Impact of antimicrobial stewardship on antibiogram, consumption and incidence of multi drug resistance

Darwish, Rula M.; Matar, Sajeda Ghassan; Snaineh, Ahmad Atef Abu; Alsharif, Mohammad Refat; Yahia, Ahmad Bassam; Mustafa, Haneen Nidal; Hasabo, Elfatih A.

doi:10.1186/s12879-022-07906-1

BMC Infectious Diseases

Table 2 Percentage of antibiotics’ sensitivity toward different bacteria in Hospital “A” before and after the implementation of Antimicrobial Stewardship Program

From: Impact of antimicrobial stewardship on antibiogram, consumption and incidence of multi drug resistance

Bacteria	Number of cultures			Percentage of sensitive cultures for each antibiotic				P-value to compare between pre and one year after	P-value to compare between one year and two years after
Bacteria	One year before application of AMS program	One year after application of AMS program	Two year after application of AMS program	One year before application of AMS program	One year after application of AMS program	Two year after application of AMS program		P-value to compare between pre and one year after	P-value to compare between one year and two years after
E. coli	456	355	324	Piperacillin/tazobactam				0.632	0.461
				80	82	85		0.632	0.461
				Cefuroxime				–	0.477
				48	48	50		–	0.477
				Ceftazidime				0.7	0.705
				48	49	50		0.7	0.705
				Ertapenem				< 0.001	< 0.001
				93	69	94		< 0.001	< 0.001
				Imipenem				< 0.001	< 0.001
				93	69	94		< 0.001	< 0.001
				Gentamycin				0.002	0.709
				69	79	77		0.002	0.709
				Amikacin				0.077	0.18
				97	99	97		0.077	0.18
				Ciprofloxacin				1	1
				53	54	53		1	1
				Tigecycline				0.405	–
				95	97	97		0.405	–
				TMP/SMX				1	0.74
				41	43	45		1	0.74
Klebsiella pneumonia	140	75	88	Piperacillin/tazobactam				0.442	0.542
				63	68	76		0.442	0.542
				Cefuroxime				0.627	–
				45	51	51		0.627	–
				Ceftazidime				0.755	0.864
				42	48	51		0.755	0.864
				Ertapenem				< 0.001	< 0.001
				79	84	86		< 0.001	< 0.001
				Imipenem				1	0.815
				79	84	86		1	0.815
				Gentamycin				0.229	0.152
				75	64	76		0.229	0.152
				Amikacin				0.581	0.774
				92	89	91		0.581	0.774
				Ciprofloxacin				0.006	0.458
				47	73	69		0.006	0.458
				Tigecycline				0.405	–
				81	84	90		0.405	–
				TMP/SMX				0.533	0.652
				56	57	51		0.533	0.652
Pseudomonas aeruginosa	95	41	51	Piperacillin/tazobactam				0.629	0.07
				75	80	94		0.629	0.07
				Ceftazidime				–	0.774
				78	78	84		–	0.774
				Imipenem				1	0.092
				62	71	82		1	0.092
				Gentamycin				–	0.424
				73	73	86		–	0.424
				Amikacin				0.774	0.754
				84	83	88		0.774	0.754
				Ciprofloxacin				0.096	0.503
				67	56	69		0.096	0.503
Acinetobacter	65	20	26	Tigecycline				0.227	0.388
Acinetobacter	65	20	26	69	50	65		0.227	0.388
Enterobacter	33	20	12	Piperacillin/tazobactam				0.549
				54	60	100		0.549
				Cefuroxime				0.18	0.18
				36	50	83		0.18	0.18
				Ceftazidime				0.289	0.219
				36	50	83		0.289	0.219
				Ertapenem				1	0.375
				72	75	99		1	0.375
				Imipenem				1	0.625
				72	75	99		1	0.625
				Gentamycin				0.289	0.625
				63	80	99		0.289	0.625
				Ciprofloxacin				0.344	1
				54	80	75		0.344	1
				TMP/SMX ( Trimethoprim / Sulfamethoxazole)				0.004	0.375
				27	65	50		0.004	0.375
Proetus mirabilis	30	21	15	Cefuroxime				0.727	1
				73	76	67		0.727	1
				Piperacillin/tazobactam				0.549	1
				54	60	100		0.549	1
				Ceftazidime				1	1
				73	76	67		1	1
				Imipenem				1	1
				6	10	13		1	1
				Gentamycin				0.727	0.462
				53	57	60		0.727	0.462
				Amikacin				0.625	1
				93	86	93		0.625	1
				Ciprofloxacin				0.581	1
				50	62	76		0.581	1
				TMP-SMX				1	1
				36	43	47		1	1
S. aureus	97	81	80	Oxacillin				0.337	0.87
				39	31	29		0.337	0.87
				Piperacillin/tazobactam					0.86
					31	29			0.86
				Gentamycin				0.458	0.071
				87	88	85		0.458	0.071
				Ciprofloxacin				0.093	0.004
				72	79	64		0.093	0.004
				TMP-SMX ( Trimethoprim / Sulfamethoxazole)				0.629	0.815
				88	77	94		0.629	0.815
				Clindamycin				0.487	1
				61	65	66		0.487	1
				Rifampin				0.388	0.549
				91	95	91		0.388	0.549
E. faecalis	48	30	30	Ciprofloxacin				0.087	–
				54	60	60		0.087	–
				Vancomycin				0.002	0.871
				87	93	100		0.002	0.871
				Teicoplanin				< 0.001	0.851
				87	93	100		< 0.001	0.851
E. faecium	22	2	10	Ciprofloxacin				1	1
E. faecium	22	2	10	18	50	36		1	1
Strep. Viridians	25	15	11	Ciprofloxacin				0.727	1
				60	70	80		0.727	1
				Piperacillin/tazobactam				–	1
					75	80		–	1
Total number of cases with improved antibiotics’ sensitivity				When comparing 1 year before AMS and 1 year after: 6			When comparing 1 year after and 2 years after AMS: 3
Total number of cases with decreased antibiotics’ sensitivity				When comparing 1 year before AMS and 1 year after: 2			When comparing 1 year after and 2 years after AMS: 1

Statistically significant values are shown in bold

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ISSN: 1471-2334

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