Table 4 Adherence to post-discharge continuation of initial antibiotic withholding in patients with low procalcitonin levels (< 0.25 mcg/L) in the hospital, and impact on antibiotic-days by Day 30, by lower respiratory tract infection type
Adherence | # of antibiotic-days by Day 30; mean (SD) | Differencea | p-valuea | |
|---|---|---|---|---|
Procalcitonina | Usual care | |||
a. Community-acquired pneumonia | ||||
100% | 4.6 (4.9) | 7.2 (6.0) | − 2.5 | < 0.001 |
95% | 4.9 (5.2) | 7.2 (6.0) | − 2.3 | < 0.001 |
90% | 5.1 (5.4) | 7.2 (6.0) | − 2.1 | 0.002 |
85% | 5.3 (5.6) | 7.2 (6.0) | − 1.8 | 0.008 |
80% | 5.5 (5.8) | 7.2 (6.0) | − 1.6 | 0.021 |
75% | 5.8 (6.0) | 7.2 (6.0) | − 1.4 | 0.055 |
b. Chronic obstructive pulmonary disease | ||||
100% | 3.3 (4.3) | 5.2 (5.3) | − 1.9 | < 0.001 |
95% | 3.5 (4.5) | 5.2 (5.3) | − 1.8 | < 0.001 |
90% | 3.6 (4.7) | 5.2 (5.3) | − 1.6 | 0.001 |
85% | 3.8 (4.9) | 5.2 (5.3) | − 1.4 | 0.004 |
80% | 4.0 (5.1) | 5.2 (5.3) | − 1.2 | 0.016 |
75% | 4.2 (5.3) | 5.2 (5.3) | − 1.0 | 0.045 |
c. Acute bronchitis | ||||
100% | 1.7 (4.0) | 3.6 (5.5) | − 1.9 | < 0.001 |
95% | 2.0 (4.4) | 3.6 (5.5) | − 1.6 | 0.002 |
90% | 2.2 (4.7) | 3.6 (5.5) | − 1.3 | 0.013 |
85% | 2.5 (4.9) | 3.6 (5.5) | − 1.1 | 0.053 |
d. Asthma | ||||
100% | 2.2 (3.9) | 3.6 (4.9) | − 1.4 | < 0.001 |
95% | 2.4 (4.1) | 3.6 (4.9) | − 1.1 | 0.003 |
90% | 2.6 (4.3) | 3.6 (4.9) | − 0.9 | 0.017 |
85% | 2.9 (4.5) | 3.6 (4.9) | − 0.7 | 0.071 |
80% | 3.1 (4.7) | 3.6 (4.9) | − 0.5 | 0.214 |
75% | 3.3 (4.9) | 3.6 (4.9) | − 0.3 | 0.489 |