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Table 5 The association of age, sex, obesity, commodities, and prior COVID-19 infection with local and systemic reactogenicities following the first dose of all vaccines in multiple logistic regression

From: Reactogenicity within the first week after Sinopharm, Sputnik V, AZD1222, and COVIran Barekat vaccines: findings from the Iranian active vaccine surveillance system

Adverse effects

Female sex

Age (year)

Commodities

Prior COVID-19 disease

Obesity

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Local

 Pain

2.54 (2.22–2.91)

< 0.001

0.95 (0.95–0.96)

< 0.001

1.08 (0.92–1.27)

0.327

1.79 (1.50–2.12)

< 0.001

0.85 (0.70–1.03)

0.099

 Redness

3.20 (2.13–4.81)

< 0.001

0.96 (0.95–0.97)

< 0.001

0.80 (0.52–1.22)

0.309

1.28 (0.87–1.88)

0.199

2.05 (1.30–3.22)

0.002

 Swelling

2.37 (1.85–3.04)

< 0.001

0.97 (0.96–0.97)

< 0.001

1.07 (0.80–1.44)

0.613

1.29 (1.00–1.67)

0.046

1.51 (1.09–2.09)

0.012

 Induration

2.28 (1.87–2.77)

< 0.001

0.96 (0.95–0.97)

< 0.001

0.81 (0.64–1.02)

0.077

1.17 (0.94–1.44)

0.146

1.30 (1.00–1.71)

0.048

 Bruise

2.11 (1.38–3.22)

0.001

0.98 (0.97–0.99)

0.007

0.67 (0.42–1.08)

0.103

1.08 (0.68–1.72)

0.725

0.60 (0.30–1.22)

0.162

 Warmness

2.29 (1.79–2.93)

< 0.001

0.96 (0.95–0.97)

< 0.001

1.18 (0.87–1.59)

0.269

1.02 (0.78–1.33)

0.872

1.16 (0.81–1.66)

0.398

 Itching

2.28 (1.60–3.24)

< 0.001

0.97 (0.96–0.98)

< 0.001

1.03 (0.69–1.55)

0.866

1.17 (0.80–1.69)

0.404

1.62 (1.05–2.52)

0.029

Systemic

 Fever

1.57 (1.37–1.80)

< 0.001

0.96 (0.96–0.97)

< 0.001

1.04 (0.88–1.23)

0.610

1.15 (0.98–1.35)

0.084

1.01 (0.82–1.24)

0.877

 Nausea

2.91 (2.37–3.57)

< 0.001

0.97 (0.96–0.97)

< 0.001

0.85 (0.67–1.07)

0.176

1.04 (0.83–1.30)

0.702

0.97 (0.72–1.29)

0.839

 Malaise

1.83 (1.61–2.08)

< 0.001

0.97 (0.97–0.98)

< 0.001

0.99 (0.84–1.16)

0.933

1.22 (1.04–1.42)

0.010

0.94 (0.78–1.14)

0.579

 Chills

1.61 (1.38–1.87)

< 0.001

0.96 (0.95–0.96)

< 0.001

1.14 (0.94–1.38)

0.170

1.24 (1.04–1.48)

0.014

1.12 (0.89–1.40)

0.325

 Headache

1.85 (1.62–2.11)

< 0.001

0.96 (0.96–0.97)

< 0.001

0.81 (0.69–0.96)

0.016

1.23 (1.05–1.44)

0.008

0.95 (0.78–1.16)

0.641

 Joint pain

1.87 (1.62–2.15)

< 0.001

0.97 (0.96–0.97)

< 0.001

1.04 (0.88–1.24)

0.602

1.25 (1.06–1.47)

0.007

0.84 (0.68–1.04)

0.115

 Myalgia

1.68 (1.47–1.92)

< 0.001

0.96 (0.96–0.97)

< 0.001

0.94 (0.80–1.11)

0.506

1.23 (1.05–1.44)

0.008

0.92 (0.76–1.13)

0.466

 Fatigue

1.65 (1.45–1.86)

< 0.001

0.97 (0.96–0.97)

< 0.001

0.88 (0.75–1.02)

0.11

1.18 (1.01–1.37)

0.033

0.97 (0.81–1.17)

0.790

  1. OR odds ratio, CI confidence intervals
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