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Table 6 Estimated Influenza-Associated Excess All-Cause Deaths, in Absolute Number of Cases and per 100,000 People, by Age Group and Epidemic Season in Spain Between 2008/2009 and 2017/2018

From: Excess hospitalizations and mortality associated with seasonal influenza in Spain, 2008–2018

  

Influenza-Associated Excess All-Cause Deaths per Age Group

0–4

5–18

19–49

50–64

65–74

 ≥ 75

 ≥ 65

All Ages

2008/2009

N

79

a,d

234

566

1,509

12,824

14,193

14,078

Ratee

3.2

d

1.1

7.2

40.1

335.9

187.2

30.6

95% CI

1.3–5.3

d

0.4–1.8

4–11

30.4–49.7

264.1–405.4

149.4–225.5

24.4–37.5

2009/2010

N

a,d

38

291

214a

155a

633a

520a

1,525a

Ratee

d

0.6

1.3

2.7

4.1

16.1

6.7

3.3

95% CI

d

0.2–0

0.8–1.9

0–5.4

− 3.5 to 11.4

− 39.7 to 70.6

− 22.4 to 37.1

− 1.7 to 8.8

2010/2011

N

42a

a,d

351

898

841

4,695

5,693

5,169

Ratee

1.7

d

1.6

11

21.9

115.8

72.1

11.1

95% CI

− 0.1 to 3.3

d

1.1–2.1

8.4–14

13.3–30.1

60–175.7

42.1–104.2

5.8–16.8

2011/2012

N

53a

7a

176

1,054

1,317

16,913

18,744

20,974

Ratee

2.1

0.1

0.8

12.7

33.9

405.8

232.7

44.9

95% CI

0.2–4

− 0.3 to 0.6

0.2–1.4

9.9–15.8

24.4–42.7

347.9–468.1

201.3–266

38.8–51.2

2012/2013

N

a,d

a,d

94a

664

14a

3,205a

3,810a

2,070a

Ratee

d

d

0.4

7.8

0.4

75.4

46.5

4.4

95% CI

d

d

− 0.2 to 1

4.8–10.9

− 9 to 9.1

4.7–139.7

8.9–80.1

− 1.9 to 10.5

2013/2014

N

35a

a,d

240

799

795

4,419

4,923

7,353

Ratee

1.5

d

1.2

9.2

19.6

103

58.9

15.8

95% CI

0.1–2.9

d

0.6–1.7

6.7–11.7

11.6–27.2

54.1–154.3

32.1–85.7

10.4–20.5

2014/2015

N

17a

15a

130a

935

1,931

23,510

24,282

24,268

Ratee

0.8

0.2

0.6

10.6

45.7

547.5

285.1

52.2

95% CI

− 0.9 to 2.5

− 0.2 to 0.6

0.1–1.2

7.9–13.5

36.9–54.2

487.2–608.2

251.4–317.6

46.5–58

2015/2016

N

a,d

a,d

224

713

755

804a

1,015a

3,883a

Ratee

d

d

1.1

7.9

17.5

18.6

11.7

8.4

95% CI

d

d

0.6–1.7

5.1–11.1

8.3–25.8

− 43.8 to 85.1

−21.4 to 47.8

1.9–14.8

2016/2017

N

33a

5a

182

726

1,473

17,607

19,074

18,763

Ratee

1.5

0.1

0.9

7.9

33.7

401.7

217.8

40.4

95% CI

0.1–3.2

− 0.3 to 0.4

0.4–1.4

5.4–10.5

26.2–41.6

353.3–452.9

191.5–245.6

35.6–45.5

2017/2018

N

63

7a

161

1,247

1,778

14,736

16,685

19,306

Ratee

3

0.1

0.8

13.2

39.7

334.1

187.7

41.4

95% CI

1.2–4.6

− 0.3 to 0.5

0.2–1.4

10.6–16

30.8–48

274.3–391.9

156.1–219.2

35.3–47.3

9 years meanb

N

36

4

199

845

1,157

10,968

12,047

12,874

Ratee

1.5

0.1

0.9

9.7

28.1

259.8

144.4

27.7

95% CI

− 0.2 to 3.3

− 0.5 to 0.4

0.4–1.5

7–12.7

19.2–36.5

200.2–320.2

112.4–176.9

21.9–33.5

3 years meanc

N

32

4

189

895

1,335

11,049

12,258

13,984

Ratee

1.5

0.1

0.9

9.7

30.3

251.5

139.1

30.1

95% CI

− 0.2 to 3.3

− 0.4 to 0.4

0.4–1.5

7–12.5

21.8–38.4

194.6–310

108.7–170.9

24.3–35.9

  1. CI: Confidence interval; N: Number of influenza-associated excess all-cause deaths
  2. a P-value associated to the ILI incidence variable > 0.05; b Includes the following seasons: 2008/2009, 2010/2011, 2011/2012, 2012/2013, 2013/2014, 2014/2015, 2015/2016, 2016/2017, 2017/2018. Excludes season 2009/10, since it was affected by the 2009 influenza A (H1N1) pandemic. Seasonal negative excess estimates were truncated to zero to compute the mean; c Includes the most recent seasons, namely 2015/2016, 2016/2017, 2017/2018. Seasonal negative excess estimates were truncated to zero to compute the mean; d No influenza-associated excess deaths estimated for this age group/season; e Rate of influenza-associated excess all-cause deaths per 100,000 people