Table 3 Adjusted rates and risk differences for adverse inpatient outcomes according to statin intensity, Northwestern Medical Group, March 2020-September 2022
Outcome | Estimated Rate per 100 admitted Patients (95% CI) | Risk Difference (vs non-user) (95% CI) | ||
|---|---|---|---|---|
A. Adjusting Baseline covariates only | ||||
 Composite |  |  | ||
  Non-user | 18.84 (18.07, 19.61) | NA | ||
  Low-moderate intensity | 15.17 (13.34, 17) |  − 3.67 (− 5.65, − 1.7)* | ||
  High intensity | 15.96 (13.84, 18.08) |  − 2.88 (− 5.12, − 0.63)* | ||
 ICU admission |  |  | ||
  Non-user | 17.89 (17.14, 18.64) | NA | ||
  Low-moderate intensity | 14.09 (12.32, 15.87) |  − 3.8 (− 5.72, − 1.87)* | ||
  High intensity | 15.5 (13.42, 17.58) |  − 2.39 (− 4.6, − 0.18)* | ||
 Intubation |  |  | ||
  Non-user | 7.76 (7.24, 8.27) | NA | ||
  Low-moderate intensity | 6.02 (4.73, 7.31) |  − 1.74 (− 3.11, − 0.36)* | ||
  High intensity | 5.68 (4.31, 7.06) |  − 2.07 (− 3.54, − 0.61)* | ||
 Inpatient Death |  |  | ||
  Non-user | 5.14 (4.71, 5.57) | NA | ||
  Low-moderate intensity | 4.7 (3.77, 5.62) |  − 0.44 (− 1.45, 0.56) | ||
  High intensity | 3.93 (2.95, 4.91) |  − 1.21 (− 2.28, − 0.15)* | ||
B. Adjusting for Baseline and site variables | ||||
 Composite |  |  | ||
  Non-user | 18.83 (18.07, 19.6) | NA | ||
  Low-moderate intensity | 15.14 (13.35, 16.92) |  − 3.7 (− 5.63, − 1.77)* | ||
  High intensity | 15.9 (13.82, 17.98) |  − 2.93 (− 5.14, − 0.72)* | ||
 ICU admission |  |  | ||
  Non-user | 17.88 (17.13, 18.63) | NA | ||
  Low-moderate intensity | 14.23 (12.49, 15.97) |  − 3.65 (− 5.53, − 1.76)* | ||
  High intensity | 15.67 (13.58, 17.77) |  − 2.21 (− 4.43, 0.02) | ||
 Intubation |  |  | ||
  Non-user | 7.71 (7.2, 8.21) | NA | ||
  Low-moderate intensity | 6.06 (4.79, 7.33) |  − 1.65 (− 3.01, − 0.28)* | ||
  High intensity | 5.68 (4.34, 7.03) |  − 2.02 (− 3.46, − 0.59)* | ||
 Inpatient Death |  |  | ||
  Non-user | 5.11 (4.69, 5.54) | NA | ||
  Low-moderate intensity | 4.79 (3.84, 5.74) |  − 0.33 (− 1.36, 0.7) | ||
  High intensity | 3.87 (2.93, 4.82) |  − 1.24 (− 2.27, − 0.21)* | ||
C. Adjusting for Baseline, site, and clinical variables | ||||
 Composite |  |  | ||
  Non-user | 18.64 (17.89, 19.39) | NA | ||
  Low-moderate intensity | 15.53 (13.72, 17.34) |  − 3.11 (− 5.05, − 1.17)* | ||
  High intensity | 16.01 (14, 18.03) |  − 2.62 (− 4.75, − 0.5)* | ||
 ICU admission | ||||
  Non-user | 17.88 (17.13, 18.62) | NA | ||
  Low-moderate intensity | 14.13 (12.39, 15.88) |  − 3.74 (− 5.63, − 1.85)* | ||
  High intensity | 15.47 (13.4, 17.54) |  − 2.4 (− 4.59, − 0.22)* | ||
 Intubation | ||||
  Non-user | 7.71 (7.2, 8.22) | NA | ||
  Low-moderate intensity | 6.21 (4.88, 7.53) |  − 1.5 (− 2.91, − 0.09)* | ||
  High intensity | 5.65 (4.31, 6.98) |  − 2.06 (− 3.49, − 0.64)* | ||
 Inpatient Death | ||||
  Non-user | 5.09 (4.66, 5.51) | NA | ||
  Low-moderate intensity | 4.82 (3.88, 5.77) |  − 0.26 (− 1.29, 0.76) | ||
  High intensity | 3.88 (2.95, 4.82) |  − 1.2 (− 2.22, − 0.19)* | ||