Table 3 A table showing unadjusted and adjusted prevalence ratios for factors associated with adverse events for the MDR-TB patients on second line anti-TB drugs
Variables | No AEs | AEs | Unadjusted | Adjusted PR | ||
|---|---|---|---|---|---|---|
PR | 95% CI | PR | 95% CI | |||
Number of Patients | 487 (56.9%) | 369 (43.1%) | ||||
Age | ||||||
0–14 | 29 (5.9%) | 10 (2.7%) | 1 | |||
15–24 | 78 (16%) | 55 (14.9%) | 1.6 | (0.91–2.85) | ||
25–34 | 162 (33.3%) | 129 (34.9%) | 1.7 | (0.99–2.99) | ||
35–44 | 128 (26.3%) | 102 (27.6%) | 1.7 | (0.99–3.01) | ||
45–54 | 61 (12.5%) | 53 (14.3%) | 1.8 | (1.02–3.21) | ||
55+ | 29 (5.9%) | 20 (5.4%) | 1.5 | (0.84–2.99) | ||
Weight | ||||||
1-29.9 kg | 54 (11.1%) | 23 (6.2%) | 1 | |||
30-35.9 kg | 18 (3.7%) | 9 (2.4%) | 1.1 | (0.59–2.11) | ||
36-45.9 kg | 103 (21.1%) | 86 (23.3%) | 1.5 | (1.04–2.21) | ||
46-55.9 kg | 171 (35.1%) | 149 (40.4%) | 1.5 | (1.08–2.23) | ||
56-69.9 kg | 117 (24.0%) | 84 (22.7%) | 1.3 | (0.95–2.04) | ||
70 kg+ | 24 (4.9%) | 42 (4.9%) | 1.4 | (0.88–2.34) | ||
Sex | ||||||
Male | 316 (64.9%) | 227 (61.5%) | 1 | |||
Female | 171 (35.1%) | 142 (38.5%) | 1.1 | (0.92–1.27) | ||
Marital Status | ||||||
Single | 201 (41.3%) | 153 (41.5%) | 1 | |||
Married | 199 (40.9%) | 151 (41%) | 0.9 | (0.84–1.18) | ||
Separated | 87 (17.9%) | 65 (17.6%) | 0.98 | (0.79–1.23) | ||
Occupation | ||||||
Working | 360 (73.9%) | 273 (73.9%) | 1 | |||
Not working | 127 (26.1%) | 96 (26.1%) | 0.9 | (0.83–1.18) | ||
Form of employment | ||||||
Formal | 22 (6.1%) | 23 (8.4%) | 1 | |||
Informal | 339 (93.1%) | 250 (91.6%) | 0.8 | (0.61–1.12) | ||
Received Food supplies | ||||||
No | 74 (15.2%) | 92 (24.9%) | 1 | 1 | ||
Yes | 413 (84.8%) | 277 (75.1%) | 0.7 | (0.61–0.85) | 0.61 | (0.51–0.71) *** |
Received Transport | ||||||
Yes | 69 (14.2%) | 20 (5.4%) | 1 | 1 | ||
No | 418 (85.8%) | 349 (94.6%) | 2 | (1.36-3.00) | 1.9 | (1.21–3.11) *** |
Drug Abuse (Alcohol) | ||||||
No | 350 (71.9%) | 219 (59.4%) | 1 | 1 | ||
Yes | 137 (28.1%) | 150 (40.6%) | 1.3 | (1.16–1.58) | 1.2 | (1.05–1.43) ** |
Co-Infected with HIV | ||||||
No | 211 (43.3%) | 156 (42.3%) | 1 | |||
Yes | 276 (56.7%) | 213 (57.7%) | 1.02 | (1.07–1.19) | ||
Regimen | ||||||
STR | 121 (24.8%) | 56 (15.2%) | 1 | 1 | ||
LTR | 236 (48.6%) | 221 (59.9%) | 1.5 | (1.20–1.93) | 1.4 | (1.07–1.76) * |
IND | 89 (18.2%) | 73 (19.8%) | 1.4 | (1.08–1.87) | 1.5 | (1.11–1.93) ** |
m STR/STD | 41 (8.4%) | 19 (5.1%) | 1.001 | (0.65–1.53) | 1.1 | (0.69–1.64) |
Adherence to treatment | ||||||
Missed dozes | 179 (36.8%) | 112 (30.3%) | 1 | |||
All dozes taken | 308 (62.2%) | 257 (69.7%) | 1.2 | (0.99–1.40) | ||
Clinical Visits made | ||||||
Missed | 192 (39.4%) | 159 (43.1%) | 1 | |||
All Attend | 295 (60.6%) | 210 (56.9%) | 0.9 | (0.78–1.07) | ||
Place of DOT | ||||||
Initiation Site | 85 (17.4%) | 27 (7.3%) | 1 | 1 | ||
Follow Up Facility | 402 (82.6%) | 342 (92.7%) | 1.9 | (1.36–2.67) | 1.6 | (1.10–2.41) * |
TB Reg Group | ||||||
New | 255 (52.4%) | 199 (53.9%) | 1 | |||
Retreatment | 232 (47.6%) | 170 (46.1%) | 0.9 | (0.82–1.12) | ||