Table 3 Comparison of safety evaluation between polymyxin B and colistin sulfate groups
Polymyxin B (N = 68) | Colistin sulfate (N = 36) | P.value | |
|---|---|---|---|
Hepatotoxicity | |||
Total bilirubin increased | 2 (3.9%),n = 51 | 2 (6.1%),n = 33 | 0.644 |
Alanine aminotransferase increased | 5 (10.0%),n = 50 | 4 (13.3%),n = 30 | 0.722 |
Aspartate aminotransferase increased | 5 (10.9%),n = 46 | 9 (28.1%),n = 32 | 0.051 |
Nephrotoxicity | |||
Abnormal serum creatinine | 6 (14.6%),n = 41 | 3 (15.0%),n = 20 | 1.000 |
Hematotoxicity | |||
Platelet decline | 10 (21.2%),n = 47 | 4 (13.3%),n = 30 | 0.378 |