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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    Histoplasmosis is a fungal infection highly endemic in the American continent. The disease can be severe in immunocompromised subjects. In immunocompetent subjects the clinical manifestations are variable. Aim...

    Authors: Silvia Staffolani, Dora Buonfrate, Andrea Angheben, Federico Gobbi, Giovanni Giorli, Massimo Guerriero, Zeno Bisoffi and Francesco Barchiesi

    Citation: BMC Infectious Diseases 2018 18:673

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  2. Content type: Research article

    Empirical antibiotic coverage for atypical pathogens in community-acquired pneumonia (CAP) has long been debated, mainly because of a lack of epidemiological data. We aimed to assess both testing for atypical ...

    Authors: Andrea Gramegna, Giovanni Sotgiu, Marta Di Pasquale, Dejan Radovanovic, Silvia Terraneo, Luis F. Reyes, Ester Vendrell, Joao Neves, Francesco Menzella, Francesco Blasi, Stefano Aliberti and Marcos I. Restrepo

    Citation: BMC Infectious Diseases 2018 18:677

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  3. Content type: Research article

    The increased prevalence of carbapenem-resistant Gram-negative isolates caused by Metallo-β-lactamase (MBL) is worrisome in clinical settings worldwide. The mortality rate associated with infections caused by ...

    Authors: Mudathir Abdallah Adam and Wafa I. Elhag

    Citation: BMC Infectious Diseases 2018 18:668

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  4. Content type: Case report

    Endogenous endophthalmitis caused by hypervirulent Klebsiella pneumoniae (HVKP) is an emerging infectious disease commonly with a devastating visual outcome. Most HVKP strains display a wild-type susceptibility p...

    Authors: Min Xu, Ang Li, Haishen Kong, Weili Zhang, Hongchao Chen, Yajie Fu and Yiqi Fu

    Citation: BMC Infectious Diseases 2018 18:669

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  5. Content type: Case report

    Intra-osseous (IO) access is recommended in cases of pre-hospital emergency or resuscitation when intravascular (IV) route is difficult or impossible. Despite recent improvement in IO devices and increasing in...

    Authors: Thomas Chalopin, Adrien Lemaignen, Antoine Guillon, Arnaud Geffray, Gaelle Derot, Olivier Bahuaud, Charles Agout, Philippe Rosset, Claire Castellier, Gonzague De Pinieux, Anne-Sophie Valentin, Louis Bernard and Frederic Bastides

    Citation: BMC Infectious Diseases 2018 18:665

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  6. Content type: Research article

    Early antifungal therapy for invasive aspergillosis (IA) has been associated with improved outcome. Traditionally, of empiric antifungal therapy has been used for clinically suspected IA. We compared outcomes ...

    Authors: Rita Wilson Dib, Ray Y. Hachem, Anne-Marie Chaftari, Fady Ghaly, Ying Jiang and Issam Raad

    Citation: BMC Infectious Diseases 2018 18:656

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  7. Content type: Research article

    Bloodstream infection (BSI) is one of the major causes of morbidity and mortality for patients undergoing hematopoietic stem cell transplantation (HSCT). The unrelated cord blood transplantation (UCBT) can pro...

    Authors: Jing Ge, Tingting Yang, Lei Zhang, Xuhan Zhang, Xiaoyu Zhu, Baolin Tang, Xiang Wan, Juan Tong, Kaidi Song, Wen Yao, Guangyu Sun, Zimin Sun and Huilan Liu

    Citation: BMC Infectious Diseases 2018 18:654

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  8. Content type: Research article

    Infections of the ears, paranasal sinuses, nose and throat are very common and represent a serious issue for the healthcare system. Bacterial biofilms have been linked to upper respiratory tract infections and...

    Authors: Alessandro Bidossi, Roberta De Grandi, Marco Toscano, Marta Bottagisio, Elena De Vecchi, Matteo Gelardi and Lorenzo Drago

    Citation: BMC Infectious Diseases 2018 18:653

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  9. Content type: Case report

    Liver transplant recipients are at high risk of developing invasive aspergillosis and in particular by Aspergillus fumigatus which is the most commonly encountered species in this population. Other non-fumigatus ...

    Authors: Nawel Aït-Ammar, Eric Levesque, Jean-Benjamin Murat, Sébastien Imbert, Françoise Foulet, Eric Dannaoui and Françoise Botterel

    Citation: BMC Infectious Diseases 2018 18:648

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  10. Content type: Research article

    The 2010 Infectious Diseases Society of America (IDSA) guidelines for management of cryptococcal diseases recommend high dose fluconazole (≥ 800 mg/day), either alone or with other antifungal drugs, as alterna...

    Authors: Hua-Zhen Zhao, Rui-Ying Wang, Xuan Wang, Ying-Kui Jiang, Ling-Hong Zhou, Jia-Hui Cheng, Li-Ping Huang, Thomas Stephen Harrison and Li-Ping Zhu

    Citation: BMC Infectious Diseases 2018 18:643

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  11. Content type: Case report

    Melioidosis is a tropical disease caused by Burkholderia pseudomallei (B. pseudomallei). It can infect any organ system and lead to multiple abscesses. A few studies reported that central nervous system (CNS) is ...

    Authors: Wei-yuan Huang, Gang Wu, Feng Chen, Meng-meng Li and Jian-jun Li

    Citation: BMC Infectious Diseases 2018 18:649

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  12. Content type: Research article

    Disease caused by Bacillus anthracis is often accompanied by high mortality primarily due to toxin-mediated injury. In the early disease course, anthrax toxins are secreted; thus, antibiotic use is limited to the...

    Authors: Qi Tang, Siping Xiong, Xudong Liang, Xingwang Kuai, Yiwen Wang, Changjun Wang, Zhenqing Feng and Jin Zhu

    Citation: BMC Infectious Diseases 2018 18:640

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  13. Content type: Research article

    Osteomyelitis is a difficult-to-cure infection with a high relapse rate despite combined medical and surgical therapies. Some severity factors, duration of antimicrobial therapy and type of surgical procedure ...

    Authors: E. Garcia del Pozo, J. Collazos, J. A. Carton, D. Camporro and V. Asensi

    Citation: BMC Infectious Diseases 2018 18:635

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  14. Content type: Research article

    The aim of this study was to estimate the prevalence of pneumonia and secondary bacterial infections during the pandemic of influenza A(H1N1)pdm09.

    Authors: Chandini Raina MacIntyre, Abrar Ahmad Chughtai, Michelle Barnes, Iman Ridda, Holly Seale, Renin Toms and Anita Heywood

    Citation: BMC Infectious Diseases 2018 18:637

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  15. Content type: Study protocol

    Febrile Urinary Tract Infection (FUTI) is frequently treated initially with intravenous antibiotics, followed by oral antibiotics guided by clinical response and bacterial susceptibility patterns. Due to incre...

    Authors: Thijs ten Doesschate, Suzan P. van Mens, Cees van Nieuwkoop, Suzanne E. Geerlings, Andy I. M. Hoepelman and Marc J. M. Bonten

    Citation: BMC Infectious Diseases 2018 18:626

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  16. Content type: Research article

    Temporal relationships between the time to appropriate antibiotic therapy and outcomes are not well described.

    Authors: Thomas P. Lodise, Qi Zhao, Kyle Fahrbach, Patrick J. Gillard and Amber Martin

    Citation: BMC Infectious Diseases 2018 18:625

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  17. Content type: Research article

    Salmonella is an important human pathogen in Australia and annual case rates continue to increase. In addition to foodborne exposures, cases have been associated with animal and contaminated environment contact. ...

    Authors: Kelly M. J. Simpson, Grant A. Hill-Cawthorne, Michael P. Ward and Siobhan M. Mor

    Citation: BMC Infectious Diseases 2018 18:623

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  18. Content type: Research article

    Acute febrile illness (AFI) represent a significant health challenge in the Peruvian Amazon basin population due to their diverse etiologies and the unavailability of specific on-site diagnostic methods, resul...

    Authors: Fiorella Ricapa-Antay, Katia Diaz-Melon, Wilmer Silva-Caso, Luis J. del Valle, Miguel Angel Aguilar-Luis, Fernando Vasquez-Achaya, Carlos Palomares-Reyes, Pablo Weilg, Dongmei Li, Carlos Manrique and Juana del Valle-Mendoza

    Citation: BMC Infectious Diseases 2018 18:618

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  19. Content type: Case report

    Gastrointestinal (GI) cryptococcosis is rarely reported. Most cases were diagnosed during evaluation of comorbid conditions, incidental findings, or postmortem. Here, we present a case of Crohn’s disease with ...

    Authors: Natthakit Chavapradit and Nasikarn Angkasekwinai

    Citation: BMC Infectious Diseases 2018 18:620

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  20. Content type: Research article

    Despite the use of pneumococcal vaccines, indigenous populations are consistently disproportionately affected by invasive pneumococcal disease (IPD). With recent changes in Ontario’s provincial pneumococcal va...

    Authors: Daniel Dalcin, Lee Sieswerda, Sacha Dubois and Marina Ulanova

    Citation: BMC Infectious Diseases 2018 18:621

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  21. Content type: Research article

    Acinetobacter baumannii is a nosocomial pathogen which is reported as a major cause of morbidity and mortality in intensive care units (ICUs). However, there is a lack of analysis focused on multidrug-resistant A...

    Authors: Yili Chen, Lu Ai, Penghao Guo, Han Huang, Zhongwen Wu, Xiaoling Liang and Kang Liao

    Citation: BMC Infectious Diseases 2018 18:614

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  22. Content type: Research article

    There is no consensus on the most accurate combination of diagnostic criteria to define community acquired pneumonia (CAP). We describe inclusion criteria in randomized controlled trials (RCT) of CAP and asses...

    Authors: Clara Flateau, Josselin Le Bel, Sarah Tubiana, François-Xavier Blanc, Christophe Choquet, Blandine Rammaert, Patrick Ray, Christophe Rapp, Cécile Ficko, Catherine Leport, Yann-Erick Claessens and Xavier Duval

    Citation: BMC Infectious Diseases 2018 18:607

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  23. Content type: Research article

    Brucellosis is a neglected debilitating zoonosis with a high prevalence in many developing countries. Bovine brucellosis is widespread in Cameroon but the epidemiological situation of human brucellosis is not ...

    Authors: Julius Awah-Ndukum, Mohamed Moctar Mouliom Mouiche, Lucy Kouonmo-Ngnoyum, Houli Nicolas Bayang, Tanyi Kingsley Manchang, Rodrigue Simonet Namegni Poueme, Justin Kouamo, Victor Ngu-Ngwa, Emmanuel Assana, Kameni Jean Marc Feussom and André Pagnah Zoli

    Citation: BMC Infectious Diseases 2018 18:611

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  24. Content type: Research article

    Leptospirosis is an important zoonotic disease worldwide, caused by spirochetes bacteria of the genus Leptospira. In Thailand, cattle and buffalo used in agriculture are in close contact with human beings. During...

    Authors: Sudarat Chadsuthi, Karine Chalvet-Monfray, Anuwat Wiratsudakul, Duangjai Suwancharoen and Julien Cappelle

    Citation: BMC Infectious Diseases 2018 18:602

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  25. Content type: Case report

    American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infect...

    Authors: C. Nabet, C. Belzunce, D. Blanchet, P. Abboud, F. Djossou, B. Carme, C. Aznar and M. Demar

    Citation: BMC Infectious Diseases 2018 18:595

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  26. Content type: Research article

    Several different IgA-proteases exist in Haemophilus influenzae. The variants have been suggested to play differential roles in pathogenesis, but there is limited information on their distribution in clinical iso...

    Authors: Fredrik Resman, Guillaume Manat, Victor Lindh, Timothy F. Murphy and Kristian Riesbeck

    Citation: BMC Infectious Diseases 2018 18:592

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  27. Content type: Research article

    In recent years, there has been a significant increase in the incidence of fungal infections attributed to Candida species worldwide, with a major shift toward non-albicans Candida (NAC). In this study, we have d...

    Authors: Lyn Awad, Hani Tamim, Dania Abdallah, Mohammad Salameh, Anas Mugharbil, Tamima Jisr, Kamal Zahran, Nabila Droubi, Ahmad Ibrahim and Rima Moghnieh

    Citation: BMC Infectious Diseases 2018 18:589

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  28. Content type: Research article

    The aim was to evaluate the value of organ-specific weighted incidence antibiogram (OSWIA) percentages for bacterial susceptibilities of Gram-negative bacteria (GNB) collected from intra-abdominal infections (...

    Authors: Lianxin Liu and Yuxing Ni

    Citation: BMC Infectious Diseases 2018 18:584

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  29. Content type: Research article

    Leptospirosis is a zoonotic disease associated with occupations which exposed workers to environments contaminated with urine of infected animals. The objective of this study was to determine the seroprevalenc...

    Authors: Mas Harithulfadhli Agus Ab Rahman, Suhaily Mohd Hairon, Rukman Awang Hamat, Tengku Zetty Maztura Tengku Jamaluddin, Mohd Nazri Shafei, Norazlin Idris, Malina Osman, Surianti Sukeri, Zainudin A. Wahab, Wan Mohd Zahiruddin Wan Mohammad, Zawaha Idris and Aziah Daud

    Citation: BMC Infectious Diseases 2018 18:569

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  30. Content type: Research article

    Methicillin resistant Staphylococcus aureus (MRSA) is recognized worldwide as a leading cause of hospital and community infections. Biofilm formation by MRSA is an extremely important virulence factor to be under...

    Authors: Ons Haddad, Abderrahmen Merghni, Aida Elargoubi, Hajer Rhim, Yosr Kadri and Maha Mastouri

    Citation: BMC Infectious Diseases 2018 18:560

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  31. Content type: Research article

    Infection after vertebroplasty (VP) is a rare but serious complication. Previous literatures showed most pathogens for infection after VP were bacteria; tuberculosis (TB) induced infection after VP was extreme...

    Authors: Jen-Chung Liao, Po-Liang Lai, Lih-Hui Chen and Chi-Chien Niu

    Citation: BMC Infectious Diseases 2018 18:555

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  32. Content type: Research article

    The prevalence and risk factors for persistent candidemia among very low birth weight infants are poorly understood. This study aimed to investigate the epidemiology of persistent candidemia over a 4-year peri...

    Authors: Jinjian Fu, Yanling Ding, Yongjiang Jiang, Shengfu Mo, Shaolin Xu and Peixu Qin

    Citation: BMC Infectious Diseases 2018 18:558

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  33. Content type: Case report

    Genetic mutations that reduce intracellular superoxide production by granulocytes causes chronic granulomatous disease (CGD). These patients suffer from frequent and severe bacterial and fungal infections thro...

    Authors: Esmaeil Mortaz, Somayeh Sarhifynia, Majid Marjani, Afshin Moniri, Davood Mansouri, Payam Mehrian, Karin van Leeuwen, Dirk Roos, Johan Garssen, Ian M. Adcock and Payam Tabarsi

    Citation: BMC Infectious Diseases 2018 18:552

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  34. Content type: Case report

    The Leuconostoc mesenteroides are members of the Streptococcae family and currently has been recognized as potential pathogens. This case describes a bacteremia caused by L. mesenteroides in an immunocompetent pa...

    Authors: Mayra Gonçalves Menegueti, Gilberto Gambero Gaspar, Ana Maria Laus, Anibal Basile-Filho, Fernando Bellissimo-Rodrigues and Maria Auxiliadora-Martins

    Citation: BMC Infectious Diseases 2018 18:547

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  35. Content type: Research article

    Classification of pathogenic Escherichia coli (E. coli) has traditionally relied on detecting specific virulence associated genes (VAGs) or combinations thereof. For E. coli isolated from faecal samples, the pres...

    Authors: Bjørn-Arne Lindstedt, Misti D. Finton, Davide Porcellato and Lin T. Brandal

    Citation: BMC Infectious Diseases 2018 18:544

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  36. Content type: Research article

    Community acquired bloodstream infection (CABSI) in low- and middle income countries is associated with a high mortality. This study describes the clinical manifestations, laboratory findings and correlation o...

    Authors: Vu Quoc Dat, Nguyen Thanh Long, Vu Ngoc Hieu, Nguyen Dinh Hong Phuc, Nguyen Van Kinh, Nguyen Vu Trung, H. Rogier van Doorn, Ana Bonell and Behzad Nadjm

    Citation: BMC Infectious Diseases 2018 18:535

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  37. Content type: Research article

    Injection drug use (IDU) is a growing public health threat in Virginia, though there is limited knowledge of related morbidity. The purpose of this study was to describe the temporal, geographic and clinical t...

    Authors: Megan E. Gray, Elizabeth T. Rogawski McQuade, W. Michael Scheld and Rebecca A. Dillingham

    Citation: BMC Infectious Diseases 2018 18:532

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  38. Content type: Case report

    Gemella bergeri is one of the nine species of the genus Gemella and is relatively difficult to identify. We herein describe the first case of septic shock due to a Gemella bergeri coinfection with Eikenella corro...

    Authors: Toshinobu Yamagishi, Mayu Hikone, Kazuhiro Sugiyama, Takahiro Tanabe, Yasuhiro Wada, Michiko Furugaito, Yuko Arai, Yutaka Uzawa, Ryo Mizushima, Keisuke Kamada, Yasutomo Itakura, Shigekazu Iguchi, Atsushi Yoshida, Ken Kikuchi and Yuichi Hamabe

    Citation: BMC Infectious Diseases 2018 18:523

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  39. Content type: Case report

    Aerococcus urinae is a gram-positive, alpha-hemolytic coccus bacterium primarily implicated in less than 1 % of all symptomatic urinary tract infections. Risk factors for disease include male gender, advanced age...

    Authors: Joseph M. Yabes, Serafim Perdikis, David B. Graham and Ana Markelz

    Citation: BMC Infectious Diseases 2018 18:522

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  40. Content type: Research article

    We aimed to identify the main spreading clones, describe the resistance mechanisms associated with carbapenem- and/or multidrug-resistant P. aeruginosa and characterize patients at risk of acquiring these strains...

    Authors: Kaidi Telling, Mailis Laht, Age Brauer, Maido Remm, Veljo Kisand, Matti Maimets, Tanel Tenson and Irja Lutsar

    Citation: BMC Infectious Diseases 2018 18:513

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  41. Content type: Research article

    Antistaphylococcal penicillins (ASPs) and cefazolin have become the most frequent choices for the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) infections. However, the best therapeutic agent ...

    Authors: Changcheng Shi, Yubo Xiao, Qi Zhang, Qingyu Li, Fei Wang, Jing Wu and Nengming Lin

    Citation: BMC Infectious Diseases 2018 18:508

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  42. Content type: Research article

    Identification of factors associated with antifungal utilization in neonatal, pediatric, and adult patient groups is needed to guide antifungal stewardship initiatives in academic medical centers.

    Authors: Jeremy S. Stultz, Rose Kohinke and Amy L. Pakyz

    Citation: BMC Infectious Diseases 2018 18:501

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  43. Content type: Research article

    Staphylococcus aureus bacteraemia is a common and significant infection, associated with high rates of mortality. Therefore, early identification is important for the initiation of appropriate treatment. The obje...

    Authors: Yoshiro Hadano, Miwako Isoda, Kazushige Ishibashi and Tatsuyuki Kakuma

    Citation: BMC Infectious Diseases 2018 18:490

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  44. Content type: Research article

    To evaluate the susceptibility rates of aerobic and facultative Gram-negative bacterial isolates from Chinese intra-abdominal infections (IAI) and urinary tract infections (UTI) focusing on carbapenems and com...

    Authors: Hui Zhang, Haishen Kong, Yunsong Yu, Anhua Wu, Qiong Duan, Xiaofeng Jiang, Shufang Zhang, Ziyong Sun, Yuxing Ni, Weiping Wang, Yong Wang, Kang Liao, Huayin Li, Chunxia Yang, Wenxiang Huang, Bingdong Gui…

    Citation: BMC Infectious Diseases 2018 18:493

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