Prognostic significance of early platelet dynamics in Staphylococcus aureus bacteremia

BMC Infectious Diseases

Table 4 Multivariable models for 30-day mortality (n = 740) and subgroups based on platelet count trends from S. aureus bacteremia onset to Day 4

Variables	OR	95% CI		p-value
Full Model: All patients (N = 740)
TC-TC vs NP-NP	4.42	2.12	9.21	< 0.0001
TC-NP vs NP-NP	1.88	0.36	9.84	0.46
NP-TC vs NP-NP	3.26	1.25	8.53	0.02
High risk source vs Intermediate & Low	2.42	1.29	4.55	< 0.01
Severe Sepsis	3.84	1.50	9.83	< 0.01
Age	1.02	1.00	1.04	0.02
ICU stay	6.24	2.92	13.31	< 0.0001
Source control procedure not performed	2.34	1.15	4.76	0.02
Renal disease	2.25	1.13	4.47	0.02
MRSA vs MSSA	1.36	0.73	2.54	0.33
Submodel: Patients with normal platelet count on Day 1 (N = 529)
NP-TC vs NP-NP	3.57	1.34	9.49	0.01
High risk source vs Intermediate & Low	1.79	0.70	4.59	0.22
Severe Sepsis	2.17	0.69	6.80	0.18
Age	1.03	1.00	1.06	0.05
ICU stay	7.69	2.43	24.37	< 0.001
Source control procedure not performed	3.07	1.05	9.04	0.04
Renal disease	2.93	1.08	7.94	0.03
MRSA vs MSSA	0.57	0.21	1.55	0.27
Submodel: Patients with thrombocytopenia on Day 1 (N = 211)
TC-TC vs TC-NP	2.06	0.40	10.66	0.39
High source risk vs Intermediate & Low	3.38	1.35	8.44	< 0.01
Severe Sepsis	10.03	1.23	81.75	0.03
Age	1.02	1.00	1.05	0.08
ICU stay	5.95	2.10	16.89	< 0.001
Source control procedure not performed	1.87	0.68	5.19	0.23
Renal disease	2.05	0.76	5.51	0.16
MRSA vs MSSA	2.64	1.10	6.34	0.03

CI: confidence interval; OR: odds ratio; TC-TC: thrombocytopenia on Day 1 and Day 4; NP-TC: normal platelet count on Day 1 but thrombocytopenia on Day 4; TC-NP: Thrombocytopenia on Day 1 with recovery to normal platelet count on Day 4; NP-NP: normal platelet count entire course; N = 740 due to missing platelet counts at day 4 and other variables with missing values
Hosmer and Lemeshow Goodness-of-Fit Test, all p-values > 0.05

ISSN: 1471-2334