Table 2 Phenotypic and genotypic characterization of fluoroquinolone resistant isolates
Isolate number | Isolate identity | MIC values (µg/ml) | ST | PMQR genes | QRDR mutations | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CIP | LEV | MX | aac(6’)-lb-cra | qnrB1 | qnrB6 | qnrS1 | Oqx | gyrA | ParC | ParE | |||
407 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 10 | + | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
415 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 617 | + | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
451 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 131 | + | − | − | − | − | S83L, | S80I | I529L |
D87N | E84V | ||||||||||||
822 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 131 | + | − | − | − | − | S83L, | S80I | I529L |
D87N | |||||||||||||
868 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 4981 | − | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
1185 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 617 | + | − | − | − | − | S83L, | S80I | I529L |
D87N | |||||||||||||
1253 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 131 | − | − | − | − | − | S83L, | S80I, | I529L |
D87N | E84V | ||||||||||||
1448 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 167 | + | − | − | − | − | S83L, | S80I | I529L |
D87N | |||||||||||||
1476 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 617 | − | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
1520 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 131 | + | − | − | − | − | S83L, | S80I | I529L |
D87N | E84V | ||||||||||||
1637 | E. coli | > 32 (R) | > 32(R) | > 32(R) | 167 | + | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
2124 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 617 | + | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
2130 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 1193 | + | − | − | − | − | S83L, | S80I | S416F |
D87N | |||||||||||||
2163 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 617 | + | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
2171 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 410 | + | − | − | − | − | S83L, | S80I | S458A |
D87N | |||||||||||||
2240 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 1193 | + | − | − | − | − | S83L, | S80I | S416F |
D87N | |||||||||||||
2258 | E. coli | > 32 (R) | > 32 (R) | > 32 (R) | 1193 | + | − | − | − | − | S83L, | S80I | S416F |
D87N | |||||||||||||
1779 | E. coli | 1 (R) | 0.50 (R) | 0.75 (R) | 131 | − | − | − | − | − | None | None | I529L |
132 | E. coli | 0.75 (R) | 0.38 (R) | 1 (R) | 34 | + | + | − | + | − | None | None | None |
453 | E. coli | 0.50 (R) | 1.5 (R) | 1.5 (R) | 155 | − | − | − | + | − | S83A | None | None |
563 | K. pneumoniae | > 32 (R) | > 32 (R) | > 32 (R) | 38 | + | + | − | − | − | None | None | None |
1424 | K. pneumoniae | > 32 (R) | > 32 (R) | > 32 (R) | 16 | − | − | − | − | + | None | None | None |
2315 | K. pneumoniae | 3 (R) | 2 (R) | 3 (R) | 231 | − | − | − | − | + | None | None | None |
2111 | K. pneumoniae | 2 (R) | 0.50 (R) | 0.75 (R) | 985 | + | + | − | − | + | None | None | None |
2166 | K. pneumoniae | 1.5 (R) | 0.50 (R) | 0.75 (R) | 348 | + | + | − | − | + | None | None | None |
58 | K. pneumoniae | 1(R) | 0.75 (R) | 1 (R) | 607 | + | + | + | + | + | None | None | None |
906 | K. pneumoniae | 1 (R) | 0.50 (R) | 0.75 (R) | 336 | + | + | − | − | + | None | None | None |
1722 | K. pneumoniae | 1(R) | 0.38 (R) | 0.75 (R) | 3559 | + | + | − | − | + | None | None | None |
2129 | K. pneumoniae | 1(R) | 0.50 (R) | 1(R) | 607 | + | + | − | + | None | None | None | |
2149 | K. pneumoniae | 1 (R) | 0.50 (R) | 0.75 (R) | 348 | + | + | − | − | + | None | None | None |
2155 | K. pneumoniae | 1 (R) | 0.50 (R) | 0.75 (R) | 429 | + | + | − | − | + | None | None | None |
2241 | K. pneumoniae | 1 (R) | 0.50 (R) | 1 (R) | 39 | + | + | − | − | + | None | None | None |
1583 | K. pneumoniae | 0.75 (R) | 0.75 (R) | 1.5 (R) | 607 | + | − | + | − | + | None | None | None |
1912 | K. pneumoniae | 0.5 (R) | 0.75 (R) | 1 (R) | 14 | − | + | − | − | + | None | None | None |
1925 | K. pneumoniae | 0.5 (R) | 0.75 (R) | 1 (R) | 14 | − | + | − | − | + | None | None | None |
2142 | K. pneumoniae | 0.5 (R) | 0.50 (R) | 0.50 (R) | 479 | − | − | − | + | + | None | None | None |
544a | E. cloacae | 1 (R) | 0.50 (R) | 1 (R) | + | + | − | − | − | ||||
645a | E. cloacae | 1 (R) | 1 (R) | 1.5 (R) | + | + | − | − | − | ||||
1501a | E. cloacae | 1 (R) | 0.75 (R) | 1 (R) | + | + | − | − | − | ||||
2167a | E. cloacae | 0.50 (R) | 0.50 (R) | 1 (R) | + | + | − | − | − | ||||
277a | C. sedlakii | 1.5 (R) | 1 (R) | 2 (R) | + | + | − | − | − | ||||
2006a | C. sedlakii | 1 (R) | 0.75 (R) | 1 (R) | + | − | − | − | − | ||||