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Table 3 Community-onset and hospital-onset BSI pathogen comparison pre-pandemic and pandemic periods

From: Epidemiology and outcomes of culture-positive bloodstream pathogens prior to and during the SARS-CoV-2 pandemic: a multicenter evaluation

Pathogen

Pre-pandemic: July 2019-February 2020

(n = 1,789,449 admissions)

Pandemic period March 2020-September 4, 2021

(n = 3,450,243 admissions)

Community-onset BSI rate/1000 Adm (n)

Hospital-onset BSI rate/1000 Adm (n)

Community-onset BSI rate/1000 Adm (n)

Hospital-onset BSI rate/1000 Adm (n)

Gram-negative

E coli

3.78 (6764)

0.23 410)

3.77 (13,001)

0.22 (766)

K pneumoniae

0.93 (1,662)

0.14 (250)

1.00 (3456)a

0.17 (597)b

P aeruginosa

0.39 (697)

0.08 (141)

0.37 (1275)

0.11 (384)b

P mirabilis

0.35 (622)

0.02 (39)

0.38 (1,294)

0.03 (89)

E cloacae

0.18 (318)

0.06 (102)

0.18 (610)

0.06 (207)

S marcescens

0.12 (208)

0.04 (64)

0.14 (477)a

0.06 (192)b

B fragilis

0.10 (171)

0.02 (35)

0.10 (339)

0.02 (65)

K oxytoca

0.09 (153)

0.02 (40)

0.11 (384)a

0.02 (65)

K (E) aerogenes

0.07 (126)

0.02 (41)

0.07 (236)

0.03 (88)

A baumannii spp

0.05 (91)

0.01 (22)

0.04 (141)

0.02 (56)

P stuartii

0.02 (33)

 < 0.01 (3)

0.02 (86)

 < 0.01 (14)

S maltophilia

0.02 (36)

0.01 (23)

0.02 (62)

0.01 (42)

M morganii

0.04 (70)

0.01 (10)

0.06 (191)a

0.01 (25)

C freundii

0.03 (49)

 < 0.01 (8)

0.03 (103)

 < 0.01 (16)

Gram-positive

S aureus

2.81 (5035)

0.45 (812)

3.05 (10,511)a

0.58 (2,016)b

Enterococcus spp

0.64 (1152)

0.16 (283)

0.74 (2559)a

0.25 (874)b

S pneumoniae

0.42 (751)

0.01 (12)

0.23 (807)a

0.01 (39)

Grp B Strep

0.42 (759)

0.01 (26)

0.45 (1543)a

0.02 (59)

Grp A Strep

0.25 (443)

0.01 (12)

0.19 (651)

 < 0.01 (13)

Fungus/Yeast

Non-C albicans

0.11 (202)

0.10 (181)

0.10 (329)

0.15 (533)b

C albicans

0.07 (121)

0.08 (147)

0.05 (189)

0.13 (446)b

Other—Candida

 < 0.01 (2)

 < 0.01 (6)

 < 0.01 (2)

 < 0.01 (6)b

Pathogen

Pre-pandemic: July 2019-

February 2020

(n = 1,789,449 admissions)

Pandemic period March 2020-

September 4, 2021

(n = 3,450,243 admissions)

Community-onset BSI rate/1000 Adm (n)

Hospital-onset BSI rate/1000 Adm (n)

Community-onset BSI rate/1000 Adm (n)

Hospital-onset BSI rate/1000 Adm (n)

Polymicrobial

0.36 (648)

0.06 (104)

0.42 (1,458)a

0.08 (272)b

  1. aP ≤ 0.0404 for community (CO) pandemic period vs. pre-pandemic period; bP ≤ 0.0093 for HO pandemic period vs pre-pandemic period