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Table 1 Baseline characteristics of the study population

From: Initial empirical antibiotics of non-carbapenems for ESBL-producing E. coli and K. pneumoniae bacteremia in children: a retrospective medical record review

Characteristics

Initial empirical antibiotics

P-value

Non-carbapenem (N = 26)

Carbapenem (N = 27)

Total (N = 53)

Median age, years (range)

3.2 (0–18.7)

3.8 (0–18.8)

3.6 (0–18.8)

0.60

Sex (M:F)

17:9

14:13

31:22

0.32

Strain (E. coli: K. pneumoniae)

17:9

12:15

29:24

0.13

Presence of underlying diseases

26 (100%)

27 (100%)

53 (100%)

 

 Hemato-oncologic disease

13 (50%)

13 (48.1%)

26 (49.1%)

0.90

 Preterm infant (GA < 37 wks)

3 (11.5%)

8 (29.6%)

11 (20.8%)

0.11

 Congenital heart disease

3 (11.5%)

4 (14.8%)

7 (13.2%)

0.73

 Vesicoureteral reflux

2 (7.7%)

0 (0%)

2 (3.8%)

0.14

 Others

5† (19.2%)

2‡ (7.4%)

7 (13.2%)

0.20

Primary focus of bacteremia

 None

2 (7.7%)

0 (0%)

2 (3.8%)

0.14

 CLABSI

16 (61.5%)

22 (81.5%)

38 (71.7%)

0.11

 Intra-abdominal infection

1 (3.8%)

5 (18.5%)

6 (11.3%)

0.09

  NEC

1 (3.8%)

4 (14.8%)

5 (9.4%)

0.17

  Peritonitis

0 (0%)

1 (3.7%)

1 (1.9%)

0.32

 Urinary tract infection

4 (15.4%)

0 (0%)

4 (7.5%)

0.03

 Pneumonia

2 (7.7%)

0 (0%)

1 (1.9%)

0.30

 Meningitis

1 (3.8%)

0 (0%)

1 (1.9%)

0.30

ICU stay prior to infection

8 (30.8%)

13 (48.1%)

21 (39.6%)

0.20

Initial presentation with severe infection

4 (15.4%)

13 (48.1%)

17 (32.1%)

0.01

 Presentation with shock

3 (11.5%)

11 (40.7%)

14 (26.4%)

0.02

 Need for higher respiratory support

3 (11.5%)

9 (33.3%)

12 (22.6%)

0.06

  1. BSI blood stream infection, CLABSI central-line-associated blood stream infection, GA gestational age, ICU intensive care unit, NEC necrotizing enterocolitis
  2. †Includes ornithine transcarbamylase deficiency (n = 1), Alagille syndrome (n = 1), bronchopulmonary dysplasia (n = 1), chronic kidney disease (n = 1), and meningomyelocele (n = 1)
  3. ‡Includes DiGeorge syndrome (n = 1) and liver transplantation state (n = 1)