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Table 1 Univariable Mendelian randomization of putative risk factors for EBV infection

From: Mendelian randomisation identifies priority groups for prophylactic EBV vaccination

Risk factor

N SNPS

OR (95% CI)

P-value

Total number of siblings

5

 

0.84

 Per increase of 1

 

1.15 (0.30–4.38)

 

Number of sexual partnersa

61

 

0.02

 < 2

 

Baseline

 

 2–5

 

2.69 (1.15–6.32)

BMI

464

 

0.29

 Per unit increase

 

1.14 (0.89–1.46)

 

Tonsillectomy

10

 

0.37

 No

 

Baseline

 

 Yes

 

0.01 (5.5 × 10–7–220.33)

Educational attainment (years)

291

 

7.20 × 10–6

 0

 

Baseline

 

 Per increase of 1

 

0.43 (0.30–0.62)

Smoking status

10

 

0.049

 Never

 

Baseline

 

 Ever

 

2.36 (1.00–5.55)

Age at smoking initiation (years)

1

 

0.80

 Per unit increase

 

0.92 (0.47–1.79)

 
  1. Putative risk factors include, total number of siblings, total number sexual partners (< 2, 2–5, ≥ 5)a (OR only calculated for < 2 and 2–5), BMI, Tonsillectomy (yes/no), Educational attainment (years), smoking status (never/ever), age at smoking initiation (years). Risk factors with p ≤ 0.05 were considered significant
  2. BMI body mass index, CI confidence intervals, N number, OR odds ratio, SNPs single nucleotide polymorphisms