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Bacterial and fungal diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Infective endocarditis (IE) is associated with high mortality. Surgery may improve survival and reduce complications, but the balance between benefit and harm is difficult and may be closely related to age and...

    Authors: Lauge Østergaard, Morten Holdgaard Smerup, Kasper Iversen, Andreas Dalsgaard Jensen, Anders Dahl, Sandra Chamat-Hedemand, Niels Eske Bruun, Jawad Haider Butt, Henning Bundgaard, Christian Torp-Pedersen, Lars Køber and Emil Fosbøl

    Citation: BMC Infectious Diseases 2020 20:705

    Content type: Research article

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  2. Treatment of gonorrhea is complicated by the development of antimicrobial resistance in Neisseria gonorrhoeae (GC) to the antibiotics recommended for treatment. Knowledge on types of plasmids and the antibiotic r...

    Authors: Mary Wandia Kivata, Margaret Mbuchi, Fredrick Eyase, Wallace Dimbuson Bulimo, Cecilia Katunge Kyanya, Valerie Oundo, Wilton Mwema Mbinda, Willy Sang, Ben Andagalu, Olusegun O. Soge, Raymond Scott McClelland and John Distelhorst

    Citation: BMC Infectious Diseases 2020 20:703

    Content type: Research article

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  3. The microbiota of the respiratory tract has an important role in maintaining respiratory health. However, little is known on the respiratory microbiota in asthmatic patients among Middle Eastern populations. T...

    Authors: Mohammad T. AL Bataineh, Rifat A. Hamoudi, Nihar R. Dash, Rakhee K. Ramakrishnan, Mohamad A. Almasalmeh, Hanan A. Sharif, Mohamed S. Al-Hajjaj and Qutayba Hamid

    Citation: BMC Infectious Diseases 2020 20:697

    Content type: Research article

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  4. From early 2009, the Dutch region of South Limburg experienced a massive outbreak of Q fever, overlapping with the influenza A(H1N1)pdm09 pandemic during the second half of the year and affecting approximately...

    Authors: Volker H. Hackert, Nicole H. T. M. Dukers-Muijrers and Christian J. P. A. Hoebe

    Citation: BMC Infectious Diseases 2020 20:690

    Content type: Research article

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  5. The effect of donor lung colonized bacteria on the prognosis of lung transplantation is not clear. We used the technique of next-generation sequencing (NGS) to detect the colonized bacteria from the lower resp...

    Authors: Dong Liu, Ji Zhang, Bo Wu, Feng Liu, Shugao Ye, Hongmei Wang, Jian Lv, Xing Weng, Yan Chen, Weili Han and Jingyu Chen

    Citation: BMC Infectious Diseases 2020 20:689

    Content type: Research article

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  6. Vogesella species are common aquatic, Gram-negative rod-shaped bacteria, originally described in 1997. Vogesella perlucida was first isolated from spring water in 2008. Furthermore, bacterial pathogenicity of Vog...

    Authors: Zengxian Yu, Fang Zhu, Xinghe Tao, Lu Zhang, Suliu Wu, Chunfu Dong, Yeqing Dong, Ge chen, Xinyang Zhou, Yinfei Fang and Kechen Xu

    Citation: BMC Infectious Diseases 2020 20:687

    Content type: Case report

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  7. Enterobacter cloacae species is responsible for nosocomial outbreaks in vulnerable patients in neonatal intensive care units (NICU). The environment can constitute the reservoir and source of infection in NICUs. ...

    Authors: Alexandrine Ferry, Frank Plaisant, Christophe Ginevra, Yann Dumont, Jacqueline Grando, Olivier Claris, François Vandenesch and Marine Butin

    Citation: BMC Infectious Diseases 2020 20:682

    Content type: Research article

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  8. Although the risk factors for positive follow-up blood cultures (FUBCs) in gram-negative bacteremia (GNB) have not been investigated extensively, FUBC has been routinely carried out in many acute care hospital...

    Authors: Jongtak Jung, Kyoung-Ho Song, Kang Il. Jun, Chang Kyoung Kang, Nak-Hyun Kim, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang-Won Park, Nam Joong Kim, Myoung-don Oh and Hong Bin Kim

    Citation: BMC Infectious Diseases 2020 20:680

    Content type: Research article

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  9. Urinary tract infection is one of the most common bacterial infections in children. Understanding the characteristics of uropathogens and their antimicrobial susceptibility pattern in a particular setting can ...

    Authors: Adugna Fenta, Mulat Dagnew, Setegn Eshetie and Teshome Belachew

    Citation: BMC Infectious Diseases 2020 20:673

    Content type: Research article

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  10. The study was to evaluate initial antimicrobial regimen and clinical outcomes and to explore risk factors for clinical failure (CF) in elderly patients with community-acquired pneumonia (CAP).

    Authors: Xiudi Han, Xuedong Liu, Liang Chen, Yimin Wang, Hui Li, Fei Zhou, Xiqian Xing, Chunxiao Zhang, Lijun Suo, Jinxiang Wang, Guohua Yu, Guangqiang Wang, Xuexin Yao, Hongxia Yu, Lei Wang, Meng Liu…

    Citation: BMC Infectious Diseases 2020 20:668

    Content type: Research article

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  11. Frequencies of polymicrobial infection and pathogens evidenced in course of infected nonunion treatment are largely unknown. Therefore, this study aims at investigating microbial patterns in infected nonunions.

    Authors: Markus Rupp, Stefanie Kern, Tobias Weber, Tamina D. Menges, Reinhard Schnettler, Christian Heiß and Volker Alt

    Citation: BMC Infectious Diseases 2020 20:667

    Content type: Research article

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  12. Neonatal sepsis is one of the major causes of death during the first month of life and early empirical treatment with injectable antibiotics is a life-saving intervention. Adherence to World Health Organisatio...

    Authors: Beatrice Ekman, Prajwal Paudel, Omkar Basnet, Ashish KC and Johan Wrammert

    Citation: BMC Infectious Diseases 2020 20:666

    Content type: Research article

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  13. Stenotrophomonas maltophilia-induced pulmonary haemorrhage is considered a fatal infection among haematological patients. The outcome can be explained by the patients’ immunity status and late diagnosis and treat...

    Authors: Stefan Andrei, Alexandra Ghiaur, Lavinia Brezeanu, Cristina Martac, Andreea Nicolau, Daniel Coriu and Gabriela Droc

    Citation: BMC Infectious Diseases 2020 20:658

    Content type: Case report

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  14. Pseudomonas aeruginosa (P. aeruginosa) is a major Gram-negative pathogen, which has been reported to result in high mortality. We aim to investigate the prognostic value and optimum cut-off point of time-to-posit...

    Authors: Huiting Xu, Jie Cheng, Qinghong Yu, Qingyuan Li, Qian Yi, Siying Luo, Yuanyuan Li, Guangli Zhang, Xiaoyin Tian, Dapeng Cheng and Zhengxiu Luo

    Citation: BMC Infectious Diseases 2020 20:665

    Content type: Research article

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  15. Diarrheagenic Escherichia coli (DEC) are among the leading pathogens associated with endemic diarrhea in low income countries. Yet, few epidemiological studies have focused the contribution of enterohemorrhagic E...

    Authors: Marcelino Garrine, Glória Matambisso, Nélio Nobela, Delfino Vubil, Sérgio Massora, Sozinho Acácio, Tacilta Nhampossa, Pedro Alonso and Inácio Mandomando

    Citation: BMC Infectious Diseases 2020 20:659

    Content type: Research article

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  16. Currently there are only two population studies on sepsis incidence in Asia. The burden of sepsis in Hong Kong is unknown. We developed a sepsis surveillance method to estimate sepsis incidence from a populati...

    Authors: Ying Zhi Liu, Raymond Chu, Anna Lee, Charles David Gomersall, Lin Zhang, Tony Gin, Matthew T. V. Chan, William K. K. Wu and Lowell Ling

    Citation: BMC Infectious Diseases 2020 20:652

    Content type: Research article

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  17. Risk factors related to mortality due to invasive pneumococcal disease (IPD) have been unveiled previously, but early clinical manifestations of IPD based on prognosis remain uncovered.

    Authors: Shuiyan Wu, Xubei Guo, Zhong Xu, Meilin Han, Lili Huang, Yunzhen Tao, Ying Li, Yanhong Li, Tao Zhang and Zhenjiang Bai

    Citation: BMC Infectious Diseases 2020 20:651

    Content type: Research article

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  18. Cryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans. Lateral flow immunochromatographic assay (LFA) is successfully applied to ...

    Authors: Li-Min Xie, Geng-Ling Lin, Hao-Neng Dong, Ying-Xia Liao, Ye-Ling Liu, Jian-Feng Qin and Xu-Guang Guo

    Citation: BMC Infectious Diseases 2020 20:650

    Content type: Research article

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  19. COVID-19 is known as a new viral infection. Viral-bacterial co-infections are one of the biggest medical concerns, resulting in increased mortality rates. To date, few studies have investigated bacterial super...

    Authors: Ehsan Sharifipour, Saeed Shams, Mohammad Esmkhani, Javad Khodadadi, Reza Fotouhi-Ardakani, Alireza Koohpaei, Zahra Doosti and Samad EJ Golzari

    Citation: BMC Infectious Diseases 2020 20:646

    Content type: Research article

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  20. The transmission features and the feasibility of containing shigellosis remain unclear among a population-based study in China.

    Authors: Jia Rui, Qi Chen, Qiuping Chen, Qingqing Hu, Mikah Ngwanguong Hannah, Zeyu Zhao, Yao Wang, Xingchun Liu, Zhao Lei, Shanshan Yu, Yi-Chen Chiang, Benhua Zhao, Yanhua Su, Bin Zhao and Tianmu Chen

    Citation: BMC Infectious Diseases 2020 20:643

    Content type: Research article

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  21. Data regarding the prevalence of metallo-β-lactamases (MBLs) among Pseudomonas aeruginosa isolates in cystic fibrosis patients are scarce. Furthermore, there is limited knowledge on the effect of MBL production o...

    Authors: M. Carugati, A. Piazza, A. M. Peri, L. Cariani, M. Brilli, D. Girelli, D. Di Carlo, A. Gramegna, M. Pappalettera, F. Comandatore, G. Grasselli, A. P. Cantù, M. Arghittu, A. Gori, C. Bandi, F. Blasi…

    Citation: BMC Infectious Diseases 2020 20:635

    Content type: Case report

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  22. People who inject drugs (PWID) have increased risk of acquiring blood-transmitted chronic viral infections such as Hepatitis B (HBV), Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) as well as increas...

    Authors: Sara Thønnings, Filip Jansåker, Christoffer Sundqvist, Rebekka Faber Thudium, Susanne Dam Nielsen and Jenny Dahl Knudsen

    Citation: BMC Infectious Diseases 2020 20:634

    Content type: Research article

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  23. Cases of refractory Mycoplasma pneumoniae pneumonia have been increasing recently; however, whether viral coinfection or macrolide-resistant M. infection contribute to the development of refractory M. pneumoniae ...

    Authors: Yajuan Zhou, Jing Wang, Wenjuan Chen, Nan Shen, Yue Tao, Ruike Zhao, Lijuan Luo, Biru Li and Qing Cao

    Citation: BMC Infectious Diseases 2020 20:633

    Content type: Research article

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  24. There is evidence that males have higher incidence rates (IR) of campylobacteriois than females. The objectives of this study were to determine whether these observations differ between age groups and are cons...

    Authors: Manfred S. Green, Naama Schwartz and Victoria Peer

    Citation: BMC Infectious Diseases 2020 20:625

    Content type: Research article

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  25. We aimed to describe an outbreak of cutaneous abscesses caused by Panton-Valentine leukocidin (PVL)-producing methicillin-susceptible Staphylococcus aureus (MSSA) among gold mine workers.

    Authors: Husna Ismail, Nelesh P. Govender, Ashika Singh-Moodley, Erika van Schalkwyk, Liliwe Shuping, Itumeleng Moema, Gal Feller, Ruth Mogokotleng, Wilhelmina Strasheim, Michelle Lowe, Ruth Mpembe, Serisha Naicker, Tsidiso G. Maphanga, Cecilia De Abreu, Farzana Ismail, Nazir Ismail…

    Citation: BMC Infectious Diseases 2020 20:621

    Content type: Research article

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  26. Neisseria macacae was discovered in the oral cavity of monkeys in 1983. In humans, it has been isolated from the upper respiratory tract of neutropenic patients. However, only two cases of N. macacae bacteremia h...

    Authors: Yasumasa Yamamoto, Norihiko Terada, Tomoyo Sugiyama, Hanako Kurai and Kiyofumi Ohkusu

    Citation: BMC Infectious Diseases 2020 20:619

    Content type: Case report

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  27. Vibrio cholerae are oxidase-positive bacteria that are classified into various serotypes based on the O surface antigen. V. cholerae serotypes are divided into two main groups: the O1 and O139 group and the non-O...

    Authors: Keisuke Tsuruta, Toru Ueyama, Tomoo Watanabe, Kenichi Nakano, Kenji Uno and Hidetada Fukushima

    Citation: BMC Infectious Diseases 2020 20:618

    Content type: Case report

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  28. The rise in antibiotic resistance is a global public health concern, and antibiotic overuse needs to be reduced. Earlier studies of out-of-hours care have indicated that antibiotic prescribing is less appropri...

    Authors: Olof Cronberg, Mia Tyrstrup, Kim Ekblom and Katarina Hedin

    Citation: BMC Infectious Diseases 2020 20:616

    Content type: Research article

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  29. The global prevalent ptxP3 strains varies from about 10% to about 50% of circulating B. pertussis population in different areas of China.

    Authors: Zengguo Wang, Yang Luan, Quanli Du, Chang Shu, Xiaokang Peng, Huijing Wei, Tiejun Hou, Ying Liu, Xiaoguai Liu and Yarong Li

    Citation: BMC Infectious Diseases 2020 20:615

    Content type: Research article

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  30. The most common aetiological agents of mucormycosis are Rhizopus, Mucor, Apophysomyces and Lichtheimia. Apophysomyces is comparatively rare, as it has been reported in less than 3% of mucormycosis cases. The genu...

    Authors: Erick Martínez-Herrera, María Guadalupe Frías-De-León, Angélica Julián-Castrejón, Luis Cruz-Benítez, Juan Xicohtencatl-Cortes and Rigoberto Hernández-Castro

    Citation: BMC Infectious Diseases 2020 20:614

    Content type: Case report

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  31. Strongyloidiasis is caused by the helminth Strongyloides stercoralis and is well-recognised amongst transplant recipients. Serious complications, including Strongyloides hyperinfection which is a syndrome of acce...

    Authors: Christina Lai, Matthew Anderson, Rebecca Davis, Lyndal Anderson, Kate Wyburn, Steve Chadban and David Gracey

    Citation: BMC Infectious Diseases 2020 20:613

    Content type: Case report

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  32. Chronic obstructive pulmonary disease (COPD) is one of the most prevalent diseases worldwide. Episodes of acute exacerbations of COPD (AECOPD) are associated with disease severity and progression. Although sub...

    Authors: Juan Wang, Jianmin Chai, Lina Sun, Jiangchao Zhao and Chun Chang

    Citation: BMC Infectious Diseases 2020 20:610

    Content type: Research article

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  33. This study aimed to identify ten different 16S rRNA methyltransferase genes (rmtA, rmtB, rmtC, rmtD, armA, rmtF, npmA, rmtH, rmtE and rmtG) and their coexisting ESBL and carbapenemase with the emergence of three

    Authors: Jayalaxmi Wangkheimayum, Mohana Bhattacharjee, Bhaskar Jyoti Das, K. Melson Singha, Debadatta Dhar Chanda and Amitabha Bhattacharjee

    Citation: BMC Infectious Diseases 2020 20:544

    Content type: Research article

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    The Correction to this article has been published in BMC Infectious Diseases 2020 20:620

  34. Invasive fungal pneumonia is a severe infectious disease with high mortality in immunocompromised patients. However, the clinical diagnosis of the pathogen(s) remains difficult since microbiological evidence i...

    Authors: Kaiyu Zhang, Chen Yu, Yuxiang Li and Yang Wang

    Citation: BMC Infectious Diseases 2020 20:608

    Content type: Case report

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  35. Infectious Diseases Society of America (IDSA) guidelines suggest 7–14 days’ duration of antibiotic treatment for uncomplicated Gram-negative bacteria (GNB) catheter-related bloodstream infection (CRBSI). The o...

    Authors: Bhitta Surapat, Preecha Montakantikul, Kumthorn Malathum, Sasisopin Kiertiburanakul, Pitak Santanirand and Busba Chindavijak

    Citation: BMC Infectious Diseases 2020 20:604

    Content type: Research article

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  36. The objectives of this study were to determine for the first time, in Morocco, the nasal carriage rate, antimicrobial susceptibility profiles and virulence genes of Staphylococcus. aureus isolated from animals an...

    Authors: Nadira Mourabit, Abdelhay Arakrak, Mohammed Bakkali, Zeineb Zian, Joaira Bakkach and Amin Laglaoui

    Citation: BMC Infectious Diseases 2020 20:602

    Content type: Research article

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  37. Listeriosis is a rare but severe foodborne infectious disease. Perinatal listeriosis is often associated with septicemia, central nervous system (CNS) infection, and serious adverse pregnancy outcomes (miscarr...

    Authors: Chunyun Li, Huihui Zeng, Xin Ding, Yi Chen, Xiaowei Liu, Li Zhou, Xin Wang, Yumei Cheng, Shanshan Hu, Zheng Cao, Ruixia Liu and Chenghong Yin

    Citation: BMC Infectious Diseases 2020 20:601

    Content type: Research article

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  38. Fungal bloodstream infections (FBI) among intensive care unit (ICU) patients are increasing. Our objective was to characterize the fungal pathogens that cause bloodstream infections and determine the epidemiol...

    Authors: Guangwen Xiao, Wanqing Liao, Yuenong Zhang, Xiaodong Luo, Cailing Zhang, Guodan Li, Yingping Yang and Yunyao Xu

    Citation: BMC Infectious Diseases 2020 20:599

    Content type: Research article

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  39. Multidrug resistant (MDR) and extensively drug resistant (XDR) Acinetobacter baumannii presents challenges for clinical treatment and causes high mortality in children. We aimed to assess the risk factors and ove...

    Authors: Jingyi Shi, Ting Sun, Yun Cui, Chunxia Wang, Fei Wang, Yiping Zhou, Huijie Miao, Yijun Shan and Yucai Zhang

    Citation: BMC Infectious Diseases 2020 20:597

    Content type: Research article

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  40. Inappropriate and excessive antimicrobial prescribing can lead to antimicrobial resistance. Antimicrobial Stewardship (AMS) principles are not well established in general practice in Australia despite the rela...

    Authors: Alicia J. Neels, Aaron E. Bloch, Stella M. Gwini and Eugene Athan

    Citation: BMC Infectious Diseases 2020 20:586

    Content type: Research article

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  41. Listeriosis is a severe food-borne infection caused by the Gram-positive rod, Listeria monocytogenes. Despite the low incidence (3–8 cases per million), Listeriosis has a case fatality rate of 20–30% as it occurs...

    Authors: Rand Al Ohaly, Nischal Ranganath, Medina G. Saffie and Anjali Shroff

    Citation: BMC Infectious Diseases 2020 20:559

    Content type: Case report

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  42. Dengue fever is endemic and a leading health problem in Sri Lanka. Increased incidence of concurrent bacteremia in patients with dengue infection is a recognized complication. However, Staphylococcal endocardi...

    Authors: Nilusha Weerasooriya, Tharanga Fernando, Pasan Serasinghe, Buddhika Alahakoon, Chirath Madurapperuma and Ananda Jayanaga

    Citation: BMC Infectious Diseases 2020 20:583

    Content type: Case report

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  43. Gram-positive anaerobic (GPA) bacteria inhabit different parts of the human body as commensals but can also cause bacteremia. In this retrospective observational study, we analyzed GPA bacteremia pathogens bef...

    Authors: Tsuyoshi Watanabe, Yuki Hara, Yusuke Yoshimi, Yoshiro Fujita, Masamichi Yokoe and Yoshinori Noguchi

    Citation: BMC Infectious Diseases 2020 20:578

    Content type: Research article

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  44. The incidence of cryptococcal meningitis (CM) has gradually increased in recent years. Cerebrospinal fluid (CSF) cytology and cell count are very important for CM on etiology diagnosis and assessment of diseas...

    Authors: Junyan Qu, Jingwen Jiang and Xiaoju Lv

    Citation: BMC Infectious Diseases 2020 20:571

    Content type: Research article

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  45. Subtenon injection of triamcinolone acetonide (STTA) has been widely adopted in the clinical setting of ophthalmology and its infectious complications are rare. However, orbital abscess following STTA has been...

    Authors: Chiharu Iwahashi, Hiroshi Eguchi, Fumika Hotta, Mayu Uezumi, Miki Sawa, Masatomo Kimura, Takashi Yaguchi and Shunji Kusaka

    Citation: BMC Infectious Diseases 2020 20:566

    Content type: Case report

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  46. Morbidity and mortality in transplant patients is increased by infection caused mainly by rare opportunistic pathogens. The present study reports a case where Hongkongmyces snookiorum caused subcutaneous phaeohyp...

    Authors: Deng Linqiang, Chen Yiguo, Xu Heping, Chen Dongke, Hu Longhua, Gui Xiaomei and Zou Xia

    Citation: BMC Infectious Diseases 2020 20:562

    Content type: Case report

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  47. Extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-PE) infections are frequent and highly impact cancer patients. We developed and validated a scoring system to identify cancer patients harboring...

    Authors: Alvaro J. Martínez-Valencia, Brian J. Gómez Martínez, Anita M. Montañez Ayala, Katherin García, Ricardo Sánchez Pedraza, Leydy P. Jiménez Cetina, Julio C. Gómez Rincón and Sonia I. Cuervo Maldonado

    Citation: BMC Infectious Diseases 2020 20:558

    Content type: Research article

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  48. Multi-drug resistance pathogens such as Extended-Spectrum Beta-Lactamase (ESBL) producing Enterobacteriaceae (ESBL-PE) are of great global health concern, since they are associated with increased morbidity and...

    Authors: Upendo O. Kibwana, Mtebe Majigo, Doreen Kamori and Joel Manyahi

    Citation: BMC Infectious Diseases 2020 20:557

    Content type: Research article

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  49. To evaluate whether soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) can be used as an early predictor of ventilator-associated pneumonia (VAP).

    Authors: Xingxing Zhao, Lixiao Xu, Zuming Yang, Bin Sun, Ying Wang, Gen Li, Chenxi Feng, Tao Pan, Tian Yu and Xing Feng

    Citation: BMC Infectious Diseases 2020 20:542

    Content type: Research article

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