Table 1 Sensitivity and specificity of Borrelia multiplex against the recomBead Borrelia IgG/IgM 2.0
Classification | Sensitivity | Specificity | ||
|---|---|---|---|---|
Manual processing | Automated processing | Manual processing | Automated processing | |
IgG/IgM | recomBead positive: 63 Borrelia multiplex: positive consensus: 59 Sens.: 93.7% (84.8–97.5%) PPV: 86.8% | recomBead positive: 63 Borrelia multiplex: positive consensus: 53 Sens.: 84.1% (73.2–91.1%) PPV: 67.9% | recomBead negative: 256 Borrelia multiplex: negative consensus: 247 Spec.: 96.5% (93.5–98.1%) NPV: 98.4% | recomBead negative: 256 Borrelia multiplex: negative consensus: 231 Spec.: 90.2% (86.0–93.3%) NPV: 95.9% |
IgG | recomBead positive: 58 Borrelia multiplex: positive consensus: 56 Sens.: 96.6% (88.3–99.4%) PPV: 93.3% | recomBead positive: 58 Borrelia multiplex: positive consensus: 50 Sens.: 86.2% (75.1–92.8%) PPV: 71.4% | recomBead negative: 261 Borrelia multiplex: negative consensus: 257 Spec.: 98.5% (96.1–99.4%) NPV: 99.2% | recomBead negative: 261 Borrelia multiplex: negative consensus: 241 Spec.: 92.3% (88.5–95.0%) NPV: 96.8% |
IgM | recomBead positive: 11 Borrelia multiplex: positive consensus: 6 Sens.: 54.5% (28.0–78.7%) PPV: 50.0% | recomBead positive: 11 Borrelia multiplex: positive consensus: 5 Sens.: 45.5% (21.3–72.0%) PPV: 45.5% | recomBead negative: 308 Borrelia multiplex: negative consensus: 302 Spec.: 98.1% (95.8–99.1%) NPV: 98.4% | recomBead negative: 308 Borrelia multiplex: negative consensus: 302 Spec.: 98.1% (95.8–99.1%) NPV: 98.1% |