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Table 3 Real time PCR detection of S. pneumoniae serotypes in patients and healthy controls

From: Pneumococcal concentration and serotype distribution in preschool children with radiologically confirmed pneumonia compared to healthy controls prior to introduction of pneumococcal vaccination in Zanzibar: an observational study

Serogroup/type, order of frequency

All participantsab

Patientsb

Healthy controls

p-valuec

(n = 809)

(n = 648)

(n = 161)

Patients vs controls

6A/B/C/D

143 (18%)

115 (18%)

28 (17%)

1.000

19F

98 (12%)

86 (13%)

12 (7%)

0.043

19A

45 (6%)

38 (6%)

7 (4%)

0.566

14

44 (5%)

39 (6%)

5 (3%)

0.175

23F

31 (4%)

25 (4%)

6 (4%)

1.000

15BC

30 (4%)

24 (4%)

6 (4%)

1.000

11

29 (4%)

25 (4%)

4 (2%)

0.486

7C

15 (2%)

14 (2%)

1 (1%)

0.327

5

12 (1%)

11 (2%)

1 (1%)

0.477

10A

12 (1%)

10 (2%)

2 (1%)

1.000

9A/V

9 (1%)

8 (1%)

1 (1%)

1.000

18

7 (1%)

5 (1%)

2 (1%)

0.631

12

7 (1%)

7 (1%)

0 (0%)

0.356

3

7 (1%)

6 (1%)

1 (1%)

1.000

20

5 (1%)

4 (1%)

1 (1%)

1.000

4

4 (0%)

3 (0%)

1 (1%)

1.000

Negative in serotyping

386 (48%)

296 (46%)

90 (56%)

0.022

One serotype detected

283 (35%)

233 (36%)

50 (31%)

0.268

Two serotypes detected

111 (14%)

93 (14%)

18 (6%)

0.370

 > 3 serotypes detected

29 (4%)

26 (4%)

3 (2%)

0.240

  1. aFor pneumococcal serotypes n < 3 and are not displayed here: S. pneumoniae spp positive: 38, 22FA, 17, 1 (n = 2), 2, 8, 9NL (n = 1) 33, 7FA (n = 0)
  2. bAll tested for S. pneumoniae
  3. cFisher’s exact test, two-sided
  4. Serotypes included in PCV7: 4, 6B, 9 V, 14, 18C, 19F, 23F. Serotypes included in PCV10: 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, 23F Serotypes included in PCV13: 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F