Table 3 The genotype and allele frequencies of TLR4/TLR9 SNPs and their associations with multiple HR-HPV infections
Gene | SNPs | Genotype/Allele | Single HR-HPV infection (n%) | Multiple HR-HPV infection (n%) | OR (95% CI) | P-Value a |
|---|---|---|---|---|---|---|
TLR4 | rs10116253 | TT | 61 (38.1) | 35 (32.1) | 1.00 | Â |
CT | 75 (46.9) | 53 (48.6) | 1.14 (0.66–1.99) | 0.635 | ||
CC | 24 (15.0) | 21 (19.3) | 1.69 (0.81–3.52) | 0.160 | ||
CT+CC | 99 (61.9) | 74 (67.9) | 1.27 (0.75–2.13) | 0.369 | ||
T | 197 (61.6) | 123 (56.4) | 1.00 | Â | ||
C | 123 (38.4) | 95 (43.6) | 1.27 (0.89–1.81) | 0.186 | ||
rs1927911 | CC | 60 (37.5) | 35 (32.1) | 1.00 | Â | |
CT | 76 (47.5) | 53 (48.6) | 1.12 (0.64–1.94) | 0.692 | ||
TT | 24 (15.0) | 21 (19.3) | 1.66 (0.80–3.45) | 0.177 | ||
CT+TT | 100 (62.5) | 74 (67.9) | 1.24 (0.74–2.08) | 0.417 | ||
C | 196 (61.3) | 123 (56.4) | 1.00 | Â | ||
T | 124 (38.7) | 95 (43.6) | 1.24 (0.87–1.77) | 0.235 | ||
rs10759931 | AA | 60 (37.5) | 36 (33.0) | 1.00 | Â | |
AG | 76 (47.5) | 53 (48.6) | 1.08 (0.62–1.88) | 0.776 | ||
GG | 24 (15.0) | 20 (18.4) | 1.54 (0.74–3.21) | 0.252 | ||
AG+GG | 100 (62.5) | 73 (67.0) | 1.19 (0.71–1.99) | 0.518 | ||
A | 196 (61.3) | 125 (57.3) | 1.00 | Â | ||
G | 124 (38.7) | 93 (42.7) | 1.16 (0.815–1.66) | 0.403 | ||
TLR9 | rs187084 | TT | 80 (50.0) | 36 (33.0) | 1.00 | Â |
CT | 61 (38.1) | 56 (51.4) | 2.01 (1.17–3.45) | 0.011 | ||
CC | 19 (11.9) | 17 (15.6) | 1.91 (0.88–4.14) | 0.100 | ||
CT+CC | 80 (50.0) | 73 (67.0) | 1.99 (1.19–3.31) | 0.008 | ||
T | 221 (69.1) | 128 (58.7) | 1.00 | Â | ||
C | 99 (30.9) | 90 (41.3) | 1.54 (1.07–2.22) | 0.020 | ||
rs352140 | CC | 78 (48.8) | 39 (35.8) | 1.00 | Â | |
CT | 63 (39.4) | 53 (48.6) | 1.64 (0.96–2.80) | 0.070 | ||
TT | 19 (11.9) | 17 (15.6) | 1.69 (0.78–3.65) | 0.180 | ||
CT+TT | 82 (51.2) | 70 (64.2) | 1.71 (1.04–2.81) | 0.036 b | ||
C | 219 (68.4) | 131 (60.1) | 1.00 | Â | ||
T | 101 (31.6) | 87 (39.9) | 1.44 (1.01–2.06) | 0.047 b |