Table 1 Clinical, laboratory variables and underlying health condition of study patients*
|  | Category | Overall | Sepsis | OR (95%C.I.) | p > χ2 | |
|---|---|---|---|---|---|---|
No | Yes | |||||
Age** | Continuous |  | 62.0 (20.6) | 71.5(18.5) | 1.03 (1.02–1.03) |  < 0.001 |
Gender | Female | 1314 (48.24) | 1197 (48.8) | 117 (43.0) | 1.00 (–) |  |
Male | 1410 (51.76) | 1255 (51.2) | 155 (57.0) | 1.26 (0.98–1.63) | 0.069 | |
Hypertension | No | 1814 (66.59) | 1651 (67.3) | 163 (59.9) | 1.00 (–) |  |
Yes | 910 (33.41) | 801 (32.7) | 109 (40.1) | 1.38 (1.07–1.78) | 0.015 | |
Dyslipidemia | No | 2471 (90.71) | 2220 (90.5) | 251 (92.3) | 1.00 (–) |  |
Yes | 253 (9.29) | 232 (9.5) | 21 (7.7) | 0.80 (0.50–1.27) | 0.336 | |
Diabetes | No | 2380 (87.37) | 2162 (88.2) | 218 (80.1) | 1.00 (–) |  |
Yes | 344 (12.63) | 290 (11.8) | 54 (19.9) | 1.85 (1.34–2.55) | < 0.001 | |
Obesity | No | 2684 (98.53) | 2418 (98.6) | 266 (97.8) | 1.00 (–) |  |
Yes | 40 (1.47) | 34 (1.4) | 6 (2.2) | 1.60 (0.67–3.86) | 0.317 | |
Smoke | No | 2624 (96.33) | 2367 (96.5) | 257 (94.5) | 1.00 (–) |  |
Yes | 100 (3.67) | 85 (3.5) | 15 (5.5) | 1.63 (0.92–2.86) | 0.109 | |
Drug addiction/alcoholism | No | 2679 (98.35) | 2414 (98.5) | 265 (97.4) | 1.00 (–) |  |
Yes | 45 (1.65) | 38 (1.5) | 7 (2.6) | 1.68 (0.74–3.80) | 0.241 | |
Anemia | No | 2584 (94.86) | 2335 (95.2) | 249 (91.5) | 1.00 (–) |  |
Yes | 140 (5.14) | 117 (4.8) | 23 (8.5) | 1.84 (1.16–2.94) | 0.015 | |
AMI | No | 2483 (91.15) | 2236 (91.2) | 247 (90.8) | 1.00 (–) |  |
Yes | 240 (8.81) | 215 (8.8) | 25 (9.2) | 1.05 (0.68–1.63) | 0.818 | |
Missing | 1 (0.04) | 1 (0.0) | 0 (0.0) | Â | Â | |
TIA | No | 2011 (73.83) | 1828 (74.6) | 183 (67.3) | 1.00 (–) |  |
Yes | 713 (26.17) | 624 (25.4) | 89 (32.7) | 1.42 (1.09–1.86) | 0.011 | |
Other CVD | No | 2568 (94.27) | 2316 (94.5) | 252 (92.6) | 1.00 (–) |  |
Yes | 156 (5.73) | 136 (5.5) | 20 (7.4) | 1.35 (0.83–2.20) | 0.241 | |
COPD | No | 2521 (92.55) | 2278 (92.9) | 243 (89.3) | 1.00 (–) |  |
Yes | 203 (7.45) | 174 (7.1) | 29 (10.7) | 1.56 (1.03–2.37) | 0.043 | |
Endocrinological diseases | No | 2567 (94.24) | 2305 (94.0) | 262 (96.3) | 1.00 (–) |  |
Yes | 157 (5.76) | 147 (6.0) | 10 (3.7) | 0.60 (0.31–1.15) | 0.099 | |
ESRD | No | 2566 (94.2) | 2339 (95.4) | 227 (83.5) | 1.00 (–) |  |
Yes | 158 (5.8) | 113 (4.6) | 45 (16.5) | 4.10 (2.83–5.95) | < 0.001 | |
Hepatitis | No | 2678 (98.31) | 2410 (98.3) | 268 (98.5) | 1.00 (–) |  |
Yes | 45 (1.65) | 41 (1.7) | 4 (1.5) | 0.88 (0.31–2.47) | 0.801 | |
Missing | 1 (0.04) | 1 (0.0) | 0 (0.0) | Â | Â | |
Connectivitis | No | 2714 (99.63) | 2443 (99.6) | 271 (99.6) | 1.00 (–) |  |
Yes | 10 (0.37) | 9 (0.4) | 1 (0.4) | 1.00 (0.13–7.94) | 0.999 | |
Other Immune Disorder | No | 2646 (97.14) | 2380 (97.1) | 266 (97.8) | 1.00 (–) |  |
Yes | 78 (2.86) | 72 (2.9) | 6 (2.2) | 0.75 (0.32–1.73) | 0.477 | |
Solid Tumor Malignancies | No | 2421 (88.88) | 2197 (89.6) | 224 (82.4) | 1.00 (–) |  |
Yes | 303 (11.12) | 255 (10.4) | 48 (17.6) | 1.85 (1.32–2.59) | < 0.001 | |
Hematologic malignancies | No | 2660 (97.65) | 2396 (97.7) | 264 (97.1) | 1.00 (–) |  |
Yes | 64 (2.35) | 56 (2.3) | 8 (2.9) | 1.30 (0.61–2.75) | 0.511 | |
HIV infection | No | 2720 (99.85) | 2448 (99.8) | 272 (100.0) | 1.00 (–) |  |
Yes | 4 (0.15) | 4 (0.2) | 0 (0.0) | 1.00 (0.05–18.59) | 0.359 | |
Neurodegenerative diseases | No | 2464 (90.46) | 2255 (92.0) | 209 (76.8) | 1.00 (–) |  |
Yes | 260 (9.54) | 197 (8.0) | 63 (23.2) | 3.45 (2.51–4.74) | < 0.001 | |
Metabolic diseases | No | 2700 (99.12) | 2434 (99.3) | 266 (97.8) | 1.00 (–) |  |
Yes | 24 (0.88) | 18 (0.7) | 6 (2.2) | 3.05 (1.20–7.75) | 0.034 | |
SIRS | 0 | 12 (0.44) | 1405 (57.3) | 13 (4.8) | 1.00 (–) |  |
1 | 862 (31.64) | 825 (33.6) | 37 (13.6) | 4.85 ( 2.56- 9.17) | < 0.001 | |
2 | 333 (12.22) | 184 (7.5) | 149 (54.8) | 87.52 (48.65- 157.45) | < 0.001 | |
3 | 98 (3.6) | 35 (1.4) | 63 (23.2) | 194.54 (98.08- 385.85) | < 0.001 | |
4 | 13 (0.48) | 3 (0.1) | 10 (3.7) | 360.26 (88.75–1462.44) | < 0.001 | |
MDW | < 22 | 2176 (79.88) | 2095 (85.4) | 81 (29.8) | 1.00 (–) |  |
≥ 22 | 548 (20.12) | 357 (14.6) | 191 (70.2) | 13.84 (10.43–18.37) | < 0.001 | |
WBCs | < 12.2 × 103/µL | 2122 (77.9) | 2025 (82.6) | 97 (35.7) | 1.00 (–) |  |
≥ 12.2 × 103/µL | 602 (22.1) | 427 (17.4) | 175 (64.3) | 8.56 (6.54–11.20) | < 0.001 | |
Neutrophils | < 8.9 × 103/µL | 2013 (73.9) | 1938 (79.0) | 75 (27.6) | 1.00 (–) |  |
≥ 8.9 × 103/µL | 711 (26.1) | 514 (21.0) | 197 (72.4) | 9.90 (7.46–13.15) | < 0.001 | |
Lymphocytes | < 1.3 × 103/µL  ≥ 1.3 × 103/µL | 1768 (64.9) | 1676 (68.4) | 92 (33.8) | 4.23 (3.24–5.51) | < 0.001 |
≥ 1.3 × 103/µL | 956 (35.1) | 776 (31.6) | 180 (66.2) | 1.00 (–) |  | |
Platelet | < 157 × 103/µL | 2360 (86.64) | 2153 (87.8) | 207 (76.1) | 2.26 (1.67–3.06) | < 0.001 |
≥ 157 × 103/µL | 364 (13.36) | 299 (12.2) | 65 (23.9) | 1.00 (–) |  | |
CRP | < 19.1 mg/L | 1645 (60.39) | 1601 (65.3) | 44 (16.2) | 1.00 (–) |  |
≥ 19.1 mg/L | 734 (26.95) | 530 (21.6) | 204 (75.0) | 14.01 (9.97–19.68) | < 0.001 | |
Missing | 345 (12.67) | 321 (13.1) | 24 (8.8) | Â | Â | |