Fig. 1

Outline of infections, dynamics of the immune component postinfusion, and mutation pedigree chart of the two patients. A Timeline of Candida albicans infection in patient one, including the symptom, culture, and drug applied to treat CRS and infection after CAR-T-cell infusion; B copy number of CAR transgene in the peripheral blood mononuclear cell of patient one; C neutrophil and lymphocyte counts for patient one postinfusion; D the serum globulin level and lymphocyte subset counts (T cell, B cell, and NK cell) for patient one; E dynamic changes in neutrophil and lymphocyte counts and the duration of each infection for patient two; F the serum globulin level and lymphocyte subset counts (T cell, B cell, and NK cell) for patient two; G pedigree of gene IL17-RA in the family of patient one (II-2); H pedigree of gene CX3CR1 in the family of patient two (II-1). CAR chimeric antigen receptor, G-CSF granulocyte colony-stimulating factor, NK natural killer