Omadacycline for management of Mycobacterium abscessus infections: a review of its effectiveness, place in therapy, and considerations for use

Table 2 Published clinical studies on omadacycline (OMA) use for Mycobacterium abscessus complex

Study and OMA treatment regimen (n)	NTM Species (n)	Infection source (n)	Duration of OMA therapy
Minhas et al. [103] OMA 150 mg PO daily	M. abscessus	Pulmonary	4 weeks
Frizzell et al. [104] OMA 450 mg PO on days 1-2 then 300 mg PO daily	M. chelonae	Cutaneous	4 months
Pearson et al. [105] Case 1: OMA 450 mg PO on days 1-2 then 300 mg PO daily	Case 1: M. bolletii	Case 1: Cutaneous	Case 1: 6 months
Case 2: OMA 450 mg PO on days 1-2 then 300 mg PO daily	Case 2: M. abscessus	Case 2: Pulmonary	Case 2: 7 months
Case 3: OMA 300 mg PO daily	Case 3: M. abscessus	Case 3: Cutaneous	Case 3: 6 months
Case 4: OMA 300 mg PO daily	Case 4: M. abscessus	Case 4: Blood/bone	Case 4: 3 months
Morrisette et al. [106] OMA 450 mg PO on days 1-2 then 300 mg PO daily (2) OMA 300 mg PO daily (10)	M. abscessus complex; no subspecies (5) M. abscessus (6) M. massiliense (1)	Pulmonary (7) Bone (2) Intra-abdominal (1) Cutaneous (1) Catheter (1)	IQR 4.2–11.0 months

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