Table 2 The genotype and allele frequencies of TLR4/TLR9 SNPs and their associations with persistent HR-HPV infection
Gene | SNPs | Genotype/Allele | Transient HR-HPV infection (n%) | Persistent HR-HPV infection (n%) | OR (95% CI) | P-Value a |
|---|---|---|---|---|---|---|
TLR4 | rs10116253 | TT | 36 (35.0) | 60 (36.1) | 1.00 | Â |
CT | 47 (45.6) | 81 (48.8) | 0.98 (0.53–1.82) | 0.950 | ||
CC | 20 (19.4) | 25 (15.1) | 0.75 (0.32–1.73) | 0.746 | ||
CT+CC | 67 (65.0) | 106 (63.9) | 0.91 (0.51–1.64) | 0.764 | ||
T | 119 (57.8) | 201 (60.5) | 1.00 | Â | ||
C | 87 (42.2) | 131 (39.5) | 0.89 (0.60–1.32) | 0.563 | ||
rs1927911 | CC | 35 (34.0) | 60 (36.1) | 1.00 | Â | |
CT | 47 (45.6) | 82 (49.4) | 0.98 (0.53–1.82) | 0.940 | ||
TT | 21 (20.4) | 24 (14.5) | 0.60 (0.26–1.39) | 0.234 | ||
CT+TT | 68 (60.0) | 106 (63.9) | 0.87 (0.48–1.55) | 0.628 | ||
C | 117 (56.8) | 202 (60.8) | 1.00 | Â | ||
T | 89 (43.2) | 130 (39.2) | 0.82 (0.55–1.22) | 0.323 | ||
rs10759931 | AA | 37 (35.9) | 59 (35.5) | 1.00 | Â | |
AG | 48 (46.6) | 81 (48.8) | 0.98 (0.53–1.82) | 0.960 | ||
GG | 18 (17.5) | 26 (15.7) | 1.01 (0.44–2.35) | 0.980 | ||
AG+GG | 66 (64.1) | 107 (64.5) | 0.99 (0.57–1.76) | 0.973 | ||
A | 122 (59.2) | 199 (59.9) | 1.00 | Â | ||
G | 84 (40.8) | 133 (40.1) | 1.00 (0.67–1.49) | 0.996 | ||
TLR9 | rs187084 | TT | 55 (53.4) | 61 (36.7) | 1.00 | Â |
CT | 37 (35.9) | 80 (48.2) | 1.98 (1.08–3.64) | 0.028 | ||
CC | 11 (10.7) | 25 (15.1) | 2.37 (0.97–5.83) | 0.059 | ||
CT+CC | 48 (46.6) | 105 (63.2) | 2.07(1.17–3.65) | 0.012 | ||
T | 147 (71.4) | 202 (60.8) | 1.00 | Â | ||
C | 59 (28.6) | 130 (39.2) | 1.70 (1.12–2.58) | 0.013 | ||
rs352140 | CC | 55 (53.4) | 62 (37.4) | 1.00 | Â | |
CT | 36 (35) | 80 (48.2) | 2.01 (1.09–3.68) | 0.024 | ||
TT | 12 (11.6) | 24 (14.4) | 1.87 (0.77–4.52) | 0.167 | ||
CT+TT | 48 (46.6) | 104 (62.6) | 1.97 (1.12–3.47) | 0.018 | ||
C | 146 (70.9) | 204 (61.4) | 1.00 | Â | ||
T | 60 (29.1) | 128 (38.6) | 1.56 (1.03–2.37) | 0.037 |