Table 3 Unadjusted and Adjusted odds ratios for severe or critical disease of covid-19 in those vaccinated
From: Risk factors for severe Covid-19 breakthrough infections: an observational longitudinal study
Severe or critical disease | Asymptomatic or mild disease | Model 1 OR(IC95%) | p-value | Model 2 OR(IC95%) | p-value | |
|---|---|---|---|---|---|---|
Total | 56 (10.8) | 562 (89.2) | – | – | – | - |
Age | 65.2 (13.0) | 55.0 (14.0) | 1.06 (1.03–1.08) | < 10–3 | 1.05 (1.02–1.07) | 0.001 |
Gender | ||||||
Female | 23(06.0) | 327 (94.0) | Reference | 0.024 | Reference | |
Male | 33 (11.1) | 237 (88.9) | 1.95 (1.09–3.49) | 2.14 [1.15–3.90] | 0.015 | |
Employment | ||||||
Healthcare worker | 8 (06.6) | 114 (93.4) | Reference | 0.458 | – | - |
Others | 43 (08.6) | 456 (91.4) | 0.74 (0.34–1.62) | – | - | |
Medical history | ||||||
Absence | 13 (04.1) | 304 (95.9) | Reference | Reference | ||
CVD | 26 (15.0) | 147 (85.0) | 4.13 (2.06–8.28) | < 10–3 | 2.70 [1.21–5.99] | 0.015 |
Others* | 12 (09.2) | 119 (90.8) | 2.35 (1.04–5.31) | 0.039 | 1.98 [0.82–4.72] | 0.124 |
Tobacco use | ||||||
Smokers | 10 (09.0) | 101 (91.0) | Reference | 0.736 | – | - |
Non-smokers | 41 (08.0) | 469 (92.0) | 0.88 (0.42–1.82) | – | - | |
Self-estimation of adherence to preventive measure | ||||||
Poor (score ≤ 4) | 11 (19.0) | 47 (81.0) | Reference | Reference | ||
Medium (5 ≤ score ≤ 7) | 24 (07.4) | 299 (92.6) | 0.34 (0.15–0.74) | 0.007 | 0.28 [0.11–0.73] | 0.001 |
High (score ≥ 8) | 16 (06.7) | 224 (93.3) | 0.30 (0.13–0.70) | 0.005 | 0.29 [0.12–0.69] | |
Vaccination schema | ||||||
Complete | 10 (05.8) | 162 (94.2) | Reference | Reference | 0.007 | |
Uncomplete | 41 (09.1) | 408 (90.9) | 1.62 (0.97–3.32) | 0.181 | 3.01 (1.34–6.78) | |
Vaccine | ||||||
Astrazeneca | 9 (15.8) | 48 (84.2) | Reference | 0.031 | – | – |
Others | 42 (07.5) | 516 (92.5) | 2.3 (1.05–5.01) | – | – |