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Table 4 Evolution over periods of time of the variables associated with 30-day mortality, multivariable analyses

From: The factors associated with the trend in incidence of Bacteraemia and associated mortality over 30 years

Characteristics

Years

1996–2000

OR, (95% CI)

2001–2005

OR, (95% CI)

2006–2010

OR, (95% CI)

2011–2015

OR, (95% CI)

2016–2020

OR, (95% CI)

Male

1.10, (0.85–1.43)

1.13, (0.88–1.45)

1.41, (1.12–1.79)*

1.25, (1.00–1.57)*

1.38, (1.10–1.74)*

Age

0.987, (0.98–0.99)*

0.999, (0.99–1.01)

1.007, (1.00–1.01)*

1.013, (1.01–1.02)*

1.02, (1.01–1.03)*

Severe sepsis/septic shock

0.62, (0.44–0.87)*

0.68, (0.49–0.94)*

0.76, (0.57–1.02)

0.93, (0.70–1.23)

0.70, (0.52–0.93)*

Neutropenia

0.77, (0.41–1.43)

0.80, (0.44–1.47)

0.48, (0.26–0.88)*

0.42, (0.23–0.75)*

0.36, (0.20–0.65)*

McCabe fatal-rapidly fatal

2.03, (1.52–2.70)*

1.67, (1.27–2.19)*

1.30, (1.01–1.68)*

1.68, (1.31–2.15)*

2.25, (1.75–2.89)*

Source

     

 Respiratory tract

1.30, (0.86–1.98)

1.26, (0.84–1.90)

1.05, (0.71–1.56)

0.85, (0.58–1.25)

0.91, (0.62–1.34)

 Intra-abdominal

0.82, (0.41–1.64)

1.64, (0.90–3.01)

0.98, (0.54–1.78)

1.14, (0.65–2.01)

0.84, (0.47–1.51)

 Spontaneous bacterial peritonitis in cirrhosis

1.23, (0.53–2.83)

0.63, (0.25–1.62)

0.36, (0.14–0.93)*

0.05, (0.01–0.26)*

0.06, (0.02–0.23)*

 Meningitis

2.80, (1.07–7.30)*

2.27, (0.86–6.01)

1.52, (0.57–4.04)

1.06, (0.40–2.86)

1.08, (0.39–2.97)

 Endocarditis

0.80, (0.49–1.31)

0.69, (0.43–1.13)

0.61, (0.39–0.95)*

0.47, (0.30–0.74)*

0.54, (0.35–0.83)*

 Urinary tract

1.06, (0.72–1.55)

1.34, (0.94–1.92)

1.16, (0.85–1.60)

1.50, (1.11–2.04)*

1.67, (1.23–2.27)*

 Biliary tract

1.13, (0.67–1.89)

1.43, (0.89–2.29)

1.44, (0.93–2.23)

1.93, (1.27–2.94)*

1.59, (1.04–2.43)*

Aetiology

     

 S. aureus

0.70, (0.46–1.06)

0.92, (0.62–1.36)

0.73, (0.50–1.05)

0.79, (0.55–1.13)

0.67, (0.47–0.97)*

 Enterococcus spp.

0.96, (0.47–1.96)

0.72, (0.35–1.47)

0.58, (0.30–1.14)

0.96, (0.52–1.80)

1.01, (0.55–1.88)

 Candida spp.

0.38, (0.12–1.20)

0.87, (0.36–2.10)

0.95, (0.42–2.15)

1.30, (0.60–2.82)

0.72, (0.32–1.61)

 Polymicrobial bacteraemia

1.60, (0.93–2.68)

1.74, (1.06–2.84)*

1.93, (1.21–3.07)*

1.38, (0.87–2.17)

1.76, (1.12–2.79)*

 Inmunosuppressive treatment

1.84, (1.17–2.90)*

2.53, (1.66–3.86)*

3.03, (2.02–4.55)*

2.65 (1,76–3.99)*

3.1, (2.09–4.6)*

 Appropriate empirical antimicrobial treatment

1.20, (0.90–1.61)

1.03, (0.78–1.36)

1.13, (0.87–1.47)

1.59, (1.23–2.05)*

1.42, (1.10–1.83)*

  1. Reference 1991–1995
  2. *p < 0.05