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Table 4 The associated factors with at least one solicited local or systemic adverse effects (AE) in multiple logistic regression models

From: Reactogenicity within the first week after Sinopharm, Sputnik V, AZD1222, and COVIran Barekat vaccines: findings from the Iranian active vaccine surveillance system

Independent variables

Local AE after 1st dose

Systemic AE after 1st dose

Local AE after 2nd dose

Systemic AE after 2nd dose

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Age

0.97 (0.97–0.98)

< 0.001

0.98 (0.97–0.98)

< 0.001

0.98 (0.97–0.98)

< 0.001

0.99 (0.99–1.00)

0.298

Female sex

2.65 (2.29–3.07)

< 0.001

1.78 (1.55–2.04)

< 0.001

2.07 (1.76–2.43)

< 0.001

1.69 (1.45–1.98)

< 0.001

Prior COVID-19

1.32 (1.17–1.50)

< 0.001

1.20 (1.07–1.35)

0.001

1.07 (0.94–1.22)

0.291

1.08 (0.96–1.23)

0.187

Vaccine brands

 Sinopharm

Reference

–

Reference

–

Reference

–

Reference

–

 Sputnik V

4.74 (3.90–5.76)

< 0.001

2.54 (2.11–3.06)

< 0.001

3.64 (2.91–4.55)

< 0.001

3.19 (2.55–3.99)

< 0.001

 AZD1222

8.73 (6.93–10.99)

< 0.001

6.79 (5.39–8.57)

< 0.001

4.14 (3.32–5.17)

< 0.001

2.56 (2.06–3.18)

< 0.001

 COVIran Barekat

1.00 (0.83–1.20)

0.969

0.56 (0.46–0.67)

< 0.001

2.98 (2.29–3.87)

< 0.001

1.10 (0.85–1.44)

0.443

Comorbidities

 Allergy

2.18 (1.16–4.08)

0.015

2.47 (1.34–4.56)

0.004

NR

–

NR

–

 Hypertension

1.25 (1.02–1.55)

0.032

NR

–

NR

–

NR

–

 Cardiac diseases

NR

–

1.55 (1.22–1.97)

< 0.001

NR

–

NR

–

 Cancer

NR

–

1.73 (1.13–1.91)

0.006

NR

–

1.87 (1.25–2.80)

0.002

  1. NR not retained in the multiple logistic regression models, OR odds ratio, CI confidence intervals