Table 4 Baseline characteristics of the study patients with HPV infections
Characteristic | Mean (SD) or N (%) | HPV16 N (%) | HPV58 | HPV18 N (%) | HPV52 N (%) | HR-HPV (13 subtypes) | ||
|---|---|---|---|---|---|---|---|---|
N (%) | N (%) | P value | HR (95% CI) | |||||
Age (years) | ||||||||
Mean (SD) | 48.1 (9.4) | 47.0 (9.4) | 51.9 (10.0) | 47.6 (8.7) | 54.1 (11.4) | 48.0 (9.5) | 0.257 | – |
≤ 48 | 795 (55.8) | 569 (71.6) | 47 (5.9) | 66 (8.3) | 21 (2.6) | 671 (84.4) | 0.057 | – |
> 48 | 630 (44.2) | 360 (57.1) | 77 (12.1) | 43 (6.8) | 43 (6.8) | 507 (80.5) | ||
FIGO stage | ||||||||
IA1–IB2 | 903 (63.4) | 590 (65.3) | 64 (7.1) | 72 (8.0) | 39 (4.3) | 736 (81.5) | 0.146 | – |
IIA1–IIA2 | 522 (36.6) | 339 (64.9) | 60 (11.5) | 37 (7.1) | 25 (4.8) | 442 (84.7) | ||
SCC-Ag (ng/ml) | ||||||||
Mean (SD) | 4.2 (7.2) | 4.3 (7.5) | 4.0 (6.3) | 4.3 (8.7) | 3.7 (7.3) | 4.2 (7.3) | 0.647 | – |
< 1.5 | 608 (42.7) | 375 (61.7) | 47 (7.7) | 54 (8.9) | 29 (4.8) | 483 (79.4) | 0.006 | 1.47 (1.12–1.94) |
≥ 1.5 | 817 (57.3) | 554 (67.8) | 77 (9.4) | 55 (6.7) | 35 (4.3) | 695 (85.1) | ||
Histological grade | ||||||||
G1 | 199 (14.0) | 134 (67.3) | 9 (4.5) | 7 (3.5) | 7 (3.5) | 160 (80.4) | 0.364 | – |
G2–G3 | 1226 (86.0) | 795 (64.8) | 115 (9.4) | 102 (8.3) | 57 (4.6) | 1018 (83.0) | ||
Deep stromal invasion | ||||||||
Superficial (< 1/2) | 586 (41.1) | 388 (66.2) | 46 (7.8) | 50 (8.5) | 19 (3.2) | 477 (81.4) | 0.319 | – |
Deep (≥ 1/2) | 839 (58.9) | 541 (64.5) | 78 (9.3) | 59 (7.0) | 45 (5.4) | 701 (83.6) | ||
LVSI | ||||||||
Negative | 681 (47.8) | 402 (59.0) | 64 (9.4) | 61 (9.0) | 37 (5.4) | 541 (79.4) | 0.003 | 1.54 (1.17–2.03) |
Positive | 744 (52.2) | 527 (70.8) | 60 (8.1) | 48 (6.5) | 27 (3.6) | 637 (85.6) | ||
Para-aortic/Pelvic LN | ||||||||
Negative | 1174 (82.4) | 760 (64.7) | 106 (9.0) | 92 (7.8) | 54 (4.6) | 969 (82.5) | 0.854 | – |
Positive | 251 (17.6) | 169 (67.3) | 18 (7.2) | 17 (6.8) | 10 (4.0) | 209 (83.3) | ||
Postoperative therapy | ||||||||
None | 523 (36.7) | 332 (63.5) | 41 (7.8) | 36 (6.9) | 24 (4.6) | 420 (80.3) | 0.081 | – |
Yes | 902 (63.3) | 597 (66.2) | 83 (9.2) | 73 (8.1) | 40 (4.4) | 758 (84.0) | ||
Total cases | 1425 | 929 (65.1) | 124 (8.7) | 107 (7.7) | 64 (4.5) | 1178 (82.6) | ||