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Table 2 Serological measures before and after vaccination, between prior COVID groups

From: Serological response to vaccination in post-acute sequelae of COVID

  

Prior COVID

P value

Time Period

 

Recovered COVID*

PASC*

Log 10 IgG-S levels

   

Before vaccination

3.17 [2.35, 4.26]

3.25 [2.62, 3.83]

0.75

After vaccination, 0–8 weeks

4.31 [4.10, 4.52]

4.47 [4.35, 4.81]

0.004

More than 8 weeks after vaccination

3.74 [3.36, 4.08]

3.98 [3.59, 4.45]

< 0.001

IgG-N levels

   

Before vaccination

1.42 [0.10, 3.34]

1.46 [0.49, 3.44]

0.13

After vaccination, 0–8 weeks

1.43 [0.45, 2.88]

1.86 [1.06, 3.17]

0.09

More than 8 weeks after vaccination

0.62 [0.19, 1.71]

0.82 [0.32, 1.82]

0.06

Log 10 (IgM-S + 1) levels

   

Before vaccination

0.29 [0.11, 0.56]

0.18 [0.08, 0.42]

0.034

After vaccination, 0–8 weeks

0.28 [0.15, 0.55]

0.18 [0.10, 0.24]

0.001

More than 8 weeks after vaccination

0.15 [0.09, 0.33]

0.13 [0.07, 0.28]

0.12

ACE2 Binding levels

   

Before vaccination

100.0 [98.3, 100.0]

70.2 [14.9, 99.0]

< 0.001

After vaccination, 0–8 weeks

100.0 [99.0, 100.0]

100.0 [100.0, 100.0]

0.35

More than 8 weeks after vaccination

98.2 [90.7, 99.5]

99.1 [89.9, 99.9]

0.044

  1. *Values are shown as median and interquartile range [IQR], with comparisons performed using two-sided Wilcoxon tests