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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while inva...

    Authors: Anand Mohan, Chandran Munusamy, Yee-Chin Tan, Sobana Muthuvelu, Rohaidah Hashim, Su-Lin Chien, Ming-Kui Wong, Nurul Aiman Khairuddin, Yuwana Podin, Peter Sie-Teck Lau, David Chun-Ern Ng and Mong-How Ooi

    Citation: BMC Infectious Diseases 2019 19:330

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  2. Content type: Case report

    Endograft infection is a rare but extremely dangerous complication of aortic repair (25–100% of mortality). We describe here the first case of Listeria monocytogenes abdominal periaortitis associated with a vascu...

    Authors: Aurélie Foulex, Matteo Coen, Abdessalam Cherkaoui, Vladimir Lazarevic, Nadia Gaïa, Stefano Leo, Myriam Girard, Damiano Mugnai and Jacques Schrenzel

    Citation: BMC Infectious Diseases 2019 19:326

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  3. Content type: Research article

    Group B streptococcus (GBS) is reported as the leading cause of neonatal sepsis and meningitis. Newborns from GBS colonized pregnant women are at high risk of infection.

    Authors: Musa Mohammed Ali, Yimtubezinash Woldeamanuel, Daniel Asrat Woldetsadik, Tolossa Eticha Chaka, Demissie Assegu Fenta, Muluwork Tefera Dinberu, Eskinder Kebede Weldetensaye, Samson Jamal Ismael and Birkneh Tilahun Tadesse

    Citation: BMC Infectious Diseases 2019 19:325

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  4. Content type: Study protocol

    After antibiotic treatment of Lyme borreliosis, a subset of patients report persistent symptoms, also referred to as post-treatment Lyme disease syndrome. The reported prevalence of persistent symptoms varies ...

    Authors: Hedwig D. Vrijmoeth, Jeanine Ursinus, Margriet G. Harms, Tizza P. Zomer, Stefanie A. Gauw, Anna D. Tulen, Kristin Kremer, Hein Sprong, Hans Knoop, Yolande M. Vermeeren, Barend van Kooten, Leo A. B. Joosten, Bart-Jan Kullberg, Joppe W. R. Hovius and Cees C. van den Wijngaard

    Citation: BMC Infectious Diseases 2019 19:324

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  5. Content type: Research article

    Despite major improvements in child survival rates, the number of deaths due to diarrhea remains unacceptably high. We aimed to describe diarrhea-associated mortality and evaluate risk factors for death among ...

    Authors: Sozinho Acácio, Inácio Mandomando, Tacilta Nhampossa, Llorenç Quintó, Delfino Vubil, Charfudin Sacoor, Karen Kotloff, Tamer Farag, Dilruba Nasrin, Eusébio Macete, Myron M. Levine, Pedro Alonso and Quique Bassat

    Citation: BMC Infectious Diseases 2019 19:322

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  6. Content type: Research article

    Necrotising fasciitis is a rapidly progressing soft-tissue infection with a low incidence that carries a relevant risk of morbidity and mortality. Although necrotising fasciitis is often fatal in adults, its c...

    Authors: Arne Schroder̈, Aurelié Gerin, Gregory B. Firth, Kelly S. Hoffmann, Andrew Grieve and Christina Oetzmann von Sochaczewski

    Citation: BMC Infectious Diseases 2019 19:317

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  7. Content type: Research article

    Trimethoprim-sulfamethoxazole (TMP-SMX) is the drug of choice for anti-Pneumocystis jirovecii pneumonia (PcP) prophylaxis in kidney transplant recipients (KTR). Post-transplant management balances preventing PcP ...

    Authors: G. V. Ramesh Prasad, Jill Beckley, Mohit Mathur, Madhushankar Gunasekaran, Michelle M. Nash, Lindita Rapi, Michael Huang and Jeffrey S. Zaltzman

    Citation: BMC Infectious Diseases 2019 19:311

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  8. Content type: Research article

    Early diagnosis of acute invasive fungal rhinosinusitis (AIFRS) is vital to improving outcomes in immunocompromised patients. This study evaluated the impact of a systematic protocol with nasal endoscopy and b...

    Authors: Mariana L. C. Silveira, Wilma T. Anselmo-Lima, Francesca M. Faria, Danielle L. C. Queiroz, Rodrigo L. Nogueira, Marcelo G. J. Leite, Ricardo M. Lessa, Belinda P. Simões, Edwin Tamashiro and Fabiana C. P. Valera

    Citation: BMC Infectious Diseases 2019 19:310

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  9. Content type: Case report

    Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphyl...

    Authors: Charles Vidal, Florence Moulin, Xavier Nassif, Louise Galmiche, Delphine Borgel, Alain Charbit, Capucine Picard, Jean-Paul Mira, Olivier Lortholary, Anne Jamet and Julie Toubiana

    Citation: BMC Infectious Diseases 2019 19:302

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  10. Content type: Case report

    Lactococcus garvieae is an unusual cause of infective endocarditis (IE). No current diagnostic and therapeutic guidelines are available to treat IE caused by these organisms. Based on a case report, we provide a ...

    Authors: Alexandre Malek, Alejandro De la Hoz, Sara Isabel Gomez-Villegas, Cima Nowbakht and Cesar A. Arias

    Citation: BMC Infectious Diseases 2019 19:301

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  11. Content type: Case report

    The bacterial genus Bartonella is distributed worldwide and poses a public health risk. Cat-scratch disease caused by B. henselae in Croatia was first described in 1957. It is present throughout the country: a su...

    Authors: Maja Stepanić, Sanja Duvnjak, Irena Reil, Silvio Špičić, Gordan Kompes and Relja Beck

    Citation: BMC Infectious Diseases 2019 19:299

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  12. Content type: Research article

    The Lebanese Society of Infectious Diseases and Clinical Microbiology (LSIDCM) is involved in antimicrobial stewardship. In an attempt at guiding clinicians across Lebanon in regards to the proper use of antim...

    Authors: Nicholas Haddad, Souha S. Kanj, Lyn S. Awad, Dania I. Abdallah and Rima A. Moghnieh

    Citation: BMC Infectious Diseases 2019 19:293

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  13. Content type: Research article

    Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological char...

    Authors: María Ercibengoa, Miguel Angel Goenaga, Carmen Ardanuy, Immaculada Grau, Cristina García-de-la-Maria, Manuel Almela, Jose María Miro, Enrique Navas, María Carmen Fariñas, Carlos Ruiz de Alegría, Javier de la Torre, Fernando Fernández, Mercedes Marín, Patricia Muñoz, Beatriz Orden, José Antonio Oteo…

    Citation: BMC Infectious Diseases 2019 19:291

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  14. Content type: Research article

    Purulent meningitis (PM) is a serious life-threatening infection of the central nervous system (CNS) by bacteria or fungi and associated with high mortality and high incidence of CNS sequelae in children. Howe...

    Authors: Chengna Zhao, Xi Wang, Chao Zhang, Bing Liu, Hongbo Jing, Lihua Ming, Hua Jiang, Yuling Zheng, Peng Liu, Gang Liu and Yongqiang Jiang

    Citation: BMC Infectious Diseases 2019 19:289

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  15. Content type: Research article

    Enteric fever is one of the common infectious diseases of humans. The objectives of this study were to:1) estimate the prevalence of enteric fever among febrile patients visiting Ambo hospital; 2) comparison o...

    Authors: Tolera Deksissa and Endrias Zewdu Gebremedhin

    Citation: BMC Infectious Diseases 2019 19:288

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  16. Content type: Case report

    Ruxolitinib is a highly potent janus kinase inhibitor that places its users at risk for various bacterial infections and viral reactivation. However new reports are also emerging that suggest greater immunosup...

    Authors: Katya Prakash and Douglas Richman

    Citation: BMC Infectious Diseases 2019 19:287

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  17. Content type: Research article

    Scrub typhus is an acute disease, characterized by symptoms of fever, which occurs due to infection by Orientia tsutsugamushi. In most cases, patients recover from the disease with appropriate treatment, but seri...

    Authors: Hyun Lee Kim, Hye Rim Park, Choon-Mee Kim, Youn Jung Cha, Na Ra Yun and Dong-Min Kim

    Citation: BMC Infectious Diseases 2019 19:283

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  18. Content type: Case report

    Erysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipeloid and is most frequently associated with exposure to domestic swine. Infection of native and prosthetic joints is a rarely reported manife...

    Authors: Michael Groeschel, Taya Forde, Shannon Turvey, A. Mark Joffe, Catherine Hui, Prenilla Naidu, Fabien Mavrot, Susan Kutz and Ameeta E. Singh

    Citation: BMC Infectious Diseases 2019 19:282

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  19. Content type: Research article

    We assessed the utility of a multi-target, real-time PCR assay for Bordetella pertussis detection and diagnosis in patients with severe respiratory illness (SRI), influenza-like illness (ILI), and asymptomatic co...

    Authors: Fahima Moosa, Mignon du Plessis, Nicole Wolter, Maimuna Carrim, Cheryl Cohen, Claire von Mollendorf, Sibongile Walaza, Stefano Tempia, Halima Dawood, Ebrahim Variava and Anne von Gottberg

    Citation: BMC Infectious Diseases 2019 19:276

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  20. Content type: Research article

    Little is known about the morbidity and mortality of invasive fungal disease (IFD) at a population level. The aim of this study was to determine the incidence, trends and outcomes of IFD in all haematology-onc...

    Authors: Jake C. Valentine, C. Orla Morrissey, Mark A. Tacey, Danny Liew, Sushrut Patil, Anton Y. Peleg and Michelle R. Ananda-Rajah

    Citation: BMC Infectious Diseases 2019 19:274

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  21. Content type: Case report

    Severe leptospirosis is known to cause multi organ dysfunction including cardiac involvement. In the clinical setting with limited resources, high degree of suspicion is needed to diagnose cardiac involvement ...

    Authors: P. G. N. S. Jayathilaka, A. S. V. Mendis, M. H. M. T. S. Perera, H. M. T. Damsiri, A. V. C. Gunaratne and Suneth Buddhika Agampodi

    Citation: BMC Infectious Diseases 2019 19:265

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  22. Content type: Research article

    Campylobacteriosis is a major public health concern. The weather factors that influence spatial and seasonal distributions are not fully understood.

    Authors: Abdelmajid Djennad, Giovanni Lo Iacono, Christophe Sarran, Christopher Lane, Richard Elson, Christoph Höser, Iain R. Lake, Felipe J. Colón-González, Sari Kovats, Jan C. Semenza, Trevor C. Bailey, Anthony Kessel, Lora E. Fleming and Gordon L. Nichols

    Citation: BMC Infectious Diseases 2019 19:255

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  23. Content type: Research article

    Antimicrobial resistance (AMR) is an increasing public health problem worldwide.

    Authors: László Róbert Kolozsvári, József Kónya, John Paget, Francois G. Schellevis, János Sándor, Gergő József Szőllősi, Szilvia Harsányi, Zoltán Jancsó and Imre Rurik

    Citation: BMC Infectious Diseases 2019 19:253

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  24. Content type: Case report

    During fulminant meningococcal septicaemia, meningococci are often observed in the cerebrospinal fluid (CSF) although the patients have frequently no meningeal symptoms. Meningococcal meningitis, by contrast, ...

    Authors: Mehdi Hage-Sleiman, Nicolas Derre, Charlotte Verdet, Gilles Pialoux, Olivier Gaudin, Patricia Senet, Muriel Fartoukh, Mathieu Boissan and Marc Garnier

    Citation: BMC Infectious Diseases 2019 19:252

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  25. Content type: Research article

    Increased resistance to third-generation cephalosporin (3GC) is a serious concern for community-onset Escherichia coli infection because this resistance easily delays effective treatment. This study surveyed the ...

    Authors: Wu-Pu Lin, Yu-Shan Huang, Jann-Tay Wang, Yee-Chun Chen and Shan-Chwen Chang

    Citation: BMC Infectious Diseases 2019 19:245

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  26. Content type: Research article

    Diarrheal disease kills over half a million people each year in sub-Saharan Africa; the majority are children under 5 years. About 58% of diarrhea cases are associated with poor water, sanitation, and hygiene—...

    Authors: Samantha Winter, Millicent Ningoma Dzombo and Francis Barchi

    Citation: BMC Infectious Diseases 2019 19:242

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  27. Content type: Research article

    Understanding the relationship between serotype epidemiology and antimicrobial susceptibility of Streptococcus pneumoniae is essential for the effective introduction of pneumococcal conjugate vaccines (PCVs) and ...

    Authors: Hien Anh Thi Nguyen, Hiroshi Fujii, Huong Thi Thu Vu, Christopher M. Parry, Anh Duc Dang, Koya Ariyoshi and Lay-Myint Yoshida

    Citation: BMC Infectious Diseases 2019 19:241

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  28. Content type: Case report

    Tularemia is a rare zoonotic infection caused by bacterium Francisella tularensis. It has been well described in immunocompetent patients but poorly described in immunocompromised patients notably in solid organ ...

    Authors: Olivier Bahuaud, Cécile Le Brun, Thomas Chalopin, Marion Lacasse, Julien Le Marec, Clémence Pantaleon, Charlotte Nicolas, Louise Barbier, Louis Bernard and Adrien Lemaignen

    Citation: BMC Infectious Diseases 2019 19:238

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  29. Content type: Research article

    The clinical course of Campylobacter infection varies in symptoms and severity depending on host factors, virulence of the pathogen and initiated therapy. The type VI secretion system (T6SS) has been identified a...

    Authors: Jessica Agnetti, Helena M. B. Seth-Smith, Sebastian Ursich, Josiane Reist, Marek Basler, Christian Nickel, Stefano Bassetti, Nicole Ritz, Sarah Tschudin-Sutter and Adrian Egli

    Citation: BMC Infectious Diseases 2019 19:237

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  30. Content type: Research article

    Pyogenic liver abscess (PLA) in the elderly is insufficiently elucidated. A few studies attempted to investigate the role of age in PLA have yielded controversial results. The purpose of this study was to expl...

    Authors: Jia Zhang, Zhaoqing Du, Jianbin Bi, Zheng Wu, Yi Lv, Xufeng Zhang and Rongqian Wu

    Citation: BMC Infectious Diseases 2019 19:233

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  31. Content type: Research article

    Clostridium difficile infection (CDI) is an emerging healthcare problem in the world. The purpose of this study was to perform a systematic epidemiological research of CDI in Tongji hospital, the central of China...

    Authors: Yu Zhou, Liyan Mao, Jing Yu, Qun Lin, Ying Luo, Xuhui Zhu and Ziyong Sun

    Citation: BMC Infectious Diseases 2019 19:232

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  32. Content type: Research article

    The prevalence of Helicobacter pylori (H. pylori) infection increases with age. However, the relationship between H. pylori infection and anemia in the elderly population remains to be identified. The aim of this...

    Authors: Baicun Hou, Meifang Zhang, Miao Liu, Wei Dai, Yunjuan Lin, Yuan Li, Meiliang Gong and Gangshi Wang

    Citation: BMC Infectious Diseases 2019 19:228

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  33. Content type: Research article

    Extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) represent a major problem in the management of nosocomial infections. However, ESBL-PE are not systematically monitored in African countries. T...

    Authors: Oumar Ouchar Mahamat, Manon Lounnas, Mallorie Hide, Yann Dumont, Abelsalam Tidjani, Kadidja Kamougam, Madina Abderrahmane, Julio Benavides, Jérôme Solassol, Anne-Laure Bañuls, Hélène jean-Pierre, Christian Carrière and Sylvain Godreuil

    Citation: BMC Infectious Diseases 2019 19:205

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  34. Content type: Case report

    Until now, the prevalence of macrolide-resistant Mycoplasma pneumoniae (MP) infection among adult patients has been low, and severe MP pneumonia due to a macrolide-resistant strain has seldom been reported. Here,...

    Authors: Munehiro Matsumoto, Kentaro Nagaoka, Masaru Suzuki, Satoshi Konno, Kei Takahashi, Taichi Takashina, Nobuhisa Ishiguro and Masaharu Nishimura

    Citation: BMC Infectious Diseases 2019 19:204

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  35. Content type: Research article

    Korean surveillance program for bovine brucellosis was improved by extending it to beef slaughterhouses and by pre-movement testing of bulls on May 2005 (Intervention 1). The bovine brucellosis surveillance pr...

    Authors: Sukhyun Ryu, Ricardo J. Soares Magalhães and Byung Chul Chun

    Citation: BMC Infectious Diseases 2019 19:201

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  36. Content type: Case report

    Bacillus cereus is a gram-positive rod bacterium that is responsible for food poisoning. It is naturally widely distributed, and thus often contaminates cultures. Although it is rarely considered responsible, it ...

    Authors: Ryosuke Ishida, Kazunori Ueda, Tadashi Kitano, Tomohiko Yamamoto, Yasuyoshi Mizutani, Yutaka Tsutsumi, Koji Imoto and Yuji Yamamori

    Citation: BMC Infectious Diseases 2019 19:197

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  37. Content type: Research article

    Patients with pneumonia who are elderly or severely ill are at a particularly high risk of mortality. This post hoc retrospective analysis of data from two Phase III studies evaluated early improvement outcome...

    Authors: Thomas W. L. Scheeren, Tobias Welte, Mikael Saulay, Marc Engelhardt, Anne Santerre-Henriksen and Kamal Hamed

    Citation: BMC Infectious Diseases 2019 19:195

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  38. Content type: Research article

    Clinical guidelines for the diagnosis of group A streptococcal (GAS) pharyngitis recommend the use of a rapid antigen detection test (RADT) and/or bacterial culture. This study evaluated the overall diagnosis ...

    Authors: Robert Luo, Joanna Sickler, Farnaz Vahidnia, Yuan-Chi Lee, Bianca Frogner and Matthew Thompson

    Citation: BMC Infectious Diseases 2019 19:193

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  39. Content type: Case report

    Salmonella is a notorious pathogen that causes gastroenteritis in humans and the emergence of resistance to third-generation cephalosporins and azithromycin have raised concern. There has been rare case of Salmon...

    Authors: Hye-Ran Park, Dong-Min Kim, Na-Ra Yun and Choon-Mee Kim

    Citation: BMC Infectious Diseases 2019 19:191

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  40. Content type: Case report

    Mucormycosis is a group of rare but life threatening angioinvasive infections caused by fungi of the order Mucorales that often occurs in immunocompromised patients and individuals with poorly controlled diabetes...

    Authors: Farheen Manji, John C. Lam, Bonnie L. Meatherall, Deirdre Church and Bayan Missaghi

    Citation: BMC Infectious Diseases 2019 19:184

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  41. Content type: Research article

    Osteomyelitis is often challenging to treat. This analysis examined the clinical experience of patients with gram-positive osteomyelitis treated with ceftaroline fosamil in the phase 4 Clinical Assessment Prog...

    Authors: Leonard B. Johnson, Ananthakrishnan Ramani and David J. Guervil

    Citation: BMC Infectious Diseases 2019 19:183

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  42. Content type: Research article

    Streptococcus agalactiae or Group B Streptococcus (GBS) is the leading cause of neonatal morbidity and mortality resulting in septicaemia, bacteraemia and meningitis. Long term problems in children range from los...

    Authors: Munyaradzi Mukesi, Benson C. Iweriebor, Larry C. Obi, Uchechukwu U. Nwodo, Sylvester R. Moyo and Anthony I. Okoh

    Citation: BMC Infectious Diseases 2019 19:179

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  43. Content type: Research article

    In January 2011, there was an outbreak of Panton-Valentine Leukocidin-positive methicillin-sensitive Staphylococcus aureus (PVL-MSSA) infection in a neonatal unit (NNU).

    Authors: G. Gopal Rao, R. Batura, R. Nicholl, F. Coogan, B. Patel, P. Bassett and A. M. Kearns

    Citation: BMC Infectious Diseases 2019 19:178

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  44. Content type: Case report

    Melioidosis is a life-threatening infectious disease that is caused by gram negative bacteria Burkholderia pseudomallei. This bacteria occurs as an environmental saprophyte typically in endemic regions of south-e...

    Authors: Neha Shrestha, Mahesh Adhikari, Vivek Pant, Suman Baral, Anjan Shrestha, Buddha Basnyat, Sangita Sharma and Jeevan Bahadur Sherchand

    Citation: BMC Infectious Diseases 2019 19:176

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  45. Content type: Research article

    Solithromycin, the fourth generation of ketolides, has been demonstrated potent antibacterial effect against commonly-isolated gram-positive strains. However, Staphylococcus aureus (S. aureus) strains with a high...

    Authors: Weiming Yao, Guangjian Xu, Duoyun Li, Bing Bai, Hongyan Wang, Hang Cheng, Jinxin Zheng, Xiang Sun, Zhiwei Lin, Qiwen Deng and Zhijian Yu

    Citation: BMC Infectious Diseases 2019 19:175

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  46. Content type: Research article

    In the event of a shigellosis outbreak in a childcare setting, exclusion policies are typically applied to afflicted children to limit shigellosis transmission. However, there is scarce evidence of their impact.

    Authors: Cristina Carias, Eduardo A. Undurraga, Jacqueline Hurd, Emily B. Kahn, Martin I. Meltzer and Anna Bowen

    Citation: BMC Infectious Diseases 2019 19:172

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  47. Content type: Research article

    Community- associated methicillin resistant Staphylococcus aureus (CA-MRSA) cause serious infections and rates continue to rise worldwide. Use of geocoded electronic health record (EHR) data to prevent spread of ...

    Authors: Lilly Cheng Immergluck, Traci Leong, Kevin Matthews, Khusdeep Malhotra, Trisha Chan Parker, Fatima Ali, Robert C. Jerris and George S. Rust

    Citation: BMC Infectious Diseases 2019 19:170

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  48. Content type: Research article

    The etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptoco...

    Authors: Jinjian Fu, Ling Li, Zhuoxin Liang, Shaolin Xu, Nan Lin, Peixu Qin, Xiaohua Ye and Eric McGrath

    Citation: BMC Infectious Diseases 2019 19:168

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  49. Content type: Case report

    Helicobacter cinaedi is a microaerobic Gram-negative spiral-shaped bacterium that causes enteritis, cellulitis, and bacteremia in both immunocompromised and immunocompetent patients. While there have been increas...

    Authors: Tomohiro Takehara, Tetsuo Tani, Ken Yajima, Mako Watanabe, Yoshihito Otsuka and Hidefumi Koh

    Citation: BMC Infectious Diseases 2019 19:166

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