Table 2 Agreement of individual and pooled tests
MTB/RIF | ULTRA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lao PDR | Nigeria | Overall | Lao PDR | Nigeria | Brazil | Overall | ||||||
Pooled n = 210 | Pooled n = 125 | Pooled n = 210 | Pooled n = 125 | Pooled n = 99 | ||||||||
Individual | Neg | Pos | Neg | Pos | Neg | Pos | Neg | Pos | Neg | Pos | ||
All four negative | 129 | 0 | 71 | 4 | - | 140 | 0 | 82 | 7 | 34 | 1 | - |
At least one positive | 4 | 77 | 4 | 46 | - | 0 | 70 | 1 | 35 | 3 | 61 | - |
Agreement | 206/210 (98.1%) | 117/125 (93.6%) | 323/335 (96.4%) | 210/210 (100%) | 117/125 (93.6%) | 95/99 (96.0%) | 422/434 (97.2%) | |||||
Kappa | 0.959 | 0.867 | - | 1.000 | 0.851 | 0.913 | - | |||||
Sensitivity (95% CI) | 95.1% (87.8–98.6%) | 92.0% (80.8–97.8%) | 93.9% (87.9–97.1%) | 100% (94.9-100%) | 85.7% (71.5–94.6%) | 95.3% (86.9-99.0%) | 97.6% (93.7-99.2%) | |||||
Specificity (95% CI) | 100% (97.2–100%) | 94.7% (86.9–98.5%) | 98% (94.7–99.4%) | 100% (97.4–100%) | 98.8% (93.5-99.8%) | 97.1% (85.1-99.9%) | 97% (93.9-98.6%) | |||||