Hematologic and inflammatory parameters for determining severity of odontogenic infections at admission: a retrospective study

Table 5 Comparison of hematologic and inflammatory parameters as predictive tests for necrotizing soft tissue infection

	Cut-off value	AUC	95% CI	Sensitivity (%)	Specificity	PPV	NPV (%)	LR +	LR-
CRP (mg/dl)	20.9	0.894	0.771–1.000	84.6	93.0%	37.9%	99.2	12.1	0.17
WBC (× 10³/µl)	17.5	0.857	0.754–0.961	69.2	91.1%	28.1%	98.3	7.76	0.33
LRINEC score	6	0.941	0.890–0.992	92.3	90.3%	32.4%	99.6	9.53	0.09
NLR	14.2	0.901	0.817–0.985	92.3	86.8%	26.1%	99.6	7.00	0.09
PLR	229	0.758	0.605–0.911	84.6	65.5%	11.0%	98.8	2.45	0.23
SII	495	0.870	0.754–0.986	76.9	89.5%	27.0%	98.7	7.35	0.26
CRP + NLR	27	0.947	0.910–0.948	100	82.6%	22.4%	100	5.73	0

CRP C-reactive protein, WBC white blood cell, LRINEC laboratory risk indicator for necrotizing fasciitis, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammation index, AUC area under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, LR + positive likelihood ratio, LR− negative likelihood ratio

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