Characteristics | Initial empirical antibiotics | P-value | ||
---|---|---|---|---|
Non-carbapenem (N = 26) | Carbapenem (N = 27) | Total (N = 53) | ||
Median age, years (range) | 3.2 (0–18.7) | 3.8 (0–18.8) | 3.6 (0–18.8) | 0.60 |
Sex (M:F) | 17:9 | 14:13 | 31:22 | 0.32 |
Strain (E. coli: K. pneumoniae) | 17:9 | 12:15 | 29:24 | 0.13 |
Presence of underlying diseases | 26 (100%) | 27 (100%) | 53 (100%) | Â |
 Hemato-oncologic disease | 13 (50%) | 13 (48.1%) | 26 (49.1%) | 0.90 |
 Preterm infant (GA < 37 wks) | 3 (11.5%) | 8 (29.6%) | 11 (20.8%) | 0.11 |
 Congenital heart disease | 3 (11.5%) | 4 (14.8%) | 7 (13.2%) | 0.73 |
 Vesicoureteral reflux | 2 (7.7%) | 0 (0%) | 2 (3.8%) | 0.14 |
 Others | 5†(19.2%) | 2‡ (7.4%) | 7 (13.2%) | 0.20 |
Primary focus of bacteremia | ||||
 None | 2 (7.7%) | 0 (0%) | 2 (3.8%) | 0.14 |
 CLABSI | 16 (61.5%) | 22 (81.5%) | 38 (71.7%) | 0.11 |
 Intra-abdominal infection | 1 (3.8%) | 5 (18.5%) | 6 (11.3%) | 0.09 |
  NEC | 1 (3.8%) | 4 (14.8%) | 5 (9.4%) | 0.17 |
  Peritonitis | 0 (0%) | 1 (3.7%) | 1 (1.9%) | 0.32 |
 Urinary tract infection | 4 (15.4%) | 0 (0%) | 4 (7.5%) | 0.03 |
 Pneumonia | 2 (7.7%) | 0 (0%) | 1 (1.9%) | 0.30 |
 Meningitis | 1 (3.8%) | 0 (0%) | 1 (1.9%) | 0.30 |
ICU stay prior to infection | 8 (30.8%) | 13 (48.1%) | 21 (39.6%) | 0.20 |
Initial presentation with severe infection | 4 (15.4%) | 13 (48.1%) | 17 (32.1%) | 0.01 |
 Presentation with shock | 3 (11.5%) | 11 (40.7%) | 14 (26.4%) | 0.02 |
 Need for higher respiratory support | 3 (11.5%) | 9 (33.3%) | 12 (22.6%) | 0.06 |