Effect of invasive aspergillosis on risk for different causes of death in older patients with acute myeloid leukaemia or high-risk myelodysplastic syndrome

Table 4 Estimated cause-specific hazard ratio along with their 95% confidence interval for the different causes of death ‘leukaemia’, ‘infection and other cause of death’ and ‘miscellaneous’

Leukaemia	_CSHR	95% CI	p-value
IA up until final chemotherapy cycle	1.750	1.341–2.282	< 0.001*
AML/MDS (MDS)	0.988	0.771–1.266	0.923
WBC count	1.002	1.001–1.004	0.054*
No prior haematological or oncological disease	0.938	0.751–1.169	0.567
No previous chemo- or radiotherapy	0.849	0.560–1.288	0.443
Age > 70	0.745	0.614–0.904	0.003*

Infection and other COD	_CSHR	95% CI	p-value
IA up until final chemotherapy cycle	1.359	0.958–1.909	0.085
AML/MDS (MDS)	0.827	0.623–1.210	0.403
WBC count	1.002	0.996–1.005	0.106
No prior haematological or oncological disease	1.318	0.978–1.775	0.068
No previous chemo- or radiotherapy	1.320	0.870–2.003	0.191
Age > 70	0.961	0.757–1.210	0.747

Miscellaneous	_CSHR	95% CI	p-value
IA up until final chemotherapy cycle	1.085	0.621–1.895	0.773
AML/MDS (MDS)	0.942	0.603–1.453	0.792
WBC count	0.999	0.997–1.005	0.733
No prior haematological or oncological disease	0.934	0.626–1.393	0.738
No previous chemo- or radiotherapy	0.538	0.231–1.258	0.153
Age > 70	0.855	0.607–1.206	0.373

*Statistically significant, AML acute myeloid leukaemia, COD cause of death, _CSHR cause specific hazard ratio, IA invasive aspergillosis, MDS myelodysplastic syndrome, WBC white blood cell count, 95% CI 95% confidence interval

ISSN: 1471-2334