Table 4 Performance metrics (95% CI) of BreaTB on the test data set and on different subgroups
From: A cross-sectional study: a breathomics based pulmonary tuberculosis detection method
Groups | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | AUC |
|---|---|---|---|---|---|---|
Overall | ||||||
 Test (n = 430) | 91.7 (87.4–96.0) | 93.0 (90.0–96.1) | 88.3 (84.5–92.2) | 95.1 (91.8–98.4) | 92.6 (90.1–95.0) | 0.975 (0.961–0.990) |
Age, year | ||||||
 < 30 (n = 233) | 90.6 (83.5–97.8) | 91.7 (87.6–95.9) | 80.6 (74.4–86.7) | 96.3 (91.9–100.0) | 91.4 (87.8–95.0) | 0.972 (0.951–0.993) |
 ≥ 30 (n = 197) | 92.5 (87.1–97.8) | 95.2 (91.1–99.3) | 94.5 (90.2–98.8) | 93.4 (88.3–98.5) | 93.9 (90.6–97.2) | 0.978 (0.958–0.999) |
Sex | ||||||
 Male (n = 243) | 90.1 (84.3–95.9) | 95.1 (91.5–98.6) | 92.9 (88.7–97.0) | 93.1 (88.1–98.1) | 93.0 (89.8–96.2) | 0.975 (0.955–0.994) |
 Female (n = 187) | 94.6 (88.7–100) | 90.8 (85.9–95.8) | 81.5 (74.7–88.4) | 97.5 (93.8–100) | 92.0 (88.1–95.9) | 0.981 (0.962–1.000) |
Anti-TB | ||||||
 Untreated (n = 385) | 92.9 (88.1–97.6) | 93.0 (90.0–96.1) | 84.6 (80.2–88.9) | 96.9 (93.9–100) | 93.0 (90.4–95.5) | 0.978 (0.964–0.993) |
 Treated (n = 318) | 88.9 (79.7–98.1) | 93.0 (90.0–96.1) | 67.8 (62.1–73.5) | 98.1 (94.6–100) | 92.5 (89.5–95.4) | 0.968 (0.949–0.987) |
Controls | ||||||
 HC (n = 405) | 91.7 (87.4–96.0) | 93.5 (90.5–96.6) | 90.0 (86.2–93.8) | 94.7 (91.2–98.2) | 92.8 (90.3–95.4) | 0.977 (0.962–0.991) |
 UHC (n = 182) | 91.7 (87.4–96.0) | 88.0 (75.3–100.0) | 98.0 (93.3–100) | 62.9 (55.0–70.7) | 91.2 (87.1–95.3) | 0.961 (0.933–0.989) |