Genetic diversity of transmission-blocking vaccine candidate antigens Pvs25 and Pvs28 in Plasmodium vivax isolates from China

Table 1 Amino acid variation of the Pvs25 in P. vivax isolates from China, 2009–2020

Haplotypes	Number (%)	EGF-1	EGF-2			EGF-3
Haplotypes	Number (%)	27	87	97	100	130	131
Sal-I	–	D	Q	E	T	I	Q
pv01^*				Q		T
H1	82 (25.3)					T
H2	1 (0.3)	N				T
H3	46 (14.2)			Q		T
H4	2 (0.6)				S	T
H5	176 (54.3)					T	K
H6	10 (3.1)			Q		T	K
H7	6 (1.9)		L	Q		T	K
H8	1 (0.3)	N		Q		T	K
Total	324 (100)	–	–	–	–	–	–

EGF, epidermal growth factor-like domain. Dot (•) indicates identical amino acid residues compared to the Sal-I strain. *The pv01 strain from Indonesia was used as another compared sequence, which had the same variation 130T as the isolates from China. Bold letters indicate amino acid variation compared to the Sal-I strain

ISSN: 1471-2334