From: Mycobacterium tuberculosis lineage 4 associated with cavitations and treatment failure
Variables | Total | Failure | Cure or treatment completion | p-value* |
---|---|---|---|---|
n/totala (%) | n/total (%) | n/total (%) | ||
Male | 363/645 (56.0) | 15/20 (75.0) | 348/625 (56.0) | 0.086 |
Age (years) (median [IQR]) | 56 (45–35) | 51 (33–57) | 45 (32–59) | 0.787† |
> 6 years of formal schooling | 432/645 (67.0) | 9/20 (45.0) | 423/625 (68.0) | 0.034 |
House with dirt floor | 154/645 (24.0) | 3/20 (15.0) | 151/625 (24.0) | 0.344 |
Rural residence | 81/624 (13.0) | 3/18 (17.0) | 78/606 (13.0) | 0.637 |
Nearest health center distance (meters) (median [IQR]) | 689 (412–1095) | 848 (274–1260) | 692 (412–1092) | 0.717† |
Access to social security | 225/645 (35.0) | 3/20 (15.0) | 222/625 (36.0) | 0.058 |
Used alcohol | 269/644 (42.0) | 10/20 (50.0) | 259/624 (42.0) | 0.448 |
Used tobacco | 139/644 (22.0) | 8/20 (40.0) | 131/624 (21.0) | 0.042 |
Used illegal drugs | 26/645 (4.0) | 0/20 (0.0) | 26/625 (4.0) | 0.352 |
Homelessness or residence in shelters | 14/644 (2.0) | 0/20 (0.0) | 14/624 (2.0) | 0.498 |
Diabetes mellitus type 2 | 221/645 (34.0) | 7/20 (35.0) | 214/625 (34.0) | 0.944 |
HIV coinfection | 6/635 (1.0) | 0/19 (0.0) | 6/616 (1.0) | 0.666 |
New case | 592/644 (92.0) | 17/20 (85.0) | 575/624 (92.0) | 0.248 |
AFB sputum positivity grade of 3 + | 174/645 (27.0) | 7/20 (35.0) | 167/625 (27.0) | 0.411 |
Resistance to at least one drug | 93/522 (18.0) | 13/17 (76.0) | 80/505 (16.0) | < 0.001 |
MDR | 11/522 (2.0) | 5/17 (29.0) | 6/505 (1.0) | < 0.001 |
Fever | 462/642 (72.0) | 11/20 (55.0) | 451/622 (73.0) | 0.086 |
Haemoptysis | 225/645 (35.0) | 6/20 (30.0) | 219/625 (35.0) | 0.642 |
Cavitations presence on chest radiograph | 244/545 (45.0) | 8/13 (62.0) | 236/532 (44.0) | 0.218 |
BMI (median [IQR]) | 21.0 (18.7–23.8) | 19.1 (17.6–22.5) | 21.1 (18.7–22.5) | 0.181† |
Number of days between symptom onset and start of treatment (median [IQR]) | 105 (67–197) | 152 (79–242) | 105 (66–179) | 0.120† |
Lineage by MIRU | ||||
Haarlem | 358/645 (55.5) | 5/20 (25.0) | 353/625 (56.5) | 0.005‡ |
LAM | 135/645 (20.9) | 6/20 (30.0) | 129/625 (20.6) | 0.311‡ |
RDRio | 93/135 (68.9) | 1/6 (16.7) | 92/129 (71.3) | 0.005‡ |
RD115 | 26/135 (19.3) | 2/6 (33.3) | 24/129 (18.6) | 0.371‡ |
Other than Haarlem and LAM | 152/645 (24.0) | 9/20 (45.0) | 143/625 (23.0) | 0.022‡ |
Cluster belonging | 447/645 (69.3) | 10/20 (50) | 437/625 (69.9) | 0.057 |