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Table 3 Factors independently associated with LTFU among adult PLHIV on ART in the Tanga region

From: Predictors of the observed high prevalence of loss to follow-up in ART-experienced adult PLHIV: a retrospective longitudinal cohort study in the Tanga Region, Tanzania

Study population characteristics

Univariate HR

p-value

Multivariate HR

p-value

 

95% CI

 

95% CI

 

Age group, years

    

 15–24

1.51 (1.47–1.55)

 

1.85 (1.66–2.07)

 < 0.0001

 25–34

1.22 (1.20–1.25)

 < 0.0001

1.38 (1.28–1.48)

0.0011

 35–44

Reference

 

Reference

 

 45–54

0.93 (0.91–0.95)

 

1.03 (0.96–1.11)

 < 0.0001

 55 + 

1.04 (1.02–1.06)

 

1.20 (1.11–1.32)

0.1352

Sex

    

 Female

Reference

 < 0.0001

Reference

 

 Male

0.94 (0.93–0.96)

 

2.00 (1.51–2.62)

 < .0001

District

    

 Handeni

1.18 (1.15–1.20)

 

0.92 (0.83–1.02)

0.5184

 Kilindi

1.38 (1.33–1.43)

 

0.58 (0.48–0.70)

 < 0.0001

 Korogwe

1.29 (1.26–1.32)

 < 0.0001

0.85 (0.76–0.94)

0.00074

 Lushoto

1.11 (1.08–1.14)

 

1.38 (1.25–1.53)

 < 0.0001

 Mkinga

1.14 (1.02–1.18)

 

0.41 (0.36–0.46)

 < 0.0001

 Muheza

2.49 (2.44–2.54)

 

1.22 (1.12–1.33)

 < 0.0001

 Pangani

1.22 (1.18–1.26)

 

2.13 (1.93–2.35)

 < 0.0001

 Tanga

Reference

 

references

 

Pregnant status

    

 No

Reference

 

Reference

 

 Yes

1.10 (1.05–1.16)

 < 0.0001

0.73 (0.63–0.85)

 < 0.0001

Marital status

    

 Cohabiting

0.95 (0.90–1.01)

 

0.42 (0.35–0.52)

 < 0.0001

 Divorced

1.01 (0.99–1.04)

 < 0.0001

1.35 (1.24–1.48)

 < 0.0001

 Married

Reference

 

Reference

 

 Single

1.31 (1.29–1.34)

 

1.25 (1.17–1.33)

 < 0.0001

 Widow

1.07 (1.04–1.10)

 

0.86 (0.76–0.96)

0.2

Viral load suppression

    

 Suppressed

Reference

 < 0.0001

Reference

 < 0.0001

 Non-suppressed

2.30 (2.24–2.37)

2.15 (2.02–2.29)

 

BMI (kg/m2)

    

 < 18.5

1.95 (1.84–2.07)

 < 0.0001

1.75 (1.30–2.34)

0.0472

 18.5–< 25

Reference

Reference

 

 25–30

1.57 (1.48–1.67)

1.46 (1.10–1.95)

0.5589

 30 + 

1.60 (1.50–1.68)

1.34 (0.93–1.93)

0.9229

WHO clinical stage

    

 I

Reference

 < 0.0001

Reference

 

 II

0.01 (0.88–0.92)

1.67 (1.52–1.84)

0.1226

 III

1.08 (1.06–1.09)

2.51 (2.32–2.72)

 < 0.0001

 IV

1.18 (1.15–1.21)

2.24 (2.02–2.49)

 < 0.0001

Drug type

    

 First-line

Reference

 < 0.0001

Reference

 < 0.0001

 Second-line

1.13 (1.09–1.18)

1.19 (0.84–1.69)

 

Adherence

    

 Good

Reference

 < 0.0001

Reference

 

 Poor

1.75 (1.69–1.82)

1.50 (1.23–1.75)

 < 0.0001

ART duration

    

 ≤ 1

1.10 (1.08–1.12)

 < 0.0001

0.72 (0.65–0.81)

 < 0.0001

 > 1

Reference

Reference

 

TB history

    

 No

Reference

 < 0.0001

Reference

 

 Yes

1.92 (1.79–2.05)

1.19 (0.84–1.69)

0.3187

DTG-related drug

    

 No

5.80 (4.98–6.64)

 < 0.0001

7.51 (5.88–10.79)

 < 0.0001

 Yes

Reference

Reference

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