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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    To evaluate the in vitro activities of plazomicin and comparator aminoglycosides and elucidate the underlying aminoglycoside resistance mechanisms among carbapenemase-producing K. pneumoniae isolates collected du...

    Authors: Irene Galani, Konstantina Nafplioti, Panagiota Adamou, Ilias Karaiskos, Helen Giamarellou and Maria Souli

    Citation: BMC Infectious Diseases 2019 19:167

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  2. Content type: Research article

    The etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptoco...

    Authors: Jinjian Fu, Ling Li, Zhuoxin Liang, Shaolin Xu, Nan Lin, Peixu Qin, Xiaohua Ye and Eric McGrath

    Citation: BMC Infectious Diseases 2019 19:168

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  3. Content type: Case report

    Helicobacter cinaedi is a microaerobic Gram-negative spiral-shaped bacterium that causes enteritis, cellulitis, and bacteremia in both immunocompromised and immunocompetent patients. While there have been increas...

    Authors: Tomohiro Takehara, Tetsuo Tani, Ken Yajima, Mako Watanabe, Yoshihito Otsuka and Hidefumi Koh

    Citation: BMC Infectious Diseases 2019 19:166

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  4. Content type: Research article

    A reduction in duration of antibiotic therapy is crucial in minimizing the development of antimicrobial resistance, drug-related side effects and health care costs. The minimal effective duration of antimicrob...

    Authors: Janneke Evelyne Stalenhoef, Cees van Nieuwkoop, Darius Cameron Wilson, Willize Elizabeth van der Starre, Tanny J. K. van der Reijden, Nathalie Manon Delfos, Eliane Madeleine Sophie Leyten, Ted Koster, Hans Christiaan Ablij, Johannes (Jan) Willem van ‘t Wout and Jaap Tamino van Dissel

    Citation: BMC Infectious Diseases 2019 19:161

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  5. Content type: Research article

    Clinical characteristics (taxonomy, virulence genes and antimicrobial resistance ) of Aeromonas in isolated from extra-intestinal and intestinal infections were investigated to describe epidemiology, associated v...

    Authors: Yanyan Zhou, Li Yu, Zheng Nan, Pingping Zhang, Biao Kan, Donghui Yan and Jianrong Su

    Citation: BMC Infectious Diseases 2019 19:158

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  6. Content type: Research article

    Bacterial resistance to first line antibiotics used to treat community-onset urinary tract infections (UTIs) continues to emerge. We sought to determine the association between extended-spectrum cephalosporin ...

    Authors: Judith A. Anesi, Ebbing Lautenbach, Irving Nachamkin, Charles Garrigan, Warren B. Bilker, Jacqueline Omorogbe, Lois Dankwa, Mary Wheeler, Pam Tolomeo and Jennifer H. Han

    Citation: BMC Infectious Diseases 2019 19:163

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  7. Content type: Research article

    The prognostic capability of the quick Sequential Organ Failure Assessment (qSOFA) bedside scoring tool is uncertain in non-ICU patients with sepsis due to bacteremia given the low number of patients previousl...

    Authors: Emi Minejima, Vanessa Delayo, Mimi Lou, Pamela Ny, Paul Nieberg, Rosemary C. She and Annie Wong-Beringer

    Citation: BMC Infectious Diseases 2019 19:149

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  8. Content type: Research article

    Uncomplicated urinary tract infection (uUTI) is common and a majority of patients are prescribed antibiotics. There is little knowledge about antibiotic resistance in urine samples from patients with uUTI in p...

    Authors: Helena Kornfält Isberg, Eva Melander, Katarina Hedin, Sigvard Mölstad and Anders Beckman

    Citation: BMC Infectious Diseases 2019 19:155

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  9. Content type: Research article

    The aim of this study was to evaluate whether Interleukin-6 (IL-6) could be a faster indicator of treatment success in adults with severe sepsis and septic shock compared to procalcitonin (PCT) and C-reactive ...

    Authors: Lorenz Weidhase, Daniel Wellhöfer, Gero Schulze, Thorsten Kaiser, Tim Drogies, Ulrike Wurst and Sirak Petros

    Citation: BMC Infectious Diseases 2019 19:150

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  10. Content type: Technical advance

    Emerging antimicrobial resistance is a significant threat to human health. However, methods for rapidly diagnosing antimicrobial resistance generally require multi-day culture-based assays. Macrolide efflux ge...

    Authors: Megan M. Nelson, Christopher L. Waldron and John R. Bracht

    Citation: BMC Infectious Diseases 2019 19:144

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  11. Content type: Case report

    Roseomonas mucosa, as a Gram-negative coccobacilli, is an opportunistic pathogen that has rarely been reported in human infections. Here we describe a case of bacteremia in an infective endocarditis patient with ...

    Authors: Shayuan Shao, Xin Guo, Penghao Guo, Yingpeng Cui and Yili Chen

    Citation: BMC Infectious Diseases 2019 19:140

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  12. Content type: Case report

    Melioidosis is an infection caused by Burkholderia pseudomallei, which is more prevalent in the tropics and leads to significant morbidity and mortality. It characteristically produces widespread caseous lesions ...

    Authors: H. L. P. Amarasena, F. H. D. S. Silva, P. M. Y. I. Tilakaratna, S. F. Jayamanne and U. K. Ranawaka

    Citation: BMC Infectious Diseases 2019 19:143

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  13. Content type: Research article

    Voriconazole is well established as standard treatment for invasive aspergillosis (IA). In 2017, isavuconazole, a new antifungal from the azole class, with a broader pathogen spectrum, was introduced in Sweden...

    Authors: Lefteris Floros, Daniel Kuessner, Jan Posthumus, Emma Bagshaw and Jan Sjölin

    Citation: BMC Infectious Diseases 2019 19:134

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  14. Content type: Research article

    Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli are responsible for severe infections worldwide. Whereas their genotypic and pathogenic characteristics are not documented in Democratic Republic...

    Authors: Leonid M. Irenge, Jerome Ambroise, Bertrand Bearzatto, Jean-François Durant, Raphaël B. Chirimwami and Jean-Luc Gala

    Citation: BMC Infectious Diseases 2019 19:137

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  15. Content type: Research article

    There is a lack of data regarding the prevalence of invasive group B streptococcus (GBS) infection among neonates in China. This study aimed to investigate the incidence and mortality of invasive GBS infection...

    Authors: Qunhua Ying, Shutan Wang, Xiuming Lou, Jinlong Ding and Jiefeng Ding

    Citation: BMC Infectious Diseases 2019 19:123

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  16. Content type: Research article

    More than 50% of the people are infected worldwide with H. pylori which causes significant public health morbidity and mortality. The distribution is quite different from country to country. Hence, early informat...

    Authors: Gemechu Shiferaw and Dessie Abera

    Citation: BMC Infectious Diseases 2019 19:118

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  17. Content type: Research article

    For definitive diagnosis of cryptococcal meningitis, Cryptococcus neoformans and/or C. gattii must be identified within cerebral spinal fluid from the patients. The traditional methods for detecting Cryptococcus ...

    Authors: Qinglin Ma, Jilong Yao, Shixin Yuan, Houming Liu, Ning Wei, Jianming Zhang and Wanshui Shan

    Citation: BMC Infectious Diseases 2019 19:108

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  18. Content type: Case report

    Infective endocarditis (IE) is defined as endocarditis caused by microorganisms (bacteria or fungi) involving either the heart or great vessels. The clinical course of IE can be complicated by cardiac dysfunct...

    Authors: Nao Ogura, Kouki Tomari, Tomotada Takayama, Naoya Tonegawa, Teppei Okawa, Takashi Matsuoka, Mami Nakayashiro and Tsutomu Matsumora

    Citation: BMC Infectious Diseases 2019 19:102

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  19. Content type: Research article

    War-wounded civilians in Middle East countries are at risk of post-traumatic osteomyelitis (PTO). We aimed to describe and compare the bacterial etiology and proportion of first-line antibiotics resistant bact...

    Authors: Fabien Fily, Jean-Baptiste Ronat, Nada Malou, Rupa Kanapathipillai, Caroline Seguin, Nagham Hussein, Rasheed M. Fakhri and Céline Langendorf

    Citation: BMC Infectious Diseases 2019 19:103

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  20. Content type: Research article

    The human respiratory tract represents the major portal of entry for numerous microorganisms, primarily those occurring as airborne particles such as viral and bacterial entities, or fungal spores. Microorgani...

    Authors: Giovanna Elisiana Carpagnano, Antonia Susca, Giulia Scioscia, Donato Lacedonia, Grazia Cotugno, Piera Soccio, Sonia Santamaria, Onofrio Resta, Giuseppe Logrieco and Maria Pia Foschino Barbaro

    Citation: BMC Infectious Diseases 2019 19:78

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  21. Content type: Research article

    Cholera has been endemic in Ghana since its detection in 1970. It has been shown that long-term survival of the bacteria may be attained in aquatic environments. Consequently, cholera outbreaks may be triggere...

    Authors: David Abana, Elizabeth Gyamfi, Magdalene Dogbe, Grace Opoku, David Opare, Gifty Boateng and Lydia Mosi

    Citation: BMC Infectious Diseases 2019 19:76

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  22. Content type: Case report

    Periodontal disease, including periodontitis, has been reported to be a rare cause of septic pulmonary embolism (SPE). It is however extremely difficult to isolate the causative pathogen of periodontal disease...

    Authors: Tsuyoshi Watanabe, Masamichi Yokoe and Yoshinori Noguchi

    Citation: BMC Infectious Diseases 2019 19:74

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  23. Content type: Research article

    Staphylococcus aureus is a common bacterium found in the nose and throat of healthy individuals, and presents risk factors for infection and death. We investigated environmental contamination of fitness facilitie...

    Authors: Mark Dalman, Sabana Bhatta, Nagashreyaa Nagajothi, Dipendra Thapaliya, Hailee Olson, Haji Mohammad Naimi and Tara C. Smith

    Citation: BMC Infectious Diseases 2019 19:69

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  24. Content type: Case report

    Pneumocystis pneumonia (PCP) is a common opportunistic infection caused by Pneumocystis jirovecii. Its incidence at 2 years or more after liver transplant (LT) is < 0.1%. PCP-related spontaneous pneumothorax and/...

    Authors: Wong Hoi She, Kenneth S. H. Chok, Iris W. S. Li, Ka Wing Ma, Sui Ling Sin, Wing Chiu Dai, James Y. Y. Fung and Chung Mau Lo

    Citation: BMC Infectious Diseases 2019 19:66

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  25. Content type: Research article

    Excess water in all its forms (moisture, dampness, hidden water) in buildings negatively impacts occupant health but is hard to reliably detect and quantify. Recent advances in through-wall imaging recommend m...

    Authors: Andrew Horsley and David S. Thaler

    Citation: BMC Infectious Diseases 2019 19:67

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  26. Content type: Technical advance

    Rapid and accurate pathogen identification in blood cultures is very important for septic patients and has major consequences on morbidity and mortality rates. In recent years, matrix-assisted laser desorption...

    Authors: Maya Azrad, Yoram Keness, Orna Nitzan, Nina Pastukh, Linda Tkhawkho, Victoria Freidus and Avi Peretz

    Citation: BMC Infectious Diseases 2019 19:72

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  27. Content type: Research article

    Antifungal resistance rates are increasing. We investigated the mechanisms of azole resistance of Candida spp. bloodstream isolates obtained from a surveillance study conducted between 2012 and 2015.

    Authors: Jocelyn Qi-Min Teo, Shannon Jing-Yi Lee, Ai-Ling Tan, Robyn Su-May Lim, Yiying Cai, Tze-Peng Lim and Andrea Lay-Hoon Kwa

    Citation: BMC Infectious Diseases 2019 19:63

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  28. Content type: Research article

    Extracellular hydrolases (phospholipase, aspartyl protease and haemolysin) and biofilm production are considered as major virulence factors of the opportunistic pathogenic fungus Candida albicans. However, the im...

    Authors: Houdaii H. El-Houssaini, Omnia M. Elnabawy, Hebatallah A. Nasser and Walid F. Elkhatib

    Citation: BMC Infectious Diseases 2019 19:54

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  29. Content type: Research article

    Clostridium difficile infection (CDI) is an important cause of diarrhea and continues to be a major burden within healthcare institutions and in the community. For a small subset of patients with frequently relap...

    Authors: Kevin Zhang, Patricia Beckett, Salaheddin Abouanaser, Vida Stankus, Christine Lee and Marek Smieja

    Citation: BMC Infectious Diseases 2019 19:51

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  30. Content type: Research article

    Biofilm production by Haemophilus influenzae and Streptococcus pneumoniae has been implicated in the pathogenesis of otitis media, mainly in chronic and recurrent cases. We studied the in vitro biofilm producti...

    Authors: Quentin Vermee, Robert Cohen, Constantin Hays, Emmanuelle Varon, Stephane Bonacorsi, Stephane Bechet, Franck Thollot, François Corrard, Claire Poyart, Corinne Levy and Josette Raymond

    Citation: BMC Infectious Diseases 2019 19:44

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  31. Content type: Research article

    Urinary tract infection (UTIs) is a significant health problem in diabetic patients because of the multiple effects of this disease on the urinary tract and host immune system. Complicated UTIs occur most comm...

    Authors: Hiwot Ketema Woldemariam, Dereje Assefa Geleta, Kassu Desta Tulu, Negga Asamene Aber, Melese Hailu Legese, Genet Molla Fenta and Ibrahim Ali

    Citation: BMC Infectious Diseases 2019 19:43

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  32. Content type: Research article

    Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection has recently become a challenging problem worldwide and in Japan. We experienced 10 pediatric patients infected with CA-MRSA an...

    Authors: Yuki Uehara, Takashi Sasaki, Tadashi Baba, Yujie Lu, Eri Imajo, Yuka Sato, Shigeru Tanno, Munehiro Furuichi, Miki Kawada and Keiichi Hiramatsu

    Citation: BMC Infectious Diseases 2019 19:35

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  33. Content type: Research article

    During 2015–2016 an outbreak of invasive meningococcal disease due to N. meningitidis serogroup C ST-11 (cc11) occurred in Tuscany, Italy. The outbreak affected mainly the age group 20–30 years, men who have sex ...

    Authors: Alessandro Miglietta, Francesco Innocenti, Patrizio Pezzotti, Eleonora Riccobono, Maria Moriondo, Patrizia Pecile, Francesco Nieddu, Gian Maria Rossolini, Chiara Azzari, Emanuela Balocchini, Giovanni Rezza, Fabio Voller and Paola Stefanelli

    Citation: BMC Infectious Diseases 2019 19:29

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  34. Content type: Research article

    Almost half the world’s population is infected with Helicobacter pylori (H. pylori) with the highest reported prevalence from Africa. This infection is associated with several morbid gastrointestinal conditions. ...

    Authors: Jeannine A. Aminde, Guisilla A. Dedino, Calypse A. Ngwasiri, Kingsley S. Ombaku, Cedric A. Mahop Makon and Leopold Ndemnge Aminde

    Citation: BMC Infectious Diseases 2019 19:30

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  35. Content type: Research article

    Guidelines recommend macrolides and fluoroquinolones in patients hospitalized with community-acquired pneumonia (CAP), but their use has been associated with cardiac events. We quantified associations between ...

    Authors: Douwe F. Postma, Cristian Spitoni, Cornelis H. van Werkhoven, Leontine J. R. van Elden, Jan Jelrik Oosterheert and Marc J. M. Bonten

    Citation: BMC Infectious Diseases 2019 19:17

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  36. Content type: Research article

    The aim of the present study was to gain national data on the clinical and microbiological characteristics of community-acquired infections in the Faroe Islands and to compare these data with data from other g...

    Authors: Marija Todorovic Markovic, Court Pedersen, Magnús Gottfredsson, Mirjana Todorovic Mitic and Shahin Gaini

    Citation: BMC Infectious Diseases 2019 19:16

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  37. Content type: Case report

    Thus far, studies on Klebsiella pneumoniae carbapenemase (KPC)-producing organisms have only been reported in those with a history of foreign travel, and a specific Japanese KPC-producing isolate has not yet been...

    Authors: Yusuke Ainoda, Kotaro Aoki, Yoshikazu Ishii, Kentaro Okuda, Hitomi Furukawa, Ryo Manabe, Toshinori Sahara, Fukumi Nakamura-Uchiyama, Hitomi Kurosu, Yukiko Ando, Maki Fujisawa, Hitomi Hoshino, Hideki Arima and Kenji Ohnishi

    Citation: BMC Infectious Diseases 2019 19:20

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  38. Content type: Research article

    On 18th May 2017, State Ministry of Health of former Warrap State received a report from Tonj East County of an outbreak of acute watery diarrhoea and vomiting in Makuac payam. We conducted this investigation ...

    Authors: Fred Nsubuga, Stephen Chol Garang, Mathew Tut, David Oguttu, Robert Lubajo, Dennis Lodiongo, Michael Lasuba and Allan Mpairwe

    Citation: BMC Infectious Diseases 2019 19:4

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  39. Content type: Research article

    For a long time, the Christie-Atkinson-Munch-Peterson (CAMP) test has been a standard test for the identification of Streptococcus agalactiae, and a positive result for S.agalactiae has been considered sensitive ...

    Authors: Dacheng Guo, Yu Xi, Shanmei Wang and Zeyu Wang

    Citation: BMC Infectious Diseases 2019 19:7

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  40. Content type: Case report

    Spotted fever group of rickettsial infections are emerging in Sri Lanka. We describe a patient with rapidly progressing ARDS and myocarditis secondary to spotted fever caused by Rickettsia conorii. ARDS and myoca...

    Authors: H. M. L. Y. Herath, J. M. H. D. Jayasundara, S. D. N. Senadhira, S. A. M. Kularatne and W. K. S. Kularatne

    Citation: BMC Infectious Diseases 2018 18:705

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  41. Content type: Research article

    An explosive outbreak of Legionnaires’ disease (LD) was identified on 11 December 2015 in Manzanares, Ciudad Real, Spain, and was declared closed by 03 February 2016. The number of declared cases was 593 with ...

    Authors: Fernando Cebrián, Juan C. Montero and Pedro J. Fernández

    Citation: BMC Infectious Diseases 2018 18:696

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