Table 1 Demographic characteristics, organ function scores, inflammatory indexes and TRIM7 mRNA level of the subjects in three groups

Demographics

 N

25

35

34

 Age (years)

63.3 ± 14.67

68.6 ± 14.22

68.2 ± 13.14

0.297

 Gender, male (%)

14

15

20

0.374

Comorbid conditions N (%)

 Diabetes mellitus

6

10

12

0.632

 Cardiac insufficiency

5

15

15

0.114

 Chronic obstructive pulmonary disease

1

4

3

0.594

 Chronic renal insufficency

2

2

3

0.879

 Chronic liver disease

1

2

3

0.740

 Malignancy

3

1

5

0.220

Site of infection N (%)

 Respiratory

10

15

0.209

 Urinary

9

8

0.833

 Abdominal

7

8

0.722

 Musculoskeletal, skin and soft tissue

5

5

0.950

 Bloodstream

7

6

0.803

 Others

3

1

0.317

Organ function indices and inflammatory biomarkers

 APACHE II

5 (2, 6)

9 (7, 12)^a

20 (14, 25)^a,b

0.000

 SOFA

0 (0, 0)

2 (1, 3)^a

7 (6, 10)^a,b

0.000

 WBC (10⁹/L)

6.7 ± 2.72

13.7 ± 4.49^a

14.2 ± 6.77^a

0.000

 CRP (mg/L)

2.6 ± 3.14

64.2 ± 42.37^a

114.0 ± 78.10^a,b

0.000

 PCT (µg/L)

0.16 (0.05, 0.26)

1.19 (0.12, 8.21)^a

10.10 (3.80, 62.36)^a,b

0.000

 TNF-α (ng/L)

24.34 (19.17, 43.09)

36.98 (25.12, 68.23)^a

67.48 (28.95, 92.29)^a,b

0.000

 IL-6 (ng/L)

13.30 (6.90, 35.64)

43.05 (23.45, 81.90)^a

115.33 (60.78, 246.31)^a,b

0.000

 TRIM7 mRNA (2^−△△Ct)

8.06 (5.28, 13.38)

2.86 (1.88, 3.97)^a

1.10 (0.83, 2.00)^a,b

0.000