Fig. 3

Different plans can be applied to transfer mycobacteriophages into mammalian cells to achieve M. tuberculosis: (1) The M. smegmatis infected by Mycobacteriophage doing such as carriers are phagocytized via alveolar macrophages (AMs), conveyed into phagosomes containing M. tuberculosis. Mycobacteriophages replicate into M. smegmatis, lyse it, and access the phagosome lumen, then infect and lyse M. tuberculosis. (2) Liposome-linked mycobacteriophages are more efficient in infecting mammalian cells than free phages. (3) Production of polyvalent mycobacteriophages to identify eukaryote cells additionally the M. tuberculosis cell surface receptors