Factors related to the mortality risk of severe hand, foot, and mouth diseases (HFMD): a 5-year hospital-based survey in Guangxi, Southern China

Table 2 Multivariate logistic analysis of potential risk factors for death in severe HFMD patients

Characteristics	Total(n)	β	SE	Wald χ²	p	OR	95% CI
HFMD history of playmates in last 3 months
Yes	224	0.83	0.29	8.40	< 0.01	2.30	1.31–4.03
No	1290					1
EV-A71 vaccination
Yes	616					1
No	898	1.61	0.33	24.26	< 0.01	4.98	2.63–9.43
Visiting hospital previously
Yes	37	1.44	0.55	6.95	< 0.01	4.22	1.45–12.33
No	11,477					1
Hospital grade of first visit
Village	419	1.90	0.53	12.71	< 0.01	6.67	2.35–18.94
Township	204	1.45	0.55	6.96	< 0.01	4.28	1.45–12.61
County	559	1.11	0.48	5.33	0.02	3.05	1.18–7.85
City	332					1
Correct diagnosis at first visit
Yes	1039					1
No	475	0.82	0.30	7.35	< 0.01	3.05	1.18–7.85
Time interval from first visit to diagnosis of severe HFMD
≤ 1 day	372	1.85	0.43	18.52	< 0.01	6.37	2.74–14.80
1–2 days	703	1.25	0.34	13.17	< 0.01	3.49	1.78–6.84
≥ 3 days	439					1
Rash symptoms
Yes	1485					1
No	29	1.53	0.56	7.52	< 0.01	4.60	1.54–13.67

OR odds ratio, CI confidence interval, HFMD hand, foot and mouth disease, EV-A71 enterovirus A71

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