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Table 4 Diagnostic test performance statistics of LFA for the cut-off value of 0.5 and diagnostic test performance statistics of ELISA for the cut-off value of 1.0 ODI

From: Lateral flow assay (LFA) in the diagnosis of COVID-19-associated pulmonary aspergillosis (CAPA): a single-center experience

  

95% Confidence interval lower

95% Confidence interval upper

p-value

LFA (cut-off value: 0.5)

Sensitivity

0.8

0.55

1.05

 < 0.05

Specificity

0.94

0.89

0.98

 < 0.05

PPV

0.53

0.28

0.79

 > 0.05

NPV

0.98

0.95

1.007

 < 0.05

PLR

12.34

5.65

26.94

 < 0.05

NLR

0.21

0.06

0.74

 < 0.05

Accuracy

0.92

0.88

0.97

 < 0.05

Odds ratio

57.71

10.25

325.07

 < 0.05

ELISA (cut-off value:1.0)

Sensitivity

0.2

− 0.05

0.45

 > 0.05

Specificity

0.97

0.94

0.99

 < 0.05

PPV

0.4

− 0.3

0.83

 > 0.05

NPV

0.93

0.88

0.98

 < 0.05

PLR

7.2

1.36

38.16

 < 0.05

NLR

0.83

0.61

1.12

 < 0.01

Accuracy

0.91

0.85

0.96

 < 0.05

Odds ratio

8.75

1.27

60.18

 < 0.05

  1. LFA lateral flow assay, ODI optical density index, PPV positive predictive value, NPV negative predictive value, PLR positive likelihood ratio, NLR negative likelihood ratio