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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Case report

    Idiopathic CD4 lymphocytopenia (ICL) is a rare clinical disease with relative CD4 deficiency in the absence of HIV infection. The pathogenicity of ICL is poorly understood with an unclear incidence rate in the...

    Authors: Christina S. Thornton, Oscar Larios, Jennifer Grossman, Thomas P. Griener and Steven Vaughan

    Citation: BMC Infectious Diseases 2019 19:862

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  2. Content type: Research article

    Exposure to blacklegged ticks Ixodes scapularis that transmit pathogens is thought to occur peri-domestically. However, the locations where people most frequently encounter infected ticks are not well characteriz...

    Authors: Ilya R. Fischhoff, Sarah E. Bowden, Felicia Keesing and Richard S. Ostfeld

    Citation: BMC Infectious Diseases 2019 19:861

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  3. Content type: Research article

    Enhanced surveillance for confirmed cases of invasive meningococcal disease (IMD) was introduced in the Netherlands in 2003, in which reference laboratory data (NRLBM) are linked with notification data (OSIRIS...

    Authors: Diederik A. H. Brandwagt, Arie van der Ende, Wilhelmina L. M. Ruijs, Hester E. de Melker and Mirjam J. Knol

    Citation: BMC Infectious Diseases 2019 19:860

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  4. Content type: Research article

    Between January 2015 and July 2017, we investigated the frequency of carbapenem resistant Acinetobacter baumannii (CRAB) and carbapenem resistant Pseudomonas aeruginosa (CRPA) at the Mulago Hospital intensive car...

    Authors: Dickson Aruhomukama, Christine F. Najjuka, Henry Kajumbula, Moses Okee, Gerald Mboowa, Ivan Sserwadda, Richard Mayanja, Moses L. Joloba and David P. Kateete

    Citation: BMC Infectious Diseases 2019 19:853

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  5. Content type: Research article

    To determine, from October 2010 to October 2018, the epidemiology of Deep Neck Infections (DNIs), regarding the detection, the identification and the susceptibility to antimicrobials of causative microorganism...

    Authors: Despoina Beka, Vasileios A. Lachanas, Stergios Doumas, Stelios Xytsas, Anastasios Kanatas, Efi Petinaki and Charalampos Skoulakis

    Citation: BMC Infectious Diseases 2019 19:850

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  6. Content type: Research article

    Salmonella outbreaks in childcare facilities are relatively rare, most often occurring secondary to contaminated food products or poor infection control practices. We report an outbreak of Salmonella Saintpaul at...

    Authors: Rachel M. Thomson, Hazel J. Henderson and Alison Smith-Palmer

    Citation: BMC Infectious Diseases 2019 19:847

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  7. Content type: Case report

    Cryptococcal meningitis is most commonly found in HIV-infected patients. In HIV-negative patients, its low incidence can lead to prolonged time to diagnosis. Detailed case reports of chronic cryptococcal menin...

    Authors: Alex Wagemakers, Cornelis Willem Ang, Ferry Hagen, Joost Cornelis Johannes Bot, Marije Kristianne Bomers, Marieke Christine Visser and Karin van Dijk

    Citation: BMC Infectious Diseases 2019 19:846

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  8. Content type: Research article

    The purposes of this study were to determine the incidence of central and peripheral venous catheter-related bacteraemias, the relationship between the suspected and final confirmed bacteraemia origins, and th...

    Authors: Jose Manuel Ruiz-Giardin, Iciar Ochoa Chamorro, Laura Velázquez Ríos, Jeronimo Jaqueti Aroca, Maria Isabel García Arata, Juan Víctor SanMartín López and Marta Guerrero Santillán

    Citation: BMC Infectious Diseases 2019 19:841

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  9. Content type: Case report

    Moraxella nonliquefaciens is a usually non-pathogenic biofilm-producing Gram-negative coccobacillus which may colonize the upper respiratory tract, rarely causing invasive disease. Although very rare, bloodstream...

    Authors: Carlos L. Correa-Martínez, Kerstin K. Rauwolf, Franziska Schuler, Miriam Füller, Stefanie Kampmeier and Andreas H. Groll

    Citation: BMC Infectious Diseases 2019 19:836

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  10. Content type: Research article

    Increasing number of hospitalized children with community acquired pneumonia (CAP) is co-detected with Mycoplasma pneumoniae (Mp). The clinical characteristics and impact of Mp co-detected with other bacterial an...

    Authors: Meng-chuan Zhao, Le Wang, Fang-zhou Qiu, Li Zhao, Wei-wei Guo, Shuo Yang, Zhi-shan Feng and Gui-xia Li

    Citation: BMC Infectious Diseases 2019 19:835

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  11. Content type: Research article

    Persistent symptoms attributed to Lyme borreliosis often include self-reported cognitive impairment. However, it remains unclear whether these symptoms can be substantiated by objective cognitive testing.

    Authors: Anneleen Berende, Joost Agelink van Rentergem, Andrea W. M. Evers, Hadewych J. M. ter Hofstede, Fidel J. Vos, Bart Jan Kullberg and Roy P. C. Kessels

    Citation: BMC Infectious Diseases 2019 19:833

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  12. Content type: Research article

    Whether past history of solid stage I/II inactive cancer has an impact on 28-day mortality of sepsis remains unclear. We aimed to determine the impact of history of stage I or II solid tumor malignancy in comp...

    Authors: George Dimοpoulos, Nikoletta Rovina, Maria Patrani, Eleni Antoniadou, Dimitrios Konstantonis, Konstantina Vryza, Glykeria Vlachogianni, Miltiades Kyprianou, Christina Routsi and Evangelos J. Giamarellos-Bourboulis

    Citation: BMC Infectious Diseases 2019 19:831

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  13. Content type: Research article

    Many gaps in the burden of resistant pathogens exist in endemic areas of low- and middle-income economies, especially those endemic for carbapenem resistance. The aim of this study is to evaluate risk factors ...

    Authors: Astrid V. Cienfuegos-Gallet, Ana M. Ocampo de Los Ríos, Patricia Sierra Viana, Faiver Ramirez Brinez, Carlos Restrepo Castro, Gustavo Roncancio Villamil, Helena del Corral Londoño and J. Natalia Jiménez

    Citation: BMC Infectious Diseases 2019 19:830

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  14. Content type: Research article

    To reduce acquisition and relapse of bacterial vaginosis (BV), lactobacilli must be maintained in the vaginal microbiome. Probiotic lactobacilli may aid this purpose. We investigated whether vaginal probiotics...

    Authors: Harold Marcotte, Per Göran Larsson, Kasper Krogh Andersen, Fanglei Zuo, Lasse Sommer Mikkelsen, Erik Brandsborg, Glenda Gray, Fatima Laher and Kennedy Otwombe

    Citation: BMC Infectious Diseases 2019 19:824

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  15. Content type: Research article

    The purpose of this study was to gather temporal trends on bacteria epidemiology and resistance of intraoperative bone culture from chronic ostemyelitis at an affiliated hospital in South China.

    Authors: Xianghong Zhang, Qiong Lu, Tang Liu, Zhihong Li and Weiliang Cai

    Citation: BMC Infectious Diseases 2019 19:823

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  16. Content type: Case report

    Cellulosimicrobium species, formely known as Oerskovia species, are gram-positive bacilli belonging to the order Actinomycetales. They rarely cause human infections. The genus comprises two pathogenic species in ...

    Authors: María Rivero, Javier Alonso, María Fernanda Ramón, Nancy Gonzales, Ana Pozo, Itxaso Marín, Ana Navascués and Regina Juanbeltz

    Citation: BMC Infectious Diseases 2019 19:816

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  17. Content type: Research article

    Invasive group B Streptococcus (GBS) disease in Chinese infants has gradually gained attention in recent years, but the molecular epidemiology of the pathogen is still not well known.

    Authors: Juan Li, Wenjing Ji, Kankan Gao, Haijian Zhou, Lihua Zhang, Xiaoping Mu, Chunlei Yuan, Xiaoshan Guan, Qiulian Deng, Lian Zhang, Huamin Zhong, Xiurong Gao, Fei Gao, Yan Long, Chien-Yi Chang, David J. McIver…

    Citation: BMC Infectious Diseases 2019 19:812

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  18. Content type: Research article

    Globally, diarrhea is the leading cause of morbidity and mortality among less than 5 years old children and it contributes to the deaths of approximately one million children every year. In Ethiopia, diarrhea ...

    Authors: Getachew Yismaw Workie, Temesgen Yihunie Akalu and Adhanom Gebreegziabher Baraki

    Citation: BMC Infectious Diseases 2019 19:804

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  19. Content type: Research article

    In Nepal, cases of Cholera occur annually either as sporadic or as outbreaks claiming the lives of many in rural areas. The present study is a laboratory based surveillance which aims to analyze the changing e...

    Authors: Nisha Rijal, Jyoti Acharya, Shailaja Adhikari, Bishnu Psd Upadhaya, Geeta Shakya, Palpasa Kansakar and Piyush Rajbhandari

    Citation: BMC Infectious Diseases 2019 19:801

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  20. Content type: Case report

    The number of new rickettsial species are rapidly increasing, and increasing numbers of Rickettsia raoultii (R. raoultii) infection cases have been detected in humans. However, neurological abnormalities caused b...

    Authors: Zhihui Dong, Yicheng Yang, Qian Wang, Songsong Xie, Shanshan Zhao, Wenbo Tan, Wumei Yuan and Yuanzhi Wang

    Citation: BMC Infectious Diseases 2019 19:796

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  21. Content type: Research article

    Bacteria of the Achromobacter genus, more particularly xylosoxidans species, are responsible for various healthcare associated infections (HAI) which are increasingly described since the last decade. Cystic fibro...

    Authors: Karine Marion-Sanchez, Karine Pailla, Claude Olive, Xavier Le Coutour and Christian Derancourt

    Citation: BMC Infectious Diseases 2019 19:795

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  22. Content type: Research article

    Infections by Streptococcus gallolyticus subsp. pasteurianus (SGSP) is often underestimated. Herein, the epidemiological features and resistant characteristics of SGSP in mainland China are characterized to enabl...

    Authors: Yi Li, Xingchun Chen, Zhijun Zhang, Lijun Wang, Junrui Wang, Ji Zeng, Junwen Yang and Binghuai Lu

    Citation: BMC Infectious Diseases 2019 19:791

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  23. Content type: Research article

    Genetic variant is one of the causes of sepsis patients’ mortality. Now, many studies have identified several SNPs related to sepsis. However, none of these studies were identified in a genome-wide way. We aim...

    Authors: Huijuan Wang, Zhaohui Tong, Jia Li, Kun Xiao, Feifei Ren and Lixin Xie

    Citation: BMC Infectious Diseases 2019 19:781

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  24. Content type: Study protocol

    Sepsis is still a common critical disease with high morbidity and mortality in intensive care unit. Despite published guidelines for sepsis, development of antibiotic therapy and advanced organ support technol...

    Authors: Zhigang Zhou, Tienan Feng, Yun Xie, Peijie Huang, Hui Xie, Rui Tian, Biyun Qian and Ruilan Wang

    Citation: BMC Infectious Diseases 2019 19:780

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  25. Content type: Case report

    Splenic abscess usually arises from hematogenous spread. Causative pathogens are various and anaerobic pathogens are rarely reported.

    Authors: Jeremy Meyer, Arnaud Dupuis, Benedikt D. Huttner, Matthieu Tihy and Léo Bühler

    Citation: BMC Infectious Diseases 2019 19:777

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  26. Content type: Research article

    Carbapenem-resistant Enterobacteriaceae (CRE) represent an important global threat. The aim of this study is to describe the clinical course and outcomes of patients with CRE infections treated with ceftazidime-a...

    Authors: Basem M. Alraddadi, Mohammed Saeedi, Mohammed Qutub, Abeer Alshukairi, Ashraf Hassanien and Ghassan Wali

    Citation: BMC Infectious Diseases 2019 19:772

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  27. Content type: Research article

    Health-workers in developing countries rely on clinical algorithms, such as the Integrated Management of Childhood Illnesses (IMCI), for the management of patients, including diagnosis of serious bacterial inf...

    Authors: Kristina Keitel, Mary Kilowoko, Esther Kyungu, Blaise Genton and Valérie D’Acremont

    Citation: BMC Infectious Diseases 2019 19:769

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  28. Content type: Research article

    Bacterial ophthalmic infections are common. Empirical treatment with topical broad-spectrum antibiotics is recommended for severe cases. Antimicrobial resistance (AMR) to agents used for bacterial ophthalmic i...

    Authors: Alice E. Lee, Kanchana Niruttan, Timothy M. Rawson and Luke S. P. Moore

    Citation: BMC Infectious Diseases 2019 19:768

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  29. Content type: Case report

    Actinomycetes can rarely cause intracranial infection and may cause a variety of complications. We describe a fatal case of intracranial and intra-orbital actinomycosis of odontogenic origin with a unique present...

    Authors: G. J. Hötte, M. J. Koudstaal, R. M. Verdijk, M. J. Titulaer, J. F. H. M. Claes, E. M. Strabbing, A. van der Lugt and D. Paridaens

    Citation: BMC Infectious Diseases 2019 19:763

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  30. Content type: Research article

    Aspiration pneumonia is a serious problem among elderly patients; it is caused by many risk factors including dysphagia, poor oral hygiene, malnutrition, and sedative medications. The aim of this study was to ...

    Authors: Tomotaka Nishizawa, Yuichi Niikura, Keiichi Akasaka, Masato Watanabe, Daisuke Kurai, Masako Amano, Haruyuki Ishii, Hidekazu Matsushima, Naomi Yamashita and Hajime Takizawa

    Citation: BMC Infectious Diseases 2019 19:761

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  31. Content type: Research article

    Early diagnosis of sepsis in pediatric patients is vital but remains a major challenge. Previous studies showed that presepsin is potentially a reliable diagnostic biomarker for sepsis in adult and neonates. H...

    Authors: Seo Hee Yoon, Eun Hwa Kim, Ha Yan Kim and Jong Gyun Ahn

    Citation: BMC Infectious Diseases 2019 19:760

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  32. Content type: Research article

    Surveillance of current changes in the epidemiology of Invasive Fungal Diseases (IFDs) as an important component of the antifungal stewardship programs (ASP), requires careful regular monitoring, especially in hi...

    Authors: Seyedeh Sedigheh Hamzavi, Ali Amanati, Parisa Badiee, Mohammad Rahim Kadivar, Hadis Jafarian, Fatemeh Ghasemi, Sezaneh Haghpanah, Mansooreh Dehghani and Abbas Norouzian Baghani

    Citation: BMC Infectious Diseases 2019 19:759

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  33. Content type: Research article

    Stenotrophomonas maltophilia is an important nosocomial pathogen. This pathogen has intrinsic or acquired resistance to a number of antibiotics classes. Furthermore, Stenotrophomonas infections have been associat...

    Authors: Eun Jin Kim, Yong Chan Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom and Young Goo Song

    Citation: BMC Infectious Diseases 2019 19:754

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  34. Content type: Research article

    Antimicrobial resistance is one of the most serious public health threats of the twenty-first century. The implementation of AMR surveillance in Zimbabwe is limited. However, data from a private laboratory in ...

    Authors: Marvellous Mhondoro, Nqobile Ndlovu, Donewell Bangure, Tsitsi Juru, Notion Tafara Gombe, Gerald Shambira, Peter Nsubuga and Mufuta Tshimanga

    Citation: BMC Infectious Diseases 2019 19:746

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  35. Content type: Research article

    Due to the similar clinical, lung imaging, and pathological characteristics, talaromycosis is most commonly misdiagnosed as tuberculosis. This study aimed to identify the characteristics of talaromycosis pleur...

    Authors: Ye Qiu, Wen Zeng, Hui Zhang, Xiaoning Zhong, Shudan Tang and Jianquan Zhang

    Citation: BMC Infectious Diseases 2019 19:745

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  36. Content type: Research article

    Multidrug resistant (MDR) enterococci are important nosocomial pathogens causing serious problem in hospitalized patients. The aim of present study was to investigate the frequency of high-level aminoglycoside...

    Authors: Fakhri Haghi, Vahid Lohrasbi and Habib Zeighami

    Citation: BMC Infectious Diseases 2019 19:744

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  37. Content type: Research article

    Trends in antimicrobial resistance help inform infection control efforts. We examined trends in resistance for Enterobacteriaceae and Acinetobacter spp. from 2013 to 2017 in hospitalized US patients.

    Authors: Vikas Gupta, Gang Ye, Melanie Olesky, Kenneth Lawrence, John Murray and Kalvin Yu

    Citation: BMC Infectious Diseases 2019 19:742

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  38. Content type: Study protocol

    Lyme borreliosis (LB) is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato species. Due to a variety of clinical manifestations, diagnosing LB can be challenging, and lab...

    Authors: F. R. van de Schoor, M. E. Baarsma, S. A. Gauw, L. A. B. Joosten, B. J. Kullberg, C. C. van den Wijngaard and J. W. Hovius

    Citation: BMC Infectious Diseases 2019 19:732

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  39. Content type: Case report

    Solobacterium moorei, the only species in the genus Solobacterium, is a Gram-positive, non-spore-forming, strict anaerobic, short to long bacillus. It has rarely been documented to cause blood stream infections. ...

    Authors: Wen-Jing Liu, Meng Xiao, Jie Yi, Ying Li, Timothy Kudinha and Ying-Chun Xu

    Citation: BMC Infectious Diseases 2019 19:730

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  40. Content type: Case report

    Coccidioides spp. are dimorphic fungi endemic to Central America, regions of South America and southwestern USA. Two species cause most human disease: Coccidioides immitis (primarily California isolates) and Cocc...

    Authors: Raynell Lang, William Stokes, Jane Lemaire, Andrew Johnson and John Conly

    Citation: BMC Infectious Diseases 2019 19:722

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  41. Content type: Case report

    Clostridium perfringens can cause various infections, including food poisoning, gas gangrene, cellulitis and fasciitis. C. perfringens septicemia is rare, but is a known cause of hemolysis by damaging red blood c...

    Authors: Masahide Sakaue, Koshi Ota, Eriko Nakamura, Masahiko Nitta, Masahiro Oka, Yasuo Oishi, Yohei Sano, Shinya Yonogi and Akira Takasu

    Citation: BMC Infectious Diseases 2019 19:719

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  42. Content type: Research article

    We developed a clinical bedside tool to simultaneously estimate the probabilities of third-generation cephalosporin-resistant Enterobacteriaceae (3GC-R), carbapenem-resistant Enterobacteriaceae (CRE), and mult...

    Authors: Thomas P. Lodise, Nicole Gidaya Bonine, Jiatao Michael Ye, Henry J. Folse and Patrick Gillard

    Citation: BMC Infectious Diseases 2019 19:718

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  43. Content type: Research article

    Coagulase-negative Staphylococci (CoNS) have emerged as a major causative agent of blood-stream infections (BSI). Linezolid (LZD) is currently used for treating glycopeptide and methicillin-resistant staphyloc...

    Authors: Gajanand Mittal, Vasundhra Bhandari, Rajni Gaind, Vandana Rani, Shimpi Chopra, Reetika Dawar, Raman Sardana and P. K. Verma

    Citation: BMC Infectious Diseases 2019 19:717

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  44. Content type: Research article

    Asymptom of invasive candidiasis (IC) and low positive rate of blood culture lead to delay diagnose of neonatal infection. Serum (1,3)-β-D-glucan (BDG) performs well in adult IC, but its use in neonatal IC is ...

    Authors: Junfei Guo, Yongbing Wu, Weiming Lai, Weiming Lu and Xiaoping Mu

    Citation: BMC Infectious Diseases 2019 19:716

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  45. Content type: Research article

    Management of partially-treated, community-acquired bacterial meningitis (PCBM) is commonly compromised by lack of microbiological diagnosis. We aimed to analyze the impact of FilmArray Meningitis-Encephalitis...

    Authors: Yair Mina, Vered Schechner, Michal Savion, Dafna Yahav, Efraim Bilavsky, Nadav Sorek, Haim Ben-Zvi and Amos Adler

    Citation: BMC Infectious Diseases 2019 19:713

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  46. Content type: Research article

    Vancomycin resistant enterococci (VRE) infections are of increasing concern in many hospitalized patients. Patients with cirrhosis are at added risk of infection with VRE, with associated increased risk for co...

    Authors: Melissa Barger, Emily Blodget, Sol Pena, Wendy Mack and Tse-Ling Fong

    Citation: BMC Infectious Diseases 2019 19:711

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  47. Content type: Case report

    Pulmonary Cryptococcosis (PC) is diagnosed with increasing incidence in recent years, but it does not commonly involve the pleural space. Here, we report a HIV-negative case with advanced stage IIIB non-small ...

    Authors: Yuan Zhang, Sean X. Zhang, Julie Trivedi, Adam D. Toll, Julie Brahmer, Russell Hales, Sarah Bonerigo, Mingying Zeng, Huiping Li and Rex C. Yung

    Citation: BMC Infectious Diseases 2019 19:710

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