Table 2 Comparison of the sensitivity, specificity and positive rate of QFT-PLUS and T-SPOT.TB
Studies (n) | Participants (n) | QFT-PLUS positive | I2 (%) | T-SPOT.TB positive | I2 (%) | RD-test | I2 (%) | |
|---|---|---|---|---|---|---|---|---|
Active TB | 3 | 317 | 0.947 (0.873–0.990) | 81 | 0.872 (0.643–0.991) | 96 | 0.09 (− 0.09–0.28) | 96 |
Populations with very low risk of TB exposure | 2 | 224 | 0.995 (0.959–1.000) | 76 | 1.000 (0.996–1.000) | 0 | 0.00 (− 0.02–0.01) | 76 |
High-risk populations | 6 | 2582 | 0.103 (0.047–0.179) | 95 | 0.069 (0.010–0.174) | 98 | 0.01 (− 0.01–0.04) | 54 |
Immunocompromised patients | 2 | 320 | NA | NA | NA | NA | 0.04 (0.00–0.07) | 0 |
With possibility of contact | 2 | 644 | NA | NA | NA | NA | − 0.01 (− 0.06–0.05) | 56 |
With possibility of immunosuppression | 2 | 1618 | NA | NA | NA | NA | 0.02 (− 0.04–0.08) | 74 |