Table 1 Number of positive S. pneumoniae samples, proportion of total positive samples, odds ratio of carriage by serotype comparing children with ARI to healthy children in the community and odds ratio comparing serotypes causing IPD to carriage in healthy children in the community
Serotype | Community samples | ARI samples | ARI/community samples | IPD samples | IPD/community samples | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Spn positive (freq) | Proportion (%) [95% CI] (N = 3078) | Spn positive (freq) | Proportion (%) [95% CI] (N = 389) | OR (p value) [95% CI] | Age-adjusted OR (p value) [95% CI] | Spn positive (freq) | Proportion (%) [95% CI] (N = 149) | OR (p value) [95% CI] | Age-adjusted OR (p value) [95% CI] | |
19F | 146 | 4.7 [4.0–5.6] | 29 | 7.5 [5.0–10.5] | 1.62 (0.023) [1.05–2.41] | 1.81 (0.007) [1.16–2.75] | 1 | 0.7 [0.0–3.7] | 0.14 (0.047) [0.01–0.61] | 0.15 (0.061) [0.01–0.69] |
3 | 122 | 3.9 [3.3–4.7] | 9 | 2.3 [1.1–4.3] | 0.57 (0.112) | 0.67 (0.266) [0.31–1.28] | 4 | 2.7 [0.7–6.7] | 0.67 (0.434) [0.20–1.62] | 0.82 (0.699) [0.24–2.01] |
23F | 120 | 3.9 [3.2–4.6] | 18 | 4.6 [2.8–7.2] | [0.27–1.08] 1.20 (0.489) [0.70–1.93] | 1.29 (0.347) [0.74–2.12] | 11 | 7.4 [3.7–12.8] | 1.96 (0.039) [0.98–3.57] | 2.06 (0.032) [1.01–3.84] |
14 | 91 | 3.0 [2.4–3.6] | 8 | 2.0 [0.9–4.0] | 0.69 (0.318) [0.31–1.34] | 0.66 (0.270) [0.29–1.30] | 5 | 3.4 [1.1–7.7] | 1.14 (0.780) [0.40–2.58] | 1.06 (0.909) [0.36–2.45] |
6A | 89 | 2.9 [2.3–3.5] | 3 | 0.8 [0.2–2.2] | 0.26 (0.023) [0.06–0.70] | 0.26 (0.023) [0.06–0.70 | 5 | 3.4 [1.1–7.7] | 1.17 (0.742) [0.41–2.64] | 1.19 (0.717) [0.41–2.76] |
19A | 44 | 1.4 [1.0–1.9] | 10 | 2.5 [1.2–4.7] | 1.82 (0.091) [0.86–3.50] | 2.01 (0.061) [0.92–4.01] | 0 | 0 | 0 (0.979) | 0 (0.979) |
9V | 29 | 0.9 [0.6–1.3] | 2 | 0.5 [0.1–1.8] | 0.54 (0.405) [0.09–1.81] | 0.57 (0.444) [0.09–1.95] | 2 | 1.3 [0.2–4.8] | 1.43 (0.627) [0.23–4.81] | 1.67 (0.498) [0.26–5.91] |
6B | 27 | 0.9 [0.6–1.3] | 4 | 1.0 [0.3–2.6] | 1.17 (0.766) [0.35–3.02] | 1.08 (0.888) [0.31–2.86] | 6 | 4.0 [1.5–8.6] | 4.74 (< 0.001)* [1.75–10.93] | 4.73 (0.001)* [1.66–11.64] |
18C | 16 | 0.5 [0.3–0.8] | 0 | 0 | 0 (0.986) | 0 (0.986) | 3 | 2.0 [0.4–5.8] | 3.93 (0.031) [0.91–11.97] | 3.67 (0.053) [0.80–12.18] |
1 | 13 | 0.4 [0.2–0.7] | 1 | 0.3 [0.0–1.4] | 0.61 (0.632) [0.03–3.06] | 0.81 (0.840) [0.04–4.45] | 13 | 8.7 [4.7–14.4] | 22.54 (< 0.001)* [10.16–50.0] | 23.38 (< 0.001)* [9.75–56.06] |
4 | 12 | 0.4 [0.2–0.6] | 1 | 0.3 [0.0–1.4] | 0.66 (0.688) [0.04–3.35] | 0.81 (0.846) [0.04–4.52] | 1 | 0.7 [0.0–3.7] | 1.73 (0.601) [0.09–8.85] | 2.76 (0.341) [0.15–15.08] |
5 | 7 | 0.2 [0.1–0.5] | 3 | 0.8 [0.2–2.2] | 3.41 (0.076) [0.73–12.32] | 6.09 (0.018) [1.18–25.24] | 8 | 5.4 [2.3–10.3] | 24.89 (< 0.001)* [8.82–71.92] | 24.73 (< 0.001)* [7.90–78.56] |
7F | 3 | 0.1 [0.0–0.3] | 2 | 0.5 [0.1–1.8] | 5.30 (0.068) [0.70–32.06] | 5.53 (0.082) [0.67–39.03] | 1 | 0.7 [0.0–3.7] | 6.93 (0.095) [0.34–54.46] | 6.60 (0.132) [0.29–62.57] |
Total VT | 719 | 23.4 [21.9–24.9] | 90 | 23.1 [19.0–27.7] | – | – | 60 | 40.3 [32.3–48.6] | – | – |
Total NVT | 2359 | 76.6 [75.1–78.1] | 299 | 76.9 [72.3–81.0] | – | – | 89 | 59.7 [51.4–67.7] | – | – |
Total | 3078 | 389 | 149 | |||||||