Serotype distribution and antimicrobial susceptibility of invasive Streptococcus pneumoniae isolates among adult and elderly population before and after introduction of pneumococcal conjugate vaccine in Casablanca, Morocco

Table 2 Serotype distribution during the pre- and post-vaccination period (early and mature post-vaccine period) in the adult patients (15–59 years)

Serotype	Pre-vaccine period (2007–2010): N = 71			Early post-vaccine period (2011–2014): N = 57			Mature post-vaccine period (2015–2019): N = 58
Serotype	n	%	Cumulative %	n	%	Cumulative %	n	%	Cumulative %
4	0	0	0	1	1.75	1.75	0	0	0
6B	1	1.41	1.41	5	8.77	10.52	1	1.72	1.72
9V	1	1.41	2.82	1	1.75	12.28	1	1.72	3.45
14	1	1.41	4.23	1	1.75	14.03	0	0	3.45
18C	6	8.45	12.68	0	0	14.03	0	0	3.45
19F	2	2.82	15.49	1	1.75	15.79	0	0	3.45
23F	3	4.23	19.72	4	7.02	22.8	0	0	3.45
1	3	4.23	23.94	4	7.02	29.82	1	1.72	5.17
5	1	1.41	25.35	0	0	29.82	1	1.72	6.9
7F	2	2.82	28.17	3	5.26	35.08	0	0	6.9
Total PCV-10	20	28.17		20	35.09	P = 0.4031	4	6.9	P = 0.0021
3	2	2.82	30.99	5	8.77	43.86	5	8.62	15.52
6A	2	2.82	33.8	0	0	43.86	1	1.72	17.24
19A	9	12.68	46.48	0	0	43.86	5	8.62	25.86
Total PCV-13	33	46.48		25	43.86	P = 0.7682	15	25.86	P = 0.0164
2	1	1.41	47.89	0	0	43.86	0	0	25.86
7A	1	1.41	49.3	2	3.51	47.36	0	0	25.86
7C	1	1.41	50.7	0	0	47.36	0	0	25.86
8	7	9.86	60.56	4	7.02	54.38	4	6.9	32.76
10	2	2.82	63.38	1	1.75	56.14	0	0	32.76
11	0	0	63.38	2	3.51	59.64	1	1.72	34.48
12F	3	4.23	67.61	2	3.51	63.15	0	0	34.48
17F	0	0	67.61	2	3.51	66.66	3	5.17	39.66
22F	0	0	67.61	1	1.75	68.42	1	1.72	41.38
23A	2	2.82	70.42	0	0	68.42	1	1.72	43.1
33	0	0	70.42	1	1.75	70.17	3	5.17	48.27
34	3	4.23	74.65	1	1.75	71.93	1	1.72	49.99
9N	0	0	74.65	0	0	71.93	1	1.72	51.71
35F	0	0	74.65	1	1.75	73.68	0	0	51.71
NVT	18	25.35	100	15	26.32	100	28	48.28	100
Total non PCV-13	38	54		32	56.14	P = 0.8096	43	74.14	P = 0.0189

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