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Table 1 Comparison of the baseline characteristics of the children in the booster group and nonbooster group and those of their mothers

From: A booster hepatitis B vaccine for children with maternal HBsAg positivity before 2 years of age could effectively prevent vaccine breakthrough infections

 

Overall

Booster group

Nonbooster group

Pc

Mothers

    

 Number

454

208

246

 

 Age (years), median (range)

25.70 (18.50–43.00)

25.85 (18.60–43.00)

25.65 (18.50–43.00)

0.825

 HBeAg positivity, n (%)

150 (33.04%)

59 (28.37%)

91 (36.99%)

0.052

 HBV DNA (log10 IU/mL), median (range)

3.03 (1.18–9.13)

2.95 (1.18–9.07)

3.14 (1.18–9.13)

0.150

 HBsAg (log10 IU/mL), median (range)

3.59 (− 1.30–4.97)

3.62 (0.61–4.97)

3.56 (− 1.30–4.97)

0.913

Maternal genotypea, n

    

  B

38

18

20

0.935

  C

265

116

149

 Mixed B + C, D

11

5

6

Infants

    

 Sex, male: female

236: 218

107: 101

129:117

0.832

 Anti-HBs (log10 mIU/mL), median (range)

2.88 (1.02–4.23)

2.81 (1.02–3.96)

2.93 (1.07–4.23)

 < 0.001

 Birth weight (kg), median (range)

3.50 (2.40–5.40)

3.40 (2.40–5.40)

3.50 (2.50–4.50)

0.086

 Parturition manner, caesarean: vaginal

290: 164

130: 78

160: 86

0.574

 Feeding pattern, breastb: artificial

163: 291

73: 135

90: 156

0.742

  1. aGenotypes were not successfully identified for 140 pregnant women, including 69 and 71 pregnant women in the booster group and nonbooster group, respectively
  2. bBreast feeding included mixed feeding
  3. cP values represent the significant differences between the booster group and the nonbooster group