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Table 3 Outcome and follow-up of the 64 cases of BKVN and matched controls

From: Characteristics, risk factors and outcome of BKV nephropathy in kidney transplant recipients: a case–control study

Variable

BKVN cases (N = 64)

n (%); median [IQR]

Controls (N = 64)

n (%); median [IQR]

p-value

Median duration of follow-up (months)

40 [21–81]

39 [20–85]

0.77

Acute rejection episodes

12 (19)

2 (3)

0.003

 Antibody-mediated

8

2

 

 Cellular-mediated

2

0

 

 Mixed rejection

2

0

 

de novo DSA (MFI > 3000)

27 (42)

16 (25)

0.04

Return to dialysis

22 (34)

3 (5)

 < 0.0001

Death

4 (6)

4 (6)

1

Kidney function at last follow-up (N = 40*)

   

 Serum creatinine level (µmol/L)

214 [147–272]

139 [112–166]

0.025

 eGFR (ml/min/1.73 m2)

26 [19–43]

44.5 [35–56]

0.82

 Proteinuria (mg/mmol)

37 [14–74]

16 [8–30]

0.047

  1. p < 0.05 values are statistically significant and shown in bold
  2. BKVN BK-virus associated nephropathy, DSA donor-specific antibodies, eGFR estimated glomerular filtration rate (using MDRD [modification of diet in renal disease]), IQR interquartile range, MFI mean fluorescence intensity
  3. *Kidney function was assessed at last follow-up only for the 40 cases (and matched controls) who were alive and had not returned to dialysis