. C. van den Beld, Esther Warmelink, Alexander W. Friedrich, Frans A. G. Reubsaet, Maarten Schipper, Richard F. de Boer, Daan W. Notermans, Mariska W. F. Petrignani, Evert van Zanten, John W. A. Rossen, Ingrid H. M. Friesema and A. M. D. ( Mirjam) Kooistra-Smid

    Citation: BMC Infectious Diseases 2019 19:1037

    Content type: Research article

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  3. The cytokine gene polymorphism is important for the genetic susceptibility of infectious diseases. The aim of the present study was to investigate the relationship between TNF-α, IL-12, and IL-13 gene polymorp...

    Authors: Sima Kazemi, Asad Vaisi-Raygani, Fariba Keramat, Massoud Saidijam, Ali Reza Soltanian, Mahdi Alahgholi-Hajibehzad, Seyed Hamid Hashemi and Mohammad Yousef Alikhani

    Citation: BMC Infectious Diseases 2019 19:1036

    Content type: Research article

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  4. The incidence of Taralomyces marneffei infection in HIV-infected individuals has been decreasing, whereas its rate is rising among non-HIV immunodeficient persons, particularly patients with anti-interferon-gamma...

    Authors: Thanyarak Wongkamhla, Piriyaporn Chongtrakool and Anupop Jitmuang

    Citation: BMC Infectious Diseases 2019 19:1034

    Content type: Case report

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  5. Staphylococcus aureus carriage is a known risk factor for staphylococcal disease. However, the carriage rates vary by country, demographic group and profession. This study aimed to determine the S. aureus carriag...

    Authors: David Patrick Kateete, Benon B. Asiimwe, Raymond Mayanja, Brian Mujuni, Freddie Bwanga, Christine F. Najjuka, Karin Källander and Elizeus Rutebemberwa

    Citation: BMC Infectious Diseases 2019 19:1023

    Content type: Research article

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  6. Vitamin D deficiency, determined by blood levels of 25-hydroxyvitamin D [25(OH) D, i.e. the major vitamin D form in blood], has been shown to associate with all-cause mortalities. We recently demonstrated that...

    Authors: Chih-Huang Li, Xiaolei Tang, Samiksha Wasnik, Xiaohua Wang, Jintao Zhang, Yi Xu, Kin-Hing William Lau, H. Bryant Nguyen and David J. Baylink

    Citation: BMC Infectious Diseases 2019 19:1020

    Content type: Research article

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  7. Although, India has made steady progress in reducing deaths in children younger than 5 years, the proportional mortality accounted by diarrhoeal diseases still remains high. The present hospital based cross se...

    Authors: Sonam S. Moharana, Rakesh K. Panda, Muktikesh Dash, Nirupama Chayani, Priyanka Bokade, Sanghamitra Pati and Debdutta Bhattacharya

    Citation: BMC Infectious Diseases 2019 19:1018

    Content type: Research article

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  8. Antibiotics remain the cornerstone of modern medicine. Yet there exists an inherent dilemma in their use: we are able to prevent harm by administering antibiotic treatment as necessary to both humans and anima...

    Authors: Gwenan M. Knight, Nicholas G. Davies, Caroline Colijn, Francesc Coll, Tjibbe Donker, Danna R. Gifford, Rebecca E. Glover, Mark Jit, Elizabeth Klemm, Sonja Lehtinen, Jodi A. Lindsay, Marc Lipsitch, Martin J. Llewelyn, Ana L. P. Mateus, Julie V. Robotham, Mike Sharland…

    Citation: BMC Infectious Diseases 2019 19:1011

    Content type: Debate

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  9. Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection a...

    Authors: Yoan Mboussou, Julien Jaubert, Sophie Larrieu, Laura Atiana, Florence Naze, Christine Folio, Hanitra Randrianaivo, Antoine Bertolotti, Sandrine Picot, Pierre-Yves Robillard, Malik Boukerrou and Patrick Gérardin

    Citation: BMC Infectious Diseases 2019 19:1001

    Content type: Research article

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  10. Histoplasmosis is one of the invasive fungal infections and presents with symptoms mainly in the lungs. Disseminated histoplasmosis (DH) is rare and its lesions in the gastrointestinal tract are even uncommon....

    Authors: Yini Dang, Longfeng Jiang, Jianfu Zhang, Beijing Pan, Guoqin Zhu, Feipeng Zhu, Zhe Guo, Biao Wang, Guoxin Zhang, Yali Weng and Jun Li

    Citation: BMC Infectious Diseases 2019 19:992

    Content type: Case report

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  11. A bacteremia diagnosis with speeded-up identification and antimicrobial susceptibility testing (AST) is mandatory to adjust empirical broad-spectrum antibiotherapy and avoid the emergence of multi-resistant ba...

    Authors: Lidvine Boland, Corentin Streel, Hélène De Wolf, Hector Rodriguez and Alexia Verroken

    Citation: BMC Infectious Diseases 2019 19:989

    Content type: Research article

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  12. Infective endocarditis (IE) is a serious mainly bacterial infection associated with high mortality. Epidemiology of fatal IE is however largely unknown. We studied occurrence and trends of fatal IE in a popula...

    Authors: Elina Ahtela, Jarmo Oksi, Jussi Sipilä, Päivi Rautava and Ville Kytö

    Citation: BMC Infectious Diseases 2019 19:987

    Content type: Research article

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  13. Burkholderia pseudomallei is a gram-negative bacterium and the causative pathogen of melioidosis, which manifests a variety ranges of infection symptoms. However, deep venous thrombosis (DVT) and pulmonary emboli...

    Authors: Hua Wu, Dongliang Huang, Biao Wu, Mengjie Pan and Binghuai Lu

    Citation: BMC Infectious Diseases 2019 19:984

    Content type: Case report

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  14. Dermatophytosis is a fungal infectious disease caused by dermatophytes, which produce protease and keratinase to digest keratin, leading to the colonization, invasion, and infection of the stratum corneum of t...

    Authors: Mingrui Zhang, Lanxiang Jiang, Fuqiu Li, Yangchun Xu, Sha Lv and Bing Wang

    Citation: BMC Infectious Diseases 2019 19:983

    Content type: Case report

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  15. Intra-abdominal infections (IAIs) represent a most frequent gastrointestinal emergency and serious cause of morbimortality. A full classification, including all facets of IAIs, does not exist. Two classificati...

    Authors: João Silva-Nunes and Teresa Cardoso

    Citation: BMC Infectious Diseases 2019 19:980

    Content type: Research article

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  16. Fluoroquinolones are commonly recommended as treatment for urinary tract infections (UTIs). The development of resistance to these agents, particularly in gram-negative microorganisms complicates treatment of ...

    Authors: Dalia Nabil Kotb, Wafaa Khairy Mahdy, Mahmoud Shokry Mahmoud and Rasha M. M. Khairy

    Citation: BMC Infectious Diseases 2019 19:979

    Content type: Research article

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  17. Diagnosing pneumonia can be challenging in general practice but is essential to distinguish from other respiratory tract infections because of treatment choice and outcome prediction. We determined predictive ...

    Authors: G. H. Groeneveld, J. W. van ’t Wout, N. J. Aarts, C. J. van Rooden, T. J. M. Verheij, C. M. Cobbaert, E. J. Kuijper, J. J. C. de Vries and J. T. van Dissel

    Citation: BMC Infectious Diseases 2019 19:976

    Content type: Research article

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  18. Diabetes is one of the underlying risk factors for developing community-acquired pneumonia (CAP). The high prevalence of diabetes among population and the rising incidence of this illness, converts it as an im...

    Authors: Loreto Arias Fernández, Jacobo Pardo Seco, Miriam Cebey-López, Ruth Gil Prieto, Irene Rivero-Calle, Federico Martinon-Torres, Ángel Gil de Miguel, F. Martinón-Torres, D. Vargas, E. Mascarós, E. Redondo, J. L. Díaz-Maroto, M. Linares-Rufo, A. Gil, J. Molina, D. Ocaña…

    Citation: BMC Infectious Diseases 2019 19:973

    Content type: Research article

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  19. Recent reports of the National Ministry of Health and Treatment of Iran (NMHT) show that Gilan has a higher annual incidence rate of leptospirosis than other provinces across the country. Despite several effor...

    Authors: Ali Mohammadinia, Bahram Saeidian, Biswajeet Pradhan and Zeinab Ghaemi

    Citation: BMC Infectious Diseases 2019 19:971

    Content type: Research article

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  20. This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus...

    Authors: Juhyun Song, Dae Won Park, Sungwoo Moon, Han-Jin Cho, Jong Hak Park, Hyeri Seok and Won Seok Choi

    Citation: BMC Infectious Diseases 2019 19:968

    Content type: Research article

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  21. Clostridioides difficile is considered the main pathogen responsible for hospital-acquired infections. This prospective study determined the prevalence, molecular epidemiological characteristics, and risk factors...

    Authors: Yingchao Cui, Danfeng Dong, Lihua Zhang, Daosheng Wang, Cen Jiang, Qi Ni, Chen Wang, Enqiang Mao and Yibing Peng

    Citation: BMC Infectious Diseases 2019 19:961

    Content type: Research article

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  22. Streptococcus oralis belongs to the Streptococcus mitis group and is part of the normal flora of the nasal and oropharynx (Koneman et al., The Gram-positive cocci part II: streptococci, enterococci and the ‘Strep...

    Authors: Kishan Patel, Zain Memon, Adam Prince, Connie Park, Abin Sajan and Nazish Ilyas

    Citation: BMC Infectious Diseases 2019 19:960

    Content type: Case report

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  23. Patients with multiple myeloma (MM) are known to be immune incompetent and experience higher incidences of infectious diseases. However, infective endocarditis (IE) is rarely observed in patients with MM and Morg...

    Authors: Renée van Bentum, Judith Nieken, Esther de Waal and Mels Hoogendoorn

    Citation: BMC Infectious Diseases 2019 19:957

    Content type: Case report

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  24. Localized `and disseminated Nocardia farcinica infection is frequently reported in immunocompromised patients. However, orbital nocardiosis is rare, and, to our knowledge, traumatic orbital nocardiosis that affec...

    Authors: Anan Wang, Qihua Xu, Yaohua Wang and Hongfei Liao

    Citation: BMC Infectious Diseases 2019 19:953

    Content type: Case report

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  25. Osteomyelitis of the pubic symphysis is a rare cause of pelvic pain after delivery, mainly caused by Staphylococcus aureus and Pseudomonas aeruginosa.

    Authors: Stefano Cosma, Fulvio Borella, Andrea Carosso, Agata Ingala, Federica Fassio, Tiziana Robba, Aldo Maina, Luca Bertero and Chiara Benedetto

    Citation: BMC Infectious Diseases 2019 19:952

    Content type: Case report

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  26. Bacterial infection of the urinary tract is among the common reasons for seeking medical attention in the community. Rapidly increasing antibiotic resistance of uropathogens is resulting in limited treatment o...

    Authors: Guesh Gebremariam, Haftom Legese, Yemane Woldu, Tadele Araya, Kiflom Hagos and Araya GebreyesusWasihun

    Citation: BMC Infectious Diseases 2019 19:950

    Content type: Research article

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  27. Enterohemorrhagic Escherichia coli (EHEC) is an important pathogen that causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). After an EHEC outbreak involving uncooked beef, serving raw beef ...

    Authors: Kentaro Iwata and Michihiko Goto

    Citation: BMC Infectious Diseases 2019 19:949

    Content type: Research article

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  28. In the pre-vaccine era, invasive disease with Haemophilus influenzae, type b (Hib) commonly presented with osteoarticular involvement. Haemophilus influenzae, type a (Hia) sepsis is a rare but emerging problem in...

    Authors: Tiffany Albrecht, Kristina Poss, Satja Issaranggoon Na Ayuthaya, Lori Triden, Katherine L. Schleiss and Mark R. Schleiss

    Citation: BMC Infectious Diseases 2019 19:947

    Content type: Case report

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  29. Klebsiella variicola and K. quasipneumoniae are new species distinguishable from K. pneumoniae but they are often misidentified as K. pneumoniae in clinical settings. Several reports have demonstrated the possibi...

    Authors: Kazuo Imai, Noriomi Ishibashi, Masahiro Kodana, Norihito Tarumoto, Jun Sakai, Toru Kawamura, Shinichi Takeuchi, Yoshitada Taji, Yasuhiro Ebihara, Kenji Ikebuchi, Takashi Murakami, Takuya Maeda, Kotaro Mitsutake and Shigefumi Maesaki

    Citation: BMC Infectious Diseases 2019 19:946

    Content type: Research article

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  30. Infective endocarditis (IE) is a lethal disease which has been changing significantly over the past decades; however, information about IE in China remains scarce. This study surveyed the changes in clinical c...

    Authors: Zuning Ren, Xichao Mo, Hongjie Chen and Jie Peng

    Citation: BMC Infectious Diseases 2019 19:945

    Content type: Research article

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  31. In recent years, the number of infective endocarditis (IE) cases associated with injection drug use has increased. Clinical guidelines suggest deferring surgery for IE in people who inject drugs (PWID) due to ...

    Authors: David Goodman-Meza, Robert E. Weiss, Sebastián Gamboa, Abel Gallegos, Alex A. T. Bui, Matthew B. Goetz, Steven Shoptaw and Raphael J. Landovitz

    Citation: BMC Infectious Diseases 2019 19:918

    Content type: Research article

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  32. Initiating early effective antimicrobial therapy is the most important intervention demonstrated to decrease mortality in patients with gram-negative bacteremia with sepsis. Rapid MIC-based susceptibility resu...

    Authors: Gerald Elliott, Michael Malczynski, Viktorjia O. Barr, Doaa Aljefri, David Martin, Sarah Sutton, Teresa R. Zembower, Michael Postelnick and Chao Qi

    Citation: BMC Infectious Diseases 2019 19:942

    Content type: Research article

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  33. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been rapidly developed and widely used as an analytical technique in clinical laboratories with high accuracy in ...

    Authors: Ying Li, Mingzhu Shan, Zuobin Zhu, Xuhua Mao, Mingju Yan, Ying Chen, Qiuju Zhu, Hongchun Li and Bing Gu

    Citation: BMC Infectious Diseases 2019 19:941

    Content type: Research article

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  34. Bacillus anthracis causes a highly lethal infectious disease primarily due to toxin-mediated injury. Antibiotics are no longer effective to treat the accumulation of anthrax toxin, thereby new strategies of antib...

    Authors: Siping Xiong, Tingting Zhou, Feng Zheng, Xudong Liang, Yongping Cao, Chunhui Wang, Zhengqin Feng, Qi Tang and Jin Zhu

    Citation: BMC Infectious Diseases 2019 19:940

    Content type: Research article

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  35. Invasive candidiasis (IC) is the most common invasive fungal infection. The epidemiology of IC in hospitalized patients has been widely investigated in many metropolitan cities; however, little information fro...

    Authors: Zhang-rui Zeng, Gang Tian, Yin-huan Ding, Kui Yang, Jin-bo Liu and Jian Deng

    Citation: BMC Infectious Diseases 2019 19:939

    Content type: Research article

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  36. Viral bronchiolitis is the most common cause of respiratory failure requiring invasive ventilation in young children. Bacterial co-infections may complicate and prolong paediatric intensive care unit (PICU) st...

    Authors: Hanke M. G. Wiegers, Lisa van Nijen, Job B. M. van Woensel, Reinout A. Bem, Menno D. de Jong and Job C. J. Calis

    Citation: BMC Infectious Diseases 2019 19:938

    Content type: Research article

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  37. The sepsis-induced immunodepression contributes to impaired clinical outcomes of various stress conditions. This syndrome is well documented and characterized by attenuated function of innate and adaptive immu...

    Authors: Didier Payen, Valerie Faivre, Jordi Miatello, Jenneke Leentjens, Caren Brumpt, Pierre Tissières, Claire Dupuis, Peter Pickkers and Anne Claire Lukaszewicz

    Citation: BMC Infectious Diseases 2019 19:931

    Content type: Research article

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  38. Endemic presence of Klebsiella pneumoniae resistant to carbapenem in Italy has been due principally to the clonal expansion of CC258 isolates; however, recent studies suggest an ongoing epidemiological change in ...

    Authors: Teresa Fasciana, Bernardina Gentile, Maria Aquilina, Andrea Ciammaruconi, Chiara Mascarella, Anna Anselmo, Antonella Fortunato, Silvia Fillo, Giancarlo Petralito, Florigio Lista and Anna Giammanco

    Citation: BMC Infectious Diseases 2019 19:928

    Content type: Research article

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  39. Capnocytophaga canimorsus is a gram-negative bacterium and an oral commensal in dogs and cats, but occasionally causes serious infections in humans. Septicemia is one of the most fulminant forms, but diagnosis of...

    Authors: Jun Sakai, Kazuhito Imanaka, Masahiro Kodana, Kana Ohgane, Susumu Sekine, Kei Yamamoto, Yusuke Nishida, Toru Kawamura, Takahiro Matsuoka, Shigefumi Maesaki, Hideaki Oka and Hideaki Ohno

    Citation: BMC Infectious Diseases 2019 19:927

    Content type: Case report

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  40. Pertussis causes severe disease in young unvaccinated infants, with preterms potentially at highest risk. We studied pertussis in hospitalized infants as related to gestational age (GA) and vaccination history.

    Authors: Nicoline A. T. van der Maas, Elisabeth A. M. Sanders, Florens G. A. Versteegh, Albertine Baauw, Anneke Westerhof and Hester E. de Melker

    Citation: BMC Infectious Diseases 2019 19:919

    Content type: Research article

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  41. Cyst infection is a prevalent complication in autosomal dominant polycystic kidney disease (ADPKD) patients, however therapeutic and diagnostic approaches towards this condition remain unclear. The confirmatio...

    Authors: Laura Onuchic, Victor Augusto Hamamoto Sato, Precil Diego Miranda de Menezes Neves, Bruno Eduardo Pedroso Balbo, Antônio Abel Portela-Neto, Fernanda Trani Ferreira, Elieser Hitoshi Watanabe, Andreia Watanabe, Maria Cláudia Stockler de Almeida, Leonardo de Abreu Testagrossa, Pedro Renato Chocair and Luiz Fernando Onuchic

    Citation: BMC Infectious Diseases 2019 19:911

    Content type: Case report

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  42. Acute Q fever usually presents as a nonspecific febrile illness, and its occurrence is rapidly increasing in South Korea. This study investigated the clinical characteristics of acute Q fever patients in South...

    Authors: Jung Yeon Heo, Young Wha Choi, Eun Jin Kim, Seung Hun Lee, Seung Kwan Lim, Seon Do Hwang, Ju Young Lee and Hye Won Jeong

    Citation: BMC Infectious Diseases 2019 19:903

    Content type: Research article

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  43. Several reports designate the recent increase in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) nasal carriage. Because of the scanty information regarding the nasal carriage sate of MRS...

    Authors: Elham Ahmadi, Mohammad Khojasteh, Seyed Mohammad Mortazavi, Fatemeh Khan-Mohammadi, Ali Kazemnia, Javad Beheshtipour and Mahdieh Raeeszadeh

    Citation: BMC Infectious Diseases 2019 19:899

    Content type: Research article

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  44. Salmonella infection poses significant public health threat globally, especially in resource-limited countries. Emergence and spread of antibiotic resistant strains to fluoroquinolones have led to treatment failu...

    Authors: Godfred Acheampong, Michael Owusu, Alex Owusu-Ofori, Isaac Osei, Nimako Sarpong, Augustina Sylverken, Hung-Jui Kung, Shu-Ting Cho, Chih-Horng Kuo, Se Eun Park, Florian Marks, Yaw Adu-Sarkodie and Ellis Owusu-Dabo

    Citation: BMC Infectious Diseases 2019 19:898

    Content type: Research article

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  45. The impact of animals sources of food as a possible reservoir for extended-spectrum β-lactamase (ESBL) - Producing E. coli, and the dissemination of such strains into the food production chain need to be asses...

    Authors: Mengistu Abayneh, Getnet Tesfaw, Kifle Woldemichael, Moti Yohannis and Alemseged Abdissa

    Citation: BMC Infectious Diseases 2019 19:897

    Content type: Research article

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