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Table 6 Unadjusted and adjusted Hazard Ratios for all-cause mortality in partner participants

From: Causes and risk factors of death among people who inject drugs in Indonesia, Ukraine and Vietnam: findings from HPTN 074 randomized trial

 

Unadjusted Cox Model

Adjusted Cox Model1

Multivariable Cox Model2

HR

95% CI3

p-value4

aHR

95% CI3

p-value4

aHR

95% CI3

p-value4

Age

1.04

0.97, 1.11

0.264

1.04

0.97, 1.12

0.211

1.04

0.97, 1.11

0.230

Gender

  

0.801

  

0.409

  

0.522

 Female

REF

  

REF

  

REF

 

 Male

1.20

0.34, 7.58

 

1.80

0.50,11.49

 

1.58

0.44,10.13

Study site

  

0.173

  

0.130

  

0.061

 Indonesia

REF

  

REF

  

REF

 

 Ukraine

1.78

0.57, 7.81

 

1.57

0.49, 7.02

 

2.02

0.63, 8.97

 Vietnam

0.66

0.15, 3.35

 

0.52

0.11, 2.70

 

0.56

0.12, 2.90

Study arm

  

0.026

  

0.023

  

0.029

 SOC

REF

  

REF

  

REF

  

 Intervention

0.17

0.01, 0.84

 

0.17

0.01, 0.82

 

0.18

0.01, 0.86

 

Alcohol use in the past 3 months

  

0.225

  

0.393

   

 Non Hazardous alcohol use

REF

  

REF

     

 Hazardous alcohol use

1.76

0.70, 4.36

 

1.51

0.58, 3.94

    

Injecting opioids in the past 3 months5

  

0.071

  

0.103

   

 No

REF

  

REF

     

 Yes

3.64

0.48,466.7

 

3.06

0.37,399.1

    

Injecting stimulants in the past 3 months

  

0.790

  

0.239

   

 No

REF

  

REF

     

 Yes

0.85

0.20, 2.55

 

0.48

0.11, 1.58

    

Injecting other drugs in the past 3 months

  

0.294

  

0.933

   

 No

REF

  

REF

     

 Yes

1.71

0.60, 4.34

 

0.95

0.30, 3.00

    

No injecting drug use in the past 3 months5

  

0.090

  

0.149

   

 No

REF

  

REF

     

 Yes

0.32

0.00, 2.48

 

0.41

0.00, 3.73

    

Injecting polydrug use in the past 3 months

  

0.320

  

0.635

   

 No

REF

  

REF

     

 Yes

1.60

0.62, 3.95

 

0.75

0.24, 2.61

    

 # of days of injecting drugs use in the past month

1.03

0.99, 1.08

0.134

1.03

0.98, 1.08

0.277

   

Non-injecting opioids use in the past 3 months

  

0.754

  

0.989

   

 No

REF

  

REF

     

 Yes

0.74

0.04, 3.57

 

0.99

0.05, 5.18

    

Non-injecting stimulants use in the past 3 months

  

0.700

  

0.753

   

 No

REF

  

REF

     

 Yes

0.82

0.26, 2.15

 

0.84

0.25, 2.37

    

Non-injecting other drug use in the past 3 months

  

0.857

  

0.884

   

 No

REF

  

REF

     

 Yes

1.09

0.44, 2.81

 

0.93

0.37, 2.49

    

No non-injecting drug use in the past 3 months

  

0.965

  

0.799

   

 No

REF

  

REF

     

 Yes

1.02

0.36, 2.59

 

1.14

0.39, 2.98

    

Non-injecting polydrug use in the past 3 months

  

0.822

  

0.916

   

 No

REF

  

REF

     

 Yes

0.88

0.25, 2.43

 

0.94

0.25, 2.76

    

OAT status

  

0.046

  

0.036

  

0.081

 ever used

REF

  

REF

  

REF

 

 OAT naïve

2.68

1.02, 8.32

 

2.81

1.06, 8.78

 

2.38

0.90, 7.40

  1. 1 Age, gender, site, arm was adjusted for in the Adjusted Cox Models
  2. 2 Those significant in the adjusted cox models were selected in this model with conservative cutoff point of 0.1. adjusting for age, gender, site, arm, only those with p-value < 0.1 will be left in the final model
  3. 3 Profile likelihood 95% confidence interval
  4. 4 Logrank type3 p-value
  5. 5 Firth's method with Breslow for ties was used when there was a zero event count. Elsewhere Efron's method was used for ties
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BMC Infectious Diseases

ISSN: 1471-2334

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