Table 5 Risk factors associated with mortality within 30Â days of Candida bloodstream infection diagnosis
Risk factors for mortality | Patients who died during the follow-up period | Patients who survived | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|
|  | N = 14 | N = 63 | OR (95% CI) | p-value | aOR (95% CI) | p-value |
Age less than 12 months | 9 (64) | 35 (56) | 1.4 (0.4–4.8) | 0.6 | 0.4 (0.04–3.7) | 0.4 |
Severe underweight (weight for age < -3 z score) | 7 (50) | 23 (37) | 1.7 (0.5–5.6) | 0.4 | 7.4 (0.9–61.5) | 0.1 |
Disseminated intravascular coagulopathy | 5 (36) | 4 (6) | 8.2 (1.8–36.4) | 0.01 | 6.9 (0.6–74.8) | 0.1 |
Required vasopressor therapy | 9 (64) | 13 (21) | 6.9 (2.0–24.2) |  < 0.01 | 53.3 (2.3–1028.7) | 0.01 |
Renal dysfunction | 3 (21) | 12 (19) | 1.2 (0.3–4.8) | 0.8 | 1.2 (0.1–15.3) | 0.9 |
Hepatic dysfunction | 6 (43) | 9 (14) | 4.5 (1.3–16.1) | 0.02 | 12.7 (1.1–145.8) | 0.04 |
White cell count < 4000 cells/µL | 3 (21) | 13 (21) | 1.2 (0.3–4.8) | 0.8 | – | – |
Presence of an immunosuppressive conditiona | 2 (14) | 11 (17) | 0.8 (0.2–4.0) | 0.8 | 0.6 (0.03–11.7) | 0.7 |
Present in ICU during Candida BSI | 10 (71) | 39 (62) | 1.5 (0.4–5.5) | 0.5 | 0.02 (0–1.3) | 0.1 |
Presence of definable focus of infection | 7 (50) | 28 (44) | 1.3 (0.4–4.0) | 0.7 | 0.9 (0.1–6.3) | 0.9 |
Presence of concomitant bacterial BSI during Candida BSI | 9 (64) | 14 (22) | 6.3 (1.8–21.9) |  < 0.01 | 9.5 (1.5–60.0) | 0.02 |
Non-Candida albicans BSI | 8 (57) | 31 (49) | 1.4 (0.4–4.4) | 0.6 | 3.6 (0.3–49.6) | 0.3 |